DUF676 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania major

UniProt:

Q4QB85_LEIMA

TriTrypDb:

LmjF.23.0780 , LMJLV39_230016500 , LMJSD75_230016800

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB85

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.609
CLV_C14_Caspase3-7	224	228	PF00656	0.671
CLV_C14_Caspase3-7	34	38	PF00656	0.782
CLV_NRD_NRD_1	255	257	PF00675	0.708
CLV_NRD_NRD_1	305	307	PF00675	0.493
CLV_NRD_NRD_1	329	331	PF00675	0.640
CLV_NRD_NRD_1	462	464	PF00675	0.476
CLV_NRD_NRD_1	478	480	PF00675	0.257
CLV_NRD_NRD_1	735	737	PF00675	0.706
CLV_NRD_NRD_1	747	749	PF00675	0.564
CLV_NRD_NRD_1	775	777	PF00675	0.679
CLV_NRD_NRD_1	798	800	PF00675	0.594
CLV_NRD_NRD_1	883	885	PF00675	0.492
CLV_PCSK_FUR_1	796	800	PF00082	0.573
CLV_PCSK_KEX2_1	21	23	PF00082	0.680
CLV_PCSK_KEX2_1	255	257	PF00082	0.708
CLV_PCSK_KEX2_1	305	307	PF00082	0.493
CLV_PCSK_KEX2_1	329	331	PF00082	0.640
CLV_PCSK_KEX2_1	462	464	PF00082	0.369
CLV_PCSK_KEX2_1	477	479	PF00082	0.369
CLV_PCSK_KEX2_1	734	736	PF00082	0.715
CLV_PCSK_KEX2_1	747	749	PF00082	0.553
CLV_PCSK_KEX2_1	775	777	PF00082	0.822
CLV_PCSK_KEX2_1	798	800	PF00082	0.585
CLV_PCSK_KEX2_1	883	885	PF00082	0.617
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.680
CLV_PCSK_PC7_1	251	257	PF00082	0.488
CLV_PCSK_PC7_1	458	464	PF00082	0.510
CLV_PCSK_SKI1_1	197	201	PF00082	0.749
CLV_PCSK_SKI1_1	305	309	PF00082	0.489
CLV_PCSK_SKI1_1	329	333	PF00082	0.562
CLV_PCSK_SKI1_1	373	377	PF00082	0.501
CLV_PCSK_SKI1_1	462	466	PF00082	0.530
CLV_PCSK_SKI1_1	478	482	PF00082	0.265
CLV_PCSK_SKI1_1	487	491	PF00082	0.381
CLV_PCSK_SKI1_1	533	537	PF00082	0.718
CLV_PCSK_SKI1_1	728	732	PF00082	0.553
DEG_APCC_DBOX_1	304	312	PF00400	0.471
DEG_APCC_DBOX_1	372	380	PF00400	0.530
DEG_APCC_DBOX_1	400	408	PF00400	0.530
DEG_COP1_1	167	175	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.718
DEG_SCF_FBW7_1	812	818	PF00400	0.551
DEG_SPOP_SBC_1	176	180	PF00917	0.720
DEG_SPOP_SBC_1	632	636	PF00917	0.824
DEG_SPOP_SBC_1	657	661	PF00917	0.790
DOC_CKS1_1	417	422	PF01111	0.530
DOC_CKS1_1	812	817	PF01111	0.548
DOC_CYCLIN_RxL_1	458	467	PF00134	0.529
DOC_CYCLIN_RxL_1	476	485	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	726	732	PF00134	0.712
DOC_MAPK_gen_1	401	409	PF00069	0.530
DOC_MAPK_gen_1	734	741	PF00069	0.713
DOC_MAPK_HePTP_8	460	472	PF00069	0.491
DOC_MAPK_MEF2A_6	373	380	PF00069	0.379
DOC_MAPK_MEF2A_6	403	411	PF00069	0.530
DOC_MAPK_MEF2A_6	463	472	PF00069	0.530
DOC_MAPK_NFAT4_5	373	381	PF00069	0.530
DOC_PP1_RVXF_1	476	483	PF00149	0.530
