ATP pyrophosphate-lyase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB79_LEIMA

TriTrypDb:

LmjF.23.0840 , LMJLV39_230017300 , LMJSD75_230017600

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QB79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.448
CLV_NRD_NRD_1	21	23	PF00675	0.540
CLV_NRD_NRD_1	214	216	PF00675	0.585
CLV_NRD_NRD_1	361	363	PF00675	0.624
CLV_NRD_NRD_1	514	516	PF00675	0.505
CLV_NRD_NRD_1	6	8	PF00675	0.695
CLV_PCSK_KEX2_1	21	23	PF00082	0.540
CLV_PCSK_KEX2_1	361	363	PF00082	0.628
CLV_PCSK_KEX2_1	516	518	PF00082	0.507
CLV_PCSK_KEX2_1	6	8	PF00082	0.695
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.499
CLV_PCSK_SKI1_1	21	25	PF00082	0.551
CLV_PCSK_SKI1_1	215	219	PF00082	0.611
CLV_PCSK_SKI1_1	361	365	PF00082	0.582
CLV_PCSK_SKI1_1	96	100	PF00082	0.600
DEG_Nend_UBRbox_1	1	4	PF02207	0.653
DEG_SIAH_1	242	250	PF03145	0.488
DOC_CDC14_PxL_1	275	283	PF14671	0.397
DOC_CKS1_1	249	254	PF01111	0.415
DOC_MAPK_FxFP_2	198	201	PF00069	0.357
DOC_MAPK_gen_1	21	29	PF00069	0.398
DOC_MAPK_gen_1	472	482	PF00069	0.305
DOC_MAPK_HePTP_8	18	30	PF00069	0.470
DOC_MAPK_MEF2A_6	164	173	PF00069	0.350
DOC_MAPK_MEF2A_6	21	30	PF00069	0.443
DOC_MAPK_MEF2A_6	475	482	PF00069	0.321
DOC_PP2B_LxvP_1	49	52	PF13499	0.380
DOC_PP4_FxxP_1	198	201	PF00568	0.389
DOC_USP7_MATH_1	130	134	PF00917	0.393
DOC_USP7_MATH_1	259	263	PF00917	0.478
DOC_USP7_MATH_1	377	381	PF00917	0.482
DOC_USP7_MATH_1	441	445	PF00917	0.507
DOC_USP7_MATH_1	461	465	PF00917	0.389
DOC_USP7_MATH_1	58	62	PF00917	0.353
DOC_USP7_MATH_1	97	101	PF00917	0.406
DOC_USP7_MATH_2	302	308	PF00917	0.464
DOC_WW_Pin1_4	219	224	PF00397	0.439
DOC_WW_Pin1_4	245	250	PF00397	0.441
DOC_WW_Pin1_4	293	298	PF00397	0.444
DOC_WW_Pin1_4	402	407	PF00397	0.444
DOC_WW_Pin1_4	453	458	PF00397	0.494
LIG_14-3-3_CanoR_1	367	377	PF00244	0.408
LIG_14-3-3_CanoR_1	515	521	PF00244	0.737
LIG_Actin_WH2_2	124	139	PF00022	0.433
LIG_BRCT_BRCA1_1	144	148	PF00533	0.380
LIG_BRCT_BRCA1_1	175	179	PF00533	0.412
LIG_CSL_BTD_1	403	406	PF09270	0.391
LIG_CtBP_PxDLS_1	160	164	PF00389	0.339
LIG_deltaCOP1_diTrp_1	334	340	PF00928	0.395
LIG_EH_1	300	304	PF12763	0.543
LIG_FHA_1	219	225	PF00498	0.439
LIG_FHA_1	294	300	PF00498	0.480
LIG_FHA_1	419	425	PF00498	0.392
LIG_FHA_1	460	466	PF00498	0.488
LIG_FHA_2	249	255	PF00498	0.441
LIG_FHA_2	271	277	PF00498	0.406
