Beta-fructosidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-fructosidase-like protein

Species:

Leishmania major

UniProt:

Q4QB76_LEIMA

TriTrypDb:

LmjF.23.0870 , LMJLV39_230017900 , LMJSD75_230018100

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QB76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB76

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.313
CLV_NRD_NRD_1	271	273	PF00675	0.266
CLV_NRD_NRD_1	354	356	PF00675	0.326
CLV_PCSK_KEX2_1	354	356	PF00082	0.326
CLV_PCSK_KEX2_1	465	467	PF00082	0.332
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.320
CLV_PCSK_SKI1_1	211	215	PF00082	0.355
CLV_PCSK_SKI1_1	245	249	PF00082	0.351
CLV_PCSK_SKI1_1	400	404	PF00082	0.316
CLV_PCSK_SKI1_1	466	470	PF00082	0.339
DEG_Nend_UBRbox_3	1	3	PF02207	0.516
DOC_CYCLIN_RxL_1	380	391	PF00134	0.292
DOC_MAPK_MEF2A_6	257	265	PF00069	0.299
DOC_MAPK_MEF2A_6	482	490	PF00069	0.398
DOC_MAPK_MEF2A_6	500	507	PF00069	0.261
DOC_PP2B_LxvP_1	379	382	PF13499	0.323
DOC_PP4_FxxP_1	192	195	PF00568	0.323
DOC_PP4_FxxP_1	342	345	PF00568	0.282
DOC_PP4_MxPP_1	396	399	PF00568	0.308
DOC_USP7_MATH_1	12	16	PF00917	0.505
DOC_USP7_MATH_1	168	172	PF00917	0.416
DOC_USP7_MATH_1	312	316	PF00917	0.198
DOC_WW_Pin1_4	264	269	PF00397	0.292
DOC_WW_Pin1_4	304	309	PF00397	0.272
DOC_WW_Pin1_4	363	368	PF00397	0.352
LIG_14-3-3_CanoR_1	322	328	PF00244	0.273
LIG_14-3-3_CanoR_1	528	533	PF00244	0.394
LIG_Actin_WH2_2	390	408	PF00022	0.309
LIG_AP2alpha_2	388	390	PF02296	0.357
LIG_APCC_ABBA_1	494	499	PF00400	0.285
LIG_BRCT_BRCA1_1	515	519	PF00533	0.339
LIG_deltaCOP1_diTrp_1	85	92	PF00928	0.294
LIG_EH_1	80	84	PF12763	0.297
LIG_eIF4E_1	343	349	PF01652	0.219
LIG_FHA_1	212	218	PF00498	0.402
LIG_FHA_1	223	229	PF00498	0.323
LIG_FHA_1	295	301	PF00498	0.348
LIG_FHA_1	389	395	PF00498	0.400
LIG_FHA_1	419	425	PF00498	0.288
LIG_FHA_2	142	148	PF00498	0.255
LIG_FHA_2	152	158	PF00498	0.214
LIG_FHA_2	222	228	PF00498	0.344
LIG_FHA_2	428	434	PF00498	0.324
LIG_FHA_2	94	100	PF00498	0.309
LIG_KLC1_Yacidic_2	457	461	PF13176	0.428
LIG_LIR_Apic_2	341	345	PF02991	0.282
LIG_LIR_Apic_2	362	367	PF02991	0.266
LIG_LIR_Gen_1	233	241	PF02991	0.323
LIG_LIR_Nem_3	201	207	PF02991	0.350
LIG_LIR_Nem_3	233	239	PF02991	0.323
LIG_LIR_Nem_3	330	336	PF02991	0.320
LIG_NRBOX	216	222	PF00104	0.350
LIG_Pex14_1	323	327	PF04695	0.266
LIG_Pex14_1	48	52	PF04695	0.348
LIG_Pex14_2	73	77	PF04695	0.278
LIG_Pex14_2	83	87	PF04695	0.257
LIG_PTB_Apo_2	128	135	PF02174	0.276
LIG_PTB_Apo_2	467	474	PF02174	0.320
LIG_PTB_Apo_2	68	75	PF02174	0.255
LIG_PTB_Phospho_1	128	134	PF10480	0.276
LIG_PTB_Phospho_1	467	473	PF10480	0.320
LIG_PTB_Phospho_1	68	74	PF10480	0.255
LIG_RPA_C_Fungi	276	288	PF08784	0.266
LIG_SH2_GRB2like	69	72	PF00017	0.255
LIG_SH2_SRC	459	462	PF00017	0.339
LIG_SH2_STAP1	432	436	PF00017	0.316
LIG_SH2_STAT3	162	165	PF00017	0.303
LIG_SH2_STAT3	266	269	PF00017	0.266
LIG_SH2_STAT3	343	346	PF00017	0.323
LIG_SH2_STAT5	134	137	PF00017	0.323
LIG_SH2_STAT5	189	192	PF00017	0.408
LIG_SH2_STAT5	286	289	PF00017	0.350
LIG_SH2_STAT5	459	462	PF00017	0.428
LIG_SH3_3	179	185	PF00018	0.323
LIG_SUMO_SIM_anti_2	419	428	PF11976	0.245
LIG_SUMO_SIM_par_1	419	428	PF11976	0.267
LIG_TRAF2_1	25	28	PF00917	0.362
LIG_WRC_WIRS_1	324	329	PF05994	0.266
LIG_WW_1	186	189	PF00397	0.350
MOD_CDK_SPK_2	304	309	PF00069	0.245
