LeishMANIAdb
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Probable methyltransferase BMT2 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable methyltransferase BMT2 homolog
Gene product:
Probable methyltransferase BTM2 homolog
Species:
Leishmania major
UniProt:
Q4QB47_LEIMA
TriTrypDb:
LmjF.23.1090 , LMJLV39_230020200 , LMJSD75_230020500 *
Length:
672

Annotations

LeishMANIAdb annotations

Homologous to S-adenosylmethionine sensor upstream of mTORC1. Does not appear to be membrane-associated.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB47

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 10
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0032006 regulation of TOR signaling 6 2
GO:0032007 negative regulation of TOR signaling 7 2
GO:0032259 methylation 2 10
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:1902531 regulation of intracellular signal transduction 5 2
GO:1902532 negative regulation of intracellular signal transduction 6 2
GO:1903432 regulation of TORC1 signaling 7 2
GO:1904262 negative regulation of TORC1 signaling 8 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0008168 methyltransferase activity 4 10
GO:0016740 transferase activity 2 11
GO:0016741 transferase activity, transferring one-carbon groups 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 338 342 PF00656 0.514
CLV_C14_Caspase3-7 506 510 PF00656 0.534
CLV_NRD_NRD_1 174 176 PF00675 0.672
CLV_NRD_NRD_1 290 292 PF00675 0.489
CLV_NRD_NRD_1 373 375 PF00675 0.608
CLV_NRD_NRD_1 591 593 PF00675 0.353
CLV_NRD_NRD_1 633 635 PF00675 0.438
CLV_PCSK_KEX2_1 174 176 PF00082 0.719
CLV_PCSK_KEX2_1 290 292 PF00082 0.490
CLV_PCSK_KEX2_1 373 375 PF00082 0.608
CLV_PCSK_KEX2_1 590 592 PF00082 0.370
CLV_PCSK_KEX2_1 633 635 PF00082 0.360
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.719
CLV_PCSK_PC7_1 170 176 PF00082 0.683
CLV_PCSK_SKI1_1 284 288 PF00082 0.507
CLV_PCSK_SKI1_1 290 294 PF00082 0.544
CLV_PCSK_SKI1_1 299 303 PF00082 0.584
DEG_COP1_1 447 456 PF00400 0.326
DEG_ODPH_VHL_1 425 437 PF01847 0.339
DEG_SPOP_SBC_1 34 38 PF00917 0.451
DOC_CKS1_1 185 190 PF01111 0.452
DOC_CKS1_1 312 317 PF01111 0.321
DOC_CKS1_1 556 561 PF01111 0.347
DOC_MAPK_DCC_7 421 430 PF00069 0.403
DOC_MAPK_gen_1 284 294 PF00069 0.397
DOC_MAPK_MEF2A_6 574 582 PF00069 0.271
DOC_PP1_RVXF_1 288 295 PF00149 0.334
DOC_PP1_RVXF_1 558 564 PF00149 0.294
DOC_USP7_MATH_1 138 142 PF00917 0.458
