SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QB81_LEIMA

TriTrypDb:

LmjF.23.0820 , LMJLV39_230016900 , LMJSD75_230017200

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB81

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.602
CLV_C14_Caspase3-7	441	445	PF00656	0.477
CLV_NRD_NRD_1	348	350	PF00675	0.257
CLV_PCSK_KEX2_1	348	350	PF00082	0.257
CLV_PCSK_SKI1_1	279	283	PF00082	0.551
CLV_PCSK_SKI1_1	325	329	PF00082	0.392
CLV_PCSK_SKI1_1	331	335	PF00082	0.337
CLV_PCSK_SKI1_1	35	39	PF00082	0.398
CLV_PCSK_SKI1_1	89	93	PF00082	0.425
DOC_CKS1_1	120	125	PF01111	0.481
DOC_CYCLIN_RxL_1	322	330	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.428
DOC_MAPK_gen_1	348	354	PF00069	0.457
DOC_MAPK_gen_1	455	465	PF00069	0.461
DOC_PP1_RVXF_1	236	243	PF00149	0.332
DOC_PP2B_LxvP_1	75	78	PF13499	0.330
DOC_PP4_FxxP_1	168	171	PF00568	0.392
DOC_USP7_MATH_1	108	112	PF00917	0.269
DOC_USP7_MATH_1	113	117	PF00917	0.273
DOC_USP7_MATH_1	214	218	PF00917	0.720
DOC_USP7_MATH_1	226	230	PF00917	0.509
DOC_USP7_MATH_1	274	278	PF00917	0.674
DOC_USP7_MATH_1	438	442	PF00917	0.503
DOC_USP7_MATH_1	500	504	PF00917	0.438
DOC_USP7_MATH_2	405	411	PF00917	0.522
DOC_WW_Pin1_4	111	116	PF00397	0.478
DOC_WW_Pin1_4	119	124	PF00397	0.524
DOC_WW_Pin1_4	142	147	PF00397	0.695
DOC_WW_Pin1_4	167	172	PF00397	0.401
DOC_WW_Pin1_4	222	227	PF00397	0.558
DOC_WW_Pin1_4	302	307	PF00397	0.447
LIG_14-3-3_CanoR_1	163	168	PF00244	0.296
LIG_14-3-3_CanoR_1	182	191	PF00244	0.356
LIG_14-3-3_CanoR_1	246	250	PF00244	0.431
LIG_14-3-3_CanoR_1	279	284	PF00244	0.500
LIG_14-3-3_CanoR_1	331	338	PF00244	0.417
LIG_14-3-3_CanoR_1	348	353	PF00244	0.565
LIG_Actin_WH2_2	436	454	PF00022	0.532
LIG_APCC_ABBA_1	101	106	PF00400	0.406
LIG_BIR_II_1	1	5	PF00653	0.403
LIG_BRCT_BRCA1_1	120	124	PF00533	0.525
LIG_BRCT_BRCA1_1	410	414	PF00533	0.407
LIG_EVH1_2	42	46	PF00568	0.416
LIG_FHA_1	210	216	PF00498	0.670
LIG_FHA_1	242	248	PF00498	0.415
LIG_FHA_1	283	289	PF00498	0.518
LIG_FHA_1	292	298	PF00498	0.419
LIG_FHA_1	332	338	PF00498	0.389
LIG_FHA_1	379	385	PF00498	0.518
LIG_FHA_1	444	450	PF00498	0.445
LIG_FHA_1	452	458	PF00498	0.450
LIG_FHA_1	92	98	PF00498	0.399
LIG_FHA_2	139	145	PF00498	0.644
LIG_FHA_2	225	231	PF00498	0.631
LIG_FHA_2	4	10	PF00498	0.389
LIG_FHA_2	82	88	PF00498	0.535
LIG_LIR_Apic_2	111	115	PF02991	0.453
LIG_LIR_Apic_2	166	171	PF02991	0.388
