Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB48_LEIMA

TriTrypDb:

LmjF.23.1065 , LMJLV39_230020100 , LMJSD75_230020400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QB48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.656
CLV_NRD_NRD_1	340	342	PF00675	0.680
CLV_NRD_NRD_1	395	397	PF00675	0.682
CLV_PCSK_KEX2_1	136	138	PF00082	0.634
CLV_PCSK_KEX2_1	340	342	PF00082	0.680
CLV_PCSK_KEX2_1	395	397	PF00082	0.682
CLV_PCSK_KEX2_1	475	477	PF00082	0.552
CLV_PCSK_KEX2_1	75	77	PF00082	0.538
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.552
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.538
CLV_PCSK_PC7_1	391	397	PF00082	0.675
CLV_PCSK_SKI1_1	160	164	PF00082	0.503
CLV_PCSK_SKI1_1	225	229	PF00082	0.612
CLV_PCSK_SKI1_1	340	344	PF00082	0.670
DEG_APCC_DBOX_1	224	232	PF00400	0.605
DEG_Nend_UBRbox_4	1	3	PF02207	0.525
DEG_SPOP_SBC_1	407	411	PF00917	0.784
DOC_CKS1_1	288	293	PF01111	0.781
DOC_CYCLIN_RxL_1	220	229	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	446	449	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.600
DOC_MAPK_gen_1	258	267	PF00069	0.650
DOC_MAPK_gen_1	426	434	PF00069	0.695
DOC_MAPK_MEF2A_6	4	13	PF00069	0.521
DOC_PP1_RVXF_1	338	345	PF00149	0.544
DOC_PP1_RVXF_1	373	380	PF00149	0.639
DOC_PP1_RVXF_1	8	14	PF00149	0.558
DOC_PP2B_LxvP_1	446	449	PF13499	0.606
DOC_PP2B_LxvP_1	99	102	PF13499	0.590
DOC_PP2B_PxIxI_1	151	157	PF00149	0.550
DOC_PP4_FxxP_1	114	117	PF00568	0.474
DOC_PP4_FxxP_1	13	16	PF00568	0.555
DOC_PP4_FxxP_1	20	23	PF00568	0.501
DOC_PP4_FxxP_1	434	437	PF00568	0.663
DOC_PP4_FxxP_1	45	48	PF00568	0.436
DOC_USP7_MATH_1	16	20	PF00917	0.538
DOC_USP7_MATH_1	284	288	PF00917	0.681
DOC_USP7_MATH_1	318	322	PF00917	0.665
DOC_USP7_MATH_1	356	360	PF00917	0.736
DOC_USP7_MATH_1	412	416	PF00917	0.762
DOC_USP7_MATH_1	430	434	PF00917	0.466
DOC_USP7_MATH_1	84	88	PF00917	0.471
DOC_WW_Pin1_4	19	24	PF00397	0.540
DOC_WW_Pin1_4	278	283	PF00397	0.709
DOC_WW_Pin1_4	287	292	PF00397	0.725
DOC_WW_Pin1_4	314	319	PF00397	0.721
DOC_WW_Pin1_4	323	328	PF00397	0.725
DOC_WW_Pin1_4	345	350	PF00397	0.693
DOC_WW_Pin1_4	44	49	PF00397	0.429
DOC_WW_Pin1_4	97	102	PF00397	0.501
LIG_14-3-3_CanoR_1	10	16	PF00244	0.698
LIG_14-3-3_CanoR_1	129	133	PF00244	0.557
LIG_14-3-3_CanoR_1	167	172	PF00244	0.448
LIG_14-3-3_CanoR_1	201	206	PF00244	0.492
LIG_14-3-3_CanoR_1	400	408	PF00244	0.586
LIG_14-3-3_CanoR_1	429	435	PF00244	0.669
LIG_14-3-3_CanoR_1	452	459	PF00244	0.404
LIG_14-3-3_CanoR_1	82	92	PF00244	0.597
LIG_Actin_WH2_2	174	189	PF00022	0.598
LIG_Actin_WH2_2	316	334	PF00022	0.627
LIG_BRCT_BRCA1_1	16	20	PF00533	0.538
LIG_EVH1_2	438	442	PF00568	0.497
LIG_FHA_1	110	116	PF00498	0.588
LIG_FHA_1	264	270	PF00498	0.510
LIG_FHA_1	348	354	PF00498	0.759
LIG_FHA_1	417	423	PF00498	0.584
LIG_FHA_1	454	460	PF00498	0.511
LIG_FHA_2	156	162	PF00498	0.413
LIG_FHA_2	350	356	PF00498	0.754
LIG_FHA_2	468	474	PF00498	0.616
LIG_FHA_2	59	65	PF00498	0.552
LIG_FXI_DFP_1	37	41	PF00024	0.424
LIG_LIR_Apic_2	112	117	PF02991	0.579
LIG_LIR_Apic_2	17	23	PF02991	0.541
LIG_LIR_Apic_2	43	48	PF02991	0.433
LIG_LIR_Apic_2	433	437	PF02991	0.680
LIG_LIR_Gen_1	166	177	PF02991	0.482
LIG_LIR_Gen_1	325	336	PF02991	0.593
LIG_LIR_Nem_3	166	172	PF02991	0.475
LIG_LIR_Nem_3	236	242	PF02991	0.624
LIG_LIR_Nem_3	325	331	PF02991	0.602
LIG_LIR_Nem_3	43	49	PF02991	0.541
LIG_MAD2	341	349	PF02301	0.567
