Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB44_LEIMA

TriTrypDb:

LmjF.23.1120 , LMJLV39_230020700 , LMJSD75_230021000

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QB44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB44

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	481	485	PF00656	0.407
CLV_C14_Caspase3-7	598	602	PF00656	0.410
CLV_NRD_NRD_1	101	103	PF00675	0.467
CLV_NRD_NRD_1	138	140	PF00675	0.499
CLV_NRD_NRD_1	163	165	PF00675	0.507
CLV_NRD_NRD_1	487	489	PF00675	0.502
CLV_NRD_NRD_1	543	545	PF00675	0.541
CLV_NRD_NRD_1	590	592	PF00675	0.435
CLV_PCSK_KEX2_1	101	103	PF00082	0.467
CLV_PCSK_KEX2_1	138	140	PF00082	0.499
CLV_PCSK_KEX2_1	163	165	PF00082	0.507
CLV_PCSK_KEX2_1	487	489	PF00082	0.517
CLV_PCSK_KEX2_1	543	545	PF00082	0.541
CLV_PCSK_KEX2_1	549	551	PF00082	0.535
CLV_PCSK_KEX2_1	590	592	PF00082	0.435
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.481
CLV_PCSK_PC7_1	97	103	PF00082	0.554
CLV_PCSK_SKI1_1	225	229	PF00082	0.502
CLV_PCSK_SKI1_1	26	30	PF00082	0.531
CLV_PCSK_SKI1_1	280	284	PF00082	0.594
CLV_PCSK_SKI1_1	341	345	PF00082	0.540
CLV_PCSK_SKI1_1	605	609	PF00082	0.474
CLV_PCSK_SKI1_1	66	70	PF00082	0.553
DEG_APCC_DBOX_1	109	117	PF00400	0.410
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_ANK_TNKS_1	381	388	PF00023	0.545
DOC_CKS1_1	450	455	PF01111	0.420
DOC_CKS1_1	67	72	PF01111	0.531
DOC_CYCLIN_RxL_1	235	244	PF00134	0.301
DOC_CYCLIN_RxL_1	349	358	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.564
DOC_MAPK_gen_1	163	169	PF00069	0.302
DOC_MAPK_MEF2A_6	183	191	PF00069	0.246
DOC_MAPK_MEF2A_6	382	390	PF00069	0.565
DOC_MAPK_MEF2A_6	66	75	PF00069	0.419
DOC_PP1_RVXF_1	236	243	PF00149	0.302
DOC_PP1_RVXF_1	485	492	PF00149	0.515
DOC_PP1_RVXF_1	92	99	PF00149	0.555
DOC_PP2B_LxvP_1	249	252	PF13499	0.588
DOC_PP2B_LxvP_1	354	357	PF13499	0.494
DOC_PP4_FxxP_1	79	82	PF00568	0.495
DOC_USP7_MATH_1	252	256	PF00917	0.479
DOC_USP7_MATH_1	328	332	PF00917	0.441
DOC_USP7_MATH_1	498	502	PF00917	0.478
DOC_USP7_MATH_1	562	566	PF00917	0.507
DOC_WW_Pin1_4	1	6	PF00397	0.702
DOC_WW_Pin1_4	247	252	PF00397	0.560
DOC_WW_Pin1_4	35	40	PF00397	0.554
DOC_WW_Pin1_4	361	366	PF00397	0.575
DOC_WW_Pin1_4	392	397	PF00397	0.526
DOC_WW_Pin1_4	427	432	PF00397	0.575
DOC_WW_Pin1_4	449	454	PF00397	0.431
DOC_WW_Pin1_4	66	71	PF00397	0.567
LIG_14-3-3_CanoR_1	110	114	PF00244	0.424
LIG_14-3-3_CanoR_1	238	243	PF00244	0.302
LIG_14-3-3_CanoR_1	253	257	PF00244	0.610
LIG_14-3-3_CanoR_1	30	36	PF00244	0.526
LIG_14-3-3_CanoR_1	368	378	PF00244	0.488
LIG_14-3-3_CanoR_1	487	492	PF00244	0.574
LIG_Actin_WH2_2	172	190	PF00022	0.267
LIG_AP2alpha_1	242	246	PF02296	0.302
LIG_APCC_ABBA_1	189	194	PF00400	0.246
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.246
LIG_BIR_III_4	561	565	PF00653	0.476
LIG_BRCT_BRCA1_1	223	227	PF00533	0.310
LIG_Clathr_ClatBox_1	398	402	PF01394	0.465
LIG_CSL_BTD_1	450	453	PF09270	0.427
LIG_DLG_GKlike_1	238	245	PF00625	0.302
LIG_FHA_1	348	354	PF00498	0.468
LIG_FHA_1	508	514	PF00498	0.582
