Cadherin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB67_LEIMA

TriTrypDb:

LmjF.23.0960 , LMJLV39_230018800 , LMJSD75_230019000

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QB67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.601
CLV_C14_Caspase3-7	50	54	PF00656	0.672
CLV_C14_Caspase3-7	650	654	PF00656	0.660
CLV_NRD_NRD_1	244	246	PF00675	0.550
CLV_NRD_NRD_1	37	39	PF00675	0.394
CLV_NRD_NRD_1	44	46	PF00675	0.442
CLV_NRD_NRD_1	445	447	PF00675	0.454
CLV_NRD_NRD_1	521	523	PF00675	0.467
CLV_NRD_NRD_1	599	601	PF00675	0.537
CLV_PCSK_FUR_1	33	37	PF00082	0.436
CLV_PCSK_FUR_1	41	45	PF00082	0.480
CLV_PCSK_FUR_1	597	601	PF00082	0.447
CLV_PCSK_KEX2_1	244	246	PF00082	0.550
CLV_PCSK_KEX2_1	35	37	PF00082	0.391
CLV_PCSK_KEX2_1	43	45	PF00082	0.433
CLV_PCSK_KEX2_1	445	447	PF00082	0.468
CLV_PCSK_KEX2_1	520	522	PF00082	0.474
CLV_PCSK_KEX2_1	599	601	PF00082	0.569
CLV_PCSK_KEX2_1	602	604	PF00082	0.566
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.521
CLV_PCSK_PC7_1	33	39	PF00082	0.424
CLV_PCSK_SKI1_1	390	394	PF00082	0.438
CLV_PCSK_SKI1_1	446	450	PF00082	0.491
CLV_PCSK_SKI1_1	49	53	PF00082	0.496
CLV_PCSK_SKI1_1	510	514	PF00082	0.484
CLV_PCSK_SKI1_1	643	647	PF00082	0.371
DEG_COP1_1	401	410	PF00400	0.697
DEG_SIAH_1	271	279	PF03145	0.724
DEG_SPOP_SBC_1	226	230	PF00917	0.640
DEG_SPOP_SBC_1	299	303	PF00917	0.677
DOC_CKS1_1	110	115	PF01111	0.631
DOC_CKS1_1	306	311	PF01111	0.703
DOC_CKS1_1	407	412	PF01111	0.669
DOC_CYCLIN_RxL_1	38	52	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.708
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	533	536	PF00134	0.632
DOC_MAPK_gen_1	36	48	PF00069	0.646
DOC_MAPK_gen_1	415	423	PF00069	0.551
DOC_MAPK_MEF2A_6	6	14	PF00069	0.364
DOC_MAPK_RevD_3	21	36	PF00069	0.395
DOC_PP1_RVXF_1	444	451	PF00149	0.689
DOC_PP2B_LxvP_1	211	214	PF13499	0.788
DOC_PP2B_LxvP_1	338	341	PF13499	0.613
DOC_PP2B_LxvP_1	533	536	PF13499	0.565
DOC_PP2B_PxIxI_1	536	542	PF00149	0.544
DOC_PP4_FxxP_1	110	113	PF00568	0.623
DOC_PP4_FxxP_1	172	175	PF00568	0.541
DOC_PP4_FxxP_1	550	553	PF00568	0.538
DOC_USP7_MATH_1	105	109	PF00917	0.644
DOC_USP7_MATH_1	226	230	PF00917	0.816
DOC_USP7_MATH_1	364	368	PF00917	0.686
DOC_USP7_MATH_1	408	412	PF00917	0.603
DOC_WW_Pin1_4	109	114	PF00397	0.566
DOC_WW_Pin1_4	209	214	PF00397	0.769
DOC_WW_Pin1_4	261	266	PF00397	0.781
DOC_WW_Pin1_4	290	295	PF00397	0.616
DOC_WW_Pin1_4	305	310	PF00397	0.545
DOC_WW_Pin1_4	312	317	PF00397	0.621
DOC_WW_Pin1_4	406	411	PF00397	0.634
