Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB51_LEIMA

TriTrypDb:

LmjF.23.1035 , LMJLV39_230019800 , LMJSD75_230020100

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.761
CLV_NRD_NRD_1	10	12	PF00675	0.645
CLV_NRD_NRD_1	128	130	PF00675	0.775
CLV_NRD_NRD_1	328	330	PF00675	0.692
CLV_NRD_NRD_1	467	469	PF00675	0.778
CLV_NRD_NRD_1	637	639	PF00675	0.669
CLV_PCSK_KEX2_1	10	12	PF00082	0.641
CLV_PCSK_KEX2_1	127	129	PF00082	0.782
CLV_PCSK_KEX2_1	486	488	PF00082	0.797
CLV_PCSK_KEX2_1	637	639	PF00082	0.572
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.802
CLV_PCSK_SKI1_1	180	184	PF00082	0.719
CLV_PCSK_SKI1_1	439	443	PF00082	0.793
CLV_PCSK_SKI1_1	460	464	PF00082	0.642
CLV_PCSK_SKI1_1	469	473	PF00082	0.651
CLV_PCSK_SKI1_1	522	526	PF00082	0.678
CLV_PCSK_SKI1_1	638	642	PF00082	0.762
CLV_PCSK_SKI1_1	646	650	PF00082	0.626
DEG_APCC_DBOX_1	636	644	PF00400	0.680
DEG_SIAH_1	544	552	PF03145	0.620
DEG_SPOP_SBC_1	390	394	PF00917	0.604
DEG_SPOP_SBC_1	421	425	PF00917	0.789
DEG_SPOP_SBC_1	48	52	PF00917	0.756
DEG_SPOP_SBC_1	657	661	PF00917	0.754
DOC_CKS1_1	205	210	PF01111	0.794
DOC_CKS1_1	663	668	PF01111	0.738
DOC_CYCLIN_RxL_1	519	527	PF00134	0.676
DOC_CYCLIN_RxL_1	632	645	PF00134	0.750
DOC_MAPK_gen_1	10	16	PF00069	0.794
DOC_MAPK_gen_1	465	474	PF00069	0.691
DOC_MAPK_gen_1	637	643	PF00069	0.683
DOC_MAPK_MEF2A_6	465	474	PF00069	0.691
DOC_PP2B_LxvP_1	199	202	PF13499	0.737
DOC_PP2B_LxvP_1	472	475	PF13499	0.713
DOC_PP4_FxxP_1	211	214	PF00568	0.755
DOC_USP7_MATH_1	114	118	PF00917	0.806
DOC_USP7_MATH_1	140	144	PF00917	0.757
DOC_USP7_MATH_1	318	322	PF00917	0.843
DOC_USP7_MATH_1	325	329	PF00917	0.725
DOC_USP7_MATH_1	34	38	PF00917	0.638
DOC_USP7_MATH_1	365	369	PF00917	0.808
DOC_USP7_MATH_1	388	392	PF00917	0.713
DOC_USP7_MATH_1	421	425	PF00917	0.789
DOC_USP7_MATH_1	446	450	PF00917	0.837
DOC_USP7_MATH_1	570	574	PF00917	0.744
DOC_USP7_MATH_1	575	579	PF00917	0.660
DOC_USP7_MATH_1	614	618	PF00917	0.641
DOC_USP7_MATH_1	656	660	PF00917	0.750
DOC_USP7_MATH_1	68	72	PF00917	0.770
DOC_USP7_MATH_1	77	81	PF00917	0.665
DOC_USP7_MATH_1	84	88	PF00917	0.579
DOC_WW_Pin1_4	133	138	PF00397	0.816
DOC_WW_Pin1_4	204	209	PF00397	0.833
DOC_WW_Pin1_4	292	297	PF00397	0.831
DOC_WW_Pin1_4	402	407	PF00397	0.654
DOC_WW_Pin1_4	428	433	PF00397	0.746
DOC_WW_Pin1_4	44	49	PF00397	0.623
DOC_WW_Pin1_4	451	456	PF00397	0.650
DOC_WW_Pin1_4	541	546	PF00397	0.775
