HIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QB49_LEIMA

TriTrypDb:

LmjF.23.1055 , LMJLV39_230020000 , LMJSD75_230020300

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB49

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0047710	bis(5'-adenosyl)-triphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.487
CLV_C14_Caspase3-7	172	176	PF00656	0.440
CLV_NRD_NRD_1	250	252	PF00675	0.362
CLV_NRD_NRD_1	3	5	PF00675	0.581
CLV_NRD_NRD_1	316	318	PF00675	0.533
CLV_PCSK_KEX2_1	250	252	PF00082	0.319
CLV_PCSK_KEX2_1	3	5	PF00082	0.581
CLV_PCSK_KEX2_1	315	317	PF00082	0.548
CLV_PCSK_SKI1_1	3	7	PF00082	0.525
CLV_PCSK_SKI1_1	333	337	PF00082	0.509
DEG_COP1_1	81	91	PF00400	0.563
DEG_SPOP_SBC_1	343	347	PF00917	0.479
DEG_SPOP_SBC_1	74	78	PF00917	0.660
DOC_CKS1_1	319	324	PF01111	0.588
DOC_CYCLIN_RxL_1	330	340	PF00134	0.422
DOC_PP4_FxxP_1	14	17	PF00568	0.625
DOC_USP7_MATH_1	157	161	PF00917	0.521
DOC_USP7_MATH_1	188	192	PF00917	0.332
DOC_USP7_MATH_1	193	197	PF00917	0.277
DOC_USP7_MATH_1	259	263	PF00917	0.531
DOC_USP7_MATH_1	342	346	PF00917	0.590
DOC_USP7_MATH_1	73	77	PF00917	0.655
DOC_USP7_MATH_1	8	12	PF00917	0.523
DOC_WW_Pin1_4	103	108	PF00397	0.659
DOC_WW_Pin1_4	13	18	PF00397	0.517
DOC_WW_Pin1_4	162	167	PF00397	0.690
DOC_WW_Pin1_4	261	266	PF00397	0.535
DOC_WW_Pin1_4	318	323	PF00397	0.611
DOC_WW_Pin1_4	54	59	PF00397	0.619
LIG_14-3-3_CanoR_1	178	182	PF00244	0.413
LIG_14-3-3_CanoR_1	219	227	PF00244	0.448
LIG_14-3-3_CanoR_1	3	8	PF00244	0.563
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	10	14	PF00533	0.616
LIG_BRCT_BRCA1_1	195	199	PF00533	0.453
LIG_FHA_1	18	24	PF00498	0.676
LIG_FHA_1	240	246	PF00498	0.443
LIG_FHA_1	262	268	PF00498	0.506
LIG_FHA_1	327	333	PF00498	0.401
LIG_FHA_1	91	97	PF00498	0.616
LIG_FHA_2	114	120	PF00498	0.543
LIG_FHA_2	124	130	PF00498	0.417
LIG_FHA_2	226	232	PF00498	0.471
LIG_FHA_2	24	30	PF00498	0.775
LIG_FHA_2	76	82	PF00498	0.717
LIG_LIR_Apic_2	11	17	PF02991	0.502
LIG_LIR_Gen_1	196	207	PF02991	0.497
LIG_LIR_Gen_1	90	99	PF02991	0.535
LIG_LIR_Nem_3	180	184	PF02991	0.349
LIG_LIR_Nem_3	196	202	PF02991	0.465
LIG_LIR_Nem_3	233	238	PF02991	0.482
LIG_LIR_Nem_3	90	95	PF02991	0.533
LIG_SH2_CRK	63	67	PF00017	0.570
LIG_SH2_NCK_1	156	160	PF00017	0.451
LIG_SH2_NCK_1	339	343	PF00017	0.559
LIG_SH2_STAP1	273	277	PF00017	0.535
LIG_SH2_STAP1	339	343	PF00017	0.493
LIG_SH2_STAT3	194	197	PF00017	0.492