DOC_PP2B_LxvP_1	739	742	PF13499	0.716
DOC_USP7_MATH_1	105	109	PF00917	0.619
DOC_USP7_MATH_1	146	150	PF00917	0.693
DOC_USP7_MATH_1	156	160	PF00917	0.703
DOC_USP7_MATH_1	31	35	PF00917	0.709
DOC_USP7_MATH_1	38	42	PF00917	0.746
DOC_USP7_MATH_1	632	636	PF00917	0.843
DOC_USP7_MATH_1	837	841	PF00917	0.616
DOC_USP7_MATH_1	846	850	PF00917	0.669
DOC_USP7_MATH_1	853	857	PF00917	0.548
DOC_USP7_MATH_1	859	863	PF00917	0.611
DOC_WW_Pin1_4	12	17	PF00397	0.707
DOC_WW_Pin1_4	124	129	PF00397	0.778
DOC_WW_Pin1_4	284	289	PF00397	0.594
DOC_WW_Pin1_4	416	421	PF00397	0.530
DOC_WW_Pin1_4	42	47	PF00397	0.600
DOC_WW_Pin1_4	606	611	PF00397	0.663
DOC_WW_Pin1_4	640	645	PF00397	0.762
DOC_WW_Pin1_4	651	656	PF00397	0.849
DOC_WW_Pin1_4	740	745	PF00397	0.787
DOC_WW_Pin1_4	811	816	PF00397	0.733
DOC_WW_Pin1_4	871	876	PF00397	0.509
DOC_WW_Pin1_4	913	918	PF00397	0.722
LIG_14-3-3_CanoR_1	116	121	PF00244	0.663
LIG_14-3-3_CanoR_1	140	146	PF00244	0.667
LIG_14-3-3_CanoR_1	162	166	PF00244	0.771
LIG_14-3-3_CanoR_1	347	356	PF00244	0.643
LIG_14-3-3_CanoR_1	387	394	PF00244	0.456
LIG_14-3-3_CanoR_1	406	412	PF00244	0.290
LIG_14-3-3_CanoR_1	565	574	PF00244	0.761
LIG_14-3-3_CanoR_1	629	638	PF00244	0.730
LIG_14-3-3_CanoR_1	664	669	PF00244	0.744
LIG_14-3-3_CanoR_1	748	757	PF00244	0.640
LIG_14-3-3_CanoR_1	776	786	PF00244	0.769
LIG_14-3-3_CanoR_1	791	800	PF00244	0.663
LIG_14-3-3_CanoR_1	847	851	PF00244	0.631
LIG_14-3-3_CanoR_1	883	889	PF00244	0.646
LIG_BRCT_BRCA1_1	496	500	PF00533	0.657
LIG_BRCT_BRCA1_1	666	670	PF00533	0.734
LIG_BRCT_BRCA1_1	726	730	PF00533	0.673
LIG_Clathr_ClatBox_1	378	382	PF01394	0.471
LIG_CSL_BTD_1	428	431	PF09270	0.530
LIG_CSL_BTD_1	812	815	PF09270	0.539
LIG_deltaCOP1_diTrp_1	426	434	PF00928	0.530
LIG_deltaCOP1_diTrp_1	809	813	PF00928	0.560
LIG_EH1_1	573	581	PF00400	0.550
LIG_eIF4E_1	574	580	PF01652	0.613
LIG_FHA_1	167	173	PF00498	0.708
LIG_FHA_1	178	184	PF00498	0.615
LIG_FHA_1	454	460	PF00498	0.282
LIG_FHA_1	493	499	PF00498	0.379
LIG_FHA_1	506	512	PF00498	0.560
LIG_FHA_1	623	629	PF00498	0.762
LIG_FHA_1	643	649	PF00498	0.583
LIG_FHA_1	663	669	PF00498	0.678
LIG_FHA_1	685	691	PF00498	0.686
LIG_FHA_1	757	763	PF00498	0.701
LIG_FHA_1	782	788	PF00498	0.742
LIG_FHA_1	822	828	PF00498	0.826
LIG_FHA_1	846	852	PF00498	0.710
LIG_FHA_2	13	19	PF00498	0.699
LIG_FHA_2	445	451	PF00498	0.530
LIG_FHA_2	483	489	PF00498	0.400
LIG_FHA_2	573	579	PF00498	0.660
LIG_FHA_2	824	830	PF00498	0.637
LIG_FHA_2	862	868	PF00498	0.724
LIG_GBD_Chelix_1	878	886	PF00786	0.648
LIG_Integrin_isoDGR_2	274	276	PF01839	0.555
