Centrosomal protein of 162 kDa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB41_LEIMA

TriTrypDb:

LmjF.23.1150 , LMJLV39_230021000

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	2
GO:0005874	microtubule	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB41

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.585
CLV_C14_Caspase3-7	254	258	PF00656	0.614
CLV_C14_Caspase3-7	31	35	PF00656	0.709
CLV_C14_Caspase3-7	475	479	PF00656	0.555
CLV_C14_Caspase3-7	531	535	PF00656	0.553
CLV_NRD_NRD_1	104	106	PF00675	0.591
CLV_NRD_NRD_1	194	196	PF00675	0.615
CLV_NRD_NRD_1	269	271	PF00675	0.661
CLV_NRD_NRD_1	396	398	PF00675	0.573
CLV_NRD_NRD_1	54	56	PF00675	0.656
CLV_NRD_NRD_1	6	8	PF00675	0.642
CLV_PCSK_KEX2_1	193	195	PF00082	0.620
CLV_PCSK_KEX2_1	344	346	PF00082	0.636
CLV_PCSK_KEX2_1	383	385	PF00082	0.553
CLV_PCSK_KEX2_1	396	398	PF00082	0.535
CLV_PCSK_KEX2_1	56	58	PF00082	0.718
CLV_PCSK_KEX2_1	565	567	PF00082	0.466
CLV_PCSK_KEX2_1	582	584	PF00082	0.601
CLV_PCSK_KEX2_1	608	610	PF00082	0.604
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.632
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.636
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.441
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.718
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.514
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.504
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.604
CLV_PCSK_SKI1_1	130	134	PF00082	0.552
CLV_PCSK_SKI1_1	195	199	PF00082	0.566
CLV_PCSK_SKI1_1	334	338	PF00082	0.551
CLV_PCSK_SKI1_1	396	400	PF00082	0.496
CLV_PCSK_SKI1_1	416	420	PF00082	0.734
CLV_PCSK_SKI1_1	469	473	PF00082	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DEG_SPOP_SBC_1	15	19	PF00917	0.493
DEG_SPOP_SBC_1	40	44	PF00917	0.573
DOC_CYCLIN_RxL_1	328	341	PF00134	0.581
DOC_MAPK_gen_1	193	200	PF00069	0.563
DOC_MAPK_gen_1	321	331	PF00069	0.582
DOC_MAPK_gen_1	590	600	PF00069	0.522
DOC_MAPK_gen_1	608	614	PF00069	0.379
DOC_MAPK_MEF2A_6	4	13	PF00069	0.591
DOC_PP1_RVXF_1	557	563	PF00149	0.532
DOC_PP2B_LxvP_1	372	375	PF13499	0.700
DOC_PP2B_LxvP_1	439	442	PF13499	0.570
DOC_SPAK_OSR1_1	609	613	PF12202	0.595
DOC_USP7_MATH_1	148	152	PF00917	0.649
DOC_USP7_MATH_1	16	20	PF00917	0.681
DOC_USP7_MATH_1	161	165	PF00917	0.528
DOC_USP7_MATH_1	169	173	PF00917	0.553
DOC_USP7_MATH_1	22	26	PF00917	0.668
DOC_USP7_MATH_1	258	262	PF00917	0.637
DOC_USP7_MATH_1	40	44	PF00917	0.704
DOC_USP7_MATH_1	402	406	PF00917	0.688
DOC_USP7_MATH_1	407	411	PF00917	0.747
DOC_USP7_MATH_1	86	90	PF00917	0.568
DOC_USP7_MATH_1	97	101	PF00917	0.469
DOC_USP7_UBL2_3	4	8	PF12436	0.513
DOC_USP7_UBL2_3	570	574	PF12436	0.635
