Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB64_LEIMA

TriTrypDb:

LmjF.23.0990 , LMJLV39_230019100 , LMJSD75_230019300

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.879
CLV_NRD_NRD_1	156	158	PF00675	0.663
CLV_NRD_NRD_1	161	163	PF00675	0.619
CLV_NRD_NRD_1	168	170	PF00675	0.640
CLV_NRD_NRD_1	187	189	PF00675	0.449
CLV_NRD_NRD_1	323	325	PF00675	0.821
CLV_NRD_NRD_1	407	409	PF00675	0.734
CLV_NRD_NRD_1	459	461	PF00675	0.790
CLV_NRD_NRD_1	550	552	PF00675	0.791
CLV_NRD_NRD_1	573	575	PF00675	0.806
CLV_NRD_NRD_1	597	599	PF00675	0.814
CLV_PCSK_FUR_1	595	599	PF00082	0.819
CLV_PCSK_KEX2_1	292	294	PF00082	0.866
CLV_PCSK_KEX2_1	323	325	PF00082	0.728
CLV_PCSK_KEX2_1	407	409	PF00082	0.734
CLV_PCSK_KEX2_1	459	461	PF00082	0.790
CLV_PCSK_KEX2_1	550	552	PF00082	0.791
CLV_PCSK_KEX2_1	597	599	PF00082	0.813
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.788
CLV_PCSK_SKI1_1	151	155	PF00082	0.560
CLV_PCSK_SKI1_1	163	167	PF00082	0.567
CLV_PCSK_SKI1_1	172	176	PF00082	0.580
CLV_PCSK_SKI1_1	28	32	PF00082	0.555
DEG_APCC_DBOX_1	550	558	PF00400	0.760
DEG_Nend_Nbox_1	1	3	PF02207	0.783
DEG_SCF_TRCP1_1	254	260	PF00400	0.679
DEG_SPOP_SBC_1	431	435	PF00917	0.752
DEG_SPOP_SBC_1	582	586	PF00917	0.782
DOC_MAPK_DCC_7	558	567	PF00069	0.760
DOC_MAPK_gen_1	274	282	PF00069	0.676
DOC_MAPK_gen_1	28	37	PF00069	0.536
DOC_MAPK_gen_1	323	330	PF00069	0.755
DOC_MAPK_gen_1	470	477	PF00069	0.641
DOC_MAPK_gen_1	550	557	PF00069	0.785
DOC_MAPK_MEF2A_6	470	477	PF00069	0.641
DOC_PP2B_LxvP_1	397	400	PF13499	0.721
DOC_USP7_MATH_1	304	308	PF00917	0.776
DOC_USP7_MATH_1	382	386	PF00917	0.642
DOC_USP7_MATH_1	578	582	PF00917	0.855
DOC_USP7_MATH_1	583	587	PF00917	0.745
DOC_USP7_MATH_1	588	592	PF00917	0.691
DOC_USP7_MATH_1	641	645	PF00917	0.845
DOC_USP7_MATH_1	745	749	PF00917	0.631
DOC_USP7_MATH_1	9	13	PF00917	0.646
DOC_USP7_UBL2_3	147	151	PF12436	0.526
DOC_USP7_UBL2_3	166	170	PF12436	0.643
DOC_WW_Pin1_4	286	291	PF00397	0.765
DOC_WW_Pin1_4	295	300	PF00397	0.820
DOC_WW_Pin1_4	3	8	PF00397	0.729
DOC_WW_Pin1_4	354	359	PF00397	0.805
DOC_WW_Pin1_4	364	369	PF00397	0.799
DOC_WW_Pin1_4	392	397	PF00397	0.771
DOC_WW_Pin1_4	427	432	PF00397	0.751
DOC_WW_Pin1_4	720	725	PF00397	0.786
LIG_14-3-3_CanoR_1	172	181	PF00244	0.594
LIG_14-3-3_CanoR_1	345	350	PF00244	0.683
