E3 ubiquitin protein ligase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB40_LEIMA

TriTrypDb:

LmjF.23.1155 , LMJLV39_230021100

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.505
CLV_NRD_NRD_1	238	240	PF00675	0.609
CLV_NRD_NRD_1	298	300	PF00675	0.589
CLV_NRD_NRD_1	359	361	PF00675	0.621
CLV_NRD_NRD_1	7	9	PF00675	0.425
CLV_PCSK_KEX2_1	126	128	PF00082	0.634
CLV_PCSK_KEX2_1	197	199	PF00082	0.757
CLV_PCSK_KEX2_1	240	242	PF00082	0.678
CLV_PCSK_KEX2_1	65	67	PF00082	0.700
CLV_PCSK_KEX2_1	7	9	PF00082	0.425
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.679
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.757
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.637
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.700
CLV_PCSK_SKI1_1	127	131	PF00082	0.589
CLV_PCSK_SKI1_1	233	237	PF00082	0.636
CLV_PCSK_SKI1_1	243	247	PF00082	0.545
CLV_PCSK_SKI1_1	477	481	PF00082	0.711
CLV_PCSK_SKI1_1	99	103	PF00082	0.617
CLV_Separin_Metazoa	96	100	PF03568	0.599
DEG_APCC_DBOX_1	9	17	PF00400	0.412
DEG_Nend_UBRbox_3	1	3	PF02207	0.445
DOC_CYCLIN_RxL_1	314	323	PF00134	0.409
DOC_CYCLIN_RxL_1	419	427	PF00134	0.491
DOC_CYCLIN_yClb1_LxF_4	483	489	PF00134	0.624
DOC_MAPK_gen_1	179	187	PF00069	0.640
DOC_MAPK_gen_1	297	305	PF00069	0.628
DOC_MAPK_gen_1	420	428	PF00069	0.541
DOC_MAPK_gen_1	7	15	PF00069	0.418
DOC_MAPK_MEF2A_6	420	428	PF00069	0.646
DOC_USP7_MATH_1	100	104	PF00917	0.658
DOC_USP7_MATH_1	467	471	PF00917	0.468
DOC_USP7_MATH_1	64	68	PF00917	0.644
DOC_WW_Pin1_4	200	205	PF00397	0.563
DOC_WW_Pin1_4	257	262	PF00397	0.677
DOC_WW_Pin1_4	36	41	PF00397	0.585
DOC_WW_Pin1_4	88	93	PF00397	0.475
LIG_14-3-3_CanoR_1	127	133	PF00244	0.611
LIG_14-3-3_CanoR_1	179	185	PF00244	0.599
LIG_14-3-3_CanoR_1	225	229	PF00244	0.630
LIG_14-3-3_CanoR_1	253	261	PF00244	0.654
LIG_14-3-3_CanoR_1	317	322	PF00244	0.545
LIG_14-3-3_CanoR_1	327	331	PF00244	0.570
LIG_14-3-3_CanoR_1	468	475	PF00244	0.604
LIG_14-3-3_CanoR_1	66	74	PF00244	0.612
LIG_FHA_1	267	273	PF00498	0.692
LIG_FHA_1	461	467	PF00498	0.632
LIG_FHA_2	128	134	PF00498	0.674
LIG_FHA_2	155	161	PF00498	0.787
LIG_FHA_2	225	231	PF00498	0.634
LIG_FHA_2	91	97	PF00498	0.694
LIG_GBD_Chelix_1	280	288	PF00786	0.684
LIG_LIR_Gen_1	404	411	PF02991	0.654
LIG_LIR_Nem_3	378	382	PF02991	0.531
LIG_LIR_Nem_3	404	410	PF02991	0.660
LIG_NRBOX	173	179	PF00104	0.455
LIG_NRBOX	381	387	PF00104	0.647
LIG_SH2_CRK	379	383	PF00017	0.589
LIG_SH2_CRK	407	411	PF00017	0.649
LIG_SH2_STAT5	218	221	PF00017	0.497
LIG_SH2_STAT5	451	454	PF00017	0.585
LIG_SH2_STAT5	485	488	PF00017	0.693
LIG_SH3_3	150	156	PF00018	0.654
LIG_SH3_3	453	459	PF00018	0.585
LIG_SUMO_SIM_par_1	265	275	PF11976	0.626
LIG_TRAF2_1	104	107	PF00917	0.730
LIG_TRAF2_1	212	215	PF00917	0.640
LIG_TRAF2_1	354	357	PF00917	0.676
LIG_TRAF2_1	403	406	PF00917	0.469
LIG_TRAF2_1	416	419	PF00917	0.473
LIG_TRAF2_1	469	472	PF00917	0.666
LIG_TRAF2_1	67	70	PF00917	0.657
LIG_UBA3_1	234	240	PF00899	0.567
MOD_CDK_SPxK_1	36	42	PF00069	0.585
MOD_CK1_1	19	25	PF00069	0.442
MOD_CK1_1	200	206	PF00069	0.523
MOD_CK1_1	320	326	PF00069	0.576
MOD_CK1_1	334	340	PF00069	0.518