DOC_WW_Pin1_4	571	576	PF00397	0.671
DOC_WW_Pin1_4	605	610	PF00397	0.771
DOC_WW_Pin1_4	71	76	PF00397	0.638
LIG_14-3-3_CanoR_1	124	133	PF00244	0.616
LIG_14-3-3_CanoR_1	258	266	PF00244	0.760
LIG_14-3-3_CanoR_1	320	324	PF00244	0.559
LIG_14-3-3_CanoR_1	337	341	PF00244	0.547
LIG_14-3-3_CanoR_1	384	392	PF00244	0.646
LIG_14-3-3_CanoR_1	418	422	PF00244	0.635
LIG_14-3-3_CanoR_1	498	503	PF00244	0.578
LIG_14-3-3_CanoR_1	510	518	PF00244	0.600
LIG_APCC_ABBAyCdc20_2	418	424	PF00400	0.588
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BIR_III_4	62	66	PF00653	0.716
LIG_Clathr_ClatBox_1	133	137	PF01394	0.581
LIG_Clathr_ClatBox_1	438	442	PF01394	0.600
LIG_eIF4E_1	159	165	PF01652	0.582
LIG_FHA_1	110	116	PF00498	0.589
LIG_FHA_1	165	171	PF00498	0.563
LIG_FHA_1	210	216	PF00498	0.775
LIG_FHA_1	233	239	PF00498	0.774
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	258	264	PF00498	0.762
LIG_FHA_1	301	307	PF00498	0.587
LIG_FHA_1	430	436	PF00498	0.560
LIG_FHA_1	464	470	PF00498	0.669
LIG_FHA_1	633	639	PF00498	0.588
LIG_FHA_1	64	70	PF00498	0.630
LIG_FHA_2	222	228	PF00498	0.773
LIG_FHA_2	299	305	PF00498	0.645
LIG_FHA_2	306	312	PF00498	0.593
LIG_FHA_2	432	438	PF00498	0.621
LIG_FHA_2	560	566	PF00498	0.646
LIG_FHA_2	629	635	PF00498	0.680
LIG_GBD_Chelix_1	22	30	PF00786	0.394
LIG_LIR_Apic_2	108	113	PF02991	0.630
LIG_LIR_Apic_2	171	175	PF02991	0.581
LIG_LIR_Apic_2	329	335	PF02991	0.577
LIG_LIR_Apic_2	401	405	PF02991	0.621
LIG_LIR_Gen_1	148	158	PF02991	0.530
LIG_LIR_Gen_1	434	444	PF02991	0.603
LIG_LIR_LC3C_4	112	116	PF02991	0.600
LIG_LIR_Nem_3	148	153	PF02991	0.561
LIG_LIR_Nem_3	162	166	PF02991	0.529
LIG_LIR_Nem_3	27	32	PF02991	0.454
LIG_LIR_Nem_3	324	330	PF02991	0.596
LIG_LIR_Nem_3	434	439	PF02991	0.589
LIG_LYPXL_yS_3	327	330	PF13949	0.611
LIG_MYND_1	213	217	PF01753	0.708
LIG_Pex14_2	645	649	PF04695	0.617
LIG_Pex14_2	682	686	PF04695	0.562
LIG_Pex14_2	86	90	PF04695	0.613
LIG_PTB_Apo_2	152	159	PF02174	0.663
LIG_PTB_Phospho_1	152	158	PF10480	0.669
LIG_RPA_C_Fungi	239	251	PF08784	0.670
LIG_RPA_C_Fungi	31	43	PF08784	0.530
LIG_SH2_CRK	166	170	PF00017	0.488
LIG_SH2_CRK	332	336	PF00017	0.455
LIG_SH2_CRK	678	682	PF00017	0.557
LIG_SH2_GRB2like	159	162	PF00017	0.398
LIG_SH2_GRB2like	58	61	PF00017	0.610
LIG_SH2_GRB2like	687	690	PF00017	0.599
LIG_SH2_NCK_1	332	336	PF00017	0.600
LIG_SH2_NCK_1	436	440	PF00017	0.522
LIG_SH2_SRC	225	228	PF00017	0.723
LIG_SH2_SRC	622	625	PF00017	0.567
LIG_SH2_STAP1	436	440	PF00017	0.518
LIG_SH2_STAT3	178	181	PF00017	0.543
