Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB88_LEIMA

TriTrypDb:

LmjF.23.0750 , LMJLV39_230016200 , LMJSD75_230016500

Length:

1033

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	639	643	PF00656	0.563
CLV_C14_Caspase3-7	670	674	PF00656	0.487
CLV_C14_Caspase3-7	744	748	PF00656	0.547
CLV_C14_Caspase3-7	890	894	PF00656	0.711
CLV_MEL_PAP_1	79	85	PF00089	0.438
CLV_NRD_NRD_1	187	189	PF00675	0.482
CLV_NRD_NRD_1	200	202	PF00675	0.462
CLV_NRD_NRD_1	26	28	PF00675	0.485
CLV_NRD_NRD_1	289	291	PF00675	0.494
CLV_NRD_NRD_1	380	382	PF00675	0.675
CLV_NRD_NRD_1	621	623	PF00675	0.410
CLV_NRD_NRD_1	863	865	PF00675	0.507
CLV_NRD_NRD_1	882	884	PF00675	0.465
CLV_PCSK_KEX2_1	189	191	PF00082	0.485
CLV_PCSK_KEX2_1	200	202	PF00082	0.486
CLV_PCSK_KEX2_1	26	28	PF00082	0.485
CLV_PCSK_KEX2_1	289	291	PF00082	0.468
CLV_PCSK_KEX2_1	380	382	PF00082	0.628
CLV_PCSK_KEX2_1	690	692	PF00082	0.521
CLV_PCSK_KEX2_1	863	865	PF00082	0.507
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.464
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.457
CLV_PCSK_SKI1_1	15	19	PF00082	0.468
CLV_PCSK_SKI1_1	200	204	PF00082	0.452
CLV_PCSK_SKI1_1	304	308	PF00082	0.566
CLV_PCSK_SKI1_1	677	681	PF00082	0.487
CLV_PCSK_SKI1_1	703	707	PF00082	0.387
DEG_COP1_1	813	820	PF00400	0.440
DEG_SPOP_SBC_1	171	175	PF00917	0.481
DEG_SPOP_SBC_1	240	244	PF00917	0.541
DOC_ANK_TNKS_1	382	389	PF00023	0.642
DOC_ANK_TNKS_1	42	49	PF00023	0.423
DOC_CKS1_1	39	44	PF01111	0.437
DOC_CYCLIN_RxL_1	417	428	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.401
DOC_MAPK_DCC_7	43	51	PF00069	0.429
DOC_MAPK_gen_1	687	697	PF00069	0.464
DOC_MAPK_gen_1	700	709	PF00069	0.399
DOC_MAPK_JIP1_4	980	986	PF00069	0.539
DOC_MAPK_MEF2A_6	211	220	PF00069	0.560
DOC_MAPK_MEF2A_6	38	46	PF00069	0.439
DOC_MAPK_MEF2A_6	690	697	PF00069	0.459
DOC_MAPK_MEF2A_6	7	14	PF00069	0.434
DOC_MAPK_MEF2A_6	700	709	PF00069	0.403
DOC_MAPK_MEF2A_6	76	83	PF00069	0.442
DOC_MAPK_NFAT4_5	76	84	PF00069	0.439
DOC_PP2B_LxvP_1	161	164	PF13499	0.450
DOC_PP2B_LxvP_1	44	47	PF13499	0.430
DOC_PP4_FxxP_1	54	57	PF00568	0.434
DOC_PP4_FxxP_1	826	829	PF00568	0.474
DOC_USP7_MATH_1	115	119	PF00917	0.494
DOC_USP7_MATH_1	240	244	PF00917	0.483
DOC_USP7_MATH_1	258	262	PF00917	0.457
DOC_USP7_MATH_1	369	373	PF00917	0.595
DOC_USP7_MATH_1	57	61	PF00917	0.428
DOC_USP7_MATH_1	759	763	PF00917	0.680
DOC_USP7_MATH_1	793	797	PF00917	0.604
DOC_USP7_MATH_1	913	917	PF00917	0.608
DOC_USP7_MATH_1	941	945	PF00917	0.476
DOC_USP7_MATH_1	991	995	PF00917	0.573
DOC_USP7_UBL2_3	24	28	PF12436	0.476
DOC_USP7_UBL2_3	298	302	PF12436	0.537
DOC_USP7_UBL2_3	880	884	PF12436	0.593
DOC_WW_Pin1_4	124	129	PF00397	0.431
DOC_WW_Pin1_4	172	177	PF00397	0.485
DOC_WW_Pin1_4	38	43	PF00397	0.444
