Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB52_LEIMA

TriTrypDb:

LmjF.23.1025 , LMJLV39_230019700 , LMJSD75_230020000

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.492
CLV_C14_Caspase3-7	502	506	PF00656	0.553
CLV_NRD_NRD_1	107	109	PF00675	0.483
CLV_NRD_NRD_1	204	206	PF00675	0.594
CLV_NRD_NRD_1	332	334	PF00675	0.643
CLV_NRD_NRD_1	356	358	PF00675	0.611
CLV_NRD_NRD_1	406	408	PF00675	0.592
CLV_NRD_NRD_1	481	483	PF00675	0.616
CLV_NRD_NRD_1	499	501	PF00675	0.699
CLV_PCSK_FUR_1	497	501	PF00082	0.592
CLV_PCSK_KEX2_1	180	182	PF00082	0.547
CLV_PCSK_KEX2_1	206	208	PF00082	0.618
CLV_PCSK_KEX2_1	302	304	PF00082	0.633
CLV_PCSK_KEX2_1	332	334	PF00082	0.643
CLV_PCSK_KEX2_1	356	358	PF00082	0.611
CLV_PCSK_KEX2_1	406	408	PF00082	0.580
CLV_PCSK_KEX2_1	481	483	PF00082	0.616
CLV_PCSK_KEX2_1	497	499	PF00082	0.611
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.547
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.568
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.675
CLV_PCSK_SKI1_1	152	156	PF00082	0.465
CLV_PCSK_SKI1_1	165	169	PF00082	0.528
CLV_PCSK_SKI1_1	198	202	PF00082	0.536
CLV_PCSK_SKI1_1	401	405	PF00082	0.553
DEG_APCC_DBOX_1	151	159	PF00400	0.499
DEG_SCF_FBW7_2	386	393	PF00400	0.581
DEG_SPOP_SBC_1	259	263	PF00917	0.634
DEG_SPOP_SBC_1	525	529	PF00917	0.633
DOC_CDC14_PxL_1	227	235	PF14671	0.662
DOC_CKS1_1	222	227	PF01111	0.520
DOC_MAPK_gen_1	108	115	PF00069	0.511
DOC_MAPK_MEF2A_6	235	244	PF00069	0.636
DOC_PP2B_LxvP_1	468	471	PF13499	0.607
DOC_PP4_FxxP_1	501	504	PF00568	0.639
DOC_PP4_FxxP_1	58	61	PF00568	0.596
DOC_USP7_MATH_1	245	249	PF00917	0.724
DOC_USP7_MATH_1	343	347	PF00917	0.773
DOC_USP7_MATH_1	486	490	PF00917	0.745
DOC_USP7_MATH_1	491	495	PF00917	0.655
DOC_USP7_MATH_1	525	529	PF00917	0.689
DOC_USP7_MATH_1	6	10	PF00917	0.665
DOC_WW_Pin1_4	158	163	PF00397	0.561
DOC_WW_Pin1_4	221	226	PF00397	0.643
DOC_WW_Pin1_4	297	302	PF00397	0.686
DOC_WW_Pin1_4	304	309	PF00397	0.615
DOC_WW_Pin1_4	386	391	PF00397	0.567
DOC_WW_Pin1_4	42	47	PF00397	0.673
DOC_WW_Pin1_4	500	505	PF00397	0.612
DOC_WW_Pin1_4	540	545	PF00397	0.587
LIG_14-3-3_CanoR_1	205	214	PF00244	0.543
LIG_14-3-3_CanoR_1	260	265	PF00244	0.636
LIG_14-3-3_CanoR_1	498	504	PF00244	0.672
LIG_Actin_WH2_2	150	167	PF00022	0.503
LIG_BRCT_BRCA1_1	488	492	PF00533	0.607
LIG_deltaCOP1_diTrp_1	442	452	PF00928	0.622
LIG_eIF4E_1	264	270	PF01652	0.645
LIG_FHA_1	222	228	PF00498	0.584
LIG_FHA_2	164	170	PF00498	0.479
LIG_FHA_2	364	370	PF00498	0.609
LIG_FHA_2	387	393	PF00498	0.572
