Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB45_LEIMA

TriTrypDb:

LmjF.23.1110 , LMJLV39_230020600 , LMJSD75_230021100 , LMJSD75_230021200

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QB45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	645	649	PF00656	0.510
CLV_NRD_NRD_1	101	103	PF00675	0.457
CLV_NRD_NRD_1	138	140	PF00675	0.496
CLV_NRD_NRD_1	163	165	PF00675	0.509
CLV_NRD_NRD_1	270	272	PF00675	0.533
CLV_NRD_NRD_1	406	408	PF00675	0.596
CLV_NRD_NRD_1	430	432	PF00675	0.504
CLV_NRD_NRD_1	457	459	PF00675	0.666
CLV_NRD_NRD_1	463	465	PF00675	0.737
CLV_NRD_NRD_1	500	502	PF00675	0.478
CLV_NRD_NRD_1	519	521	PF00675	0.647
CLV_PCSK_FUR_1	461	465	PF00082	0.660
CLV_PCSK_KEX2_1	101	103	PF00082	0.457
CLV_PCSK_KEX2_1	138	140	PF00082	0.496
CLV_PCSK_KEX2_1	163	165	PF00082	0.509
CLV_PCSK_KEX2_1	270	272	PF00082	0.565
CLV_PCSK_KEX2_1	280	282	PF00082	0.550
CLV_PCSK_KEX2_1	406	408	PF00082	0.584
CLV_PCSK_KEX2_1	430	432	PF00082	0.504
CLV_PCSK_KEX2_1	461	463	PF00082	0.785
CLV_PCSK_KEX2_1	500	502	PF00082	0.478
CLV_PCSK_KEX2_1	519	521	PF00082	0.647
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.572
CLV_PCSK_PC7_1	458	464	PF00082	0.613
CLV_PCSK_PC7_1	97	103	PF00082	0.568
CLV_PCSK_SKI1_1	225	229	PF00082	0.509
CLV_PCSK_SKI1_1	253	257	PF00082	0.570
CLV_PCSK_SKI1_1	26	30	PF00082	0.544
CLV_PCSK_SKI1_1	384	388	PF00082	0.500
CLV_PCSK_SKI1_1	453	457	PF00082	0.565
CLV_PCSK_SKI1_1	501	505	PF00082	0.487
CLV_PCSK_SKI1_1	526	530	PF00082	0.561
CLV_PCSK_SKI1_1	547	551	PF00082	0.639
CLV_PCSK_SKI1_1	66	70	PF00082	0.574
DEG_APCC_DBOX_1	109	117	PF00400	0.397
DEG_APCC_DBOX_1	300	308	PF00400	0.538
DEG_APCC_DBOX_1	383	391	PF00400	0.268
DEG_APCC_DBOX_1	406	414	PF00400	0.268
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DOC_CKS1_1	67	72	PF01111	0.561
DOC_CYCLIN_RxL_1	235	244	PF00134	0.315
DOC_CYCLIN_RxL_1	541	554	PF00134	0.631
DOC_CYCLIN_RxL_1	673	682	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.542
DOC_MAPK_gen_1	163	169	PF00069	0.309
DOC_MAPK_gen_1	280	286	PF00069	0.566
DOC_MAPK_MEF2A_6	183	191	PF00069	0.253
DOC_MAPK_MEF2A_6	579	587	PF00069	0.564
DOC_MAPK_MEF2A_6	66	75	PF00069	0.426
DOC_PP1_RVXF_1	236	243	PF00149	0.309
DOC_PP1_RVXF_1	674	680	PF00149	0.559
DOC_PP1_RVXF_1	92	99	PF00149	0.553
DOC_PP2B_LxvP_1	249	252	PF13499	0.596
DOC_PP4_FxxP_1	343	346	PF00568	0.607
DOC_PP4_FxxP_1	79	82	PF00568	0.521
DOC_SPAK_OSR1_1	599	603	PF12202	0.515
DOC_USP7_MATH_1	299	303	PF00917	0.555
DOC_USP7_MATH_1	624	628	PF00917	0.562
DOC_USP7_MATH_2	472	478	PF00917	0.643