LIG_LIR_Apic_2	196	201	PF02991	0.396
LIG_LIR_Apic_2	500	506	PF02991	0.273
LIG_LIR_Gen_1	125	136	PF02991	0.315
LIG_LIR_Gen_1	141	151	PF02991	0.291
LIG_LIR_Gen_1	177	188	PF02991	0.408
LIG_LIR_Gen_1	312	319	PF02991	0.501
LIG_LIR_Gen_1	322	333	PF02991	0.377
LIG_LIR_Gen_1	53	64	PF02991	0.347
LIG_LIR_Gen_1	65	73	PF02991	0.333
LIG_LIR_Nem_3	125	131	PF02991	0.310
LIG_LIR_Nem_3	141	146	PF02991	0.339
LIG_LIR_Nem_3	176	182	PF02991	0.411
LIG_LIR_Nem_3	231	237	PF02991	0.383
LIG_LIR_Nem_3	276	281	PF02991	0.434
LIG_LIR_Nem_3	312	318	PF02991	0.587
LIG_LIR_Nem_3	322	328	PF02991	0.410
LIG_LIR_Nem_3	334	339	PF02991	0.410
LIG_LIR_Nem_3	53	59	PF02991	0.339
LIG_LIR_Nem_3	65	70	PF02991	0.339
LIG_LYPXL_yS_3	278	281	PF13949	0.416
LIG_MLH1_MIPbox_1	175	179	PF16413	0.412
LIG_MYND_1	168	172	PF01753	0.392
LIG_PAM2_1	191	203	PF00658	0.309
LIG_PCNA_PIPBox_1	17	26	PF02747	0.480
LIG_PCNA_yPIPBox_3	14	24	PF02747	0.496
LIG_Pex14_1	233	237	PF04695	0.375
LIG_PTB_Apo_2	363	370	PF02174	0.393
LIG_RPA_C_Fungi	17	29	PF08784	0.407
LIG_SH2_CRK	503	507	PF00017	0.470
LIG_SH2_STAP1	284	288	PF00017	0.442
LIG_SH2_STAP1	467	471	PF00017	0.561
LIG_SH2_STAT3	200	203	PF00017	0.409
LIG_SH2_STAT5	234	237	PF00017	0.459
LIG_SH2_STAT5	325	328	PF00017	0.444
LIG_SH2_STAT5	425	428	PF00017	0.483
LIG_SH2_STAT5	435	438	PF00017	0.542
LIG_SH2_STAT5	503	506	PF00017	0.501
LIG_SH3_3	166	172	PF00018	0.590
LIG_SH3_3	246	252	PF00018	0.563
LIG_SH3_3	400	406	PF00018	0.494
LIG_SH3_3	57	63	PF00018	0.441
LIG_SH3_3	9	15	PF00018	0.609
LIG_SUMO_SIM_anti_2	484	489	PF11976	0.392
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.357
LIG_SUMO_SIM_par_1	495	500	PF11976	0.363
LIG_TRAF2_1	350	353	PF00917	0.485
LIG_TRAF2_1	405	408	PF00917	0.551
MOD_CK1_1	117	123	PF00069	0.543
MOD_CK1_1	138	144	PF00069	0.330
MOD_CK1_1	174	180	PF00069	0.417
MOD_CK1_1	250	256	PF00069	0.576
MOD_CK1_1	372	378	PF00069	0.535
MOD_CK1_1	456	462	PF00069	0.563
MOD_CK1_1	50	56	PF00069	0.362
MOD_CK1_1	521	527	PF00069	0.730
MOD_CK2_1	347	353	PF00069	0.489
MOD_CK2_1	402	408	PF00069	0.539
MOD_CK2_1	83	89	PF00069	0.354
MOD_GlcNHglycan	116	119	PF01048	0.376
MOD_GlcNHglycan	128	131	PF01048	0.353
MOD_GlcNHglycan	173	176	PF01048	0.425
MOD_GlcNHglycan	207	210	PF01048	0.347
MOD_GlcNHglycan	329	332	PF01048	0.470
MOD_GlcNHglycan	371	374	PF01048	0.454
MOD_GlcNHglycan	418	421	PF01048	0.528