LIG_LIR_Gen_1	374	384	PF02991	0.369
LIG_LIR_Gen_1	410	418	PF02991	0.530
LIG_LIR_Gen_1	447	453	PF02991	0.530
LIG_LIR_Gen_1	497	506	PF02991	0.694
LIG_LIR_Gen_1	52	58	PF02991	0.586
LIG_LIR_Gen_1	539	548	PF02991	0.674
LIG_LIR_Gen_1	69	78	PF02991	0.353
LIG_LIR_Nem_3	18	23	PF02991	0.664
LIG_LIR_Nem_3	366	370	PF02991	0.413
LIG_LIR_Nem_3	374	380	PF02991	0.326
LIG_LIR_Nem_3	410	414	PF02991	0.530
LIG_LIR_Nem_3	426	432	PF02991	0.530
LIG_LIR_Nem_3	447	451	PF02991	0.530
LIG_LIR_Nem_3	497	503	PF02991	0.639
LIG_LIR_Nem_3	508	513	PF02991	0.526
LIG_LIR_Nem_3	52	57	PF02991	0.590
LIG_LIR_Nem_3	69	73	PF02991	0.355
LIG_LIR_Nem_3	727	733	PF02991	0.659
LIG_NRBOX	1	7	PF00104	0.631
LIG_NRBOX	375	381	PF00104	0.530
LIG_PDZ_Class_2	926	931	PF00595	0.653
LIG_Pex14_1	429	433	PF04695	0.530
LIG_Pex14_2	670	674	PF04695	0.687
LIG_PTB_Apo_2	906	913	PF02174	0.707
LIG_REV1ctd_RIR_1	728	739	PF16727	0.612
LIG_RPA_C_Fungi	246	258	PF08784	0.497
LIG_SH2_CRK	132	136	PF00017	0.714
LIG_SH2_CRK	54	58	PF00017	0.568
LIG_SH2_GRB2like	617	620	PF00017	0.580
LIG_SH2_STAP1	336	340	PF00017	0.638
LIG_SH2_STAP1	448	452	PF00017	0.530
LIG_SH2_STAT3	263	266	PF00017	0.607
LIG_SH2_STAT5	293	296	PF00017	0.521
LIG_SH2_STAT5	377	380	PF00017	0.369
LIG_SH2_STAT5	433	436	PF00017	0.369
LIG_SH2_STAT5	574	577	PF00017	0.652
LIG_SH2_STAT5	617	620	PF00017	0.615
LIG_SH3_2	30	35	PF14604	0.519
LIG_SH3_3	170	176	PF00018	0.726
LIG_SH3_3	27	33	PF00018	0.487
LIG_SH3_3	414	420	PF00018	0.476
LIG_SH3_3	47	53	PF00018	0.531
LIG_SH3_3	528	534	PF00018	0.645
LIG_SH3_3	690	696	PF00018	0.832
LIG_SH3_3	847	853	PF00018	0.587
LIG_SUMO_SIM_anti_2	609	615	PF11976	0.660
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.580
LIG_SUMO_SIM_par_1	377	382	PF11976	0.471
LIG_SUMO_SIM_par_1	532	539	PF11976	0.637
LIG_SUMO_SIM_par_1	609	615	PF11976	0.590
LIG_TRAF2_1	539	542	PF00917	0.733
LIG_TRAF2_1	923	926	PF00917	0.570
LIG_UBA3_1	1	7	PF00899	0.747
LIG_ULM_U2AF65_1	329	334	PF00076	0.567
LIG_WRC_WIRS_1	165	170	PF05994	0.594
LIG_WRC_WIRS_1	537	542	PF05994	0.726
LIG_WRC_WIRS_1	841	846	PF05994	0.539
LIG_WW_2	30	33	PF00397	0.498
LIG_WW_3	513	517	PF00397	0.491
MOD_CDK_SPK_2	815	820	PF00069	0.730
MOD_CDK_SPK_2	871	876	PF00069	0.492
MOD_CDK_SPxxK_3	42	49	PF00069	0.589
MOD_CDK_SPxxK_3	740	747	PF00069	0.720
MOD_CK1_1	12	18	PF00069	0.682
MOD_CK1_1	167	173	PF00069	0.804
MOD_CK1_1	178	184	PF00069	0.667
MOD_CK1_1	287	293	PF00069	0.635
MOD_CK1_1	553	559	PF00069	0.655
MOD_CK1_1	563	569	PF00069	0.639
MOD_CK1_1	599	605	PF00069	0.689
