Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB66_LEIMA

TriTrypDb:

LmjF.23.0970 , LMJLV39_230018900 , LMJSD75_230019100

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.669
CLV_C14_Caspase3-7	332	336	PF00656	0.712
CLV_C14_Caspase3-7	347	351	PF00656	0.564
CLV_NRD_NRD_1	288	290	PF00675	0.528
CLV_NRD_NRD_1	291	293	PF00675	0.557
CLV_NRD_NRD_1	310	312	PF00675	0.678
CLV_NRD_NRD_1	339	341	PF00675	0.742
CLV_NRD_NRD_1	374	376	PF00675	0.636
CLV_PCSK_FUR_1	289	293	PF00082	0.550
CLV_PCSK_KEX2_1	290	292	PF00082	0.544
CLV_PCSK_KEX2_1	310	312	PF00082	0.805
CLV_PCSK_KEX2_1	339	341	PF00082	0.751
CLV_PCSK_KEX2_1	374	376	PF00082	0.636
CLV_PCSK_KEX2_1	383	385	PF00082	0.615
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.544
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.764
CLV_PCSK_SKI1_1	258	262	PF00082	0.423
CLV_PCSK_SKI1_1	278	282	PF00082	0.517
CLV_PCSK_SKI1_1	291	295	PF00082	0.567
CLV_PCSK_SKI1_1	370	374	PF00082	0.568
CLV_PCSK_SKI1_1	46	50	PF00082	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DEG_SPOP_SBC_1	322	326	PF00917	0.616
DOC_MAPK_gen_1	254	261	PF00069	0.500
DOC_MAPK_gen_1	289	296	PF00069	0.560
DOC_PP2B_LxvP_1	71	74	PF13499	0.520
DOC_USP7_MATH_1	202	206	PF00917	0.677
DOC_USP7_MATH_1	216	220	PF00917	0.453
DOC_USP7_MATH_1	228	232	PF00917	0.426
DOC_USP7_MATH_1	321	325	PF00917	0.751
DOC_USP7_MATH_1	378	382	PF00917	0.715
DOC_USP7_MATH_1	8	12	PF00917	0.609
DOC_WW_Pin1_4	11	16	PF00397	0.708
DOC_WW_Pin1_4	145	150	PF00397	0.678
DOC_WW_Pin1_4	301	306	PF00397	0.623
LIG_14-3-3_CanoR_1	172	176	PF00244	0.667
LIG_14-3-3_CanoR_1	377	385	PF00244	0.729
LIG_14-3-3_CanoR_1	6	16	PF00244	0.622
LIG_BIR_III_2	92	96	PF00653	0.525
LIG_BIR_III_4	186	190	PF00653	0.524
LIG_BIR_III_4	335	339	PF00653	0.704
LIG_DCNL_PONY_1	1	4	PF03556	0.768
LIG_eIF4E_1	44	50	PF01652	0.455
LIG_FHA_1	12	18	PF00498	0.698
LIG_FHA_1	45	51	PF00498	0.456
LIG_FHA_2	106	112	PF00498	0.696
LIG_FHA_2	323	329	PF00498	0.664
LIG_FHA_2	81	87	PF00498	0.510
LIG_Integrin_RGD_1	345	347	PF01839	0.693
LIG_LIR_Gen_1	39	50	PF02991	0.504
LIG_LIR_Nem_3	10	16	PF02991	0.609
LIG_LIR_Nem_3	382	388	PF02991	0.687
LIG_LIR_Nem_3	39	45	PF02991	0.508
LIG_LYPXL_SIV_4	41	49	PF13949	0.467
LIG_NRBOX	67	73	PF00104	0.499
LIG_SH2_CRK	13	17	PF00017	0.702
LIG_SH2_CRK	239	243	PF00017	0.444
LIG_SH2_CRK	38	42	PF00017	0.520
LIG_SH2_NCK_1	38	42	PF00017	0.520
LIG_SH2_PTP2	42	45	PF00017	0.470
LIG_SH2_SRC	42	45	PF00017	0.470
LIG_SH2_SRC	64	67	PF00017	0.464
LIG_SH2_STAP1	31	35	PF00017	0.573
LIG_SH2_STAT5	13	16	PF00017	0.706
LIG_SH2_STAT5	144	147	PF00017	0.647
LIG_SH2_STAT5	42	45	PF00017	0.470
LIG_SH2_STAT5	64	67	PF00017	0.486