MOD_GlcNHglycan	426	429	PF01048	0.473
MOD_GlcNHglycan	49	52	PF01048	0.382
MOD_GlcNHglycan	78	81	PF01048	0.403
MOD_GSK3_1	126	133	PF00069	0.438
MOD_GSK3_1	138	145	PF00069	0.386
MOD_GSK3_1	218	225	PF00069	0.466
MOD_GSK3_1	229	236	PF00069	0.527
MOD_GSK3_1	266	273	PF00069	0.443
MOD_GSK3_1	368	375	PF00069	0.494
MOD_GSK3_1	439	446	PF00069	0.670
MOD_GSK3_1	449	456	PF00069	0.572
MOD_GSK3_1	459	466	PF00069	0.571
MOD_GSK3_1	47	54	PF00069	0.417
MOD_GSK3_1	58	65	PF00069	0.494
MOD_N-GLC_1	228	233	PF02516	0.485
MOD_N-GLC_1	319	324	PF02516	0.521
MOD_N-GLC_1	377	382	PF02516	0.520
MOD_N-GLC_1	416	421	PF02516	0.590
MOD_NEK2_1	131	136	PF00069	0.369
MOD_NEK2_1	183	188	PF00069	0.462
MOD_NEK2_1	218	223	PF00069	0.500
MOD_NEK2_1	266	271	PF00069	0.368
MOD_NEK2_1	369	374	PF00069	0.464
MOD_NEK2_1	424	429	PF00069	0.563
MOD_PIKK_1	117	123	PF00454	0.471
MOD_PIKK_1	418	424	PF00454	0.458
MOD_PIKK_1	441	447	PF00454	0.609
MOD_PIKK_1	97	103	PF00454	0.558
MOD_PKA_1	515	521	PF00069	0.613
MOD_PKA_2	131	137	PF00069	0.403
MOD_PKA_2	471	477	PF00069	0.511
MOD_PKA_2	516	522	PF00069	0.597
MOD_Plk_1	210	216	PF00069	0.554
MOD_Plk_1	228	234	PF00069	0.479
MOD_Plk_1	377	383	PF00069	0.544
MOD_Plk_2-3	304	310	PF00069	0.537
MOD_Plk_4	138	144	PF00069	0.344
MOD_Plk_4	174	180	PF00069	0.485
MOD_Plk_4	183	189	PF00069	0.436
MOD_Plk_4	229	235	PF00069	0.510
MOD_Plk_4	266	272	PF00069	0.472
MOD_Plk_4	287	293	PF00069	0.464
MOD_Plk_4	443	449	PF00069	0.574
MOD_Plk_4	481	487	PF00069	0.363
MOD_Plk_4	488	494	PF00069	0.311
MOD_Plk_4	51	57	PF00069	0.415
MOD_ProDKin_1	219	225	PF00069	0.542
MOD_ProDKin_1	245	251	PF00069	0.528
MOD_ProDKin_1	293	299	PF00069	0.554
MOD_ProDKin_1	402	408	PF00069	0.539
MOD_ProDKin_1	453	459	PF00069	0.608
MOD_SUMO_rev_2	350	359	PF00179	0.380
TRG_DiLeu_LyEn_5	408	413	PF01217	0.479
TRG_ENDOCYTIC_2	113	116	PF00928	0.384
TRG_ENDOCYTIC_2	278	281	PF00928	0.451
TRG_ENDOCYTIC_2	284	287	PF00928	0.466
TRG_ENDOCYTIC_2	325	328	PF00928	0.546
TRG_ER_diArg_1	20	22	PF00400	0.424
TRG_ER_diArg_1	361	363	PF00400	0.471
TRG_ER_diArg_1	469	472	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q7	Leptomonas seymouri	32%	95%
A0A3S5H7C0	Leishmania donovani	86%	100%
A4HCV5	Leishmania braziliensis	53%	100%
A4I0D6	Leishmania infantum	85%	100%
E9AW99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%