DOC_WW_Pin1_4	547	552	PF00397	0.811
DOC_WW_Pin1_4	57	62	PF00397	0.696
DOC_WW_Pin1_4	605	610	PF00397	0.777
DOC_WW_Pin1_4	648	653	PF00397	0.642
DOC_WW_Pin1_4	658	663	PF00397	0.681
DOC_WW_Pin1_4	66	71	PF00397	0.800
DOC_WW_Pin1_4	93	98	PF00397	0.743
LIG_14-3-3_CanoR_1	115	122	PF00244	0.701
LIG_14-3-3_CanoR_1	158	163	PF00244	0.727
LIG_14-3-3_CanoR_1	169	174	PF00244	0.666
LIG_14-3-3_CanoR_1	210	214	PF00244	0.805
LIG_14-3-3_CanoR_1	221	229	PF00244	0.582
LIG_14-3-3_CanoR_1	46	55	PF00244	0.858
LIG_14-3-3_CanoR_1	637	641	PF00244	0.681
LIG_Actin_WH2_2	176	194	PF00022	0.638
LIG_Actin_WH2_2	621	639	PF00022	0.658
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BIR_III_4	376	380	PF00653	0.745
LIG_EH_1	253	257	PF12763	0.701
LIG_FHA_1	150	156	PF00498	0.660
LIG_FHA_1	159	165	PF00498	0.563
LIG_FHA_1	228	234	PF00498	0.786
LIG_FHA_1	361	367	PF00498	0.810
LIG_FHA_1	382	388	PF00498	0.818
LIG_FHA_1	391	397	PF00498	0.678
LIG_FHA_1	50	56	PF00498	0.811
LIG_FHA_1	578	584	PF00498	0.716
LIG_FHA_1	619	625	PF00498	0.749
LIG_FHA_1	658	664	PF00498	0.775
LIG_FHA_1	672	678	PF00498	0.602
LIG_FHA_2	268	274	PF00498	0.756
LIG_FHA_2	413	419	PF00498	0.688
LIG_FHA_2	51	57	PF00498	0.820
LIG_FHA_2	606	612	PF00498	0.714
LIG_FHA_2	637	643	PF00498	0.761
LIG_GBD_Chelix_1	183	191	PF00786	0.638
LIG_Integrin_RGD_1	280	282	PF01839	0.763
LIG_IRF3_LxIS_1	416	423	PF10401	0.799
LIG_LIR_Apic_2	80	84	PF02991	0.655
LIG_LIR_Gen_1	218	227	PF02991	0.647
LIG_LIR_Gen_1	415	422	PF02991	0.801
LIG_LIR_Gen_1	504	514	PF02991	0.790
LIG_LIR_Nem_3	218	222	PF02991	0.645
LIG_LIR_Nem_3	415	420	PF02991	0.738
LIG_LIR_Nem_3	504	510	PF02991	0.797
LIG_LIR_Nem_3	559	564	PF02991	0.823
LIG_MYND_1	662	666	PF01753	0.585
LIG_Pex14_1	622	626	PF04695	0.728
LIG_PTB_Apo_2	251	258	PF02174	0.621
LIG_SH2_CRK	81	85	PF00017	0.656
LIG_SH2_NCK_1	587	591	PF00017	0.785
LIG_SH2_NCK_1	81	85	PF00017	0.656
LIG_SH2_PTP2	13	16	PF00017	0.789
LIG_SH2_SRC	419	422	PF00017	0.801
LIG_SH2_SRC	532	535	PF00017	0.557
LIG_SH2_SRC	81	84	PF00017	0.657
LIG_SH2_STAP1	227	231	PF00017	0.784
LIG_SH2_STAT3	395	398	PF00017	0.772
LIG_SH2_STAT5	13	16	PF00017	0.789
LIG_SH2_STAT5	395	398	PF00017	0.846
LIG_SH2_STAT5	419	422	PF00017	0.641
LIG_SH2_STAT5	587	590	PF00017	0.786
LIG_SH3_2	357	362	PF14604	0.598
LIG_SH3_2	83	88	PF14604	0.856
LIG_SH3_3	211	217	PF00018	0.669
LIG_SH3_3	290	296	PF00018	0.664
LIG_SH3_3	299	305	PF00018	0.694