MOD_CK1_1	123	129	PF00069	0.285
MOD_CK1_1	294	300	PF00069	0.269
MOD_CK2_1	141	147	PF00069	0.266
MOD_CK2_1	22	28	PF00069	0.494
MOD_CK2_1	298	304	PF00069	0.276
MOD_CK2_1	427	433	PF00069	0.320
MOD_CK2_1	440	446	PF00069	0.320
MOD_CK2_1	451	457	PF00069	0.320
MOD_CK2_1	498	504	PF00069	0.320
MOD_Cter_Amidation	352	355	PF01082	0.283
MOD_GlcNHglycan	122	125	PF01048	0.317
MOD_GlcNHglycan	14	17	PF01048	0.544
MOD_GlcNHglycan	149	152	PF01048	0.337
MOD_GlcNHglycan	283	286	PF01048	0.305
MOD_GlcNHglycan	312	315	PF01048	0.250
MOD_GlcNHglycan	375	378	PF01048	0.369
MOD_GlcNHglycan	4	7	PF01048	0.508
MOD_GlcNHglycan	453	456	PF01048	0.339
MOD_GlcNHglycan	478	481	PF01048	0.319
MOD_GSK3_1	143	150	PF00069	0.268
MOD_GSK3_1	2	9	PF00069	0.524
MOD_GSK3_1	287	294	PF00069	0.315
MOD_GSK3_1	304	311	PF00069	0.268
MOD_GSK3_1	323	330	PF00069	0.197
MOD_GSK3_1	363	370	PF00069	0.319
MOD_GSK3_1	373	380	PF00069	0.331
MOD_GSK3_1	476	483	PF00069	0.320
MOD_GSK3_1	528	535	PF00069	0.301
MOD_N-GLC_1	151	156	PF02516	0.198
MOD_N-GLC_1	291	296	PF02516	0.259
MOD_N-GLC_1	532	537	PF02516	0.381
MOD_NEK2_1	122	127	PF00069	0.323
MOD_NEK2_1	287	292	PF00069	0.245
MOD_NEK2_1	327	332	PF00069	0.292
MOD_NEK2_1	390	395	PF00069	0.343
MOD_NEK2_1	425	430	PF00069	0.253
MOD_NEK2_1	440	445	PF00069	0.368
MOD_NEK2_1	546	551	PF00069	0.473
MOD_PIKK_1	327	333	PF00454	0.266
MOD_PK_1	528	534	PF00069	0.293
MOD_PKA_2	499	505	PF00069	0.285
MOD_PKB_1	279	287	PF00069	0.292
MOD_Plk_1	291	297	PF00069	0.271
MOD_Plk_1	33	39	PF00069	0.358
MOD_Plk_1	498	504	PF00069	0.320
MOD_Plk_1	510	516	PF00069	0.320
MOD_Plk_2-3	499	505	PF00069	0.320
MOD_Plk_4	157	163	PF00069	0.276
MOD_Plk_4	291	297	PF00069	0.266
MOD_Plk_4	344	350	PF00069	0.381
MOD_Plk_4	408	414	PF00069	0.338
MOD_Plk_4	539	545	PF00069	0.412
MOD_ProDKin_1	264	270	PF00069	0.292
MOD_ProDKin_1	304	310	PF00069	0.272
MOD_ProDKin_1	363	369	PF00069	0.352
MOD_SUMO_for_1	20	23	PF00179	0.471
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.255
TRG_ENDOCYTIC_2	189	192	PF00928	0.350
TRG_ENDOCYTIC_2	74	77	PF00928	0.323
TRG_ENDOCYTIC_2	80	83	PF00928	0.323
TRG_ER_diArg_1	278	281	PF00400	0.323
TRG_ER_diArg_1	354	356	PF00400	0.317
TRG_NES_CRM1_1	485	499	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	50%	100%
A0A0N1PBT6	Leptomonas seymouri	25%	86%
A0A1X0NFY9	Trypanosomatidae	24%	100%
A0A1X0NTL0	Trypanosomatidae	24%	87%
A0A1X0NTM3	Trypanosomatidae	25%	87%
A0A1X0NY19	Trypanosomatidae	25%	87%
A0A1X0P322	Trypanosomatidae	24%	87%
A0A1X0P5Y7	Trypanosomatidae	25%	86%
A0A3Q8IB13	Leishmania donovani	94%	100%
A0A3Q8IFU7	Leishmania donovani	78%	100%
A0A3S5H595	Leishmania donovani	25%	86%
A0A3S5H7I4	Leishmania donovani	50%	100%
A0A3S7WXQ4	Leishmania donovani	66%	100%
A0A3S7WXS2	Leishmania donovani	78%	100%
A1STJ9	Psychromonas ingrahamii (strain 37)	33%	100%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A2X5P7	Oryza sativa subsp. indica	26%	96%
A2YZ01	Oryza sativa subsp. indica	22%	93%
A4H3V1	Leishmania braziliensis	26%	86%
A4HCV9	Leishmania braziliensis	82%	100%
A4HCW0	Leishmania braziliensis	66%	100%
A4HG14	Leishmania braziliensis	48%	100%
A4HS26	Leishmania infantum	25%	86%
A4I0D9	Leishmania infantum	94%	100%
A4I0E0	Leishmania infantum	67%	100%
A4I336	Leishmania infantum	50%	100%
A4IAW1	Leishmania infantum	26%	79%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	31%	100%
