TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB78_LEIMA

TriTrypDb:

LmjF.23.0850 , LMJLV39_230017700 , LMJSD75_230017900

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.384
CLV_C14_Caspase3-7	566	570	PF00656	0.404
CLV_NRD_NRD_1	187	189	PF00675	0.371
CLV_NRD_NRD_1	313	315	PF00675	0.618
CLV_NRD_NRD_1	422	424	PF00675	0.370
CLV_NRD_NRD_1	592	594	PF00675	0.466
CLV_NRD_NRD_1	633	635	PF00675	0.440
CLV_PCSK_KEX2_1	187	189	PF00082	0.371
CLV_PCSK_KEX2_1	313	315	PF00082	0.618
CLV_PCSK_KEX2_1	422	424	PF00082	0.389
CLV_PCSK_KEX2_1	592	594	PF00082	0.466
CLV_PCSK_KEX2_1	622	624	PF00082	0.501
CLV_PCSK_KEX2_1	633	635	PF00082	0.341
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.501
CLV_PCSK_SKI1_1	179	183	PF00082	0.402
CLV_PCSK_SKI1_1	22	26	PF00082	0.524
CLV_PCSK_SKI1_1	231	235	PF00082	0.361
CLV_PCSK_SKI1_1	573	577	PF00082	0.389
CLV_PCSK_SKI1_1	711	715	PF00082	0.693
CLV_PCSK_SKI1_1	761	765	PF00082	0.592
CLV_PCSK_SKI1_1	87	91	PF00082	0.469
CLV_Separin_Metazoa	762	766	PF03568	0.583
DEG_APCC_DBOX_1	230	238	PF00400	0.355
DEG_APCC_DBOX_1	64	72	PF00400	0.346
DEG_APCC_DBOX_1	760	768	PF00400	0.588
DEG_ODPH_VHL_1	400	413	PF01847	0.286
DEG_SIAH_1	269	277	PF03145	0.571
DEG_SPOP_SBC_1	495	499	PF00917	0.515
DOC_CKS1_1	112	117	PF01111	0.544
DOC_CYCLIN_RxL_1	176	185	PF00134	0.403
DOC_CYCLIN_RxL_1	19	29	PF00134	0.482
DOC_CYCLIN_RxL_1	228	235	PF00134	0.365
DOC_MAPK_gen_1	735	744	PF00069	0.641
DOC_MAPK_MEF2A_6	405	413	PF00069	0.391
DOC_MAPK_RevD_3	173	188	PF00069	0.349
DOC_MAPK_RevD_3	407	423	PF00069	0.340
DOC_PP2B_PxIxI_1	227	233	PF00149	0.368
DOC_SPAK_OSR1_1	357	361	PF12202	0.373
DOC_USP7_MATH_1	212	216	PF00917	0.357
DOC_USP7_MATH_1	253	257	PF00917	0.550
DOC_USP7_MATH_1	279	283	PF00917	0.662
DOC_USP7_MATH_1	286	290	PF00917	0.622
DOC_USP7_MATH_1	293	297	PF00917	0.546
DOC_USP7_MATH_1	312	316	PF00917	0.486
DOC_USP7_MATH_1	445	449	PF00917	0.420
DOC_USP7_MATH_1	468	472	PF00917	0.367
DOC_USP7_MATH_1	479	483	PF00917	0.439
DOC_USP7_MATH_1	484	488	PF00917	0.514
DOC_USP7_MATH_1	495	499	PF00917	0.517
DOC_USP7_MATH_1	533	537	PF00917	0.632
DOC_USP7_MATH_1	552	556	PF00917	0.599
DOC_USP7_UBL2_3	239	243	PF12436	0.381
DOC_USP7_UBL2_3	618	622	PF12436	0.500
DOC_WW_Pin1_4	111	116	PF00397	0.594