DOC_WW_Pin1_4	491	496	PF00397	0.629
DOC_WW_Pin1_4	53	58	PF00397	0.429
DOC_WW_Pin1_4	788	793	PF00397	0.588
DOC_WW_Pin1_4	942	947	PF00397	0.406
LIG_14-3-3_CanoR_1	1024	1029	PF00244	0.506
LIG_14-3-3_CanoR_1	116	121	PF00244	0.477
LIG_14-3-3_CanoR_1	172	176	PF00244	0.498
LIG_14-3-3_CanoR_1	200	205	PF00244	0.494
LIG_14-3-3_CanoR_1	259	263	PF00244	0.439
LIG_14-3-3_CanoR_1	469	474	PF00244	0.534
LIG_14-3-3_CanoR_1	521	530	PF00244	0.535
LIG_14-3-3_CanoR_1	544	550	PF00244	0.328
LIG_14-3-3_CanoR_1	58	62	PF00244	0.433
LIG_14-3-3_CanoR_1	677	686	PF00244	0.467
LIG_14-3-3_CanoR_1	76	80	PF00244	0.440
LIG_14-3-3_CanoR_1	840	848	PF00244	0.410
LIG_14-3-3_CanoR_1	863	870	PF00244	0.570
LIG_14-3-3_CanoR_1	90	95	PF00244	0.465
LIG_14-3-3_CanoR_1	938	946	PF00244	0.491
LIG_Actin_WH2_2	1009	1026	PF00022	0.512
LIG_Actin_WH2_2	195	213	PF00022	0.448
LIG_Actin_WH2_2	702	719	PF00022	0.367
LIG_BIR_III_4	642	646	PF00653	0.579
LIG_BIR_III_4	712	716	PF00653	0.485
LIG_BIR_III_4	893	897	PF00653	0.612
LIG_BRCT_BRCA1_1	1026	1030	PF00533	0.587
LIG_BRCT_BRCA1_1	67	71	PF00533	0.435
LIG_BRCT_BRCA1_1	675	679	PF00533	0.503
LIG_Clathr_ClatBox_1	424	428	PF01394	0.344
LIG_CSL_BTD_1	465	468	PF09270	0.565
LIG_EVH1_1	161	165	PF00568	0.447
LIG_FHA_1	211	217	PF00498	0.576
LIG_FHA_1	315	321	PF00498	0.562
LIG_FHA_1	39	45	PF00498	0.436
LIG_FHA_1	413	419	PF00498	0.430
LIG_FHA_1	492	498	PF00498	0.494
LIG_FHA_1	552	558	PF00498	0.288
LIG_FHA_1	654	660	PF00498	0.610
LIG_FHA_1	678	684	PF00498	0.468
LIG_FHA_1	758	764	PF00498	0.687
LIG_FHA_1	842	848	PF00498	0.413
LIG_FHA_2	1015	1021	PF00498	0.443
LIG_FHA_2	331	337	PF00498	0.635
LIG_FHA_2	341	347	PF00498	0.625
LIG_LIR_Apic_2	261	266	PF02991	0.467
LIG_LIR_Apic_2	813	818	PF02991	0.561
LIG_LIR_Apic_2	823	829	PF02991	0.422
LIG_LIR_Gen_1	203	214	PF02991	0.519
LIG_LIR_Gen_1	250	260	PF02991	0.438
LIG_LIR_Gen_1	66	77	PF02991	0.432
LIG_LIR_Gen_1	845	856	PF02991	0.339
LIG_LIR_Nem_3	213	217	PF02991	0.480
LIG_LIR_Nem_3	250	256	PF02991	0.427
LIG_LIR_Nem_3	261	265	PF02991	0.455
LIG_LIR_Nem_3	566	572	PF02991	0.334
LIG_LIR_Nem_3	66	72	PF02991	0.433
LIG_LIR_Nem_3	801	806	PF02991	0.313
LIG_LIR_Nem_3	845	851	PF02991	0.335
LIG_MYND_1	109	113	PF01753	0.452
LIG_Pex14_2	220	224	PF04695	0.449
LIG_PTB_Apo_2	218	225	PF02174	0.411
LIG_RPA_C_Fungi	22	34	PF08784	0.481
LIG_SH2_CRK	214	218	PF00017	0.445
LIG_SH2_CRK	263	267	PF00017	0.499
LIG_SH2_CRK	409	413	PF00017	0.499
LIG_SH2_CRK	547	551	PF00017	0.311
LIG_SH2_CRK	843	847	PF00017	0.394
LIG_SH2_NCK_1	263	267	PF00017	0.499
LIG_SH2_SRC	179	182	PF00017	0.479
LIG_SH2_SRC	274	277	PF00017	0.501
LIG_SH2_STAP1	843	847	PF00017	0.413
LIG_SH2_STAP1	848	852	PF00017	0.384
LIG_SH2_STAT3	564	567	PF00017	0.452