LIG_PDZ_Class_1	479	484	PF00595	0.592
LIG_SH2_CRK	208	212	PF00017	0.595
LIG_SH2_CRK	328	332	PF00017	0.587
LIG_SH2_CRK	93	97	PF00017	0.570
LIG_SH2_STAP1	165	169	PF00017	0.419
LIG_SH2_STAP1	217	221	PF00017	0.485
LIG_SH2_STAT5	155	158	PF00017	0.374
LIG_SH3_2	102	107	PF14604	0.517
LIG_SH3_3	146	152	PF00018	0.626
LIG_SH3_3	433	439	PF00018	0.596
LIG_SH3_3	442	448	PF00018	0.422
LIG_SH3_3	46	52	PF00018	0.558
LIG_SH3_3	99	105	PF00018	0.446
LIG_TRAF2_1	233	236	PF00917	0.570
LIG_TRAF2_1	470	473	PF00917	0.613
LIG_TYR_ITIM	237	242	PF00017	0.684
LIG_UBA3_1	118	127	PF00899	0.448
LIG_WRC_WIRS_1	264	269	PF05994	0.542
MOD_CK1_1	14	20	PF00069	0.691
MOD_CK1_1	278	284	PF00069	0.762
MOD_CK1_1	287	293	PF00069	0.581
MOD_CK1_1	322	328	PF00069	0.649
MOD_CK1_1	347	353	PF00069	0.688
MOD_CK1_1	457	463	PF00069	0.548
MOD_CK1_1	95	101	PF00069	0.417
MOD_CK2_1	349	355	PF00069	0.745
MOD_CK2_1	467	473	PF00069	0.608
MOD_Cter_Amidation	393	396	PF01082	0.588
MOD_GlcNHglycan	250	253	PF01048	0.695
MOD_GlcNHglycan	358	361	PF01048	0.642
MOD_GlcNHglycan	383	386	PF01048	0.679
MOD_GlcNHglycan	404	407	PF01048	0.689
MOD_GlcNHglycan	412	415	PF01048	0.712
MOD_GlcNHglycan	459	462	PF01048	0.571
MOD_GlcNHglycan	61	64	PF01048	0.547
MOD_GlcNHglycan	86	89	PF01048	0.516
MOD_GSK3_1	11	18	PF00069	0.513
MOD_GSK3_1	263	270	PF00069	0.523
MOD_GSK3_1	274	281	PF00069	0.689
MOD_GSK3_1	283	290	PF00069	0.824
MOD_GSK3_1	302	309	PF00069	0.796
MOD_GSK3_1	314	321	PF00069	0.642
MOD_GSK3_1	322	329	PF00069	0.448
MOD_GSK3_1	343	350	PF00069	0.754
MOD_GSK3_1	40	47	PF00069	0.433
MOD_GSK3_1	402	409	PF00069	0.814
MOD_GSK3_1	412	419	PF00069	0.626
MOD_GSK3_1	453	460	PF00069	0.633
MOD_GSK3_1	475	482	PF00069	0.432
MOD_N-GLC_1	246	251	PF02516	0.581
MOD_NEK2_1	11	16	PF00069	0.518
MOD_NEK2_1	267	272	PF00069	0.522
MOD_NEK2_1	343	348	PF00069	0.747
MOD_NEK2_1	379	384	PF00069	0.743
MOD_NEK2_1	40	45	PF00069	0.424
MOD_PIKK_1	139	145	PF00454	0.646
MOD_PK_1	454	460	PF00069	0.550
MOD_PKA_1	475	481	PF00069	0.465
MOD_PKA_2	128	134	PF00069	0.639
MOD_PKA_2	453	459	PF00069	0.634
MOD_PKA_2	475	481	PF00069	0.465
MOD_PKB_1	452	460	PF00069	0.403
MOD_Plk_1	109	115	PF00069	0.589
MOD_Plk_1	373	379	PF00069	0.638
MOD_Plk_4	109	115	PF00069	0.549
MOD_Plk_4	326	332	PF00069	0.578
MOD_Plk_4	40	46	PF00069	0.432
MOD_Plk_4	454	460	PF00069	0.550
MOD_ProDKin_1	19	25	PF00069	0.540
MOD_ProDKin_1	278	284	PF00069	0.710
MOD_ProDKin_1	287	293	PF00069	0.718
MOD_ProDKin_1	314	320	PF00069	0.719
MOD_ProDKin_1	323	329	PF00069	0.717
MOD_ProDKin_1	345	351	PF00069	0.693
MOD_ProDKin_1	44	50	PF00069	0.430
MOD_ProDKin_1	97	103	PF00069	0.497
MOD_SUMO_rev_2	351	359	PF00179	0.746
MOD_SUMO_rev_2	472	477	PF00179	0.635
TRG_DiLeu_BaEn_2	109	115	PF01217	0.589
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.581
TRG_ENDOCYTIC_2	165	168	PF00928	0.499
TRG_ENDOCYTIC_2	239	242	PF00928	0.702
TRG_ENDOCYTIC_2	328	331	PF00928	0.593
TRG_ENDOCYTIC_2	93	96	PF00928	0.571
TRG_ER_diArg_1	136	138	PF00400	0.630
TRG_ER_diArg_1	340	342	PF00400	0.563
TRG_ER_diArg_1	395	397	PF00400	0.649
TRG_ER_diArg_1	451	454	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R2	Leptomonas seymouri	44%	100%
A0A3Q8IBT7	Leishmania donovani	94%	100%
A4HCX8	Leishmania braziliensis	72%	100%
A4I0G1	Leishmania infantum	94%	100%
E9AWC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	90%