DOC_WW_Pin1_4	133	138	PF00397	0.586
DOC_WW_Pin1_4	272	277	PF00397	0.644
DOC_WW_Pin1_4	282	287	PF00397	0.627
DOC_WW_Pin1_4	289	294	PF00397	0.614
DOC_WW_Pin1_4	295	300	PF00397	0.536
DOC_WW_Pin1_4	313	318	PF00397	0.549
DOC_WW_Pin1_4	584	589	PF00397	0.468
DOC_WW_Pin1_4	696	701	PF00397	0.483
LIG_14-3-3_CanoR_1	313	317	PF00244	0.557
LIG_14-3-3_CanoR_1	467	473	PF00244	0.366
LIG_14-3-3_CanoR_1	476	485	PF00244	0.437
LIG_14-3-3_CanoR_1	486	490	PF00244	0.538
LIG_14-3-3_CanoR_1	507	516	PF00244	0.554
LIG_14-3-3_CanoR_1	557	561	PF00244	0.564
LIG_14-3-3_CanoR_1	623	630	PF00244	0.602
LIG_14-3-3_CanoR_1	644	650	PF00244	0.360
LIG_14-3-3_CanoR_1	670	675	PF00244	0.452
LIG_Actin_WH2_1	433	449	PF00022	0.409
LIG_Actin_WH2_2	432	449	PF00022	0.409
LIG_APCC_ABBA_1	119	124	PF00400	0.432
LIG_APCC_ABBA_1	614	619	PF00400	0.404
LIG_BRCT_BRCA1_1	355	359	PF00533	0.356
LIG_BRCT_BRCA1_1	430	434	PF00533	0.415
LIG_EH1_1	640	648	PF00400	0.432
LIG_FHA_1	124	130	PF00498	0.526
LIG_FHA_1	170	176	PF00498	0.433
LIG_FHA_1	240	246	PF00498	0.345
LIG_FHA_1	35	41	PF00498	0.399
LIG_FHA_1	404	410	PF00498	0.354
LIG_FHA_1	504	510	PF00498	0.565
LIG_FHA_1	511	517	PF00498	0.591
LIG_FHA_1	609	615	PF00498	0.368
LIG_FHA_1	83	89	PF00498	0.513
LIG_FHA_2	169	175	PF00498	0.387
LIG_FHA_2	206	212	PF00498	0.380
LIG_FHA_2	219	225	PF00498	0.404
LIG_FHA_2	51	57	PF00498	0.491
LIG_FHA_2	512	518	PF00498	0.561
LIG_FHA_2	686	692	PF00498	0.426
LIG_GBD_Chelix_1	330	338	PF00786	0.408
LIG_LIR_Apic_2	724	729	PF02991	0.541
LIG_LIR_Gen_1	316	327	PF02991	0.523
LIG_LIR_Gen_1	356	367	PF02991	0.284
LIG_LIR_Gen_1	431	442	PF02991	0.408
LIG_LIR_Gen_1	574	584	PF02991	0.368
LIG_LIR_Nem_3	114	120	PF02991	0.571
LIG_LIR_Nem_3	185	189	PF02991	0.418
LIG_LIR_Nem_3	196	202	PF02991	0.338
LIG_LIR_Nem_3	218	223	PF02991	0.408
LIG_LIR_Nem_3	29	35	PF02991	0.448
LIG_LIR_Nem_3	316	322	PF02991	0.590
LIG_LIR_Nem_3	356	362	PF02991	0.290
LIG_LIR_Nem_3	380	386	PF02991	0.331
LIG_LIR_Nem_3	431	437	PF02991	0.378
LIG_LIR_Nem_3	574	580	PF02991	0.367
LIG_MLH1_MIPbox_1	355	359	PF16413	0.356
LIG_NRBOX	67	73	PF00104	0.467
LIG_NRP_CendR_1	773	776	PF00754	0.636
LIG_Pex14_2	391	395	PF04695	0.402
LIG_SH2_CRK	117	121	PF00017	0.478
LIG_SH2_CRK	200	204	PF00017	0.405
LIG_SH2_CRK	319	323	PF00017	0.562
LIG_SH2_CRK	35	39	PF00017	0.410