LIG_LIR_Apic_2	400	404	PF02991	0.518
LIG_LIR_Gen_1	287	297	PF02991	0.413
LIG_LIR_Gen_1	298	307	PF02991	0.334
LIG_LIR_Gen_1	411	421	PF02991	0.513
LIG_LIR_Gen_1	98	109	PF02991	0.412
LIG_LIR_Nem_3	287	293	PF02991	0.416
LIG_LIR_Nem_3	298	303	PF02991	0.328
LIG_LIR_Nem_3	311	315	PF02991	0.279
LIG_LIR_Nem_3	411	417	PF02991	0.513
LIG_LIR_Nem_3	464	470	PF02991	0.443
LIG_LIR_Nem_3	70	75	PF02991	0.435
LIG_LIR_Nem_3	98	104	PF02991	0.418
LIG_NRBOX	323	329	PF00104	0.480
LIG_NRBOX	422	428	PF00104	0.528
LIG_PCNA_PIPBox_1	481	490	PF02747	0.455
LIG_PCNA_yPIPBox_3	477	488	PF02747	0.434
LIG_PTB_Apo_2	483	490	PF02174	0.497
LIG_SH2_CRK	424	428	PF00017	0.528
LIG_SH2_PTP2	401	404	PF00017	0.532
LIG_SH2_PTP2	467	470	PF00017	0.390
LIG_SH2_STAT3	265	268	PF00017	0.509
LIG_SH2_STAT5	167	170	PF00017	0.404
LIG_SH2_STAT5	265	268	PF00017	0.376
LIG_SH2_STAT5	401	404	PF00017	0.530
LIG_SH2_STAT5	467	470	PF00017	0.375
LIG_SH2_STAT5	487	490	PF00017	0.371
LIG_SH3_3	107	113	PF00018	0.322
LIG_SH3_3	399	405	PF00018	0.491
LIG_SH3_3	7	13	PF00018	0.406
LIG_SUMO_SIM_par_1	116	122	PF11976	0.506
LIG_SUMO_SIM_par_1	294	301	PF11976	0.269
LIG_SUMO_SIM_par_1	461	466	PF11976	0.532
LIG_TRFH_1	401	405	PF08558	0.532
LIG_TYR_ITIM	465	470	PF00017	0.506
MOD_CK1_1	111	117	PF00069	0.417
MOD_CK1_1	130	136	PF00069	0.300
MOD_CK1_1	217	223	PF00069	0.734
MOD_CK1_1	224	230	PF00069	0.581
MOD_CK1_1	28	34	PF00069	0.438
MOD_CK1_1	284	290	PF00069	0.527
MOD_CK1_1	316	322	PF00069	0.502
MOD_CK1_1	380	386	PF00069	0.503
MOD_CK1_1	425	431	PF00069	0.518
MOD_CK2_1	138	144	PF00069	0.707
MOD_CK2_1	224	230	PF00069	0.628
MOD_CK2_1	3	9	PF00069	0.396
MOD_CK2_1	473	479	PF00069	0.439
MOD_CK2_1	81	87	PF00069	0.501
MOD_GlcNHglycan	146	149	PF01048	0.690
MOD_GlcNHglycan	216	219	PF01048	0.747
MOD_GlcNHglycan	276	279	PF01048	0.695
MOD_GlcNHglycan	32	35	PF01048	0.559
MOD_GlcNHglycan	339	342	PF01048	0.410
MOD_GlcNHglycan	38	41	PF01048	0.530
MOD_GlcNHglycan	410	413	PF01048	0.274
MOD_GlcNHglycan	502	505	PF01048	0.488
MOD_GlcNHglycan	84	87	PF01048	0.540
MOD_GlcNHglycan	9	13	PF01048	0.406
MOD_GSK3_1	138	145	PF00069	0.633
MOD_GSK3_1	163	170	PF00069	0.370
MOD_GSK3_1	209	216	PF00069	0.703
MOD_GSK3_1	217	224	PF00069	0.660
MOD_GSK3_1	225	232	PF00069	0.374
MOD_GSK3_1	241	248	PF00069	0.433
MOD_GSK3_1	25	32	PF00069	0.429
MOD_GSK3_1	291	298	PF00069	0.452
MOD_GSK3_1	4	11	PF00069	0.387
MOD_GSK3_1	439	446	PF00069	0.455