LIG_SH3_3	351	357	PF00018	0.836
LIG_SH3_3	438	444	PF00018	0.693
LIG_SH3_3	67	73	PF00018	0.790
LIG_SH3_3	80	86	PF00018	0.681
LIG_SH3_4	330	337	PF00018	0.579
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.562
LIG_SUMO_SIM_par_1	497	504	PF11976	0.812
LIG_SUMO_SIM_par_1	639	645	PF11976	0.767
LIG_SUMO_SIM_par_1	672	678	PF11976	0.666
LIG_TRAF2_1	283	286	PF00917	0.643
LIG_TRAF2_2	277	282	PF00917	0.751
LIG_WRC_WIRS_1	216	221	PF05994	0.647
LIG_WW_3	301	305	PF00397	0.744
MOD_CDC14_SPxK_1	550	553	PF00782	0.618
MOD_CDK_SPxK_1	204	210	PF00069	0.835
MOD_CDK_SPxK_1	547	553	PF00069	0.622
MOD_CDK_SPxK_1	57	63	PF00069	0.623
MOD_CDK_SPxxK_3	451	458	PF00069	0.781
MOD_CK1_1	109	115	PF00069	0.759
MOD_CK1_1	136	142	PF00069	0.789
MOD_CK1_1	197	203	PF00069	0.815
MOD_CK1_1	37	43	PF00069	0.713
MOD_CK1_1	391	397	PF00069	0.796
MOD_CK1_1	449	455	PF00069	0.602
MOD_CK1_1	47	53	PF00069	0.772
MOD_CK1_1	598	604	PF00069	0.704
MOD_CK1_1	651	657	PF00069	0.694
MOD_CK1_1	687	693	PF00069	0.705
MOD_CK1_1	69	75	PF00069	0.626
MOD_CK2_1	150	156	PF00069	0.693
MOD_CK2_1	234	240	PF00069	0.835
MOD_CK2_1	284	290	PF00069	0.877
MOD_CK2_1	412	418	PF00069	0.652
MOD_CK2_1	50	56	PF00069	0.846
MOD_CK2_1	570	576	PF00069	0.809
MOD_CK2_1	605	611	PF00069	0.715
MOD_CK2_1	636	642	PF00069	0.754
MOD_CK2_1	647	653	PF00069	0.579
MOD_GlcNHglycan	1	4	PF01048	0.587
MOD_GlcNHglycan	108	111	PF01048	0.764
MOD_GlcNHglycan	142	145	PF01048	0.747
MOD_GlcNHglycan	196	199	PF01048	0.769
MOD_GlcNHglycan	211	214	PF01048	0.542
MOD_GlcNHglycan	236	239	PF01048	0.798
MOD_GlcNHglycan	257	260	PF01048	0.786
MOD_GlcNHglycan	285	289	PF01048	0.837
MOD_GlcNHglycan	315	318	PF01048	0.748
MOD_GlcNHglycan	320	323	PF01048	0.740
MOD_GlcNHglycan	349	352	PF01048	0.758
MOD_GlcNHglycan	36	39	PF01048	0.668
MOD_GlcNHglycan	465	468	PF01048	0.594
MOD_GlcNHglycan	558	561	PF01048	0.624
MOD_GlcNHglycan	576	580	PF01048	0.504
MOD_GSK3_1	102	109	PF00069	0.698
MOD_GSK3_1	131	138	PF00069	0.808
MOD_GSK3_1	200	207	PF00069	0.740
MOD_GSK3_1	263	270	PF00069	0.739
MOD_GSK3_1	313	320	PF00069	0.770
MOD_GSK3_1	325	332	PF00069	0.724
MOD_GSK3_1	34	41	PF00069	0.815
MOD_GSK3_1	390	397	PF00069	0.786
MOD_GSK3_1	422	429	PF00069	0.767
MOD_GSK3_1	44	51	PF00069	0.734
MOD_GSK3_1	447	454	PF00069	0.643
MOD_GSK3_1	57	64	PF00069	0.580
MOD_GSK3_1	598	605	PF00069	0.797
MOD_GSK3_1	610	617	PF00069	0.544
MOD_GSK3_1	642	649	PF00069	0.628