LIG_FHA_2	301	307	PF00498	0.610
LIG_FHA_2	587	593	PF00498	0.489
LIG_HCF-1_HBM_1	576	579	PF13415	0.524
LIG_Integrin_RGD_1	573	575	PF01839	0.447
LIG_LIR_Apic_2	200	206	PF02991	0.293
LIG_LIR_Apic_2	78	82	PF02991	0.390
LIG_LIR_Gen_1	105	113	PF02991	0.422
LIG_LIR_Gen_1	241	251	PF02991	0.302
LIG_LIR_Gen_1	25	36	PF02991	0.545
LIG_LIR_Gen_1	433	443	PF02991	0.495
LIG_LIR_Gen_1	45	56	PF02991	0.341
LIG_LIR_Gen_1	576	586	PF02991	0.482
LIG_LIR_Gen_1	594	604	PF02991	0.471
LIG_LIR_Gen_1	74	85	PF02991	0.395
LIG_LIR_Nem_3	105	109	PF02991	0.351
LIG_LIR_Nem_3	181	187	PF02991	0.313
LIG_LIR_Nem_3	224	230	PF02991	0.310
LIG_LIR_Nem_3	241	246	PF02991	0.302
LIG_LIR_Nem_3	25	31	PF02991	0.608
LIG_LIR_Nem_3	372	378	PF02991	0.529
LIG_LIR_Nem_3	402	407	PF02991	0.453
LIG_LIR_Nem_3	433	438	PF02991	0.523
LIG_LIR_Nem_3	45	51	PF02991	0.356
LIG_LIR_Nem_3	501	506	PF02991	0.480
LIG_LIR_Nem_3	523	529	PF02991	0.494
LIG_LIR_Nem_3	575	581	PF02991	0.489
LIG_LIR_Nem_3	594	600	PF02991	0.484
LIG_LIR_Nem_3	74	80	PF02991	0.390
LIG_LIR_Nem_3	86	91	PF02991	0.401
LIG_MLH1_MIPbox_1	223	227	PF16413	0.302
LIG_NRP_CendR_1	613	614	PF00754	0.473
LIG_Pex14_2	226	230	PF04695	0.315
LIG_Pex14_2	242	246	PF04695	0.302
LIG_SH2_CRK	404	408	PF00017	0.443
LIG_SH2_CRK	579	583	PF00017	0.526
LIG_SH2_CRK	77	81	PF00017	0.386
LIG_SH2_GRB2like	229	232	PF00017	0.315
LIG_SH2_GRB2like	375	378	PF00017	0.453
LIG_SH2_NCK_1	14	18	PF00017	0.684
LIG_SH2_NCK_1	429	433	PF00017	0.513
LIG_SH2_NCK_1	552	556	PF00017	0.533
LIG_SH2_SRC	392	395	PF00017	0.453
LIG_SH2_SRC	552	555	PF00017	0.573
LIG_SH2_STAP1	48	52	PF00017	0.534
LIG_SH2_STAP1	579	583	PF00017	0.526
LIG_SH2_STAT5	166	169	PF00017	0.302
LIG_SH2_STAT5	229	232	PF00017	0.280
LIG_SH2_STAT5	35	38	PF00017	0.556
LIG_SH2_STAT5	77	80	PF00017	0.389
LIG_SH3_2	248	253	PF14604	0.573
LIG_SH3_2	535	540	PF14604	0.540
LIG_SH3_3	245	251	PF00018	0.438
LIG_SH3_3	33	39	PF00018	0.557
LIG_SH3_3	340	346	PF00018	0.550
LIG_SH3_3	425	431	PF00018	0.518
LIG_SH3_3	510	516	PF00018	0.510
LIG_SH3_3	532	538	PF00018	0.527
LIG_SH3_3	64	70	PF00018	0.468
LIG_SH3_3	79	85	PF00018	0.426
LIG_SUMO_SIM_par_1	350	358	PF11976	0.485
LIG_SUMO_SIM_par_1	397	402	PF11976	0.466
LIG_TRAF2_1	197	200	PF00917	0.267
LIG_TRAF2_1	313	316	PF00917	0.482
LIG_TYR_ITIM	524	529	PF00017	0.513
LIG_TYR_ITIM	75	80	PF00017	0.386
LIG_WRC_WIRS_1	76	81	PF05994	0.491
LIG_WW_3	250	254	PF00397	0.588
MOD_CDC14_SPxK_1	250	253	PF00782	0.562
MOD_CDK_SPK_2	361	366	PF00069	0.564
MOD_CDK_SPxK_1	247	253	PF00069	0.563
MOD_CDK_SPxxK_3	361	368	PF00069	0.501
MOD_CDK_SPxxK_3	449	456	PF00069	0.428
MOD_CK1_1	112	118	PF00069	0.419
MOD_CK1_1	15	21	PF00069	0.698
MOD_CK1_1	262	268	PF00069	0.579
MOD_CK1_1	272	278	PF00069	0.589
MOD_CK1_1	347	353	PF00069	0.558
MOD_CK2_1	112	118	PF00069	0.494
MOD_CK2_1	194	200	PF00069	0.302
MOD_CK2_1	300	306	PF00069	0.616
MOD_CK2_1	35	41	PF00069	0.517
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.560
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.571
MOD_GlcNHglycan	196	199	PF01048	0.614