MOD_GSK3_1	500	507	PF00069	0.589
MOD_GSK3_1	54	61	PF00069	0.344
MOD_N-GLC_1	430	435	PF02516	0.234
MOD_NEK2_1	118	123	PF00069	0.464
MOD_NEK2_1	129	134	PF00069	0.448
MOD_NEK2_1	183	188	PF00069	0.489
MOD_NEK2_1	3	8	PF00069	0.397
MOD_NEK2_1	30	35	PF00069	0.433
MOD_NEK2_1	337	342	PF00069	0.391
MOD_NEK2_1	36	41	PF00069	0.418
MOD_NEK2_1	430	435	PF00069	0.471
MOD_NEK2_1	451	456	PF00069	0.487
MOD_NEK2_1	463	468	PF00069	0.398
MOD_NEK2_2	487	492	PF00069	0.397
MOD_OFUCOSY	429	434	PF10250	0.332
MOD_PIKK_1	156	162	PF00454	0.431
MOD_PIKK_1	209	215	PF00454	0.613
MOD_PIKK_1	291	297	PF00454	0.495
MOD_PIKK_1	331	337	PF00454	0.380
MOD_PKA_1	348	354	PF00069	0.457
MOD_PKA_2	191	197	PF00069	0.520
MOD_PKA_2	245	251	PF00069	0.430
MOD_PKA_2	348	354	PF00069	0.532
MOD_Plk_1	229	235	PF00069	0.460
MOD_Plk_1	25	31	PF00069	0.427
MOD_Plk_1	430	436	PF00069	0.496
MOD_Plk_4	113	119	PF00069	0.468
MOD_Plk_4	163	169	PF00069	0.372
MOD_Plk_4	284	290	PF00069	0.422
MOD_Plk_4	295	301	PF00069	0.520
MOD_Plk_4	316	322	PF00069	0.387
MOD_Plk_4	348	354	PF00069	0.555
MOD_Plk_4	364	370	PF00069	0.435
MOD_Plk_4	422	428	PF00069	0.534
MOD_Plk_4	67	73	PF00069	0.470
MOD_ProDKin_1	111	117	PF00069	0.476
MOD_ProDKin_1	119	125	PF00069	0.515
MOD_ProDKin_1	142	148	PF00069	0.693
MOD_ProDKin_1	167	173	PF00069	0.399
MOD_ProDKin_1	222	228	PF00069	0.546
MOD_ProDKin_1	302	308	PF00069	0.459
MOD_SUMO_rev_2	205	210	PF00179	0.667
MOD_SUMO_rev_2	85	91	PF00179	0.508
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.436
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.357
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.404
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.379
TRG_ENDOCYTIC_2	290	293	PF00928	0.505
TRG_ENDOCYTIC_2	424	427	PF00928	0.528
TRG_ENDOCYTIC_2	467	470	PF00928	0.390
TRG_ENDOCYTIC_2	55	58	PF00928	0.347
TRG_NES_CRM1_1	67	80	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL96	Leptomonas seymouri	54%	100%
A0A0S4IN59	Bodo saltans	30%	100%
A0A1X0NWW3	Trypanosomatidae	38%	100%
A0A3Q8IBR8	Leishmania donovani	92%	100%
A0A422N8X4	Trypanosoma rangeli	39%	100%
A4HCV2	Leishmania braziliensis	77%	100%
A4I0D3	Leishmania infantum	92%	100%
C9ZV37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AW97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q6GMV2	Homo sapiens	25%	100%
V5BBM7	Trypanosoma cruzi	38%	100%