LIG_SH2_STAT5	117	120	PF00017	0.477
LIG_SH2_STAT5	126	129	PF00017	0.546
LIG_SH2_STAT5	166	169	PF00017	0.419
LIG_SH2_STAT5	200	203	PF00017	0.470
LIG_SH2_STAT5	332	335	PF00017	0.462
LIG_SH2_STAT5	402	405	PF00017	0.614
LIG_SH2_STAT5	422	425	PF00017	0.451
LIG_SH2_STAT5	561	564	PF00017	0.434
LIG_SH2_STAT5	639	642	PF00017	0.421
LIG_SH2_STAT5	687	690	PF00017	0.599
LIG_SH3_1	402	408	PF00018	0.642
LIG_SH3_3	210	216	PF00018	0.760
LIG_SH3_3	260	266	PF00018	0.764
LIG_SH3_3	283	289	PF00018	0.534
LIG_SH3_3	303	309	PF00018	0.317
LIG_SH3_3	402	408	PF00018	0.499
LIG_SH3_3	570	576	PF00018	0.538
LIG_SH3_3	69	75	PF00018	0.652
LIG_Sin3_3	391	398	PF02671	0.502
LIG_SUMO_SIM_par_1	131	137	PF11976	0.474
LIG_SUMO_SIM_par_1	19	25	PF11976	0.469
LIG_SUMO_SIM_par_1	461	468	PF11976	0.565
LIG_TRAF2_1	94	97	PF00917	0.543
LIG_TYR_ITIM	115	120	PF00017	0.470
LIG_TYR_ITSM	432	439	PF00017	0.527
LIG_WRC_WIRS_1	48	53	PF05994	0.603
LIG_WW_2	213	216	PF00397	0.652
MOD_CDK_SPxxK_3	406	413	PF00069	0.578
MOD_CK1_1	106	112	PF00069	0.539
MOD_CK1_1	142	148	PF00069	0.618
MOD_CK1_1	209	215	PF00069	0.683
MOD_CK1_1	261	267	PF00069	0.756
MOD_CK1_1	326	332	PF00069	0.494
MOD_CK1_1	375	381	PF00069	0.676
MOD_CK1_1	386	392	PF00069	0.349
MOD_CK1_1	468	474	PF00069	0.440
MOD_CK1_1	71	77	PF00069	0.523
MOD_CK2_1	221	227	PF00069	0.738
MOD_CK2_1	292	298	PF00069	0.625
MOD_CK2_1	305	311	PF00069	0.496
MOD_CK2_1	431	437	PF00069	0.540
MOD_CK2_1	539	545	PF00069	0.504
MOD_CK2_1	628	634	PF00069	0.592
MOD_Cter_Amidation	600	603	PF01082	0.770
MOD_GlcNHglycan	105	108	PF01048	0.613
MOD_GlcNHglycan	208	211	PF01048	0.706
MOD_GlcNHglycan	229	232	PF01048	0.739
MOD_GlcNHglycan	272	275	PF01048	0.767
MOD_GlcNHglycan	277	281	PF01048	0.703
MOD_GlcNHglycan	294	297	PF01048	0.482
MOD_GlcNHglycan	366	369	PF01048	0.580
MOD_GlcNHglycan	370	373	PF01048	0.605
MOD_GlcNHglycan	374	377	PF01048	0.627
MOD_GlcNHglycan	381	384	PF01048	0.501
MOD_GlcNHglycan	385	388	PF01048	0.441
MOD_GlcNHglycan	479	482	PF01048	0.589
MOD_GlcNHglycan	669	672	PF01048	0.668
MOD_GlcNHglycan	80	83	PF01048	0.621
MOD_GSK3_1	105	112	PF00069	0.529
MOD_GSK3_1	142	149	PF00069	0.578
MOD_GSK3_1	205	212	PF00069	0.660
MOD_GSK3_1	221	228	PF00069	0.675
MOD_GSK3_1	24	31	PF00069	0.246
MOD_GSK3_1	257	264	PF00069	0.732
MOD_GSK3_1	272	279	PF00069	0.771
MOD_GSK3_1	319	326	PF00069	0.469
MOD_GSK3_1	341	348	PF00069	0.593
MOD_GSK3_1	364	371	PF00069	0.642
MOD_GSK3_1	375	382	PF00069	0.640
MOD_GSK3_1	473	480	PF00069	0.501
MOD_GSK3_1	506	513	PF00069	0.570
MOD_GSK3_1	559	566	PF00069	0.417