MOD_CK1_1	643	649	PF00069	0.650
MOD_CK1_1	712	718	PF00069	0.823
MOD_CK1_1	724	730	PF00069	0.601
MOD_CK1_1	749	755	PF00069	0.582
MOD_CK1_1	770	776	PF00069	0.754
MOD_CK1_1	777	783	PF00069	0.663
MOD_CK1_1	840	846	PF00069	0.592
MOD_CK2_1	105	111	PF00069	0.566
MOD_CK2_1	444	450	PF00069	0.530
MOD_CK2_1	536	542	PF00069	0.576
MOD_CK2_1	599	605	PF00069	0.666
MOD_CK2_1	609	615	PF00069	0.693
MOD_CK2_1	749	755	PF00069	0.621
MOD_CK2_1	81	87	PF00069	0.582
MOD_CK2_1	823	829	PF00069	0.644
MOD_GlcNHglycan	107	110	PF01048	0.628
MOD_GlcNHglycan	123	127	PF01048	0.622
MOD_GlcNHglycan	142	145	PF01048	0.480
MOD_GlcNHglycan	146	149	PF01048	0.759
MOD_GlcNHglycan	157	161	PF01048	0.584
MOD_GlcNHglycan	184	187	PF01048	0.638
MOD_GlcNHglycan	227	230	PF01048	0.726
MOD_GlcNHglycan	232	235	PF01048	0.769
MOD_GlcNHglycan	279	282	PF01048	0.643
MOD_GlcNHglycan	39	43	PF01048	0.787
MOD_GlcNHglycan	565	568	PF01048	0.715
MOD_GlcNHglycan	586	589	PF01048	0.709
MOD_GlcNHglycan	601	604	PF01048	0.659
MOD_GlcNHglycan	65	68	PF01048	0.637
MOD_GlcNHglycan	716	719	PF01048	0.776
MOD_GlcNHglycan	844	847	PF01048	0.645
MOD_GlcNHglycan	861	864	PF01048	0.637
MOD_GSK3_1	101	108	PF00069	0.456
MOD_GSK3_1	135	142	PF00069	0.726
MOD_GSK3_1	164	171	PF00069	0.692
MOD_GSK3_1	175	182	PF00069	0.643
MOD_GSK3_1	293	300	PF00069	0.598
MOD_GSK3_1	336	343	PF00069	0.569
MOD_GSK3_1	38	45	PF00069	0.748
MOD_GSK3_1	550	557	PF00069	0.796
MOD_GSK3_1	566	573	PF00069	0.537
MOD_GSK3_1	579	586	PF00069	0.406
MOD_GSK3_1	618	625	PF00069	0.821
MOD_GSK3_1	638	645	PF00069	0.503
MOD_GSK3_1	647	654	PF00069	0.703
MOD_GSK3_1	656	663	PF00069	0.753
MOD_GSK3_1	709	716	PF00069	0.659
MOD_GSK3_1	717	724	PF00069	0.664
MOD_GSK3_1	746	753	PF00069	0.581
MOD_GSK3_1	767	774	PF00069	0.753
MOD_GSK3_1	777	784	PF00069	0.624
MOD_GSK3_1	811	818	PF00069	0.577
MOD_GSK3_1	823	830	PF00069	0.722
MOD_GSK3_1	842	849	PF00069	0.643
MOD_GSK3_1	878	885	PF00069	0.551
MOD_N-GLC_1	407	412	PF02516	0.413
MOD_N-GLC_1	618	623	PF02516	0.583
MOD_N-GLC_1	709	714	PF02516	0.636
MOD_N-GLC_1	778	783	PF02516	0.750
MOD_NEK2_1	10	15	PF00069	0.695
MOD_NEK2_1	168	173	PF00069	0.728
MOD_NEK2_1	277	282	PF00069	0.628
MOD_NEK2_1	363	368	PF00069	0.530
MOD_NEK2_1	453	458	PF00069	0.282
MOD_NEK2_1	482	487	PF00069	0.530
MOD_NEK2_1	579	584	PF00069	0.457
MOD_NEK2_1	624	629	PF00069	0.742
MOD_NEK2_1	670	675	PF00069	0.762
MOD_NEK2_1	746	751	PF00069	0.591
MOD_NEK2_1	827	832	PF00069	0.735
MOD_NEK2_1	842	847	PF00069	0.535
MOD_NEK2_1	861	866	PF00069	0.642
MOD_NEK2_1	882	887	PF00069	0.528
MOD_PIKK_1	297	303	PF00454	0.635