LIG_SH2_STAT3	956	959	PF00017	0.444
LIG_SH2_STAT5	40	43	PF00017	0.431
LIG_SH2_STAT5	423	426	PF00017	0.349
LIG_SH2_STAT5	431	434	PF00017	0.403
LIG_SH2_STAT5	696	699	PF00017	0.426
LIG_SH2_STAT5	74	77	PF00017	0.439
LIG_SH2_STAT5	810	813	PF00017	0.395
LIG_SH2_STAT5	815	818	PF00017	0.336
LIG_SH2_STAT5	843	846	PF00017	0.402
LIG_SH3_1	160	166	PF00018	0.452
LIG_SH3_1	234	240	PF00018	0.493
LIG_SH3_3	1026	1032	PF00018	0.588
LIG_SH3_3	122	128	PF00018	0.470
LIG_SH3_3	156	162	PF00018	0.494
LIG_SH3_3	234	240	PF00018	0.482
LIG_SH3_3	262	268	PF00018	0.520
LIG_SH3_3	483	489	PF00018	0.587
LIG_SH3_3	631	637	PF00018	0.511
LIG_SH3_3	806	812	PF00018	0.342
LIG_SH3_3	826	832	PF00018	0.293
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.388
LIG_SUMO_SIM_anti_2	554	559	PF11976	0.241
LIG_SUMO_SIM_par_1	414	419	PF11976	0.418
LIG_SUMO_SIM_par_1	591	597	PF11976	0.358
LIG_SUMO_SIM_par_1	759	764	PF11976	0.572
LIG_SUMO_SIM_par_1	966	972	PF11976	0.406
LIG_TRAF2_1	372	375	PF00917	0.644
LIG_TYR_ITIM	841	846	PF00017	0.392
LIG_UBA3_1	17	24	PF00899	0.471
LIG_UBA3_1	590	598	PF00899	0.288
LIG_UBA3_1	704	708	PF00899	0.385
LIG_WW_3	466	470	PF00397	0.579
MOD_CDK_SPK_2	38	43	PF00069	0.444
MOD_CDK_SPK_2	53	58	PF00069	0.429
MOD_CDK_SPK_2	942	947	PF00069	0.465
MOD_CK1_1	119	125	PF00069	0.469
MOD_CK1_1	147	153	PF00069	0.440
MOD_CK1_1	540	546	PF00069	0.436
MOD_CK1_1	56	62	PF00069	0.433
MOD_CK1_1	594	600	PF00069	0.395
MOD_CK1_1	65	71	PF00069	0.436
MOD_CK1_1	788	794	PF00069	0.613
MOD_CK1_1	882	888	PF00069	0.581
MOD_CK2_1	330	336	PF00069	0.586
MOD_CK2_1	340	346	PF00069	0.579
MOD_CK2_1	369	375	PF00069	0.639
MOD_CK2_1	600	606	PF00069	0.333
MOD_CK2_1	678	684	PF00069	0.491
MOD_CK2_1	922	928	PF00069	0.640
MOD_GlcNHglycan	34	37	PF01048	0.480
MOD_GlcNHglycan	364	367	PF01048	0.614
MOD_GlcNHglycan	524	527	PF01048	0.422
MOD_GlcNHglycan	680	683	PF01048	0.483
MOD_GlcNHglycan	742	746	PF01048	0.640
MOD_GlcNHglycan	795	798	PF01048	0.556
MOD_GlcNHglycan	865	868	PF01048	0.601
MOD_GlcNHglycan	884	887	PF01048	0.468
MOD_GlcNHglycan	915	918	PF01048	0.762
MOD_GlcNHglycan	971	974	PF01048	0.483
MOD_GlcNHglycan	993	996	PF01048	0.575
MOD_GSK3_1	115	122	PF00069	0.478
MOD_GSK3_1	235	242	PF00069	0.478
MOD_GSK3_1	358	365	PF00069	0.587
MOD_GSK3_1	412	419	PF00069	0.439
MOD_GSK3_1	499	506	PF00069	0.534
MOD_GSK3_1	53	60	PF00069	0.456
MOD_GSK3_1	673	680	PF00069	0.451
MOD_GSK3_1	782	789	PF00069	0.600
MOD_GSK3_1	816	823	PF00069	0.413
MOD_GSK3_1	90	97	PF00069	0.451
MOD_GSK3_1	918	925	PF00069	0.679
MOD_GSK3_1	942	949	PF00069	0.427
MOD_N-GLC_1	330	335	PF02516	0.560
MOD_N-GLC_1	469	474	PF02516	0.534
MOD_NEK2_1	144	149	PF00069	0.390
MOD_NEK2_1	210	215	PF00069	0.586
MOD_NEK2_1	241	246	PF00069	0.526
