Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB43_LEIMA

TriTrypDb:

LmjF.23.1130 , LMJLV39_230020800 , LMJSD75_230021300

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005874	microtubule	6	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0035371	microtubule plus-end	3	2
GO:0051233	spindle midzone	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2
GO:1990752	microtubule end	2	2

Expansion

Sequence features

Q4QB43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB43

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0031110	regulation of microtubule polymerization or depolymerization	6	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033036	macromolecule localization	2	2
GO:0033043	regulation of organelle organization	5	2
GO:0033365	protein localization to organelle	5	2
GO:0035372	protein localization to microtubule	8	2
GO:0044380	protein localization to cytoskeleton	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	2
GO:0051225	spindle assembly	4	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0051641	cellular localization	2	2
GO:0065007	biological regulation	1	2
GO:0070507	regulation of microtubule cytoskeleton organization	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072698	protein localization to microtubule cytoskeleton	7	2
GO:0140694	non-membrane-bounded organelle assembly	6	2
GO:1904825	protein localization to microtubule plus-end	10	2
GO:1905725	protein localization to microtubule end	9	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0051010	microtubule plus-end binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.643
CLV_C14_Caspase3-7	31	35	PF00656	0.319
CLV_NRD_NRD_1	10	12	PF00675	0.507
CLV_NRD_NRD_1	194	196	PF00675	0.702
CLV_PCSK_KEX2_1	194	196	PF00082	0.695
CLV_PCSK_SKI1_1	12	16	PF00082	0.494
CLV_PCSK_SKI1_1	130	134	PF00082	0.463
CLV_PCSK_SKI1_1	159	163	PF00082	0.476
CLV_PCSK_SKI1_1	342	346	PF00082	0.609
CLV_Separin_Metazoa	304	308	PF03568	0.673
DEG_APCC_DBOX_1	326	334	PF00400	0.515
DEG_SPOP_SBC_1	265	269	PF00917	0.651
DOC_CKS1_1	252	257	PF01111	0.737
DOC_CYCLIN_RxL_1	139	151	PF00134	0.475
DOC_MAPK_gen_1	383	391	PF00069	0.506
DOC_PP1_RVXF_1	75	81	PF00149	0.374
DOC_PP1_RVXF_1	98	105	PF00149	0.400
DOC_PP4_FxxP_1	252	255	PF00568	0.695
DOC_USP7_MATH_1	229	233	PF00917	0.706
DOC_USP7_MATH_1	245	249	PF00917	0.664
DOC_USP7_MATH_1	265	269	PF00917	0.598
DOC_USP7_MATH_1	28	32	PF00917	0.448
DOC_USP7_MATH_1	418	422	PF00917	0.464
DOC_USP7_MATH_1	55	59	PF00917	0.597
DOC_USP7_MATH_1	90	94	PF00917	0.582
DOC_USP7_UBL2_3	160	164	PF12436	0.563
DOC_WW_Pin1_4	215	220	PF00397	0.767
DOC_WW_Pin1_4	224	229	PF00397	0.732
DOC_WW_Pin1_4	247	252	PF00397	0.710
DOC_WW_Pin1_4	285	290	PF00397	0.707
LIG_14-3-3_CanoR_1	123	127	PF00244	0.512
LIG_14-3-3_CanoR_1	279	289	PF00244	0.712
LIG_14-3-3_CanoR_1	327	331	PF00244	0.514
LIG_14-3-3_CanoR_1	366	371	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_FHA_1	131	137	PF00498	0.583
LIG_FHA_1	179	185	PF00498	0.623
LIG_FHA_1	317	323	PF00498	0.610
LIG_FHA_1	386	392	PF00498	0.586
LIG_FHA_1	414	420	PF00498	0.464
LIG_FHA_1	81	87	PF00498	0.449
LIG_FHA_2	235	241	PF00498	0.721
LIG_FHA_2	38	44	PF00498	0.394
LIG_Integrin_RGD_1	241	243	PF01839	0.630
LIG_LIR_Apic_2	250	255	PF02991	0.687
LIG_LIR_Gen_1	101	110	PF02991	0.360
LIG_LIR_Nem_3	23	29	PF02991	0.359
LIG_LYPXL_yS_3	26	29	PF13949	0.352
LIG_NRBOX	393	399	PF00104	0.488
LIG_NRBOX	435	441	PF00104	0.514
LIG_Pex14_1	145	149	PF04695	0.372
LIG_SH2_CRK	38	42	PF00017	0.336
LIG_SH2_NCK_1	408	412	PF00017	0.500
LIG_SH2_STAP1	157	161	PF00017	0.469
LIG_SH2_STAT5	147	150	PF00017	0.421
LIG_SH2_STAT5	297	300	PF00017	0.790
LIG_SH2_STAT5	315	318	PF00017	0.531
LIG_SH2_STAT5	38	41	PF00017	0.338
LIG_SH2_STAT5	74	77	PF00017	0.442
LIG_SH3_3	252	258	PF00018	0.643
LIG_SH3_3	425	431	PF00018	0.548
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.435
LIG_SUMO_SIM_anti_2	205	214	PF11976	0.538
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.496
LIG_SUMO_SIM_par_1	387	393	PF11976	0.524
LIG_TRAF2_1	301	304	PF00917	0.604
LIG_TRAF2_1	390	393	PF00917	0.576
LIG_UBA3_1	14	20	PF00899	0.440
MOD_CDC14_SPxK_1	250	253	PF00782	0.833
MOD_CDK_SPK_2	215	220	PF00069	0.673
MOD_CDK_SPxK_1	247	253	PF00069	0.735
MOD_CK1_1	2	8	PF00069	0.582
MOD_CK1_1	281	287	PF00069	0.737
MOD_CK1_1	421	427	PF00069	0.513
MOD_CK1_1	93	99	PF00069	0.401
MOD_CK2_1	229	235	PF00069	0.771
MOD_CK2_1	298	304	PF00069	0.676
MOD_CK2_1	357	363	PF00069	0.628
MOD_CK2_1	37	43	PF00069	0.444
MOD_CK2_1	387	393	PF00069	0.567
MOD_CK2_1	95	101	PF00069	0.468
MOD_Cter_Amidation	9	12	PF01082	0.505
MOD_GlcNHglycan	1	4	PF01048	0.576
MOD_GlcNHglycan	243	246	PF01048	0.689
MOD_GlcNHglycan	283	286	PF01048	0.683
MOD_GlcNHglycan	300	303	PF01048	0.812
MOD_GlcNHglycan	420	423	PF01048	0.574
MOD_GlcNHglycan	79	83	PF01048	0.495
MOD_GlcNHglycan	8	11	PF01048	0.398
MOD_GSK3_1	183	190	PF00069	0.629
MOD_GSK3_1	2	9	PF00069	0.615
MOD_GSK3_1	230	237	PF00069	0.669
MOD_GSK3_1	241	248	PF00069	0.591
MOD_GSK3_1	277	284	PF00069	0.699
MOD_GSK3_1	353	360	PF00069	0.540
MOD_N-GLC_1	178	183	PF02516	0.606
MOD_N-GLC_1	214	219	PF02516	0.635
MOD_NEK2_1	148	153	PF00069	0.478
MOD_NEK2_1	178	183	PF00069	0.546
MOD_NEK2_1	326	331	PF00069	0.510
MOD_NEK2_1	78	83	PF00069	0.477
MOD_NEK2_2	28	33	PF00069	0.405
MOD_PIKK_1	421	427	PF00454	0.545
MOD_PIKK_1	53	59	PF00454	0.514
MOD_PK_1	366	372	PF00069	0.583
MOD_PKA_2	122	128	PF00069	0.500
MOD_PKA_2	245	251	PF00069	0.741
MOD_PKA_2	278	284	PF00069	0.666
MOD_PKA_2	316	322	PF00069	0.598
MOD_PKA_2	326	332	PF00069	0.541
MOD_PKA_2	357	363	PF00069	0.565
MOD_PKA_2	385	391	PF00069	0.604
MOD_PKA_2	93	99	PF00069	0.581
MOD_PKB_1	185	193	PF00069	0.638
MOD_PKB_1	239	247	PF00069	0.646
MOD_Plk_1	178	184	PF00069	0.638
MOD_Plk_1	307	313	PF00069	0.669
MOD_Plk_1	377	383	PF00069	0.575
MOD_Plk_2-3	387	393	PF00069	0.583
MOD_Plk_2-3	95	101	PF00069	0.465
MOD_Plk_4	37	43	PF00069	0.389
MOD_ProDKin_1	215	221	PF00069	0.769
MOD_ProDKin_1	224	230	PF00069	0.734
MOD_ProDKin_1	247	253	PF00069	0.714
MOD_ProDKin_1	285	291	PF00069	0.706
MOD_SUMO_for_1	211	214	PF00179	0.679
MOD_SUMO_rev_2	158	166	PF00179	0.550
MOD_SUMO_rev_2	243	251	PF00179	0.547
TRG_DiLeu_BaEn_1	393	398	PF01217	0.543
TRG_DiLeu_BaEn_4	399	405	PF01217	0.462
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.411
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.549
TRG_ENDOCYTIC_2	147	150	PF00928	0.471
TRG_ENDOCYTIC_2	26	29	PF00928	0.352
TRG_ENDOCYTIC_2	38	41	PF00928	0.338
TRG_ENDOCYTIC_2	408	411	PF00928	0.521
TRG_ER_diArg_1	182	185	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ6	Leptomonas seymouri	55%	100%
A0A1X0NWV1	Trypanosomatidae	34%	100%
A0A3S7WXV0	Leishmania donovani	93%	100%
A4HCY2	Leishmania braziliensis	80%	100%
A4I0G7	Leishmania infantum	94%	100%
C9ZV68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%