DOC_WW_Pin1_4	210	215	PF00397	0.699
LIG_14-3-3_CanoR_1	10	16	PF00244	0.725
LIG_14-3-3_CanoR_1	360	366	PF00244	0.587
LIG_14-3-3_CanoR_1	384	389	PF00244	0.584
LIG_14-3-3_CanoR_1	469	474	PF00244	0.633
LIG_14-3-3_CanoR_1	55	65	PF00244	0.702
LIG_Actin_WH2_2	381	398	PF00022	0.576
LIG_BRCT_BRCA1_1	88	92	PF00533	0.520
LIG_FAT_LD_1	614	622	PF03623	0.461
LIG_FHA_1	18	24	PF00498	0.707
LIG_FHA_1	211	217	PF00498	0.727
LIG_FHA_1	40	46	PF00498	0.740
LIG_FHA_1	517	523	PF00498	0.397
LIG_FHA_1	573	579	PF00498	0.586
LIG_FHA_1	594	600	PF00498	0.562
LIG_FHA_2	166	172	PF00498	0.594
LIG_FHA_2	185	191	PF00498	0.628
LIG_FHA_2	262	268	PF00498	0.577
LIG_FHA_2	362	368	PF00498	0.631
LIG_Integrin_RGD_1	532	534	PF01839	0.504
LIG_LIR_Gen_1	100	108	PF02991	0.652
LIG_LIR_Gen_1	140	148	PF02991	0.601
LIG_LIR_Nem_3	100	104	PF02991	0.594
LIG_LIR_Nem_3	140	146	PF02991	0.596
LIG_MLH1_MIPbox_1	88	92	PF16413	0.520
LIG_NRBOX	613	619	PF00104	0.462
LIG_PCNA_yPIPBox_3	608	618	PF02747	0.592
LIG_SH2_STAP1	549	553	PF00017	0.637
LIG_SH2_STAT5	567	570	PF00017	0.518
LIG_SH2_STAT5	91	94	PF00017	0.736
LIG_SH3_4	433	440	PF00018	0.794
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.705
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.710
LIG_SUMO_SIM_par_1	28	35	PF11976	0.710
LIG_SUMO_SIM_par_1	519	525	PF11976	0.512
LIG_SUMO_SIM_par_1	552	558	PF11976	0.612
LIG_TRAF2_1	346	349	PF00917	0.637
LIG_UBA3_1	29	38	PF00899	0.710
LIG_UBA3_1	521	529	PF00899	0.548
LIG_UBA3_1	578	582	PF00899	0.592
MOD_CK1_1	17	23	PF00069	0.707
MOD_CK1_1	261	267	PF00069	0.610
MOD_CK1_1	275	281	PF00069	0.471
MOD_CK1_1	286	292	PF00069	0.603
MOD_CK1_1	41	47	PF00069	0.673
MOD_CK1_1	516	522	PF00069	0.613
MOD_CK1_1	525	531	PF00069	0.542
MOD_CK1_1	535	541	PF00069	0.375
MOD_CK1_1	73	79	PF00069	0.681
MOD_CK1_1	90	96	PF00069	0.691
MOD_CK2_1	184	190	PF00069	0.630
MOD_CK2_1	22	28	PF00069	0.671
MOD_CK2_1	261	267	PF00069	0.576
MOD_CK2_1	361	367	PF00069	0.630
MOD_CK2_1	383	389	PF00069	0.598
MOD_CK2_1	451	457	PF00069	0.558
MOD_CK2_1	508	514	PF00069	0.635
MOD_Cter_Amidation	53	56	PF01082	0.590
MOD_GlcNHglycan	154	157	PF01048	0.570
MOD_GlcNHglycan	171	174	PF01048	0.390
MOD_GlcNHglycan	218	221	PF01048	0.777
MOD_GlcNHglycan	295	298	PF01048	0.533
MOD_GlcNHglycan	315	318	PF01048	0.691
MOD_GlcNHglycan	409	412	PF01048	0.685
MOD_GlcNHglycan	50	53	PF01048	0.719
MOD_GlcNHglycan	503	506	PF01048	0.634
MOD_GlcNHglycan	72	75	PF01048	0.766
MOD_GlcNHglycan	93	96	PF01048	0.574
MOD_GSK3_1	11	18	PF00069	0.672
MOD_GSK3_1	148	155	PF00069	0.539
MOD_GSK3_1	161	168	PF00069	0.497
MOD_GSK3_1	184	191	PF00069	0.604
MOD_GSK3_1	206	213	PF00069	0.660
MOD_GSK3_1	216	223	PF00069	0.578
