Coronin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Coronin

Gene product:

coronin, putative

Species:

Leishmania major

UniProt:

Q4QB38_LEIMA

TriTrypDb:

LmjF.23.1165 , LMJLV39_230021300 , LMJSD75_230021700

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005840	ribosome	5	11
GO:0020016	ciliary pocket	2	2
GO:0032991	protein-containing complex	1	11
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000139	Golgi membrane	5	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

Q4QB38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB38

PDB structure(s): 6icr_A , 6icr_B , 6icr_C , 6icr_D

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007015	actin filament organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0019894	kinesin binding	4	2
GO:0044877	protein-containing complex binding	2	2
GO:0051015	actin filament binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.309
CLV_NRD_NRD_1	244	246	PF00675	0.420
CLV_NRD_NRD_1	343	345	PF00675	0.249
CLV_NRD_NRD_1	470	472	PF00675	0.574
CLV_NRD_NRD_1	489	491	PF00675	0.411
CLV_PCSK_KEX2_1	221	223	PF00082	0.309
CLV_PCSK_KEX2_1	470	472	PF00082	0.612
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.352
CLV_PCSK_SKI1_1	148	152	PF00082	0.256
CLV_PCSK_SKI1_1	18	22	PF00082	0.315
CLV_PCSK_SKI1_1	237	241	PF00082	0.390
CLV_PCSK_SKI1_1	463	467	PF00082	0.437
CLV_PCSK_SKI1_1	490	494	PF00082	0.536
CLV_PCSK_SKI1_1	90	94	PF00082	0.356
DEG_APCC_DBOX_1	178	186	PF00400	0.304
DEG_SPOP_SBC_1	23	27	PF00917	0.380
DOC_CYCLIN_RxL_1	12	25	PF00134	0.296
DOC_MAPK_gen_1	126	133	PF00069	0.411
DOC_MAPK_gen_1	15	23	PF00069	0.371
DOC_MAPK_gen_1	221	229	PF00069	0.313
DOC_MAPK_gen_1	428	435	PF00069	0.674
DOC_MAPK_MEF2A_6	63	72	PF00069	0.381
DOC_MAPK_MEF2A_6	75	83	PF00069	0.342
DOC_USP7_MATH_1	361	365	PF00917	0.394
DOC_USP7_MATH_1	436	440	PF00917	0.636
DOC_USP7_UBL2_3	122	126	PF12436	0.506
DOC_WW_Pin1_4	113	118	PF00397	0.413
DOC_WW_Pin1_4	246	251	PF00397	0.347
DOC_WW_Pin1_4	389	394	PF00397	0.527
DOC_WW_Pin1_4	397	402	PF00397	0.577
LIG_14-3-3_CanoR_1	344	351	PF00244	0.326
LIG_14-3-3_CanoR_1	5	13	PF00244	0.294
LIG_Actin_WH2_2	178	195	PF00022	0.310
LIG_AP2alpha_2	84	86	PF02296	0.432
LIG_APCC_ABBA_1	264	269	PF00400	0.318
LIG_APCC_ABBA_1	83	88	PF00400	0.235
LIG_BIR_II_1	1	5	PF00653	0.292
LIG_BRCT_BRCA1_1	259	263	PF00533	0.397
LIG_BRCT_BRCA1_1	384	388	PF00533	0.555
LIG_Clathr_ClatBox_1	335	339	PF01394	0.412
LIG_deltaCOP1_diTrp_1	175	183	PF00928	0.416
LIG_EH1_1	335	343	PF00400	0.361
LIG_FHA_1	189	195	PF00498	0.450
