BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB65_LEIMA

TriTrypDb:

LmjF.23.0980 , LMJLV39_230019000 , LMJSD75_230019200

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.507
CLV_NRD_NRD_1	192	194	PF00675	0.497
CLV_NRD_NRD_1	211	213	PF00675	0.418
CLV_PCSK_KEX2_1	211	213	PF00082	0.483
CLV_PCSK_KEX2_1	227	229	PF00082	0.358
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.450
CLV_PCSK_PC7_1	207	213	PF00082	0.428
CLV_PCSK_SKI1_1	180	184	PF00082	0.444
CLV_PCSK_SKI1_1	187	191	PF00082	0.420
CLV_PCSK_SKI1_1	228	232	PF00082	0.457
CLV_PCSK_SKI1_1	66	70	PF00082	0.427
DEG_Nend_UBRbox_2	1	3	PF02207	0.483
DEG_SCF_FBW7_1	289	296	PF00400	0.516
DOC_CYCLIN_RxL_1	61	71	PF00134	0.413
DOC_MAPK_gen_1	303	311	PF00069	0.543
DOC_MAPK_gen_1	66	75	PF00069	0.534
DOC_USP7_MATH_1	141	145	PF00917	0.372
DOC_USP7_MATH_1	293	297	PF00917	0.527
DOC_USP7_MATH_1	44	48	PF00917	0.686
DOC_USP7_MATH_1	8	12	PF00917	0.490
DOC_USP7_UBL2_3	190	194	PF12436	0.530
DOC_USP7_UBL2_3	227	231	PF12436	0.580
DOC_WW_Pin1_4	289	294	PF00397	0.514
DOC_WW_Pin1_4	86	91	PF00397	0.410
LIG_14-3-3_CanoR_1	173	177	PF00244	0.424
LIG_14-3-3_CanoR_1	180	189	PF00244	0.357
LIG_14-3-3_CanoR_1	193	197	PF00244	0.278
LIG_14-3-3_CanoR_1	52	62	PF00244	0.500
LIG_Actin_WH2_2	174	192	PF00022	0.492
LIG_Actin_WH2_2	79	96	PF00022	0.404
LIG_BIR_III_4	35	39	PF00653	0.523
LIG_BRCT_BRCA1_1	260	264	PF00533	0.453
LIG_FHA_1	173	179	PF00498	0.485
LIG_FHA_1	266	272	PF00498	0.518
LIG_FHA_1	284	290	PF00498	0.386
LIG_FHA_1	334	340	PF00498	0.619
LIG_FHA_1	63	69	PF00498	0.384
LIG_FHA_1	83	89	PF00498	0.290
LIG_FHA_2	148	154	PF00498	0.431
LIG_FHA_2	243	249	PF00498	0.495
LIG_LIR_Gen_1	248	258	PF02991	0.422
LIG_LIR_Gen_1	316	327	PF02991	0.576
LIG_LIR_Gen_1	71	80	PF02991	0.477
LIG_LIR_Gen_1	98	107	PF02991	0.608
LIG_LIR_Nem_3	142	148	PF02991	0.484
LIG_LIR_Nem_3	248	253	PF02991	0.551
LIG_LIR_Nem_3	71	75	PF02991	0.405
LIG_LIR_Nem_3	98	103	PF02991	0.608
LIG_SH2_CRK	100	104	PF00017	0.394
LIG_SH2_CRK	72	76	PF00017	0.448
LIG_SH2_GRB2like	100	103	PF00017	0.497
LIG_SH2_SRC	254	257	PF00017	0.444
LIG_SH2_STAP1	229	233	PF00017	0.500
LIG_SH2_STAP1	254	258	PF00017	0.379
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.304
LIG_SUMO_SIM_par_1	174	179	PF11976	0.412
LIG_SUMO_SIM_par_1	285	292	PF11976	0.504
LIG_TYR_ITIM	70	75	PF00017	0.480
LIG_TYR_ITSM	96	103	PF00017	0.490
LIG_WRC_WIRS_1	148	153	PF05994	0.476
MOD_CK1_1	11	17	PF00069	0.505
MOD_CK1_1	112	118	PF00069	0.565
MOD_CK1_1	266	272	PF00069	0.434
MOD_CK1_1	332	338	PF00069	0.745
MOD_CK2_1	147	153	PF00069	0.429
MOD_CK2_1	207	213	PF00069	0.560
MOD_CK2_1	242	248	PF00069	0.501
MOD_Cter_Amidation	191	194	PF01082	0.471
MOD_GlcNHglycan	111	114	PF01048	0.613
MOD_GlcNHglycan	42	45	PF01048	0.660
MOD_GSK3_1	127	134	PF00069	0.549
MOD_GSK3_1	238	245	PF00069	0.531
MOD_GSK3_1	24	31	PF00069	0.600
MOD_GSK3_1	283	290	PF00069	0.443
MOD_GSK3_1	293	300	PF00069	0.541
MOD_GSK3_1	327	334	PF00069	0.606
MOD_GSK3_1	40	47	PF00069	0.723
MOD_GSK3_1	78	85	PF00069	0.408
MOD_N-GLC_1	40	45	PF02516	0.591
MOD_N-GLC_2	102	104	PF02516	0.448
MOD_N-GLC_2	116	118	PF02516	0.506
MOD_NEK2_1	223	228	PF00069	0.648
MOD_NEK2_1	264	269	PF00069	0.411
MOD_NEK2_1	327	332	PF00069	0.631
MOD_NEK2_1	333	338	PF00069	0.605
MOD_NEK2_1	37	42	PF00069	0.609
MOD_NEK2_1	68	73	PF00069	0.427
MOD_NEK2_2	192	197	PF00069	0.427
MOD_PIKK_1	258	264	PF00454	0.379
MOD_PKA_2	172	178	PF00069	0.415
MOD_PKA_2	192	198	PF00069	0.372
MOD_Plk_1	141	147	PF00069	0.482
MOD_Plk_2-3	172	178	PF00069	0.422
MOD_Plk_4	238	244	PF00069	0.485
MOD_Plk_4	68	74	PF00069	0.465
MOD_ProDKin_1	289	295	PF00069	0.509
MOD_ProDKin_1	86	92	PF00069	0.415
MOD_SUMO_rev_2	153	160	PF00179	0.466
TRG_ENDOCYTIC_2	100	103	PF00928	0.461
TRG_ENDOCYTIC_2	145	148	PF00928	0.463
TRG_ENDOCYTIC_2	254	257	PF00928	0.407
TRG_ENDOCYTIC_2	280	283	PF00928	0.391
TRG_ENDOCYTIC_2	72	75	PF00928	0.428
TRG_ER_diArg_1	133	136	PF00400	0.562
TRG_ER_diArg_1	302	305	PF00400	0.531
TRG_NES_CRM1_1	172	186	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C0	Leptomonas seymouri	34%	100%
A0A3S7WXR6	Leishmania donovani	89%	100%
A4HCW7	Leishmania braziliensis	55%	100%
A4I0E7	Leishmania infantum	89%	100%
E9AWB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%