DOC_USP7_MATH_1 144 148 PF00917 0.460
DOC_USP7_MATH_1 163 167 PF00917 0.434
DOC_USP7_MATH_1 204 208 PF00917 0.457
DOC_USP7_MATH_1 325 329 PF00917 0.502
DOC_USP7_MATH_1 34 38 PF00917 0.564
DOC_USP7_MATH_1 503 507 PF00917 0.429
DOC_USP7_MATH_1 518 522 PF00917 0.520
DOC_USP7_MATH_1 530 534 PF00917 0.512
DOC_USP7_MATH_1 65 69 PF00917 0.425
DOC_WW_Pin1_4 132 137 PF00397 0.530
DOC_WW_Pin1_4 184 189 PF00397 0.454
DOC_WW_Pin1_4 25 30 PF00397 0.504
DOC_WW_Pin1_4 257 262 PF00397 0.461
DOC_WW_Pin1_4 311 316 PF00397 0.411
DOC_WW_Pin1_4 391 396 PF00397 0.513
DOC_WW_Pin1_4 452 457 PF00397 0.359
DOC_WW_Pin1_4 555 560 PF00397 0.350
DOC_WW_Pin1_4 624 629 PF00397 0.532
LIG_14-3-3_CanoR_1 103 107 PF00244 0.414
LIG_14-3-3_CanoR_1 114 122 PF00244 0.395
LIG_14-3-3_CanoR_1 175 185 PF00244 0.481
LIG_14-3-3_CanoR_1 212 220 PF00244 0.355
LIG_14-3-3_CanoR_1 299 306 PF00244 0.322
LIG_14-3-3_CanoR_1 373 380 PF00244 0.295
LIG_14-3-3_CanoR_1 480 488 PF00244 0.438
LIG_14-3-3_CanoR_1 502 508 PF00244 0.490
LIG_14-3-3_CanoR_1 592 602 PF00244 0.540
LIG_14-3-3_CanoR_1 633 637 PF00244 0.642
LIG_BIR_II_1 1 5 PF00653 0.472
LIG_BRCT_BRCA1_1 603 607 PF00533 0.518
LIG_deltaCOP1_diTrp_1 462 469 PF00928 0.280
LIG_FHA_1 345 351 PF00498 0.359
LIG_FHA_1 402 408 PF00498 0.347
LIG_FHA_1 44 50 PF00498 0.470
LIG_FHA_1 556 562 PF00498 0.361
LIG_FHA_1 597 603 PF00498 0.521
LIG_FHA_2 203 209 PF00498 0.492
LIG_FHA_2 300 306 PF00498 0.319
LIG_FHA_2 431 437 PF00498 0.286
LIG_FHA_2 488 494 PF00498 0.383
LIG_FHA_2 660 666 PF00498 0.560
LIG_LIR_Apic_2 127 132 PF02991 0.382
LIG_LIR_Gen_1 462 470 PF02991 0.284
LIG_LIR_Gen_1 542 552 PF02991 0.343
LIG_LIR_Gen_1 604 614 PF02991 0.576
LIG_LIR_Gen_1 622 630 PF02991 0.577
LIG_LIR_Nem_3 273 278 PF02991 0.308
LIG_LIR_Nem_3 409 414 PF02991 0.276
LIG_LIR_Nem_3 542 547 PF02991 0.254
LIG_LIR_Nem_3 604 610 PF02991 0.572
LIG_LIR_Nem_3 622 626 PF02991 0.557
LIG_LYPXL_SIV_4 117 125 PF13949 0.347
LIG_REV1ctd_RIR_1 291 300 PF16727 0.350
LIG_SH2_CRK 544 548 PF00017 0.296
LIG_SH2_GRB2like 129 132 PF00017 0.405
LIG_SH2_NCK_1 544 548 PF00017 0.325
LIG_SH2_SRC 118 121 PF00017 0.343
LIG_SH2_STAP1 118 122 PF00017 0.310
LIG_SH2_STAP1 214 218 PF00017 0.337
LIG_SH2_STAP1 544 548 PF00017 0.296
LIG_SH2_STAT3 220 223 PF00017 0.329
LIG_SH2_STAT3 498 501 PF00017 0.376
LIG_SH2_STAT5 220 223 PF00017 0.334
LIG_SH2_STAT5 229 232 PF00017 0.250
LIG_SH2_STAT5 386 389 PF00017 0.378