LIG_FHA_1	8	14	PF00498	0.272
LIG_FHA_2	170	176	PF00498	0.346
LIG_FHA_2	252	258	PF00498	0.362
LIG_FHA_2	357	363	PF00498	0.282
LIG_FHA_2	424	430	PF00498	0.574
LIG_FHA_2	459	465	PF00498	0.603
LIG_FHA_2	91	97	PF00498	0.298
LIG_LIR_Gen_1	331	340	PF02991	0.396
LIG_LIR_Gen_1	40	50	PF02991	0.249
LIG_LIR_Nem_3	323	327	PF02991	0.429
LIG_LIR_Nem_3	331	335	PF02991	0.389
LIG_LIR_Nem_3	40	45	PF02991	0.249
LIG_LIR_Nem_3	59	64	PF02991	0.303
LIG_LIR_Nem_3	80	86	PF02991	0.291
LIG_Pex14_2	356	360	PF04695	0.326
LIG_Rb_pABgroove_1	382	390	PF01858	0.411
LIG_REV1ctd_RIR_1	369	377	PF16727	0.331
LIG_SH2_CRK	332	336	PF00017	0.436
LIG_SH2_STAP1	267	271	PF00017	0.403
LIG_SH3_1	63	69	PF00018	0.434
LIG_SH3_3	10	16	PF00018	0.380
LIG_SH3_3	191	197	PF00018	0.308
LIG_SH3_3	40	46	PF00018	0.348
LIG_SH3_3	430	436	PF00018	0.638
LIG_SH3_3	63	69	PF00018	0.437
LIG_SUMO_SIM_par_1	272	278	PF11976	0.298
LIG_TYR_ITIM	330	335	PF00017	0.421
LIG_UBA3_1	114	122	PF00899	0.179
LIG_UBA3_1	226	233	PF00899	0.426
LIG_UBA3_1	273	279	PF00899	0.436
LIG_WRC_WIRS_1	130	135	PF05994	0.425
MOD_CDC14_SPxK_1	402	405	PF00782	0.634
MOD_CDK_SPK_2	389	394	PF00069	0.439
MOD_CDK_SPxK_1	399	405	PF00069	0.625
MOD_CK1_1	165	171	PF00069	0.390
MOD_CK1_1	205	211	PF00069	0.371
MOD_CK1_1	249	255	PF00069	0.525
MOD_CK1_1	334	340	PF00069	0.417
MOD_CK1_1	364	370	PF00069	0.319
MOD_CK1_1	399	405	PF00069	0.714
MOD_CK1_1	431	437	PF00069	0.708
MOD_CK1_1	439	445	PF00069	0.671
MOD_CK2_1	169	175	PF00069	0.423
MOD_CK2_1	201	207	PF00069	0.479
MOD_CK2_1	249	255	PF00069	0.460
MOD_CK2_1	275	281	PF00069	0.329
MOD_CK2_1	344	350	PF00069	0.328
MOD_CK2_1	364	370	PF00069	0.187
MOD_CK2_1	423	429	PF00069	0.782
MOD_CK2_1	431	437	PF00069	0.616
MOD_CK2_1	90	96	PF00069	0.284
MOD_GlcNHglycan	135	138	PF01048	0.216
MOD_GlcNHglycan	142	145	PF01048	0.206
MOD_GlcNHglycan	210	213	PF01048	0.362
MOD_GlcNHglycan	259	262	PF01048	0.528
MOD_GlcNHglycan	362	366	PF01048	0.459
MOD_GlcNHglycan	383	387	PF01048	0.510
MOD_GlcNHglycan	442	445	PF01048	0.657
MOD_GlcNHglycan	485	489	PF01048	0.576
MOD_GSK3_1	109	116	PF00069	0.254
MOD_GSK3_1	129	136	PF00069	0.395
MOD_GSK3_1	156	163	PF00069	0.413
MOD_GSK3_1	165	172	PF00069	0.424
MOD_GSK3_1	184	191	PF00069	0.321
MOD_GSK3_1	198	205	PF00069	0.313
MOD_GSK3_1	225	232	PF00069	0.391
MOD_GSK3_1	30	37	PF00069	0.405
MOD_GSK3_1	431	438	PF00069	0.637
MOD_GSK3_1	439	446	PF00069	0.623
MOD_GSK3_1	46	53	PF00069	0.380
MOD_GSK3_1	92	99	PF00069	0.349
MOD_N-GLC_1	21	26	PF02516	0.291
MOD_NEK2_1	1	6	PF00069	0.249
MOD_NEK2_1	178	183	PF00069	0.287
MOD_NEK2_1	21	26	PF00069	0.402