MOD_NEK2_1	551	556	PF00069	0.308
MOD_NEK2_1	774	779	PF00069	0.732
MOD_NEK2_1	81	86	PF00069	0.438
MOD_NEK2_1	847	852	PF00069	0.460
MOD_NEK2_1	879	884	PF00069	0.592
MOD_NEK2_1	939	944	PF00069	0.419
MOD_NEK2_1	98	103	PF00069	0.435
MOD_NEK2_2	258	263	PF00069	0.426
MOD_NEK2_2	568	573	PF00069	0.288
MOD_NEK2_2	57	62	PF00069	0.430
MOD_NEK2_2	75	80	PF00069	0.430
MOD_OFUCOSY	142	148	PF10250	0.396
MOD_PIKK_1	116	122	PF00454	0.478
MOD_PIKK_1	563	569	PF00454	0.358
MOD_PIKK_1	804	810	PF00454	0.336
MOD_PIKK_1	946	952	PF00454	0.466
MOD_PK_1	1024	1030	PF00069	0.509
MOD_PK_1	27	33	PF00069	0.489
MOD_PKA_1	200	206	PF00069	0.486
MOD_PKA_1	27	33	PF00069	0.489
MOD_PKA_1	863	869	PF00069	0.522
MOD_PKA_2	115	121	PF00069	0.478
MOD_PKA_2	171	177	PF00069	0.474
MOD_PKA_2	200	206	PF00069	0.496
MOD_PKA_2	258	264	PF00069	0.510
MOD_PKA_2	57	63	PF00069	0.428
MOD_PKA_2	716	722	PF00069	0.465
MOD_PKA_2	75	81	PF00069	0.430
MOD_PKA_2	863	869	PF00069	0.521
MOD_PKA_2	871	877	PF00069	0.513
MOD_PKA_2	882	888	PF00069	0.549
MOD_Plk_1	374	380	PF00069	0.625
MOD_Plk_1	469	475	PF00069	0.557
MOD_Plk_1	779	785	PF00069	0.563
MOD_Plk_2-3	871	877	PF00069	0.562
MOD_Plk_2-3	998	1004	PF00069	0.656
MOD_Plk_4	119	125	PF00069	0.469
MOD_Plk_4	205	211	PF00069	0.496
MOD_Plk_4	258	264	PF00069	0.475
MOD_Plk_4	553	559	PF00069	0.241
MOD_Plk_4	607	613	PF00069	0.454
MOD_Plk_4	654	660	PF00069	0.610
MOD_Plk_4	811	817	PF00069	0.366
MOD_Plk_4	842	848	PF00069	0.410
MOD_Plk_4	99	105	PF00069	0.446
MOD_ProDKin_1	124	130	PF00069	0.427
MOD_ProDKin_1	172	178	PF00069	0.476
MOD_ProDKin_1	38	44	PF00069	0.443
MOD_ProDKin_1	491	497	PF00069	0.628
MOD_ProDKin_1	53	59	PF00069	0.428
MOD_ProDKin_1	788	794	PF00069	0.585
MOD_ProDKin_1	942	948	PF00069	0.410
MOD_SUMO_rev_2	183	191	PF00179	0.475
MOD_SUMO_rev_2	249	258	PF00179	0.391
TRG_DiLeu_BaEn_1	1021	1026	PF01217	0.556
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.463
TRG_DiLeu_LyEn_5	1021	1026	PF01217	0.533
TRG_ENDOCYTIC_2	206	209	PF00928	0.500
TRG_ENDOCYTIC_2	214	217	PF00928	0.466
TRG_ENDOCYTIC_2	696	699	PF00928	0.432
TRG_ENDOCYTIC_2	74	77	PF00928	0.439
TRG_ENDOCYTIC_2	843	846	PF00928	0.443
TRG_ENDOCYTIC_2	848	851	PF00928	0.449
TRG_ER_diArg_1	188	191	PF00400	0.487
TRG_ER_diArg_1	199	201	PF00400	0.486
TRG_ER_diArg_1	288	290	PF00400	0.401
TRG_ER_diArg_1	379	381	PF00400	0.635
TRG_ER_diArg_1	383	386	PF00400	0.597
TRG_ER_diArg_1	862	864	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	952	957	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S9	Leptomonas seymouri	34%	100%
A0A3S7WXS1	Leishmania donovani	82%	100%
A4HCU0	Leishmania braziliensis	60%	100%
A4I0C6	Leishmania infantum	79%	100%
E9AW90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%