LIG_SH2_CRK	4	8	PF00017	0.518
LIG_SH2_CRK	726	730	PF00017	0.559
LIG_SH2_NCK_1	4	8	PF00017	0.518
LIG_SH2_STAP1	200	204	PF00017	0.467
LIG_SH2_STAP1	241	245	PF00017	0.384
LIG_SH2_STAP1	374	378	PF00017	0.407
LIG_SH2_STAT3	148	151	PF00017	0.508
LIG_SH2_STAT5	148	151	PF00017	0.508
LIG_SH2_STAT5	180	183	PF00017	0.338
LIG_SH2_STAT5	220	223	PF00017	0.412
LIG_SH2_STAT5	236	239	PF00017	0.424
LIG_SH2_STAT5	241	244	PF00017	0.404
LIG_SH2_STAT5	265	268	PF00017	0.577
LIG_SH2_STAT5	319	322	PF00017	0.637
LIG_SH2_STAT5	35	38	PF00017	0.416
LIG_SH2_STAT5	579	582	PF00017	0.378
LIG_SH3_1	134	140	PF00018	0.652
LIG_SH3_3	106	112	PF00018	0.545
LIG_SH3_3	134	140	PF00018	0.652
LIG_SH3_3	321	327	PF00018	0.385
LIG_SH3_3	359	365	PF00018	0.275
LIG_SH3_3	76	82	PF00018	0.441
LIG_Sin3_3	525	532	PF02671	0.603
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.371
LIG_SUMO_SIM_par_1	214	221	PF11976	0.429
LIG_TRAF2_1	244	247	PF00917	0.426
LIG_TYR_ITIM	184	189	PF00017	0.417
LIG_UBA3_1	233	239	PF00899	0.352
MOD_CDK_SPxxK_3	111	118	PF00069	0.590
MOD_CK1_1	282	288	PF00069	0.639
MOD_CK1_1	289	295	PF00069	0.670
MOD_CK1_1	333	339	PF00069	0.465
MOD_CK1_1	488	494	PF00069	0.559
MOD_CK1_1	49	55	PF00069	0.457
MOD_CK1_1	556	562	PF00069	0.608
MOD_CK2_1	212	218	PF00069	0.361
MOD_CK2_1	346	352	PF00069	0.427
MOD_CK2_1	511	517	PF00069	0.564
MOD_CK2_1	685	691	PF00069	0.426
MOD_Cter_Amidation	590	593	PF01082	0.465
MOD_GlcNHglycan	251	254	PF01048	0.523
MOD_GlcNHglycan	396	399	PF01048	0.450
MOD_GlcNHglycan	443	446	PF01048	0.376
MOD_GlcNHglycan	447	450	PF01048	0.429
MOD_GlcNHglycan	487	490	PF01048	0.631
MOD_GlcNHglycan	503	506	PF01048	0.583
MOD_GlcNHglycan	66	71	PF01048	0.476
MOD_GSK3_1	165	172	PF00069	0.491
MOD_GSK3_1	249	256	PF00069	0.483
MOD_GSK3_1	282	289	PF00069	0.654
MOD_GSK3_1	291	298	PF00069	0.637
MOD_GSK3_1	302	309	PF00069	0.632
MOD_GSK3_1	313	320	PF00069	0.652
MOD_GSK3_1	403	410	PF00069	0.379
MOD_GSK3_1	441	448	PF00069	0.403
MOD_GSK3_1	46	53	PF00069	0.446
MOD_GSK3_1	484	491	PF00069	0.511
MOD_GSK3_1	552	559	PF00069	0.632
MOD_N-GLC_1	468	473	PF02516	0.428
MOD_N-GLC_1	533	538	PF02516	0.537
MOD_N-GLC_1	623	628	PF02516	0.427
MOD_NEK2_1	182	187	PF00069	0.496
MOD_NEK2_1	407	412	PF00069	0.392
MOD_NEK2_1	43	48	PF00069	0.424