LIG_FHA_2	433	439	PF00498	0.611
LIG_FHA_2	47	53	PF00498	0.543
LIG_FHA_2	533	539	PF00498	0.658
LIG_IBAR_NPY_1	419	421	PF08397	0.631
LIG_LIR_Apic_2	55	61	PF02991	0.590
LIG_LIR_Gen_1	171	182	PF02991	0.555
LIG_LIR_Nem_3	171	177	PF02991	0.470
LIG_LIR_Nem_3	261	267	PF02991	0.569
LIG_LIR_Nem_3	311	315	PF02991	0.618
LIG_LIR_Nem_3	66	72	PF02991	0.516
LIG_LYPXL_yS_3	239	242	PF13949	0.636
LIG_NRBOX	95	101	PF00104	0.464
LIG_SH2_CRK	174	178	PF00017	0.438
LIG_SH2_CRK	214	218	PF00017	0.519
LIG_SH2_CRK	264	268	PF00017	0.643
LIG_SH2_CRK	360	364	PF00017	0.537
LIG_SH2_CRK	69	73	PF00017	0.554
LIG_SH2_SRC	360	363	PF00017	0.535
LIG_SH2_SRC	554	557	PF00017	0.574
LIG_SH2_STAP1	293	297	PF00017	0.664
LIG_SH2_STAP1	325	329	PF00017	0.587
LIG_SH2_STAP1	437	441	PF00017	0.600
LIG_SH2_STAP1	73	77	PF00017	0.503
LIG_SH2_STAP1	89	93	PF00017	0.390
LIG_SH2_STAT3	421	424	PF00017	0.581
LIG_SH2_STAT3	77	80	PF00017	0.453
LIG_SH2_STAT5	174	177	PF00017	0.502
LIG_SH3_1	235	241	PF00018	0.567
LIG_SH3_1	482	488	PF00018	0.697
LIG_SH3_3	214	220	PF00018	0.587
LIG_SH3_3	235	241	PF00018	0.573
LIG_SH3_3	422	428	PF00018	0.644
LIG_SH3_3	456	462	PF00018	0.653
LIG_SH3_3	463	469	PF00018	0.598
LIG_SH3_3	482	488	PF00018	0.756
LIG_SH3_3	58	64	PF00018	0.579
LIG_SH3_4	189	196	PF00018	0.544
LIG_SUMO_SIM_par_1	156	161	PF11976	0.557
LIG_SUMO_SIM_par_1	240	246	PF11976	0.623
LIG_SUMO_SIM_par_1	267	274	PF11976	0.670
LIG_TRAF2_1	24	27	PF00917	0.632
LIG_TRAF2_1	390	393	PF00917	0.538
LIG_TYR_ITSM	170	177	PF00017	0.488
LIG_TYR_ITSM	260	267	PF00017	0.638
LIG_WW_2	466	469	PF00397	0.590
MOD_CDC14_SPxK_1	300	303	PF00782	0.623
MOD_CDC14_SPxK_1	543	546	PF00782	0.550
MOD_CDK_SPK_2	297	302	PF00069	0.621
MOD_CDK_SPK_2	304	309	PF00069	0.550
MOD_CDK_SPxK_1	297	303	PF00069	0.623
MOD_CDK_SPxK_1	540	546	PF00069	0.556
MOD_CDK_SPxxK_3	158	165	PF00069	0.561
MOD_CK1_1	163	169	PF00069	0.545
MOD_CK1_1	274	280	PF00069	0.676
MOD_CK1_1	503	509	PF00069	0.639
MOD_CK1_1	519	525	PF00069	0.680
MOD_CK2_1	163	169	PF00069	0.462
MOD_CK2_1	21	27	PF00069	0.573
MOD_CK2_1	240	246	PF00069	0.550
MOD_CK2_1	363	369	PF00069	0.605
MOD_CK2_1	386	392	PF00069	0.594
MOD_CK2_1	432	438	PF00069	0.653
MOD_CK2_1	532	538	PF00069	0.657
MOD_Cter_Amidation	479	482	PF01082	0.652
MOD_GlcNHglycan	118	121	PF01048	0.562
MOD_GlcNHglycan	282	287	PF01048	0.635
MOD_GlcNHglycan	315	318	PF01048	0.546
MOD_GlcNHglycan	345	348	PF01048	0.685
MOD_GlcNHglycan	350	353	PF01048	0.721
MOD_GlcNHglycan	372	375	PF01048	0.712
MOD_GlcNHglycan	438	442	PF01048	0.621