MOD_PIKK_1	560	566	PF00454	0.667
MOD_PIKK_1	649	655	PF00454	0.848
MOD_PIKK_1	662	668	PF00454	0.577
MOD_PIKK_1	709	715	PF00454	0.754
MOD_PK_1	116	122	PF00069	0.665
MOD_PK_1	915	921	PF00069	0.696
MOD_PKA_1	735	741	PF00069	0.673
MOD_PKA_2	139	145	PF00069	0.795
MOD_PKA_2	161	167	PF00069	0.697
MOD_PKA_2	346	352	PF00069	0.651
MOD_PKA_2	386	392	PF00069	0.530
MOD_PKA_2	735	741	PF00069	0.723
MOD_PKA_2	746	752	PF00069	0.632
MOD_PKA_2	774	780	PF00069	0.788
MOD_PKA_2	846	852	PF00069	0.717
MOD_PKA_2	882	888	PF00069	0.524
MOD_PKB_1	776	784	PF00069	0.750
MOD_Plk_1	407	413	PF00069	0.401
MOD_Plk_1	684	690	PF00069	0.766
MOD_Plk_1	778	784	PF00069	0.749
MOD_Plk_1	81	87	PF00069	0.582
MOD_Plk_1	822	828	PF00069	0.798
MOD_Plk_1	854	860	PF00069	0.593
MOD_Plk_2-3	823	829	PF00069	0.605
MOD_Plk_4	161	167	PF00069	0.736
MOD_Plk_4	314	320	PF00069	0.600
MOD_Plk_4	494	500	PF00069	0.494
MOD_Plk_4	609	615	PF00069	0.782
MOD_Plk_4	664	670	PF00069	0.667
MOD_Plk_4	721	727	PF00069	0.687
MOD_Plk_4	735	741	PF00069	0.594
MOD_Plk_4	782	788	PF00069	0.820
MOD_Plk_4	81	87	PF00069	0.568
MOD_Plk_4	837	843	PF00069	0.692
MOD_Plk_4	846	852	PF00069	0.614
MOD_Plk_4	915	921	PF00069	0.696
MOD_ProDKin_1	12	18	PF00069	0.705
MOD_ProDKin_1	124	130	PF00069	0.773
MOD_ProDKin_1	284	290	PF00069	0.599
MOD_ProDKin_1	416	422	PF00069	0.530
MOD_ProDKin_1	42	48	PF00069	0.597
MOD_ProDKin_1	606	612	PF00069	0.663
MOD_ProDKin_1	640	646	PF00069	0.761
MOD_ProDKin_1	651	657	PF00069	0.842
MOD_ProDKin_1	740	746	PF00069	0.790
MOD_ProDKin_1	811	817	PF00069	0.737
MOD_ProDKin_1	871	877	PF00069	0.503
MOD_ProDKin_1	913	919	PF00069	0.712
MOD_SUMO_for_1	331	334	PF00179	0.418
TRG_DiLeu_BaEn_1	374	379	PF01217	0.530
TRG_DiLeu_BaEn_3	925	931	PF01217	0.658
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.530
TRG_DiLeu_BaLyEn_6	741	746	PF01217	0.715
TRG_ENDOCYTIC_2	377	380	PF00928	0.369
TRG_ENDOCYTIC_2	448	451	PF00928	0.389
TRG_ENDOCYTIC_2	54	57	PF00928	0.570
TRG_ER_diArg_1	305	307	PF00400	0.493
TRG_ER_diArg_1	400	403	PF00400	0.530
TRG_ER_diArg_1	462	464	PF00400	0.465
TRG_ER_diArg_1	476	479	PF00400	0.276
TRG_ER_diArg_1	733	736	PF00400	0.714
TRG_ER_diArg_1	746	748	PF00400	0.549
TRG_ER_diArg_1	775	778	PF00400	0.755
TRG_ER_diArg_1	796	799	PF00400	0.613
TRG_ER_diArg_1	882	884	PF00400	0.605
TRG_ER_diArg_1	888	891	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFT8	Leishmania donovani	87%	100%
A4HCU8	Leishmania braziliensis	66%	100%
A4I0C9	Leishmania infantum	87%	100%
E9AW93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%