LIG_SH2_STAT5 555 558 PF00017 0.325
LIG_SH2_STAT5 61 64 PF00017 0.308
LIG_SH3_1 421 427 PF00018 0.422
LIG_SH3_3 182 188 PF00018 0.474
LIG_SH3_3 23 29 PF00018 0.561
LIG_SH3_3 258 264 PF00018 0.350
LIG_SH3_3 282 288 PF00018 0.377
LIG_SH3_3 309 315 PF00018 0.453
LIG_SH3_3 421 427 PF00018 0.425
LIG_SH3_3 450 456 PF00018 0.420
LIG_SUMO_SIM_par_1 308 314 PF11976 0.253
LIG_SUMO_SIM_par_1 403 409 PF11976 0.251
LIG_SUMO_SIM_par_1 577 584 PF11976 0.271
LIG_SxIP_EBH_1 549 562 PF03271 0.269
LIG_TRAF2_1 490 493 PF00917 0.337
LIG_TRAF2_1 613 616 PF00917 0.588
LIG_WW_1 92 95 PF00397 0.335
MOD_CDK_SPK_2 555 560 PF00069 0.350
MOD_CDK_SPxK_1 311 317 PF00069 0.354
MOD_CDK_SPxxK_3 555 562 PF00069 0.347
MOD_CK1_1 178 184 PF00069 0.471
MOD_CK1_1 224 230 PF00069 0.412
MOD_CK1_1 311 317 PF00069 0.412
MOD_CK1_1 334 340 PF00069 0.510
MOD_CK1_1 343 349 PF00069 0.500
MOD_CK1_1 375 381 PF00069 0.337
MOD_CK1_1 583 589 PF00069 0.569
MOD_CK1_1 596 602 PF00069 0.508
MOD_CK1_1 635 641 PF00069 0.551
MOD_CK1_1 648 654 PF00069 0.496
MOD_CK1_1 68 74 PF00069 0.419
MOD_CK1_1 84 90 PF00069 0.341
MOD_CK2_1 299 305 PF00069 0.312
MOD_CK2_1 36 42 PF00069 0.534
MOD_CK2_1 487 493 PF00069 0.427
MOD_CK2_1 610 616 PF00069 0.546
MOD_CK2_1 91 97 PF00069 0.435
MOD_GlcNHglycan 115 118 PF01048 0.583
MOD_GlcNHglycan 132 135 PF01048 0.700
MOD_GlcNHglycan 140 143 PF01048 0.707
MOD_GlcNHglycan 145 149 PF01048 0.681
MOD_GlcNHglycan 189 192 PF01048 0.630
MOD_GlcNHglycan 254 257 PF01048 0.628
MOD_GlcNHglycan 341 345 PF01048 0.681
MOD_GlcNHglycan 396 399 PF01048 0.686
MOD_GlcNHglycan 513 516 PF01048 0.734
MOD_GlcNHglycan 523 527 PF01048 0.672
MOD_GlcNHglycan 628 631 PF01048 0.376
MOD_GlcNHglycan 652 655 PF01048 0.323
MOD_GlcNHglycan 67 70 PF01048 0.603
MOD_GlcNHglycan 72 75 PF01048 0.655
MOD_GlcNHglycan 88 91 PF01048 0.517
MOD_GSK3_1 198 205 PF00069 0.568
MOD_GSK3_1 208 215 PF00069 0.444
MOD_GSK3_1 313 320 PF00069 0.431
MOD_GSK3_1 325 332 PF00069 0.449
MOD_GSK3_1 333 340 PF00069 0.473
MOD_GSK3_1 34 41 PF00069 0.589
MOD_GSK3_1 368 375 PF00069 0.467
MOD_GSK3_1 518 525 PF00069 0.492
MOD_GSK3_1 530 537 PF00069 0.268
MOD_GSK3_1 551 558 PF00069 0.354
MOD_GSK3_1 645 652 PF00069 0.611
MOD_GSK3_1 68 75 PF00069 0.473
MOD_LATS_1 210 216 PF00433 0.423
MOD_NEK2_1 164 169 PF00069 0.534
MOD_NEK2_1 206 211 PF00069 0.468
MOD_NEK2_1 333 338 PF00069 0.440
MOD_NEK2_1 35 40 PF00069 0.539
MOD_NEK2_1 384 389 PF00069 0.344
MOD_NEK2_1 414 419 PF00069 0.372