MOD_GSK3_1	658	665	PF00069	0.802
MOD_GSK3_1	671	678	PF00069	0.594
MOD_GSK3_1	93	100	PF00069	0.748
MOD_LATS_1	668	674	PF00433	0.688
MOD_N-GLC_1	234	239	PF02516	0.831
MOD_N-GLC_1	388	393	PF02516	0.753
MOD_N-GLC_1	44	49	PF02516	0.623
MOD_N-GLC_1	57	62	PF02516	0.560
MOD_NEK2_1	164	169	PF00069	0.778
MOD_NEK2_1	310	315	PF00069	0.628
MOD_NEK2_1	426	431	PF00069	0.614
MOD_NEK2_1	447	452	PF00069	0.787
MOD_NEK2_1	463	468	PF00069	0.527
MOD_NEK2_1	49	54	PF00069	0.835
MOD_NEK2_1	636	641	PF00069	0.751
MOD_NEK2_1	671	676	PF00069	0.790
MOD_PIKK_1	342	348	PF00454	0.811
MOD_PIKK_1	394	400	PF00454	0.795
MOD_PIKK_1	449	455	PF00454	0.594
MOD_PKA_1	329	335	PF00069	0.782
MOD_PKA_2	114	120	PF00069	0.802
MOD_PKA_2	131	137	PF00069	0.529
MOD_PKA_2	209	215	PF00069	0.808
MOD_PKA_2	636	642	PF00069	0.681
MOD_Plk_1	518	524	PF00069	0.523
MOD_Plk_1	671	677	PF00069	0.710
MOD_Plk_4	215	221	PF00069	0.754
MOD_Plk_4	391	397	PF00069	0.726
MOD_Plk_4	412	418	PF00069	0.806
MOD_Plk_4	50	56	PF00069	0.627
MOD_Plk_4	527	533	PF00069	0.537
MOD_Plk_4	577	583	PF00069	0.580
MOD_Plk_4	618	624	PF00069	0.684
MOD_Plk_4	687	693	PF00069	0.538
MOD_ProDKin_1	133	139	PF00069	0.819
MOD_ProDKin_1	204	210	PF00069	0.835
MOD_ProDKin_1	292	298	PF00069	0.834
MOD_ProDKin_1	402	408	PF00069	0.653
MOD_ProDKin_1	428	434	PF00069	0.747
MOD_ProDKin_1	44	50	PF00069	0.622
MOD_ProDKin_1	451	457	PF00069	0.646
MOD_ProDKin_1	541	547	PF00069	0.779
MOD_ProDKin_1	57	63	PF00069	0.696
MOD_ProDKin_1	605	611	PF00069	0.779
MOD_ProDKin_1	648	654	PF00069	0.645
MOD_ProDKin_1	658	664	PF00069	0.680
MOD_ProDKin_1	66	72	PF00069	0.800
MOD_ProDKin_1	93	99	PF00069	0.741
MOD_SUMO_rev_2	286	296	PF00179	0.750
MOD_SUMO_rev_2	431	441	PF00179	0.832
TRG_DiLeu_BaEn_4	30	36	PF01217	0.790
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.560
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.591
TRG_ENDOCYTIC_2	13	16	PF00928	0.762
TRG_ENDOCYTIC_2	419	422	PF00928	0.641
TRG_ENDOCYTIC_2	561	564	PF00928	0.829
TRG_ER_diArg_1	126	129	PF00400	0.777
TRG_ER_diArg_1	168	171	PF00400	0.795
TRG_ER_diArg_1	277	280	PF00400	0.824
TRG_ER_diArg_1	636	638	PF00400	0.669
TRG_ER_diArg_1	9	11	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK4	Leishmania donovani	90%	100%
A4HCX5	Leishmania braziliensis	61%	100%
A4I0F8	Leishmania infantum	90%	100%
E9AWC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%