Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB83_LEIMA

TriTrypDb:

LmjF.23.0800 , LMJLV39_230016700 , LMJSD75_230017000

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QB83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.360
CLV_PCSK_KEX2_1	172	174	PF00082	0.509
CLV_PCSK_KEX2_1	71	73	PF00082	0.435
CLV_PCSK_KEX2_1	93	95	PF00082	0.329
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.509
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.435
DOC_PP2B_LxvP_1	103	106	PF13499	0.300
DOC_PP4_FxxP_1	187	190	PF00568	0.365
DOC_USP7_MATH_1	149	153	PF00917	0.339
DOC_USP7_MATH_1	21	25	PF00917	0.662
DOC_USP7_UBL2_3	48	52	PF12436	0.635
DOC_WW_Pin1_4	139	144	PF00397	0.352
LIG_14-3-3_CanoR_1	164	171	PF00244	0.443
LIG_14-3-3_CanoR_1	181	190	PF00244	0.324
LIG_14-3-3_CanoR_1	98	106	PF00244	0.300
LIG_Clathr_ClatBox_1	197	201	PF01394	0.340
LIG_FHA_1	153	159	PF00498	0.377
LIG_FHA_1	190	196	PF00498	0.291
LIG_FHA_1	98	104	PF00498	0.332
LIG_FHA_2	203	209	PF00498	0.288
LIG_LIR_Apic_2	185	190	PF02991	0.364
LIG_LIR_Gen_1	100	110	PF02991	0.216
LIG_LIR_Nem_3	100	105	PF02991	0.216
LIG_NRBOX	128	134	PF00104	0.357
LIG_PCNA_yPIPBox_3	122	133	PF02747	0.272
LIG_Pex14_1	171	175	PF04695	0.296
LIG_SH2_STAP1	175	179	PF00017	0.382
LIG_SH2_STAP1	99	103	PF00017	0.300
LIG_SH2_STAT5	96	99	PF00017	0.550
MOD_CDK_SPK_2	139	144	PF00069	0.352
MOD_CDK_SPxxK_3	139	146	PF00069	0.354
MOD_CK1_1	142	148	PF00069	0.364
MOD_CK1_1	152	158	PF00069	0.438
MOD_CK1_1	22	28	PF00069	0.657
MOD_CK1_1	32	38	PF00069	0.739
MOD_CK2_1	182	188	PF00069	0.345
MOD_CK2_1	202	208	PF00069	0.283
MOD_CK2_1	60	66	PF00069	0.632
MOD_GlcNHglycan	16	19	PF01048	0.512
MOD_GlcNHglycan	184	187	PF01048	0.618
MOD_GlcNHglycan	31	34	PF01048	0.438
MOD_GSK3_1	138	145	PF00069	0.348
MOD_GSK3_1	32	39	PF00069	0.740
MOD_GSK3_1	97	104	PF00069	0.460
MOD_N-GLC_1	202	207	PF02516	0.482
MOD_NEK2_1	110	115	PF00069	0.297
MOD_NEK2_1	180	185	PF00069	0.378
MOD_NEK2_1	60	65	PF00069	0.604
MOD_PKA_2	180	186	PF00069	0.355
MOD_PKA_2	188	194	PF00069	0.349
MOD_PKA_2	19	25	PF00069	0.638
MOD_PKA_2	60	66	PF00069	0.595
MOD_PKA_2	97	103	PF00069	0.460
MOD_Plk_2-3	62	68	PF00069	0.593
MOD_Plk_4	112	118	PF00069	0.395
MOD_ProDKin_1	139	145	PF00069	0.349
MOD_SUMO_rev_2	45	49	PF00179	0.581
TRG_ENDOCYTIC_2	150	153	PF00928	0.340
TRG_ENDOCYTIC_2	99	102	PF00928	0.300
TRG_ER_diArg_1	163	166	PF00400	0.319
TRG_ER_diArg_1	92	94	PF00400	0.538
TRG_NES_CRM1_1	128	140	PF08389	0.283
TRG_NLS_MonoExtC_3	49	54	PF00514	0.585
TRG_NLS_MonoExtN_4	48	54	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P744	Leptomonas seymouri	69%	91%
A0A1X0NYB1	Trypanosomatidae	55%	96%
A4HCV0	Leishmania braziliensis	76%	100%
E9AW95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	95%