MOD_NEK2_1	485	490	PF00069	0.510
MOD_NEK2_1	501	506	PF00069	0.651
MOD_NEK2_1	685	690	PF00069	0.446
MOD_NEK2_2	34	39	PF00069	0.409
MOD_NEK2_2	468	473	PF00069	0.356
MOD_PIKK_1	147	153	PF00454	0.501
MOD_PIKK_1	50	56	PF00454	0.506
MOD_PIKK_1	82	88	PF00454	0.517
MOD_PK_1	3	9	PF00069	0.587
MOD_PKA_2	312	318	PF00069	0.555
MOD_PKA_2	485	491	PF00069	0.549
MOD_PKA_2	556	562	PF00069	0.563
MOD_PKB_1	668	676	PF00069	0.455
MOD_Plk_1	165	171	PF00069	0.431
MOD_Plk_1	429	435	PF00069	0.396
MOD_Plk_1	468	474	PF00069	0.408
MOD_Plk_1	495	501	PF00069	0.516
MOD_Plk_1	553	559	PF00069	0.615
MOD_Plk_1	66	72	PF00069	0.417
MOD_Plk_2-3	678	684	PF00069	0.431
MOD_Plk_4	165	171	PF00069	0.467
MOD_Plk_4	212	218	PF00069	0.387
MOD_Plk_4	330	336	PF00069	0.401
MOD_Plk_4	407	413	PF00069	0.389
MOD_Plk_4	43	49	PF00069	0.390
MOD_Plk_4	468	474	PF00069	0.340
MOD_Plk_4	496	502	PF00069	0.585
MOD_Plk_4	670	676	PF00069	0.457
MOD_ProDKin_1	111	117	PF00069	0.590
MOD_ProDKin_1	133	139	PF00069	0.585
MOD_ProDKin_1	272	278	PF00069	0.646
MOD_ProDKin_1	282	288	PF00069	0.629
MOD_ProDKin_1	289	295	PF00069	0.614
MOD_ProDKin_1	313	319	PF00069	0.729
MOD_ProDKin_1	584	590	PF00069	0.467
MOD_ProDKin_1	696	702	PF00069	0.492
TRG_DiLeu_BaEn_1	524	529	PF01217	0.604
TRG_DiLeu_BaEn_1	610	615	PF01217	0.368
TRG_DiLeu_BaEn_1	67	72	PF01217	0.597
TRG_DiLeu_BaEn_1	701	706	PF01217	0.525
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.384
TRG_ENDOCYTIC_2	117	120	PF00928	0.474
TRG_ENDOCYTIC_2	186	189	PF00928	0.464
TRG_ENDOCYTIC_2	200	203	PF00928	0.297
TRG_ENDOCYTIC_2	220	223	PF00928	0.320
TRG_ENDOCYTIC_2	319	322	PF00928	0.575
TRG_ENDOCYTIC_2	35	38	PF00928	0.405
TRG_ENDOCYTIC_2	4	7	PF00928	0.530
TRG_ENDOCYTIC_2	669	672	PF00928	0.382
TRG_ER_diArg_1	186	188	PF00400	0.367
TRG_ER_diArg_1	228	231	PF00400	0.371
TRG_ER_diArg_1	422	424	PF00400	0.419
TRG_ER_diArg_1	473	476	PF00400	0.384
TRG_ER_diArg_1	592	594	PF00400	0.466
TRG_NES_CRM1_1	62	78	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	761	766	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B3	Leptomonas seymouri	57%	88%
A0A3Q8ICJ7	Leishmania donovani	95%	100%
A4HCV7	Leishmania braziliensis	81%	99%
A4I0D7	Leishmania infantum	95%	100%
E9AWA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%