DOC_WW_Pin1_4	1	6	PF00397	0.631
DOC_WW_Pin1_4	247	252	PF00397	0.553
DOC_WW_Pin1_4	35	40	PF00397	0.574
DOC_WW_Pin1_4	414	419	PF00397	0.309
DOC_WW_Pin1_4	634	639	PF00397	0.458
DOC_WW_Pin1_4	66	71	PF00397	0.569
LIG_14-3-3_CanoR_1	110	114	PF00244	0.397
LIG_14-3-3_CanoR_1	238	243	PF00244	0.309
LIG_14-3-3_CanoR_1	270	276	PF00244	0.535
LIG_14-3-3_CanoR_1	30	36	PF00244	0.524
LIG_14-3-3_CanoR_1	301	305	PF00244	0.524
LIG_14-3-3_CanoR_1	332	338	PF00244	0.504
LIG_14-3-3_CanoR_1	430	438	PF00244	0.531
LIG_14-3-3_CanoR_1	444	450	PF00244	0.462
LIG_14-3-3_CanoR_1	453	460	PF00244	0.555
LIG_14-3-3_CanoR_1	462	472	PF00244	0.584
LIG_14-3-3_CanoR_1	481	491	PF00244	0.551
LIG_14-3-3_CanoR_1	500	506	PF00244	0.448
LIG_14-3-3_CanoR_1	526	532	PF00244	0.566
LIG_14-3-3_CanoR_1	553	558	PF00244	0.578
LIG_14-3-3_CanoR_1	633	637	PF00244	0.552
LIG_Actin_WH2_2	172	190	PF00022	0.274
LIG_Actin_WH2_2	644	659	PF00022	0.506
LIG_AP2alpha_1	242	246	PF02296	0.309
LIG_APCC_ABBA_1	189	194	PF00400	0.253
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.253
LIG_BRCT_BRCA1_1	223	227	PF00533	0.309
LIG_BRCT_BRCA1_1	636	640	PF00533	0.440
LIG_CaM_IQ_9	436	452	PF13499	0.527
LIG_Clathr_ClatBox_2	688	693	PF01394	0.394
LIG_DLG_GKlike_1	238	245	PF00625	0.309
LIG_FHA_1	324	330	PF00498	0.529
LIG_FHA_1	432	438	PF00498	0.536
LIG_FHA_1	527	533	PF00498	0.520
LIG_FHA_1	591	597	PF00498	0.464
LIG_FHA_1	656	662	PF00498	0.555
LIG_FHA_2	387	393	PF00498	0.268
LIG_FHA_2	399	405	PF00498	0.221
LIG_FHA_2	640	646	PF00498	0.504
LIG_LIR_Apic_2	200	206	PF02991	0.300
LIG_LIR_Apic_2	292	298	PF02991	0.546
LIG_LIR_Apic_2	691	696	PF02991	0.451
LIG_LIR_Apic_2	78	82	PF02991	0.394
LIG_LIR_Gen_1	105	113	PF02991	0.413
LIG_LIR_Gen_1	241	251	PF02991	0.268
LIG_LIR_Gen_1	25	36	PF02991	0.558
LIG_LIR_Gen_1	372	382	PF02991	0.343
LIG_LIR_Gen_1	45	56	PF02991	0.340
LIG_LIR_Gen_1	604	613	PF02991	0.545
LIG_LIR_Gen_1	637	647	PF02991	0.440
LIG_LIR_Gen_1	74	85	PF02991	0.398
LIG_LIR_Nem_3	105	109	PF02991	0.343
LIG_LIR_Nem_3	181	187	PF02991	0.312
LIG_LIR_Nem_3	224	230	PF02991	0.309
LIG_LIR_Nem_3	241	246	PF02991	0.309
LIG_LIR_Nem_3	25	31	PF02991	0.623
LIG_LIR_Nem_3	419	425	PF02991	0.294
LIG_LIR_Nem_3	45	51	PF02991	0.347
LIG_LIR_Nem_3	595	601	PF02991	0.704
LIG_LIR_Nem_3	604	609	PF02991	0.527
LIG_LIR_Nem_3	637	643	PF02991	0.425
LIG_LIR_Nem_3	74	80	PF02991	0.389
LIG_LIR_Nem_3	86	91	PF02991	0.407
LIG_MLH1_MIPbox_1	223	227	PF16413	0.309
LIG_PCNA_yPIPBox_3	519	532	PF02747	0.522
LIG_PDZ_Class_3	692	697	PF00595	0.454
LIG_Pex14_2	226	230	PF04695	0.380
LIG_Pex14_2	242	246	PF04695	0.269