MOD_GlcNHglycan	493	496	PF01048	0.724
MOD_GlcNHglycan	505	508	PF01048	0.686
MOD_GlcNHglycan	516	519	PF01048	0.627
MOD_GlcNHglycan	8	11	PF01048	0.666
MOD_GSK3_1	156	163	PF00069	0.494
MOD_GSK3_1	169	176	PF00069	0.423
MOD_GSK3_1	247	254	PF00069	0.580
MOD_GSK3_1	282	289	PF00069	0.751
MOD_GSK3_1	376	383	PF00069	0.637
MOD_GSK3_1	42	49	PF00069	0.707
MOD_GSK3_1	486	493	PF00069	0.611
MOD_GSK3_1	499	506	PF00069	0.613
MOD_GSK3_1	514	521	PF00069	0.790
MOD_GSK3_1	532	539	PF00069	0.561
MOD_N-GLC_1	370	375	PF02516	0.758
MOD_NEK2_1	271	276	PF00069	0.686
MOD_NEK2_1	350	355	PF00069	0.748
MOD_NEK2_1	370	375	PF00069	0.665
MOD_NEK2_1	547	552	PF00069	0.599
MOD_NEK2_2	173	178	PF00069	0.530
MOD_PIKK_1	394	400	PF00454	0.548
MOD_PIKK_1	526	532	PF00454	0.669
MOD_PK_1	516	522	PF00069	0.574
MOD_PKA_1	206	212	PF00069	0.626
MOD_PKA_1	499	505	PF00069	0.559
MOD_PKA_2	206	212	PF00069	0.669
MOD_PKA_2	259	265	PF00069	0.637
MOD_PKA_2	343	349	PF00069	0.689
MOD_PKA_2	499	505	PF00069	0.549
MOD_PKA_2	523	529	PF00069	0.663
MOD_PKA_2	532	538	PF00069	0.612
MOD_PKB_1	497	505	PF00069	0.689
MOD_Plk_1	271	277	PF00069	0.652
MOD_Plk_4	169	175	PF00069	0.605
MOD_Plk_4	251	257	PF00069	0.625
MOD_Plk_4	381	387	PF00069	0.583
MOD_ProDKin_1	158	164	PF00069	0.557
MOD_ProDKin_1	221	227	PF00069	0.647
MOD_ProDKin_1	297	303	PF00069	0.688
MOD_ProDKin_1	304	310	PF00069	0.612
MOD_ProDKin_1	386	392	PF00069	0.564
MOD_ProDKin_1	42	48	PF00069	0.677
MOD_ProDKin_1	500	506	PF00069	0.612
MOD_ProDKin_1	540	546	PF00069	0.587
TRG_DiLeu_BaEn_1	149	154	PF01217	0.450
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.671
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.490
TRG_DiLeu_LyEn_5	149	154	PF01217	0.494
TRG_ENDOCYTIC_2	174	177	PF00928	0.440
TRG_ENDOCYTIC_2	214	217	PF00928	0.524
TRG_ENDOCYTIC_2	239	242	PF00928	0.636
TRG_ENDOCYTIC_2	264	267	PF00928	0.644
TRG_ENDOCYTIC_2	360	363	PF00928	0.535
TRG_ENDOCYTIC_2	554	557	PF00928	0.585
TRG_ENDOCYTIC_2	69	72	PF00928	0.549
TRG_ER_diArg_1	136	139	PF00400	0.531
TRG_ER_diArg_1	141	144	PF00400	0.504
TRG_ER_diArg_1	205	208	PF00400	0.689
TRG_ER_diArg_1	331	333	PF00400	0.632
TRG_ER_diArg_1	481	483	PF00400	0.621
TRG_ER_diArg_1	496	499	PF00400	0.661
TRG_NLS_MonoExtN_4	301	306	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I063	Leptomonas seymouri	48%	100%
A0A3S7WXT8	Leishmania donovani	91%	100%
A4HCX4	Leishmania braziliensis	67%	100%
A4I0F7	Leishmania infantum	91%	100%
E9AWC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%