Putative mitochondrial RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QB87_LEIMA

TriTrypDb:

LmjF.23.0760 , LMJLV39_230016300 , LMJSD75_230016600

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB87

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.307
CLV_NRD_NRD_1	104	106	PF00675	0.515
CLV_NRD_NRD_1	182	184	PF00675	0.512
CLV_NRD_NRD_1	212	214	PF00675	0.539
CLV_NRD_NRD_1	279	281	PF00675	0.549
CLV_NRD_NRD_1	3	5	PF00675	0.656
CLV_NRD_NRD_1	310	312	PF00675	0.469
CLV_PCSK_KEX2_1	182	184	PF00082	0.603
CLV_PCSK_KEX2_1	212	214	PF00082	0.539
CLV_PCSK_KEX2_1	3	5	PF00082	0.656
CLV_PCSK_KEX2_1	309	311	PF00082	0.428
DEG_APCC_DBOX_1	3	11	PF00400	0.659
DEG_APCC_KENBOX_2	137	141	PF00400	0.606
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DOC_MAPK_gen_1	309	315	PF00069	0.342
DOC_PP1_RVXF_1	109	115	PF00149	0.460
DOC_PP2B_LxvP_1	88	91	PF13499	0.332
DOC_USP7_MATH_1	147	151	PF00917	0.473
DOC_USP7_MATH_1	273	277	PF00917	0.665
DOC_USP7_MATH_1	97	101	PF00917	0.460
DOC_USP7_UBL2_3	155	159	PF12436	0.527
DOC_WW_Pin1_4	43	48	PF00397	0.345
DOC_WW_Pin1_4	86	91	PF00397	0.329
LIG_14-3-3_CanoR_1	122	126	PF00244	0.528
LIG_14-3-3_CanoR_1	3	8	PF00244	0.714
LIG_BRCT_BRCA1_1	200	204	PF00533	0.633
LIG_Clathr_ClatBox_1	327	331	PF01394	0.401
LIG_Clathr_ClatBox_1	81	85	PF01394	0.342
LIG_DLG_GKlike_1	3	10	PF00625	0.629
LIG_FHA_1	24	30	PF00498	0.501
LIG_FHA_1	264	270	PF00498	0.514
LIG_FHA_1	69	75	PF00498	0.315
LIG_FHA_2	291	297	PF00498	0.451
LIG_LIR_Apic_2	298	303	PF02991	0.322
LIG_LIR_Gen_1	190	199	PF02991	0.424
LIG_LIR_Nem_3	190	195	PF02991	0.435
LIG_LIR_Nem_3	216	220	PF02991	0.486
LIG_Pex14_2	282	286	PF04695	0.620
LIG_REV1ctd_RIR_1	215	221	PF16727	0.437
LIG_SH2_STAT5	209	212	PF00017	0.429
LIG_SH3_3	259	265	PF00018	0.529
LIG_Sin3_3	16	23	PF02671	0.489
LIG_SUMO_SIM_par_1	25	31	PF11976	0.328
LIG_TRFH_1	218	222	PF08558	0.549
LIG_WRC_WIRS_1	264	269	PF05994	0.510
MOD_CK1_1	100	106	PF00069	0.464
MOD_CK1_1	124	130	PF00069	0.575
MOD_CK1_1	164	170	PF00069	0.581
MOD_CK1_1	178	184	PF00069	0.363
MOD_CK1_1	276	282	PF00069	0.675
MOD_CK1_1	316	322	PF00069	0.481
MOD_CK2_1	164	170	PF00069	0.572
MOD_CK2_1	86	92	PF00069	0.309
MOD_GlcNHglycan	166	169	PF01048	0.566
MOD_GlcNHglycan	177	180	PF01048	0.362
MOD_GlcNHglycan	205	208	PF01048	0.446
MOD_GlcNHglycan	269	272	PF01048	0.517
MOD_GlcNHglycan	319	322	PF01048	0.376
MOD_GlcNHglycan	7	10	PF01048	0.703
MOD_GSK3_1	147	154	PF00069	0.459
MOD_GSK3_1	160	167	PF00069	0.541
MOD_GSK3_1	19	26	PF00069	0.669
MOD_GSK3_1	263	270	PF00069	0.554
MOD_GSK3_1	313	320	PF00069	0.467
MOD_GSK3_1	97	104	PF00069	0.457
MOD_NEK2_1	153	158	PF00069	0.523
MOD_NEK2_1	160	165	PF00069	0.362
MOD_NEK2_1	208	213	PF00069	0.457
MOD_PIKK_1	153	159	PF00454	0.577
MOD_PIKK_1	161	167	PF00454	0.333
MOD_PIKK_1	28	34	PF00454	0.307
MOD_PIKK_1	68	74	PF00454	0.322
MOD_PKA_1	3	9	PF00069	0.695
MOD_PKA_2	121	127	PF00069	0.596
MOD_PKA_2	147	153	PF00069	0.443
MOD_PKA_2	3	9	PF00069	0.713
MOD_Plk_4	147	153	PF00069	0.481
MOD_Plk_4	263	269	PF00069	0.500
MOD_ProDKin_1	43	49	PF00069	0.345
MOD_ProDKin_1	86	92	PF00069	0.329
MOD_SUMO_for_1	62	65	PF00179	0.451
TRG_DiLeu_BaEn_1	190	195	PF01217	0.461
TRG_ENDOCYTIC_2	325	328	PF00928	0.451
TRG_ER_diArg_1	182	184	PF00400	0.603
TRG_ER_diArg_1	2	4	PF00400	0.651
TRG_ER_diArg_1	309	311	PF00400	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F7	Leptomonas seymouri	82%	100%
A0A0S4IYJ9	Bodo saltans	45%	100%
A0A1X0NXK3	Trypanosomatidae	70%	100%
A0A3Q8IB02	Leishmania donovani	98%	100%
A0A3R7MG63	Trypanosoma rangeli	72%	100%
A4HCU6	Leishmania braziliensis	93%	100%
A4I0C7	Leishmania infantum	98%	100%
C9ZV43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AW91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BBM3	Trypanosoma cruzi	70%	93%