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.500
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.501
LIG_TRAF2_1	280	283	PF00917	0.510
LIG_TRAF2_1	325	328	PF00917	0.584
LIG_TRAF2_1	359	362	PF00917	0.695
LIG_TYR_ITIM	237	242	PF00017	0.440
LIG_WRC_WIRS_1	220	225	PF05994	0.541
MOD_CDK_SPxK_1	301	307	PF00069	0.648
MOD_CK1_1	11	17	PF00069	0.621
MOD_CK1_1	147	153	PF00069	0.669
MOD_CK1_1	167	173	PF00069	0.455
MOD_CK1_1	219	225	PF00069	0.557
MOD_CK1_1	29	35	PF00069	0.513
MOD_CK1_1	75	81	PF00069	0.563
MOD_CK2_1	105	111	PF00069	0.705
MOD_CK2_1	202	208	PF00069	0.612
MOD_CK2_1	249	255	PF00069	0.482
MOD_CK2_1	321	327	PF00069	0.579
MOD_CK2_1	80	86	PF00069	0.469
MOD_Cter_Amidation	337	340	PF01082	0.754
MOD_GlcNHglycan	100	103	PF01048	0.772
MOD_GlcNHglycan	224	227	PF01048	0.649
MOD_GlcNHglycan	251	254	PF01048	0.436
MOD_GlcNHglycan	269	272	PF01048	0.621
MOD_GlcNHglycan	31	34	PF01048	0.582
MOD_GlcNHglycan	319	322	PF01048	0.798
MOD_GlcNHglycan	331	334	PF01048	0.593
MOD_GSK3_1	129	136	PF00069	0.660
MOD_GSK3_1	167	174	PF00069	0.656
MOD_GSK3_1	22	29	PF00069	0.429
MOD_GSK3_1	224	231	PF00069	0.526
MOD_GSK3_1	313	320	PF00069	0.698
MOD_GSK3_1	7	14	PF00069	0.724
MOD_N-GLC_1	301	306	PF02516	0.783
MOD_N-GLC_1	322	327	PF02516	0.693
MOD_N-GLC_1	80	85	PF02516	0.517
MOD_NEK2_1	2	7	PF00069	0.656
MOD_NEK2_1	22	27	PF00069	0.341
MOD_NEK2_1	261	266	PF00069	0.504
MOD_NEK2_1	50	55	PF00069	0.478
MOD_PIKK_1	75	81	PF00454	0.563
MOD_PK_1	284	290	PF00069	0.517
MOD_PKA_2	171	177	PF00069	0.736
MOD_PKA_2	2	8	PF00069	0.651
MOD_PKA_2	379	385	PF00069	0.736
MOD_Plk_1	104	110	PF00069	0.647
MOD_Plk_2-3	105	111	PF00069	0.755
MOD_Plk_2-3	129	135	PF00069	0.680
MOD_Plk_4	216	222	PF00069	0.553
MOD_Plk_4	22	28	PF00069	0.593
MOD_Plk_4	368	374	PF00069	0.589
MOD_Plk_4	44	50	PF00069	0.455
MOD_ProDKin_1	11	17	PF00069	0.705
MOD_ProDKin_1	145	151	PF00069	0.681
MOD_ProDKin_1	301	307	PF00069	0.625
TRG_DiLeu_BaEn_1	257	262	PF01217	0.496
TRG_DiLeu_BaEn_2	85	91	PF01217	0.501
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.653
TRG_ENDOCYTIC_2	13	16	PF00928	0.605
TRG_ENDOCYTIC_2	239	242	PF00928	0.439
TRG_ENDOCYTIC_2	385	388	PF00928	0.699
TRG_ENDOCYTIC_2	42	45	PF00928	0.470
TRG_ER_diArg_1	288	291	PF00400	0.532
TRG_ER_diArg_1	310	312	PF00400	0.801
TRG_ER_diArg_1	373	375	PF00400	0.581
TRG_NLS_MonoCore_2	288	293	PF00514	0.543
TRG_NLS_MonoExtN_4	289	294	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP9	Leptomonas seymouri	52%	100%
A0A3S5H7C1	Leishmania donovani	89%	99%
A4HCW6	Leishmania braziliensis	74%	100%
A4I0E6	Leishmania infantum	90%	100%
E9AWA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%