SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QB84_LEIMA

TriTrypDb:

LmjF.23.0790 , LMJLV39_230016600 , LMJSD75_230016900

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB84

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	3
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.753
CLV_C14_Caspase3-7	464	468	PF00656	0.605
CLV_C14_Caspase3-7	492	496	PF00656	0.558
CLV_C14_Caspase3-7	622	626	PF00656	0.751
CLV_NRD_NRD_1	206	208	PF00675	0.629
CLV_NRD_NRD_1	209	211	PF00675	0.640
CLV_NRD_NRD_1	218	220	PF00675	0.616
CLV_NRD_NRD_1	22	24	PF00675	0.628
CLV_NRD_NRD_1	245	247	PF00675	0.614
CLV_NRD_NRD_1	250	252	PF00675	0.609
CLV_NRD_NRD_1	260	262	PF00675	0.622
CLV_NRD_NRD_1	501	503	PF00675	0.703
CLV_NRD_NRD_1	735	737	PF00675	0.444
CLV_PCSK_FUR_1	246	250	PF00082	0.670
CLV_PCSK_KEX2_1	22	24	PF00082	0.628
CLV_PCSK_KEX2_1	244	246	PF00082	0.611
CLV_PCSK_KEX2_1	248	250	PF00082	0.612
CLV_PCSK_KEX2_1	260	262	PF00082	0.598
CLV_PCSK_KEX2_1	501	503	PF00082	0.703
CLV_PCSK_KEX2_1	600	602	PF00082	0.462
CLV_PCSK_KEX2_1	734	736	PF00082	0.428
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.530
CLV_PCSK_PC7_1	244	250	PF00082	0.687
CLV_PCSK_PC7_1	596	602	PF00082	0.435
CLV_PCSK_SKI1_1	600	604	PF00082	0.440
CLV_PCSK_SKI1_1	615	619	PF00082	0.674
CLV_PCSK_SKI1_1	736	740	PF00082	0.432
CLV_PCSK_SKI1_1	74	78	PF00082	0.592
DEG_APCC_DBOX_1	152	160	PF00400	0.628
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SCF_FBW7_1	821	828	PF00400	0.706
DEG_SPOP_SBC_1	123	127	PF00917	0.539
DEG_SPOP_SBC_1	333	337	PF00917	0.696
DEG_SPOP_SBC_1	358	362	PF00917	0.692
DEG_SPOP_SBC_1	458	462	PF00917	0.731
DOC_CYCLIN_RxL_1	227	240	PF00134	0.669
DOC_CYCLIN_RxL_1	733	741	PF00134	0.429
DOC_MAPK_gen_1	219	226	PF00069	0.589
DOC_MAPK_gen_1	248	258	PF00069	0.718
DOC_PP1_RVXF_1	363	370	PF00149	0.565
DOC_PP2B_LxvP_1	805	808	PF13499	0.592
DOC_PP4_FxxP_1	786	789	PF00568	0.641
DOC_USP7_MATH_1	212	216	PF00917	0.637
DOC_USP7_MATH_1	282	286	PF00917	0.467
DOC_USP7_MATH_1	546	550	PF00917	0.723
DOC_USP7_MATH_1	681	685	PF00917	0.476
DOC_USP7_MATH_1	814	818	PF00917	0.684
DOC_USP7_MATH_1	93	97	PF00917	0.778
DOC_USP7_MATH_1	98	102	PF00917	0.788
DOC_USP7_UBL2_3	55	59	PF12436	0.487
DOC_USP7_UBL2_3	74	78	PF12436	0.579
DOC_WW_Pin1_4	119	124	PF00397	0.677
DOC_WW_Pin1_4	130	135	PF00397	0.517
DOC_WW_Pin1_4	23	28	PF00397	0.473
DOC_WW_Pin1_4	438	443	PF00397	0.788
DOC_WW_Pin1_4	523	528	PF00397	0.802
DOC_WW_Pin1_4	564	569	PF00397	0.601
DOC_WW_Pin1_4	779	784	PF00397	0.712
DOC_WW_Pin1_4	810	815	PF00397	0.706
DOC_WW_Pin1_4	817	822	PF00397	0.633
LIG_14-3-3_CanoR_1	128	134	PF00244	0.609
LIG_14-3-3_CanoR_1	153	163	PF00244	0.468
LIG_14-3-3_CanoR_1	359	364	PF00244	0.593
LIG_14-3-3_CanoR_1	452	458	PF00244	0.745
LIG_14-3-3_CanoR_1	505	510	PF00244	0.641
LIG_14-3-3_CanoR_1	541	548	PF00244	0.704
LIG_14-3-3_CanoR_1	588	592	PF00244	0.488
LIG_14-3-3_CanoR_1	615	620	PF00244	0.724
LIG_14-3-3_CanoR_1	736	745	PF00244	0.364
LIG_APCC_ABBA_1	677	682	PF00400	0.489
LIG_BIR_III_2	495	499	PF00653	0.665
LIG_BRCT_BRCA1_1	137	141	PF00533	0.544
LIG_BRCT_BRCA1_1	269	273	PF00533	0.695
LIG_BRCT_BRCA1_1	370	374	PF00533	0.469
LIG_CSL_BTD_1	822	825	PF09270	0.536
LIG_FHA_1	328	334	PF00498	0.607
LIG_FHA_1	488	494	PF00498	0.654
LIG_FHA_1	514	520	PF00498	0.717
LIG_FHA_1	616	622	PF00498	0.716
LIG_FHA_1	640	646	PF00498	0.599
LIG_FHA_2	108	114	PF00498	0.587
LIG_FHA_2	429	435	PF00498	0.747
LIG_FHA_2	462	468	PF00498	0.608
LIG_FHA_2	722	728	PF00498	0.661
LIG_FHA_2	826	832	PF00498	0.637
LIG_Integrin_RGD_1	189	191	PF01839	0.590
LIG_LIR_Gen_1	133	144	PF02991	0.573
LIG_LIR_Gen_1	368	377	PF02991	0.437
LIG_LIR_Gen_1	567	576	PF02991	0.598
LIG_LIR_Gen_1	650	660	PF02991	0.401
LIG_LIR_Gen_1	720	729	PF02991	0.551
LIG_LIR_Nem_3	133	139	PF02991	0.536
LIG_LIR_Nem_3	319	324	PF02991	0.524
LIG_LIR_Nem_3	368	372	PF02991	0.447
LIG_LIR_Nem_3	567	573	PF02991	0.604
LIG_LIR_Nem_3	589	594	PF02991	0.461
LIG_LIR_Nem_3	650	656	PF02991	0.410
LIG_LIR_Nem_3	664	668	PF02991	0.386
LIG_LIR_Nem_3	720	726	PF02991	0.476
LIG_LIR_Nem_3	740	745	PF02991	0.231
LIG_LYPXL_S_1	320	324	PF13949	0.431
LIG_LYPXL_yS_3	321	324	PF13949	0.440
LIG_NRBOX	605	611	PF00104	0.575
LIG_PTB_Apo_2	39	46	PF02174	0.505
LIG_PTB_Phospho_1	39	45	PF10480	0.418
LIG_SH2_GRB2like	685	688	PF00017	0.476
LIG_SH2_NCK_1	723	727	PF00017	0.593
LIG_SH2_STAP1	570	574	PF00017	0.570
LIG_SH2_STAP1	708	712	PF00017	0.576
LIG_SH2_STAT3	668	671	PF00017	0.576
LIG_SH2_STAT5	130	133	PF00017	0.534
LIG_SH2_STAT5	329	332	PF00017	0.611
LIG_SH2_STAT5	45	48	PF00017	0.431
LIG_SH2_STAT5	51	54	PF00017	0.447
LIG_SH2_STAT5	652	655	PF00017	0.512
LIG_SH2_STAT5	685	688	PF00017	0.476
LIG_SH2_STAT5	723	726	PF00017	0.444
LIG_SH2_STAT5	801	804	PF00017	0.434
LIG_SH3_1	801	807	PF00018	0.465
LIG_SH3_3	344	350	PF00018	0.713
LIG_SH3_3	37	43	PF00018	0.493
LIG_SH3_3	407	413	PF00018	0.700
LIG_SH3_3	436	442	PF00018	0.734
LIG_SH3_3	466	472	PF00018	0.702
LIG_SH3_3	504	510	PF00018	0.729
LIG_SH3_3	768	774	PF00018	0.699
LIG_SH3_3	801	807	PF00018	0.487
LIG_SUMO_SIM_anti_2	490	495	PF11976	0.584
LIG_SUMO_SIM_anti_2	577	584	PF11976	0.479