LIG_SH2_STAT5	194	197	PF00017	0.480
LIG_SH2_STAT5	339	342	PF00017	0.511
LIG_SH3_1	316	322	PF00018	0.612
LIG_SH3_3	187	193	PF00018	0.486
LIG_SH3_3	204	210	PF00018	0.371
LIG_SH3_3	262	268	PF00018	0.469
LIG_SH3_3	293	299	PF00018	0.453
LIG_SH3_3	316	322	PF00018	0.612
LIG_SH3_4	139	146	PF00018	0.475
LIG_TRAF2_1	106	109	PF00917	0.591
LIG_TRAF2_1	228	231	PF00917	0.501
LIG_TRFH_1	69	73	PF08558	0.601
LIG_UBA3_1	169	174	PF00899	0.484
LIG_WW_3	317	321	PF00397	0.551
MOD_CK1_1	261	267	PF00069	0.538
MOD_CK1_1	345	351	PF00069	0.732
MOD_CK2_1	103	109	PF00069	0.694
MOD_CK2_1	123	129	PF00069	0.591
MOD_CK2_1	225	231	PF00069	0.440
MOD_CK2_1	30	36	PF00069	0.639
MOD_CK2_1	75	81	PF00069	0.719
MOD_GlcNHglycan	108	113	PF01048	0.649
MOD_GlcNHglycan	186	189	PF01048	0.459
MOD_GlcNHglycan	261	264	PF01048	0.366
MOD_GlcNHglycan	32	35	PF01048	0.797
MOD_GSK3_1	113	120	PF00069	0.620
MOD_GSK3_1	157	164	PF00069	0.518
MOD_GSK3_1	184	191	PF00069	0.353
MOD_GSK3_1	23	30	PF00069	0.731
MOD_GSK3_1	8	15	PF00069	0.511
MOD_N-GLC_1	12	17	PF02516	0.546
MOD_N-GLC_1	162	167	PF02516	0.636
MOD_N-GLC_1	271	276	PF02516	0.334
MOD_NEK2_1	12	17	PF00069	0.510
MOD_NEK2_1	184	189	PF00069	0.526
MOD_NEK2_1	23	28	PF00069	0.627
MOD_NEK2_1	239	244	PF00069	0.455
MOD_NEK2_2	177	182	PF00069	0.325
MOD_NEK2_2	220	225	PF00069	0.466
MOD_PIKK_1	193	199	PF00454	0.349
MOD_PKA_1	3	9	PF00069	0.599
MOD_PKA_2	177	183	PF00069	0.370
MOD_PKA_2	252	258	PF00069	0.541
MOD_PKA_2	3	9	PF00069	0.595
MOD_PKB_1	133	141	PF00069	0.356
MOD_Plk_1	117	123	PF00069	0.600
MOD_Plk_1	271	277	PF00069	0.535
MOD_Plk_4	165	171	PF00069	0.608
MOD_ProDKin_1	103	109	PF00069	0.659
MOD_ProDKin_1	13	19	PF00069	0.522
MOD_ProDKin_1	162	168	PF00069	0.696
MOD_ProDKin_1	261	267	PF00069	0.535
MOD_ProDKin_1	318	324	PF00069	0.607
MOD_ProDKin_1	54	60	PF00069	0.613
TRG_ENDOCYTIC_2	45	48	PF00928	0.571
TRG_ENDOCYTIC_2	63	66	PF00928	0.494
TRG_ER_diArg_1	249	251	PF00400	0.562
TRG_ER_diArg_1	3	5	PF00400	0.583
TRG_ER_diArg_1	315	317	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P352	Leptomonas seymouri	55%	81%
A0A0S4JIU0	Bodo saltans	31%	92%
A0A1X0NWV2	Trypanosomatidae	37%	77%
A0A3S7WXW4	Leishmania donovani	93%	100%
A4HCX7	Leishmania braziliensis	81%	100%
A4I0G0	Leishmania infantum	93%	100%
C9ZV80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	84%
E9AWC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BJC2	Trypanosoma cruzi	44%	86%