MOD_NEK2_1 430 435 PF00069 0.255
MOD_NEK2_1 534 539 PF00069 0.385
MOD_NEK2_1 551 556 PF00069 0.191
MOD_NEK2_1 649 654 PF00069 0.629
MOD_NEK2_1 86 91 PF00069 0.413
MOD_PIKK_1 27 33 PF00454 0.485
MOD_PIKK_1 36 42 PF00454 0.433
MOD_PIKK_1 583 589 PF00454 0.569
MOD_PKA_1 175 181 PF00069 0.472
MOD_PKA_2 102 108 PF00069 0.361
MOD_PKA_2 113 119 PF00069 0.285
MOD_PKA_2 176 182 PF00069 0.517
MOD_PKA_2 252 258 PF00069 0.424
MOD_PKA_2 372 378 PF00069 0.315
MOD_PKA_2 632 638 PF00069 0.599
MOD_PKA_2 659 665 PF00069 0.541
MOD_PKB_1 500 508 PF00069 0.379
MOD_Plk_1 270 276 PF00069 0.319
MOD_Plk_1 367 373 PF00069 0.501
MOD_Plk_1 375 381 PF00069 0.420
MOD_Plk_2-3 472 478 PF00069 0.340
MOD_Plk_4 124 130 PF00069 0.369
MOD_Plk_4 224 230 PF00069 0.306
MOD_Plk_4 414 420 PF00069 0.443
MOD_Plk_4 50 56 PF00069 0.371
MOD_Plk_4 551 557 PF00069 0.291
MOD_Plk_4 645 651 PF00069 0.540
MOD_ProDKin_1 132 138 PF00069 0.533
MOD_ProDKin_1 184 190 PF00069 0.454
MOD_ProDKin_1 25 31 PF00069 0.505
MOD_ProDKin_1 257 263 PF00069 0.459
MOD_ProDKin_1 311 317 PF00069 0.419
MOD_ProDKin_1 391 397 PF00069 0.508
MOD_ProDKin_1 452 458 PF00069 0.350
MOD_ProDKin_1 555 561 PF00069 0.349
MOD_ProDKin_1 624 630 PF00069 0.535
MOD_SUMO_rev_2 94 101 PF00179 0.359
TRG_DiLeu_BaEn_1 305 310 PF01217 0.382
TRG_DiLeu_BaEn_1 575 580 PF01217 0.349
TRG_ENDOCYTIC_2 297 300 PF00928 0.368
TRG_ENDOCYTIC_2 411 414 PF00928 0.269
TRG_ENDOCYTIC_2 544 547 PF00928 0.325
TRG_ER_diArg_1 149 152 PF00400 0.414
TRG_ER_diArg_1 289 291 PF00400 0.285
TRG_ER_diArg_1 372 374 PF00400 0.422
TRG_ER_diArg_1 495 498 PF00400 0.342
TRG_ER_diArg_1 500 503 PF00400 0.372
TRG_ER_diArg_1 559 562 PF00400 0.248
TRG_ER_diArg_1 589 592 PF00400 0.668
TRG_ER_diArg_1 632 634 PF00400 0.558
TRG_NLS_MonoExtC_3 174 180 PF00514 0.471
TRG_NLS_MonoExtN_4 174 179 PF00514 0.471
TRG_NLS_MonoExtN_4 325 330 PF00514 0.381
TRG_Pf-PMV_PEXEL_1 290 295 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 354 358 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHP2 Leptomonas seymouri 47% 100%
A0A1X0NWU4 Trypanosomatidae 29% 100%
A0A3Q8IM81 Leishmania donovani 89% 100%
A0A3R7NJ73 Trypanosoma rangeli 29% 100%
A4HCX9 Leishmania braziliensis 73% 100%
A4I0G2 Leishmania infantum 89% 100%
C9ZV78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AWC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
V5BEP9 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS