Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB43_LEIMA

TriTrypDb:

LmjF.23.1130 , LMJLV39_230020800 , LMJSD75_230021300

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005874	microtubule	6	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0035371	microtubule plus-end	3	2
GO:0051233	spindle midzone	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QB43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB43

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0051010	microtubule plus-end binding	6	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.643
CLV_C14_Caspase3-7	31	35	PF00656	0.319
CLV_NRD_NRD_1	10	12	PF00675	0.507
CLV_NRD_NRD_1	194	196	PF00675	0.702
CLV_PCSK_KEX2_1	194	196	PF00082	0.695
CLV_PCSK_SKI1_1	12	16	PF00082	0.494
CLV_PCSK_SKI1_1	130	134	PF00082	0.463
CLV_PCSK_SKI1_1	159	163	PF00082	0.476
CLV_PCSK_SKI1_1	342	346	PF00082	0.609
CLV_Separin_Metazoa	304	308	PF03568	0.673

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ6	Leptomonas seymouri	55%	100%
A0A1X0NWV1	Trypanosomatidae	34%	100%
A0A3S7WXV0	Leishmania donovani	93%	100%
A4HCY2	Leishmania braziliensis	80%	100%
A4I0G7	Leishmania infantum	94%	100%
C9ZV68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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