MOD_GSK3_1	247	254	PF00069	0.570
MOD_GSK3_1	261	268	PF00069	0.392
MOD_GSK3_1	40	47	PF00069	0.737
MOD_GSK3_1	447	454	PF00069	0.580
MOD_GSK3_1	472	479	PF00069	0.571
MOD_GSK3_1	80	87	PF00069	0.643
MOD_N-GLC_1	121	126	PF02516	0.584
MOD_N-GLC_1	169	174	PF02516	0.649
MOD_N-GLC_1	38	43	PF02516	0.753
MOD_N-GLC_1	469	474	PF02516	0.528
MOD_NEK2_1	152	157	PF00069	0.574
MOD_NEK2_1	206	211	PF00069	0.716
MOD_NEK2_1	242	247	PF00069	0.597
MOD_NEK2_1	308	313	PF00069	0.587
MOD_NEK2_1	447	452	PF00069	0.577
MOD_NEK2_1	50	55	PF00069	0.739
MOD_NEK2_1	513	518	PF00069	0.635
MOD_NEK2_1	522	527	PF00069	0.507
MOD_PIKK_1	107	113	PF00454	0.575
MOD_PIKK_1	242	248	PF00454	0.548
MOD_PIKK_1	286	292	PF00454	0.585
MOD_PIKK_1	516	522	PF00454	0.633
MOD_PIKK_1	602	608	PF00454	0.605
MOD_PK_1	247	253	PF00069	0.635
MOD_PK_1	476	482	PF00069	0.636
MOD_PKA_1	270	276	PF00069	0.617
MOD_PKA_1	383	389	PF00069	0.598
MOD_PKA_1	55	61	PF00069	0.712
MOD_PKA_2	242	248	PF00069	0.658
MOD_PKA_2	275	281	PF00069	0.581
MOD_PKA_2	383	389	PF00069	0.598
MOD_PKA_2	538	544	PF00069	0.609
MOD_PKA_2	56	62	PF00069	0.717
MOD_Plk_1	121	127	PF00069	0.586
MOD_Plk_1	261	267	PF00069	0.648
MOD_Plk_1	447	453	PF00069	0.640
MOD_Plk_1	469	475	PF00069	0.527
MOD_Plk_1	508	514	PF00069	0.624
MOD_Plk_1	549	555	PF00069	0.612
MOD_Plk_1	87	93	PF00069	0.697
MOD_Plk_4	121	127	PF00069	0.577
MOD_Plk_4	148	154	PF00069	0.567
MOD_Plk_4	212	218	PF00069	0.712
MOD_Plk_4	451	457	PF00069	0.569
MOD_Plk_4	549	555	PF00069	0.629
MOD_Plk_4	619	625	PF00069	0.590
MOD_Plk_4	87	93	PF00069	0.697
MOD_ProDKin_1	210	216	PF00069	0.702
MOD_SUMO_rev_2	123	132	PF00179	0.529
MOD_SUMO_rev_2	142	151	PF00179	0.363
MOD_SUMO_rev_2	267	273	PF00179	0.589
MOD_SUMO_rev_2	348	357	PF00179	0.642
MOD_SUMO_rev_2	485	493	PF00179	0.630
MOD_SUMO_rev_2	571	575	PF00179	0.590
MOD_SUMO_rev_2	577	584	PF00179	0.553
MOD_SUMO_rev_2	586	591	PF00179	0.494
MOD_SUMO_rev_2	597	605	PF00179	0.321
TRG_DiLeu_BaEn_1	594	599	PF01217	0.632
TRG_DiLeu_BaEn_2	557	563	PF01217	0.532
TRG_DiLeu_BaEn_4	508	514	PF01217	0.613
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.572
TRG_ER_diArg_1	328	331	PF00400	0.578
TRG_ER_diArg_1	368	371	PF00400	0.679
TRG_ER_diArg_1	395	397	PF00400	0.550
TRG_NES_CRM1_1	580	592	PF08389	0.533
TRG_NLS_MonoExtC_3	54	60	PF00514	0.585
TRG_NLS_MonoExtN_4	4	11	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB33	Leishmania donovani	93%	100%
A0A422NPG5	Trypanosoma rangeli	25%	84%
A4HCY4	Leishmania braziliensis	80%	100%
A4I0G9	Leishmania infantum	93%	100%
C9ZV65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	72%
E9AWD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%