Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB63_LEIMA

TriTrypDb:

LmjF.23.1000 , LMJLV39_230019300 , LMJSD75_230019500

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.409
CLV_NRD_NRD_1	203	205	PF00675	0.481
CLV_NRD_NRD_1	28	30	PF00675	0.564
CLV_PCSK_KEX2_1	148	150	PF00082	0.584
CLV_PCSK_KEX2_1	203	205	PF00082	0.473
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.584
CLV_PCSK_SKI1_1	125	129	PF00082	0.549
CLV_PCSK_SKI1_1	15	19	PF00082	0.546
CLV_PCSK_SKI1_1	158	162	PF00082	0.592
CLV_PCSK_SKI1_1	179	183	PF00082	0.556
CLV_PCSK_SKI1_1	206	210	PF00082	0.437
CLV_PCSK_SKI1_1	30	34	PF00082	0.386
DEG_APCC_DBOX_1	205	213	PF00400	0.398
DEG_APCC_DBOX_1	28	36	PF00400	0.497
DOC_MAPK_gen_1	191	200	PF00069	0.553
DOC_MAPK_gen_1	203	211	PF00069	0.544
DOC_MAPK_MEF2A_6	179	186	PF00069	0.616
DOC_MAPK_MEF2A_6	203	211	PF00069	0.427
DOC_MAPK_NFAT4_5	204	212	PF00069	0.393
DOC_USP7_MATH_1	108	112	PF00917	0.526
DOC_USP7_MATH_1	20	24	PF00917	0.615
DOC_USP7_MATH_1	37	41	PF00917	0.533
DOC_USP7_MATH_1	77	81	PF00917	0.619
DOC_USP7_UBL2_3	11	15	PF12436	0.565
DOC_USP7_UBL2_3	125	129	PF12436	0.502
DOC_USP7_UBL2_3	133	137	PF12436	0.439
DOC_USP7_UBL2_3	144	148	PF12436	0.473
DOC_USP7_UBL2_3	158	162	PF12436	0.489
DOC_USP7_UBL2_3	171	175	PF12436	0.488
DOC_WW_Pin1_4	2	7	PF00397	0.757
LIG_14-3-3_CanoR_1	29	38	PF00244	0.510
LIG_14-3-3_CanoR_1	67	73	PF00244	0.517
LIG_14-3-3_CanoR_1	92	99	PF00244	0.744
LIG_Actin_WH2_2	110	127	PF00022	0.540
LIG_APCC_Cbox_2	73	79	PF00515	0.620
LIG_BRCT_BRCA1_1	95	99	PF00533	0.667
LIG_FHA_1	112	118	PF00498	0.484
LIG_FHA_1	203	209	PF00498	0.623
LIG_FHA_2	61	67	PF00498	0.589
LIG_FHA_2	68	74	PF00498	0.599
LIG_LIR_Gen_1	196	201	PF02991	0.603
LIG_LIR_Gen_1	220	230	PF02991	0.570
LIG_LIR_Nem_3	103	109	PF02991	0.548
LIG_LIR_Nem_3	196	200	PF02991	0.561
LIG_LIR_Nem_3	220	226	PF02991	0.498
LIG_SH2_NCK_1	24	28	PF00017	0.524
LIG_SH2_STAP1	172	176	PF00017	0.561
LIG_SH2_STAT5	31	34	PF00017	0.479
LIG_UBA3_1	127	133	PF00899	0.492
MOD_CK1_1	111	117	PF00069	0.543
MOD_CK1_1	224	230	PF00069	0.614
MOD_CK1_1	23	29	PF00069	0.542
MOD_CK2_1	37	43	PF00069	0.493
MOD_CK2_1	50	56	PF00069	0.553
MOD_GlcNHglycan	118	121	PF01048	0.525
MOD_GlcNHglycan	25	28	PF01048	0.499
MOD_GlcNHglycan	79	82	PF01048	0.700
MOD_GlcNHglycan	89	92	PF01048	0.558
MOD_GlcNHglycan	95	98	PF01048	0.709
MOD_GSK3_1	111	118	PF00069	0.521
MOD_GSK3_1	147	154	PF00069	0.578
MOD_GSK3_1	170	177	PF00069	0.598
MOD_GSK3_1	217	224	PF00069	0.523
MOD_GSK3_1	77	84	PF00069	0.694
MOD_GSK3_1	87	94	PF00069	0.693
MOD_N-GLC_1	87	92	PF02516	0.707
MOD_NEK2_1	76	81	PF00069	0.646
MOD_NEK2_1	93	98	PF00069	0.711
MOD_PIKK_1	50	56	PF00454	0.655
MOD_PKA_1	147	153	PF00069	0.567
MOD_PKA_1	15	21	PF00069	0.544
MOD_PKA_2	202	208	PF00069	0.607
MOD_PKA_2	91	97	PF00069	0.698
MOD_Plk_1	38	44	PF00069	0.553
MOD_Plk_2-3	151	157	PF00069	0.650
MOD_ProDKin_1	2	8	PF00069	0.740
MOD_SUMO_rev_2	118	127	PF00179	0.554
MOD_SUMO_rev_2	150	160	PF00179	0.566
MOD_SUMO_rev_2	4	13	PF00179	0.719
TRG_DiLeu_BaEn_1	196	201	PF01217	0.535
TRG_DiLeu_BaEn_1	9	14	PF01217	0.603
TRG_ENDOCYTIC_2	223	226	PF00928	0.546
TRG_ER_diArg_1	203	206	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG3	Leptomonas seymouri	49%	99%
A0A1X0NYD1	Trypanosomatidae	29%	90%
A0A3Q8ICK8	Leishmania donovani	90%	100%
A0A3R7KGK2	Trypanosoma rangeli	28%	100%
A4HCW9	Leishmania braziliensis	62%	100%
A4I0E9	Leishmania infantum	90%	100%
E9AWB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%