LIG_14-3-3_CanoR_1	370	374	PF00244	0.748
LIG_14-3-3_CanoR_1	39	47	PF00244	0.657
LIG_14-3-3_CanoR_1	550	555	PF00244	0.844
LIG_14-3-3_CanoR_1	579	587	PF00244	0.862
LIG_14-3-3_CanoR_1	632	642	PF00244	0.822
LIG_14-3-3_CanoR_1	714	720	PF00244	0.661
LIG_14-3-3_CterR_2	744	749	PF00244	0.632
LIG_Actin_WH2_2	118	136	PF00022	0.662
LIG_BIR_III_2	410	414	PF00653	0.779
LIG_BRCT_BRCA1_1	312	316	PF00533	0.741
LIG_Clathr_ClatBox_1	562	566	PF01394	0.847
LIG_CtBP_PxDLS_1	675	679	PF00389	0.772
LIG_DLG_GKlike_1	550	557	PF00625	0.668
LIG_FHA_1	137	143	PF00498	0.489
LIG_FHA_1	226	232	PF00498	0.532
LIG_FHA_1	550	556	PF00498	0.788
LIG_FHA_1	582	588	PF00498	0.785
LIG_FHA_1	603	609	PF00498	0.723
LIG_FHA_2	201	207	PF00498	0.575
LIG_FHA_2	217	223	PF00498	0.376
LIG_FHA_2	351	357	PF00498	0.664
LIG_FHA_2	431	437	PF00498	0.873
LIG_FHA_2	469	475	PF00498	0.762
LIG_LIR_Gen_1	202	213	PF02991	0.677
LIG_LIR_Gen_1	221	231	PF02991	0.349
LIG_LIR_Gen_1	57	65	PF02991	0.595
LIG_LIR_Gen_1	77	87	PF02991	0.425
LIG_LIR_Nem_3	112	117	PF02991	0.572
LIG_LIR_Nem_3	202	208	PF02991	0.555
LIG_LIR_Nem_3	313	319	PF02991	0.725
LIG_LIR_Nem_3	57	61	PF02991	0.586
LIG_LIR_Nem_3	77	82	PF02991	0.450
LIG_NRBOX	258	264	PF00104	0.701
LIG_PDZ_Class_1	744	749	PF00595	0.764
LIG_SH2_CRK	654	658	PF00017	0.705
LIG_SH2_GRB2like	320	323	PF00017	0.811
LIG_SH2_NCK_1	386	390	PF00017	0.793
LIG_SH2_PTP2	416	419	PF00017	0.625
LIG_SH2_SRC	329	332	PF00017	0.747
LIG_SH2_STAP1	14	18	PF00017	0.589
LIG_SH2_STAP1	194	198	PF00017	0.568
LIG_SH2_STAP1	205	209	PF00017	0.543
LIG_SH2_STAT3	180	183	PF00017	0.598
LIG_SH2_STAT5	167	170	PF00017	0.617
LIG_SH2_STAT5	180	183	PF00017	0.483
LIG_SH2_STAT5	214	217	PF00017	0.570
LIG_SH2_STAT5	230	233	PF00017	0.538
LIG_SH2_STAT5	329	332	PF00017	0.774
LIG_SH2_STAT5	36	39	PF00017	0.568
LIG_SH2_STAT5	416	419	PF00017	0.781
LIG_SH2_STAT5	79	82	PF00017	0.773
LIG_SH3_3	388	394	PF00018	0.775
LIG_SH3_3	397	403	PF00018	0.756
LIG_SH3_3	496	502	PF00018	0.758
LIG_SH3_3	584	590	PF00018	0.781
LIG_SH3_3	612	618	PF00018	0.849
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.556
LIG_SUMO_SIM_par_1	563	571	PF11976	0.810
LIG_UBA3_1	105	109	PF00899	0.568
LIG_UBA3_1	554	558	PF00899	0.742
LIG_WRC_WIRS_1	198	203	PF05994	0.557
LIG_WRC_WIRS_1	79	84	PF05994	0.758
MOD_CDK_SPxK_1	286	292	PF00069	0.783