LIG_Pex14_2	286	290	PF04695	0.586
LIG_SH2_CRK	77	81	PF00017	0.391
LIG_SH2_GRB2like	229	232	PF00017	0.331
LIG_SH2_NCK_1	14	18	PF00017	0.712
LIG_SH2_PTP2	295	298	PF00017	0.559
LIG_SH2_STAP1	48	52	PF00017	0.552
LIG_SH2_STAP1	494	498	PF00017	0.567
LIG_SH2_STAT3	360	363	PF00017	0.496
LIG_SH2_STAT5	166	169	PF00017	0.309
LIG_SH2_STAT5	229	232	PF00017	0.286
LIG_SH2_STAT5	295	298	PF00017	0.603
LIG_SH2_STAT5	35	38	PF00017	0.569
LIG_SH2_STAT5	361	364	PF00017	0.473
LIG_SH2_STAT5	409	412	PF00017	0.300
LIG_SH2_STAT5	77	80	PF00017	0.392
LIG_SH3_2	248	253	PF14604	0.567
LIG_SH3_3	245	251	PF00018	0.428
LIG_SH3_3	293	299	PF00018	0.596
LIG_SH3_3	33	39	PF00018	0.574
LIG_SH3_3	466	472	PF00018	0.614
LIG_SH3_3	64	70	PF00018	0.466
LIG_SH3_3	683	689	PF00018	0.574
LIG_SH3_3	79	85	PF00018	0.407
LIG_TRAF2_1	197	200	PF00917	0.274
LIG_TRAF2_1	493	496	PF00917	0.539
LIG_TYR_ITIM	75	80	PF00017	0.390
LIG_WRC_WIRS_1	76	81	PF05994	0.517
LIG_WW_3	250	254	PF00397	0.593
MOD_CDC14_SPxK_1	250	253	PF00782	0.563
MOD_CDK_SPxK_1	247	253	PF00069	0.557
MOD_CK1_1	112	118	PF00069	0.400
MOD_CK1_1	15	21	PF00069	0.655
MOD_CK1_1	300	306	PF00069	0.549
MOD_CK1_1	551	557	PF00069	0.643
MOD_CK1_1	627	633	PF00069	0.564
MOD_CK1_1	667	673	PF00069	0.494
MOD_CK2_1	112	118	PF00069	0.484
MOD_CK2_1	194	200	PF00069	0.357
MOD_CK2_1	341	347	PF00069	0.513
MOD_CK2_1	35	41	PF00069	0.538
MOD_CK2_1	398	404	PF00069	0.300
MOD_CK2_1	489	495	PF00069	0.546
MOD_CK2_1	575	581	PF00069	0.474
MOD_CK2_1	611	617	PF00069	0.520
MOD_CMANNOS	690	693	PF00535	0.402
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.547
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.574
MOD_GlcNHglycan	196	199	PF01048	0.505
MOD_GlcNHglycan	214	217	PF01048	0.219
MOD_GlcNHglycan	44	47	PF01048	0.610
MOD_GlcNHglycan	520	523	PF01048	0.584
MOD_GlcNHglycan	533	536	PF01048	0.568
MOD_GlcNHglycan	555	558	PF01048	0.627
MOD_GlcNHglycan	566	569	PF01048	0.592
MOD_GlcNHglycan	62	65	PF01048	0.400
MOD_GlcNHglycan	626	629	PF01048	0.639
MOD_GSK3_1	285	292	PF00069	0.575
MOD_GSK3_1	31	38	PF00069	0.563
MOD_GSK3_1	501	508	PF00069	0.580
MOD_GSK3_1	520	527	PF00069	0.526
MOD_GSK3_1	571	578	PF00069	0.559
MOD_GSK3_1	590	597	PF00069	0.468
MOD_GSK3_1	62	69	PF00069	0.608
MOD_LATS_1	451	457	PF00433	0.562
MOD_N-GLC_1	147	152	PF02516	0.486
MOD_N-GLC_1	414	419	PF02516	0.405
MOD_N-GLC_1	464	469	PF02516	0.593
MOD_N-GLC_1	54	59	PF02516	0.438
MOD_N-GLC_1	624	629	PF02516	0.513
MOD_N-GLC_1	664	669	PF02516	0.550
MOD_NEK2_1	109	114	PF00069	0.395
MOD_NEK2_1	285	290	PF00069	0.599
MOD_NEK2_1	398	403	PF00069	0.348
MOD_NEK2_1	509	514	PF00069	0.543
MOD_NEK2_1	518	523	PF00069	0.543
MOD_NEK2_1	639	644	PF00069	0.490
MOD_NEK2_1	656	661	PF00069	0.468
MOD_NEK2_2	445	450	PF00069	0.567
MOD_PIKK_1	474	480	PF00454	0.637
MOD_PIKK_1	540	546	PF00454	0.631
MOD_PIKK_1	667	673	PF00454	0.450
MOD_PK_1	520	526	PF00069	0.565
MOD_PKA_1	463	469	PF00069	0.742
MOD_PKA_2	109	115	PF00069	0.396
MOD_PKA_2	269	275	PF00069	0.609
MOD_PKA_2	300	306	PF00069	0.549
MOD_PKA_2	463	469	PF00069	0.759
MOD_PKA_2	489	495	PF00069	0.570
MOD_PKA_2	518	524	PF00069	0.597
MOD_PKA_2	571	577	PF00069	0.570
MOD_PKA_2	632	638	PF00069	0.556
MOD_PKA_2	656	662	PF00069	0.534
MOD_PKB_1	461	469	PF00069	0.616
MOD_Plk_1	330	336	PF00069	0.478
MOD_Plk_1	54	60	PF00069	0.437
MOD_Plk_1	575	581	PF00069	0.583
MOD_Plk_1	594	600	PF00069	0.589
MOD_Plk_1	664	670	PF00069	0.552
MOD_Plk_4	157	163	PF00069	0.508
MOD_Plk_4	238	244	PF00069	0.357
MOD_Plk_4	285	291	PF00069	0.598
MOD_Plk_4	31	37	PF00069	0.693
MOD_Plk_4	386	392	PF00069	0.284
MOD_Plk_4	527	533	PF00069	0.520
MOD_Plk_4	54	60	PF00069	0.452
MOD_Plk_4	579	585	PF00069	0.579
MOD_Plk_4	75	81	PF00069	0.389
MOD_Plk_4	83	89	PF00069	0.417
MOD_ProDKin_1	1	7	PF00069	0.634
MOD_ProDKin_1	247	253	PF00069	0.557
MOD_ProDKin_1	35	41	PF00069	0.578
MOD_ProDKin_1	414	420	PF00069	0.357
MOD_ProDKin_1	634	640	PF00069	0.453
MOD_ProDKin_1	66	72	PF00069	0.567
MOD_SUMO_rev_2	277	282	PF00179	0.606
MOD_SUMO_rev_2	315	325	PF00179	0.424
MOD_SUMO_rev_2	492	499	PF00179	0.557
TRG_DiLeu_BaEn_3	364	370	PF01217	0.505
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.567
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.569
TRG_ENDOCYTIC_2	166	169	PF00928	0.357
TRG_ENDOCYTIC_2	375	378	PF00928	0.460
TRG_ENDOCYTIC_2	422	425	PF00928	0.373
TRG_ENDOCYTIC_2	47	50	PF00928	0.488
TRG_ENDOCYTIC_2	77	80	PF00928	0.392
TRG_ER_diArg_1	101	103	PF00400	0.460
TRG_ER_diArg_1	137	139	PF00400	0.468
TRG_ER_diArg_1	162	164	PF00400	0.357
TRG_ER_diArg_1	405	407	PF00400	0.462
TRG_ER_diArg_1	429	431	PF00400	0.500
TRG_ER_diArg_1	460	463	PF00400	0.807
TRG_ER_diArg_1	499	501	PF00400	0.470
TRG_ER_diArg_1	518	520	PF00400	0.588
TRG_NLS_MonoExtC_3	457	462	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	39%	92%
A0A3Q8ICL5	Leishmania donovani	47%	100%
A0A3Q8ICR3	Leishmania donovani	92%	88%
A0A3S7WXU9	Leishmania donovani	47%	100%
A4HCY1	Leishmania braziliensis	76%	100%
A4I0G4	Leishmania infantum	92%	100%
A4I0G5	Leishmania infantum	47%	100%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QB44	Leishmania major	65%	100%