LIG_SUMO_SIM_par_1	489	495	PF11976	0.599
LIG_TRAF2_1	11	14	PF00917	0.659
LIG_TRAF2_1	714	717	PF00917	0.576
LIG_TRAF2_1	828	831	PF00917	0.623
LIG_TYR_ITIM	721	726	PF00017	0.544
LIG_UBA3_1	477	484	PF00899	0.630
LIG_WW_1	807	810	PF00397	0.462
MOD_CDC14_SPxK_1	813	816	PF00782	0.692
MOD_CDK_SPxK_1	810	816	PF00069	0.686
MOD_CK1_1	122	128	PF00069	0.680
MOD_CK1_1	213	219	PF00069	0.692
MOD_CK1_1	267	273	PF00069	0.737
MOD_CK1_1	3	9	PF00069	0.610
MOD_CK1_1	336	342	PF00069	0.611
MOD_CK1_1	443	449	PF00069	0.726
MOD_CK1_1	453	459	PF00069	0.787
MOD_CK1_1	460	466	PF00069	0.693
MOD_CK1_1	523	529	PF00069	0.731
MOD_CK1_1	54	60	PF00069	0.651
MOD_CK1_1	544	550	PF00069	0.718
MOD_CK1_1	581	587	PF00069	0.469
MOD_CK1_1	817	823	PF00069	0.745
MOD_CK2_1	152	158	PF00069	0.625
MOD_CK2_1	23	29	PF00069	0.308
MOD_CK2_1	357	363	PF00069	0.594
MOD_CK2_1	428	434	PF00069	0.757
MOD_CK2_1	511	517	PF00069	0.767
MOD_CK2_1	64	70	PF00069	0.718
MOD_CK2_1	7	13	PF00069	0.614
MOD_CK2_1	721	727	PF00069	0.576
MOD_CK2_1	825	831	PF00069	0.656
MOD_GlcNHglycan	100	103	PF01048	0.761
MOD_GlcNHglycan	198	201	PF01048	0.644
MOD_GlcNHglycan	284	287	PF01048	0.497
MOD_GlcNHglycan	309	313	PF01048	0.495
MOD_GlcNHglycan	336	339	PF01048	0.636
MOD_GlcNHglycan	374	377	PF01048	0.514
MOD_GlcNHglycan	413	416	PF01048	0.695
MOD_GlcNHglycan	419	422	PF01048	0.706
MOD_GlcNHglycan	442	445	PF01048	0.675
MOD_GlcNHglycan	47	50	PF01048	0.463
MOD_GlcNHglycan	67	70	PF01048	0.463
MOD_GlcNHglycan	730	733	PF01048	0.575
MOD_GlcNHglycan	751	754	PF01048	0.522
MOD_GlcNHglycan	771	774	PF01048	0.693
MOD_GlcNHglycan	775	778	PF01048	0.712
MOD_GlcNHglycan	95	98	PF01048	0.751
MOD_GSK3_1	119	126	PF00069	0.658
MOD_GSK3_1	128	135	PF00069	0.536
MOD_GSK3_1	263	270	PF00069	0.704
MOD_GSK3_1	3	10	PF00069	0.568
MOD_GSK3_1	332	339	PF00069	0.639
MOD_GSK3_1	368	375	PF00069	0.491
MOD_GSK3_1	424	431	PF00069	0.758
MOD_GSK3_1	433	440	PF00069	0.738
MOD_GSK3_1	453	460	PF00069	0.740
MOD_GSK3_1	461	468	PF00069	0.686
MOD_GSK3_1	50	57	PF00069	0.627
MOD_GSK3_1	544	551	PF00069	0.740
MOD_GSK3_1	61	68	PF00069	0.624
MOD_GSK3_1	615	622	PF00069	0.692
MOD_GSK3_1	717	724	PF00069	0.575
MOD_GSK3_1	769	776	PF00069	0.675
MOD_GSK3_1	810	817	PF00069	0.711
MOD_GSK3_1	819	826	PF00069	0.654
MOD_GSK3_1	835	842	PF00069	0.424
MOD_GSK3_1	98	105	PF00069	0.799
MOD_N-GLC_1	578	583	PF02516	0.476
MOD_N-GLC_1	586	591	PF02516	0.474
MOD_N-GLC_1	686	691	PF02516	0.276
MOD_N-GLC_2	44	46	PF02516	0.593
MOD_N-GLC_2	693	695	PF02516	0.276
MOD_NEK2_1	170	175	PF00069	0.668
MOD_NEK2_1	316	321	PF00069	0.512
MOD_NEK2_1	372	377	PF00069	0.496