MOD_CDK_SPxK_1	295	301	PF00069	0.714
MOD_CDK_SPxK_1	354	360	PF00069	0.895
MOD_CDK_SPxK_1	364	370	PF00069	0.708
MOD_CDK_SPxxK_3	286	293	PF00069	0.847
MOD_CK1_1	286	292	PF00069	0.765
MOD_CK1_1	344	350	PF00069	0.817
MOD_CK1_1	364	370	PF00069	0.873
MOD_CK1_1	427	433	PF00069	0.783
MOD_CK1_1	49	55	PF00069	0.611
MOD_CK1_1	553	559	PF00069	0.765
MOD_CK1_1	568	574	PF00069	0.728
MOD_CK1_1	581	587	PF00069	0.799
MOD_CK1_1	631	637	PF00069	0.809
MOD_CK1_1	709	715	PF00069	0.882
MOD_CK2_1	158	164	PF00069	0.613
MOD_CK2_1	200	206	PF00069	0.496
MOD_CK2_1	350	356	PF00069	0.660
MOD_CK2_1	384	390	PF00069	0.867
MOD_CK2_1	468	474	PF00069	0.762
MOD_CK2_1	54	60	PF00069	0.527
MOD_Cter_Amidation	457	460	PF01082	0.789
MOD_GlcNHglycan	101	104	PF01048	0.586
MOD_GlcNHglycan	254	257	PF01048	0.728
MOD_GlcNHglycan	374	377	PF01048	0.725
MOD_GlcNHglycan	386	389	PF01048	0.664
MOD_GlcNHglycan	535	538	PF01048	0.767
MOD_GlcNHglycan	580	583	PF01048	0.795
MOD_GlcNHglycan	621	624	PF01048	0.883
MOD_GlcNHglycan	672	675	PF01048	0.689
MOD_GlcNHglycan	688	691	PF01048	0.786
MOD_GlcNHglycan	708	711	PF01048	0.549
MOD_GSK3_1	1	8	PF00069	0.750
MOD_GSK3_1	113	120	PF00069	0.592
MOD_GSK3_1	200	207	PF00069	0.573
MOD_GSK3_1	225	232	PF00069	0.547
MOD_GSK3_1	282	289	PF00069	0.750
MOD_GSK3_1	300	307	PF00069	0.708
MOD_GSK3_1	310	317	PF00069	0.662
MOD_GSK3_1	341	348	PF00069	0.842
MOD_GSK3_1	350	357	PF00069	0.770
MOD_GSK3_1	380	387	PF00069	0.747
MOD_GSK3_1	427	434	PF00069	0.835
MOD_GSK3_1	459	466	PF00069	0.814
MOD_GSK3_1	545	552	PF00069	0.752
MOD_GSK3_1	577	584	PF00069	0.841
MOD_GSK3_1	589	596	PF00069	0.632
MOD_GSK3_1	626	633	PF00069	0.805
MOD_GSK3_1	65	72	PF00069	0.652
MOD_GSK3_1	670	677	PF00069	0.878
MOD_GSK3_1	709	716	PF00069	0.806
MOD_GSK3_1	720	727	PF00069	0.856
MOD_N-GLC_1	117	122	PF02516	0.659
MOD_N-GLC_1	283	288	PF02516	0.728
MOD_N-GLC_1	314	319	PF02516	0.825
MOD_N-GLC_1	364	369	PF02516	0.874
MOD_N-GLC_1	65	70	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.736
MOD_NEK2_1	174	179	PF00069	0.592
MOD_NEK2_1	283	288	PF00069	0.741
MOD_NEK2_1	369	374	PF00069	0.622
MOD_NEK2_1	424	429	PF00069	0.817
MOD_NEK2_1	630	635	PF00069	0.782
MOD_NEK2_1	642	647	PF00069	0.778
MOD_NEK2_1	683	688	PF00069	0.791
MOD_NEK2_1	715	720	PF00069	0.793
MOD_NEK2_1	86	91	PF00069	0.641