MOD_CK1_1	346	352	PF00069	0.535
MOD_CK1_1	409	415	PF00069	0.629
MOD_CK1_1	457	463	PF00069	0.692
MOD_CK1_1	76	82	PF00069	0.708
MOD_CK1_1	88	94	PF00069	0.516
MOD_CK2_1	100	106	PF00069	0.560
MOD_CK2_1	127	133	PF00069	0.679
MOD_CK2_1	200	206	PF00069	0.692
MOD_CK2_1	208	214	PF00069	0.654
MOD_CK2_1	392	398	PF00069	0.595
MOD_CK2_1	44	50	PF00069	0.658
MOD_CK2_1	495	501	PF00069	0.633
MOD_CK2_1	64	70	PF00069	0.385
MOD_CK2_1	90	96	PF00069	0.704
MOD_GlcNHglycan	102	105	PF01048	0.570
MOD_GlcNHglycan	143	146	PF01048	0.672
MOD_GlcNHglycan	157	160	PF01048	0.577
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	210	213	PF01048	0.680
MOD_GlcNHglycan	221	224	PF01048	0.505
MOD_GlcNHglycan	348	351	PF01048	0.621
MOD_GlcNHglycan	61	65	PF01048	0.679
MOD_GlcNHglycan	78	81	PF01048	0.452
MOD_GlcNHglycan	87	90	PF01048	0.591
MOD_GSK3_1	137	144	PF00069	0.636
MOD_GSK3_1	224	231	PF00069	0.621
MOD_GSK3_1	262	269	PF00069	0.713
MOD_GSK3_1	44	51	PF00069	0.695
MOD_GSK3_1	450	457	PF00069	0.692
MOD_GSK3_1	60	67	PF00069	0.458
MOD_GSK3_1	72	79	PF00069	0.552
MOD_N-GLC_1	317	322	PF02516	0.450
MOD_N-GLC_1	34	39	PF02516	0.484
MOD_N-GLC_2	168	170	PF02516	0.735
MOD_N-GLC_2	2	4	PF02516	0.436
MOD_NEK2_1	16	21	PF00069	0.417
MOD_NEK2_1	180	185	PF00069	0.660
MOD_NEK2_1	224	229	PF00069	0.643
MOD_NEK2_1	280	285	PF00069	0.635
MOD_NEK2_1	424	429	PF00069	0.452
MOD_NEK2_1	73	78	PF00069	0.707
MOD_PIKK_1	331	337	PF00454	0.546
MOD_PIKK_1	460	466	PF00454	0.630
MOD_PIKK_1	65	71	PF00454	0.649
MOD_PKA_1	197	203	PF00069	0.520
MOD_PKA_1	65	71	PF00069	0.649
MOD_PKA_2	197	203	PF00069	0.631
MOD_PKA_2	208	214	PF00069	0.593
MOD_PKA_2	219	225	PF00069	0.564
MOD_PKA_2	252	258	PF00069	0.664
MOD_PKA_2	326	332	PF00069	0.601
MOD_PKA_2	424	430	PF00069	0.453
MOD_PKA_2	467	473	PF00069	0.564
MOD_PKA_2	495	501	PF00069	0.647
MOD_PKA_2	65	71	PF00069	0.564
MOD_PKB_1	241	249	PF00069	0.670
MOD_Plk_1	214	220	PF00069	0.625
MOD_Plk_1	266	272	PF00069	0.686
MOD_Plk_1	317	323	PF00069	0.445
MOD_Plk_1	477	483	PF00069	0.611
MOD_Plk_2-3	44	50	PF00069	0.658
MOD_Plk_4	16	22	PF00069	0.420
MOD_Plk_4	191	197	PF00069	0.678
MOD_Plk_4	266	272	PF00069	0.638
MOD_Plk_4	343	349	PF00069	0.672
MOD_Plk_4	406	412	PF00069	0.653
MOD_Plk_4	457	463	PF00069	0.692
MOD_ProDKin_1	200	206	PF00069	0.565
MOD_ProDKin_1	257	263	PF00069	0.679
MOD_ProDKin_1	36	42	PF00069	0.585
MOD_ProDKin_1	88	94	PF00069	0.472
MOD_SUMO_for_1	41	44	PF00179	0.704
TRG_DiLeu_BaEn_1	173	178	PF01217	0.454
TRG_DiLeu_BaEn_1	267	272	PF01217	0.709
TRG_DiLeu_BaEn_1	406	411	PF01217	0.410
TRG_ENDOCYTIC_2	118	121	PF00928	0.660
TRG_ENDOCYTIC_2	379	382	PF00928	0.559
TRG_ENDOCYTIC_2	407	410	PF00928	0.657
TRG_ENDOCYTIC_2	485	488	PF00928	0.693
TRG_ER_diArg_1	238	241	PF00400	0.615
TRG_ER_diArg_1	7	9	PF00400	0.425
TRG_NLS_MonoCore_2	298	303	PF00514	0.612
TRG_NLS_MonoExtC_3	238	243	PF00514	0.549
TRG_NLS_MonoExtN_4	297	304	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S1	Leptomonas seymouri	25%	100%
A0A3Q8IFW4	Leishmania donovani	90%	100%
A4HCY5	Leishmania braziliensis	69%	100%
A4I0H0	Leishmania infantum	90%	100%
E9AWD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%