MOD_NEK2_1	457	462	PF00069	0.743
MOD_NEK2_1	50	55	PF00069	0.612
MOD_NEK2_1	686	691	PF00069	0.476
MOD_NEK2_1	7	12	PF00069	0.652
MOD_NEK2_1	738	743	PF00069	0.434
MOD_NEK2_1	809	814	PF00069	0.740
MOD_PIKK_1	424	430	PF00454	0.805
MOD_PIKK_1	667	673	PF00454	0.469
MOD_PKA_1	210	216	PF00069	0.709
MOD_PKA_2	152	158	PF00069	0.625
MOD_PKA_2	358	364	PF00069	0.546
MOD_PKA_2	451	457	PF00069	0.715
MOD_PKA_2	534	540	PF00069	0.760
MOD_PKA_2	587	593	PF00069	0.491
MOD_PKA_2	749	755	PF00069	0.517
MOD_Plk_1	170	176	PF00069	0.636
MOD_Plk_1	433	439	PF00069	0.585
MOD_Plk_1	578	584	PF00069	0.495
MOD_Plk_1	586	592	PF00069	0.468
MOD_Plk_1	681	687	PF00069	0.476
MOD_Plk_1	835	841	PF00069	0.449
MOD_Plk_4	343	349	PF00069	0.771
MOD_Plk_4	368	374	PF00069	0.439
MOD_Plk_4	433	439	PF00069	0.585
MOD_Plk_4	453	459	PF00069	0.792
MOD_Plk_4	578	584	PF00069	0.496
MOD_Plk_4	681	687	PF00069	0.479
MOD_ProDKin_1	119	125	PF00069	0.667
MOD_ProDKin_1	130	136	PF00069	0.508
MOD_ProDKin_1	23	29	PF00069	0.472
MOD_ProDKin_1	438	444	PF00069	0.788
MOD_ProDKin_1	523	529	PF00069	0.803
MOD_ProDKin_1	564	570	PF00069	0.594
MOD_ProDKin_1	779	785	PF00069	0.707
MOD_ProDKin_1	810	816	PF00069	0.708
MOD_ProDKin_1	817	823	PF00069	0.636
MOD_SUMO_for_1	111	114	PF00179	0.591
MOD_SUMO_rev_2	420	427	PF00179	0.631
MOD_SUMO_rev_2	826	834	PF00179	0.434
TRG_DiLeu_BaEn_1	368	373	PF01217	0.398
TRG_DiLeu_BaEn_1	787	792	PF01217	0.612
TRG_DiLeu_BaEn_4	254	260	PF01217	0.729
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.596
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.454
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.617
TRG_ENDOCYTIC_2	321	324	PF00928	0.420
TRG_ENDOCYTIC_2	328	331	PF00928	0.479
TRG_ENDOCYTIC_2	570	573	PF00928	0.586
TRG_ENDOCYTIC_2	595	598	PF00928	0.413
TRG_ENDOCYTIC_2	723	726	PF00928	0.444
TRG_ENDOCYTIC_2	742	745	PF00928	0.400
TRG_ER_diArg_1	243	246	PF00400	0.633
TRG_ER_diArg_1	248	251	PF00400	0.624
TRG_ER_diArg_1	259	261	PF00400	0.607
TRG_ER_diArg_1	500	502	PF00400	0.697
TRG_ER_diArg_1	563	566	PF00400	0.660
TRG_ER_diArg_1	734	736	PF00400	0.428
TRG_ER_diArg_1	841	844	PF00400	0.616
TRG_NLS_MonoExtC_3	206	211	PF00514	0.726
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ6	Leptomonas seymouri	49%	100%
A0A1X0NYH3	Trypanosomatidae	30%	100%
A0A3R7KV16	Trypanosoma rangeli	31%	100%
A0A3S7WXM7	Leishmania donovani	87%	100%
A4I0D0	Leishmania infantum	87%	100%
C9ZV40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AW94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
V5ARQ1	Trypanosoma cruzi	30%	100%