MOD_GSK3_1	628	635	PF00069	0.487
MOD_GSK3_1	63	70	PF00069	0.723
MOD_GSK3_1	663	670	PF00069	0.709
MOD_N-GLC_1	232	237	PF02516	0.724
MOD_N-GLC_1	563	568	PF02516	0.539
MOD_NEK2_1	139	144	PF00069	0.606
MOD_NEK2_1	164	169	PF00069	0.469
MOD_NEK2_1	257	262	PF00069	0.729
MOD_NEK2_1	323	328	PF00069	0.463
MOD_NEK2_1	330	335	PF00069	0.428
MOD_NEK2_1	336	341	PF00069	0.447
MOD_NEK2_1	414	419	PF00069	0.493
MOD_NEK2_1	465	470	PF00069	0.480
MOD_NEK2_1	632	637	PF00069	0.674
MOD_NEK2_1	78	83	PF00069	0.646
MOD_PIKK_1	345	351	PF00454	0.616
MOD_PIKK_1	429	435	PF00454	0.488
MOD_PIKK_1	632	638	PF00454	0.623
MOD_PK_1	498	504	PF00069	0.569
MOD_PKA_2	139	145	PF00069	0.634
MOD_PKA_2	257	263	PF00069	0.638
MOD_PKA_2	319	325	PF00069	0.428
MOD_PKA_2	336	342	PF00069	0.482
MOD_PKA_2	383	389	PF00069	0.565
MOD_PKA_2	414	420	PF00069	0.612
MOD_Plk_1	145	151	PF00069	0.474
MOD_Plk_1	233	239	PF00069	0.728
MOD_Plk_4	24	30	PF00069	0.422
MOD_Plk_4	326	332	PF00069	0.439
MOD_Plk_4	341	347	PF00069	0.495
MOD_Plk_4	398	404	PF00069	0.515
MOD_Plk_4	417	423	PF00069	0.532
MOD_Plk_4	431	437	PF00069	0.480
MOD_Plk_4	628	634	PF00069	0.456
MOD_Plk_4	68	74	PF00069	0.629
MOD_ProDKin_1	109	115	PF00069	0.453
MOD_ProDKin_1	209	215	PF00069	0.739
MOD_ProDKin_1	261	267	PF00069	0.752
MOD_ProDKin_1	290	296	PF00069	0.534
MOD_ProDKin_1	305	311	PF00069	0.435
MOD_ProDKin_1	312	318	PF00069	0.524
MOD_ProDKin_1	406	412	PF00069	0.540
MOD_ProDKin_1	571	577	PF00069	0.589
MOD_ProDKin_1	605	611	PF00069	0.734
MOD_ProDKin_1	71	77	PF00069	0.550
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.771
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.567
TRG_ENDOCYTIC_2	117	120	PF00928	0.535
TRG_ENDOCYTIC_2	327	330	PF00928	0.515
TRG_ENDOCYTIC_2	436	439	PF00928	0.425
TRG_ENDOCYTIC_2	678	681	PF00928	0.537
TRG_ENDOCYTIC_2	87	90	PF00928	0.467
TRG_ER_diArg_1	118	121	PF00400	0.523
TRG_ER_diArg_1	32	35	PF00400	0.484
TRG_ER_diArg_1	36	38	PF00400	0.512
TRG_ER_diArg_1	41	44	PF00400	0.549
TRG_ER_diArg_1	412	415	PF00400	0.523
TRG_ER_diArg_1	520	522	PF00400	0.620
TRG_ER_diArg_1	597	600	PF00400	0.704
TRG_NLS_MonoExtN_4	445	450	PF00514	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q7	Leptomonas seymouri	53%	100%
A0A1X0NWT3	Trypanosomatidae	36%	100%
A0A3Q8IM61	Leishmania donovani	92%	100%
A0A3R7NT57	Trypanosoma rangeli	34%	100%
A4HCW5	Leishmania braziliensis	71%	100%
A4I0E5	Leishmania infantum	92%	100%
C9ZV90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BEP2	Trypanosoma cruzi	33%	100%