MOD_GlcNHglycan	214	217	PF01048	0.424
MOD_GlcNHglycan	334	337	PF01048	0.556
MOD_GlcNHglycan	44	47	PF01048	0.596
MOD_GlcNHglycan	494	497	PF01048	0.546
MOD_GlcNHglycan	62	65	PF01048	0.408
MOD_GSK3_1	262	269	PF00069	0.588
MOD_GSK3_1	31	38	PF00069	0.573
MOD_GSK3_1	328	335	PF00069	0.454
MOD_GSK3_1	344	351	PF00069	0.647
MOD_GSK3_1	487	494	PF00069	0.523
MOD_GSK3_1	62	69	PF00069	0.584
MOD_N-GLC_1	147	152	PF02516	0.482
MOD_N-GLC_1	259	264	PF02516	0.584
MOD_N-GLC_1	269	274	PF02516	0.622
MOD_N-GLC_1	275	280	PF02516	0.621
MOD_N-GLC_1	376	381	PF02516	0.438
MOD_N-GLC_1	54	59	PF02516	0.435
MOD_NEK2_1	109	114	PF00069	0.419
MOD_NEK2_1	413	418	PF00069	0.546
MOD_NEK2_1	586	591	PF00069	0.537
MOD_NEK2_2	252	257	PF00069	0.484
MOD_NEK2_2	498	503	PF00069	0.490
MOD_PKA_1	487	493	PF00069	0.515
MOD_PKA_2	109	115	PF00069	0.410
MOD_PKA_2	252	258	PF00069	0.600
MOD_PKA_2	262	268	PF00069	0.621
MOD_PKA_2	466	472	PF00069	0.599
MOD_PKA_2	487	493	PF00069	0.522
MOD_PKA_2	539	545	PF00069	0.617
MOD_PKB_1	366	374	PF00069	0.486
MOD_Plk_1	269	275	PF00069	0.607
MOD_Plk_1	376	382	PF00069	0.441
MOD_Plk_1	498	504	PF00069	0.480
MOD_Plk_1	54	60	PF00069	0.435
MOD_Plk_1	591	597	PF00069	0.539
MOD_Plk_4	157	163	PF00069	0.472
MOD_Plk_4	238	244	PF00069	0.302
MOD_Plk_4	31	37	PF00069	0.687
MOD_Plk_4	386	392	PF00069	0.461
MOD_Plk_4	498	504	PF00069	0.626
MOD_Plk_4	54	60	PF00069	0.449
MOD_Plk_4	577	583	PF00069	0.533
MOD_Plk_4	591	597	PF00069	0.541
MOD_Plk_4	75	81	PF00069	0.385
MOD_Plk_4	83	89	PF00069	0.408
MOD_ProDKin_1	1	7	PF00069	0.705
MOD_ProDKin_1	247	253	PF00069	0.563
MOD_ProDKin_1	35	41	PF00069	0.559
MOD_ProDKin_1	361	367	PF00069	0.572
MOD_ProDKin_1	392	398	PF00069	0.524
MOD_ProDKin_1	427	433	PF00069	0.573
MOD_ProDKin_1	449	455	PF00069	0.425
MOD_ProDKin_1	66	72	PF00069	0.565
MOD_SUMO_for_1	298	301	PF00179	0.621
MOD_SUMO_rev_2	286	296	PF00179	0.580
TRG_DiLeu_BaEn_1	603	608	PF01217	0.426
TRG_ENDOCYTIC_2	166	169	PF00928	0.302
TRG_ENDOCYTIC_2	375	378	PF00928	0.527
TRG_ENDOCYTIC_2	404	407	PF00928	0.548
TRG_ENDOCYTIC_2	429	432	PF00928	0.554
TRG_ENDOCYTIC_2	435	438	PF00928	0.564
TRG_ENDOCYTIC_2	47	50	PF00928	0.476
TRG_ENDOCYTIC_2	526	529	PF00928	0.478
TRG_ENDOCYTIC_2	578	581	PF00928	0.486
TRG_ENDOCYTIC_2	583	586	PF00928	0.463
TRG_ENDOCYTIC_2	77	80	PF00928	0.389
TRG_ER_diArg_1	101	103	PF00400	0.469
TRG_ER_diArg_1	137	139	PF00400	0.465
TRG_ER_diArg_1	162	164	PF00400	0.302
TRG_ER_diArg_1	311	314	PF00400	0.545
TRG_ER_diArg_1	365	368	PF00400	0.502
TRG_ER_diArg_1	487	489	PF00400	0.512
TRG_ER_diArg_1	543	545	PF00400	0.535
TRG_ER_diArg_1	612	614	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	61%	81%
A0A3Q8ICL5	Leishmania donovani	89%	93%
A0A3Q8ICR3	Leishmania donovani	63%	78%
A0A3S7WXU9	Leishmania donovani	89%	93%
A4HCY1	Leishmania braziliensis	58%	89%
A4I0G4	Leishmania infantum	63%	88%
A4I0G5	Leishmania infantum	89%	93%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	88%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	94%
Q4QB45	Leishmania major	65%	88%