MOD_NEK2_2	117	122	PF00069	0.659
MOD_PIKK_1	38	44	PF00454	0.652
MOD_PIKK_1	589	595	PF00454	0.782
MOD_PIKK_1	633	639	PF00454	0.891
MOD_PIKK_1	709	715	PF00454	0.766
MOD_PIKK_1	738	744	PF00454	0.868
MOD_PK_1	459	465	PF00069	0.676
MOD_PKA_1	151	157	PF00069	0.592
MOD_PKA_1	459	465	PF00069	0.793
MOD_PKA_1	550	556	PF00069	0.786
MOD_PKA_2	181	187	PF00069	0.465
MOD_PKA_2	344	350	PF00069	0.653
MOD_PKA_2	369	375	PF00069	0.778
MOD_PKA_2	38	44	PF00069	0.652
MOD_PKA_2	459	465	PF00069	0.828
MOD_PKA_2	549	555	PF00069	0.761
MOD_PKA_2	578	584	PF00069	0.849
MOD_PKA_2	631	637	PF00069	0.795
MOD_PKA_2	670	676	PF00069	0.855
MOD_PKA_2	713	719	PF00069	0.660
MOD_Plk_1	117	123	PF00069	0.571
MOD_Plk_1	314	320	PF00069	0.699
MOD_Plk_1	473	479	PF00069	0.761
MOD_Plk_1	568	574	PF00069	0.824
MOD_Plk_1	626	632	PF00069	0.810
MOD_Plk_1	642	648	PF00069	0.777
MOD_Plk_1	738	744	PF00069	0.868
MOD_Plk_4	204	210	PF00069	0.657
MOD_Plk_4	225	231	PF00069	0.545
MOD_Plk_4	315	321	PF00069	0.692
MOD_Plk_4	49	55	PF00069	0.552
MOD_Plk_4	550	556	PF00069	0.797
MOD_Plk_4	96	102	PF00069	0.573
MOD_ProDKin_1	286	292	PF00069	0.767
MOD_ProDKin_1	295	301	PF00069	0.818
MOD_ProDKin_1	3	9	PF00069	0.722
MOD_ProDKin_1	354	360	PF00069	0.806
MOD_ProDKin_1	364	370	PF00069	0.798
MOD_ProDKin_1	392	398	PF00069	0.773
MOD_ProDKin_1	427	433	PF00069	0.751
MOD_ProDKin_1	720	726	PF00069	0.785
MOD_SUMO_for_1	146	149	PF00179	0.583
MOD_SUMO_rev_2	141	148	PF00179	0.672
MOD_SUMO_rev_2	161	168	PF00179	0.357
MOD_SUMO_rev_2	191	198	PF00179	0.566
TRG_DiLeu_BaEn_1	204	209	PF01217	0.546
TRG_DiLeu_BaEn_1	21	26	PF01217	0.636
TRG_ENDOCYTIC_2	205	208	PF00928	0.522
TRG_ENDOCYTIC_2	58	61	PF00928	0.590
TRG_ENDOCYTIC_2	79	82	PF00928	0.773
TRG_ER_diArg_1	406	408	PF00400	0.741
TRG_ER_diArg_1	470	473	PF00400	0.637
TRG_ER_diArg_1	595	598	PF00400	0.793
TRG_NLS_Bipartite_1	151	173	PF00514	0.645
TRG_NLS_MonoExtC_3	168	173	PF00514	0.594
TRG_NLS_MonoExtN_4	166	173	PF00514	0.702
TRG_NLS_MonoExtN_4	598	605	PF00514	0.878
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.793
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R4	Leptomonas seymouri	38%	99%
A0A3Q8ICQ5	Leishmania donovani	92%	100%
A4HCW8	Leishmania braziliensis	60%	100%
A4I0E8	Leishmania infantum	93%	100%
E9AWB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%