MOD_NEK2_1	229	234	PF00069	0.399
MOD_NEK2_1	241	246	PF00069	0.460
MOD_NEK2_1	256	261	PF00069	0.465
MOD_NEK2_1	396	401	PF00069	0.624
MOD_NEK2_1	50	55	PF00069	0.291
MOD_NEK2_2	129	134	PF00069	0.425
MOD_PIKK_1	211	217	PF00454	0.423
MOD_PIKK_1	231	237	PF00454	0.367
MOD_PIKK_1	458	464	PF00454	0.513
MOD_PKA_1	222	228	PF00069	0.363
MOD_PKA_1	344	350	PF00069	0.380
MOD_PKA_2	156	162	PF00069	0.357
MOD_PKA_2	178	184	PF00069	0.453
MOD_PKA_2	6	12	PF00069	0.285
MOD_PKB_1	5	13	PF00069	0.380
MOD_Plk_1	188	194	PF00069	0.338
MOD_Plk_1	198	204	PF00069	0.360
MOD_Plk_1	361	367	PF00069	0.319
MOD_Plk_1	428	434	PF00069	0.793
MOD_Plk_1	484	490	PF00069	0.429
MOD_Plk_4	178	184	PF00069	0.315
MOD_Plk_4	198	204	PF00069	0.421
MOD_Plk_4	222	228	PF00069	0.363
MOD_Plk_4	331	337	PF00069	0.323
MOD_Plk_4	96	102	PF00069	0.299
MOD_ProDKin_1	113	119	PF00069	0.408
MOD_ProDKin_1	246	252	PF00069	0.342
MOD_ProDKin_1	389	395	PF00069	0.522
MOD_ProDKin_1	397	403	PF00069	0.580
MOD_SUMO_for_1	420	423	PF00179	0.650
MOD_SUMO_rev_2	443	450	PF00179	0.764
MOD_SUMO_rev_2	84	92	PF00179	0.417
TRG_DiLeu_BaEn_1	269	274	PF01217	0.406
TRG_ENDOCYTIC_2	332	335	PF00928	0.444
TRG_ER_diArg_1	470	472	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGC0	Leptomonas seymouri	61%	99%
A0A0S4IT51	Bodo saltans	49%	100%
A0A1X0NWV5	Trypanosomatidae	48%	96%
A0A3Q8IEM1	Leishmania donovani	93%	100%
A0A3R7K7Y6	Trypanosoma rangeli	48%	100%
A4HCY7	Leishmania braziliensis	78%	100%
A4I0H2	Leishmania infantum	94%	100%
A8WGE3	Xenopus tropicalis	34%	100%
B0R0D7	Danio rerio	36%	100%
C9ZV95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9AWD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O13923	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	85%
O89046	Rattus norvegicus	37%	100%
O89053	Mus musculus	37%	100%
P27133	Dictyostelium discoideum	35%	100%
P31146	Homo sapiens	34%	100%
Q06440	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	78%
Q21624	Caenorhabditis elegans	32%	84%
Q32LP9	Bos taurus	33%	97%
Q4R4J2	Macaca fascicularis	34%	100%
Q5NVK4	Pongo abelii	37%	100%
Q6DJD8	Xenopus laevis	34%	100%
Q6QEF8	Homo sapiens	36%	100%
Q8BH44	Mus musculus	33%	100%
Q8C0P5	Mus musculus	32%	97%
Q91ZN1	Rattus norvegicus	37%	100%
Q920J3	Rattus norvegicus	36%	100%
Q920M5	Mus musculus	35%	100%
Q92176	Bos taurus	34%	100%
Q92828	Homo sapiens	34%	97%
Q9BR76	Homo sapiens	37%	100%
Q9ULV4	Homo sapiens	37%	100%
Q9UQ03	Homo sapiens	33%	100%
Q9WUM3	Mus musculus	36%	100%
Q9WUM4	Mus musculus	36%	100%
Q9XS70	Oryctolagus cuniculus	36%	100%