A8W7I5	Meyerozyma guilliermondii	25%	100%
B6DXP5	Leymus chinensis	24%	92%
B6DZC8	Triticum aestivum	24%	93%
B6DZD0	Triticum urartu	24%	92%
B6DZD1	Aegilops speltoides	24%	93%
B6DZD2	Aegilops tauschii	24%	93%
D2IGW7	Bromus pictus	25%	92%
E1ABX2	Aspergillus ficuum	27%	100%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ACV4	Leishmania major	50%	93%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	87%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	38%	100%
H2DF87	Rosa hybrid cultivar	26%	94%
H2DF88	Rosa hybrid cultivar	25%	86%
K0E681	Aspergillus rugulosus	26%	100%
O07003	Bacillus subtilis (strain 168)	26%	100%
O24509	Phaseolus vulgaris	26%	85%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	95%
O74641	Aspergillus niger	25%	100%
O74642	Aspergillus niger	25%	100%
O94220	Aspergillus ficuum	25%	100%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P05656	Bacillus subtilis (strain 168)	30%	82%
P07819	Bacillus subtilis (strain 168)	34%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	38%	100%
P10594	Saccharomyces cerevisiae	24%	100%
P10596	Saccharomyces cerevisiae	23%	100%
P13394	Vibrio alginolyticus	29%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	26%	100%
P16553	Escherichia coli	44%	100%
P24133	Schwanniomyces occidentalis	24%	100%
P26792	Daucus carota	24%	93%
P27217	Klebsiella pneumoniae	34%	100%
P29000	Solanum lycopersicum	24%	87%
P29001	Vigna radiata var. radiata	26%	85%
P37075	Salmonella typhimurium	33%	100%
P40714	Escherichia coli	44%	100%
P40912	Wickerhamomyces anomalus	23%	100%
P43471	Pediococcus pentosaceus	25%	100%
P49174	Zea mays	24%	94%
P49175	Zea mays	25%	82%
P80065	Daucus carota	25%	84%
P92916	Allium cepa	24%	90%
P93761	Capsicum annuum	24%	86%
P94469	Geobacillus stearothermophilus	26%	100%
Q01IS7	Oryza sativa subsp. indica	24%	92%
Q01IS8	Oryza sativa subsp. indica	25%	94%
Q04937	Lactococcus lactis subsp. lactis	24%	100%
Q05936	Staphylococcus xylosus	29%	100%
Q0E0P0	Oryza sativa subsp. japonica	26%	96%
Q0J360	Oryza sativa subsp. japonica	23%	93%
Q0JDC5	Oryza sativa subsp. japonica	24%	92%
Q0JDC6	Oryza sativa subsp. japonica	25%	94%
Q1PEF8	Arabidopsis thaliana	26%	94%
Q2UXF7	Triticum aestivum	26%	92%
Q39041	Arabidopsis thaliana	25%	83%
Q39692	Daucus carota	27%	93%
Q39693	Daucus carota	26%	95%
Q43089	Pisum sativum	24%	99%
Q43348	Arabidopsis thaliana	26%	85%
Q43857	Vicia faba	24%	86%
Q43866	Arabidopsis thaliana	26%	95%
Q4QB75	Leishmania major	67%	96%
Q56660	Vibrio cholerae	31%	100%
Q56UD0	Oryza sativa subsp. japonica	26%	93%
Q56UD1	Oryza sativa subsp. japonica	23%	100%
Q5FC15	Asparagus officinalis	25%	90%
Q5JJV0	Oryza sativa subsp. japonica	24%	94%
Q67XZ3	Arabidopsis thaliana	27%	93%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q70AT7	Hordeum vulgare	24%	92%
Q70XE6	Beta vulgaris	26%	91%
Q76HP6	Aspergillus niger	27%	100%
Q84LA1	Triticum aestivum	24%	93%
Q84PN8	Triticum aestivum	24%	92%
Q8W413	Arabidopsis thaliana	24%	93%
Q8W4S6	Arabidopsis thaliana	23%	100%
Q96TU3	Aspergillus awamori	25%	100%
Q9FSV7	Festuca arundinacea	24%	84%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	100%
Q9LIB9	Arabidopsis thaliana	23%	97%
Q9XTP3	Leishmania major	25%	86%
Q9Y746	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	91%