LeishMANIAdb
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Membrane-bound acid phosphatase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase 2
Gene product:
membrane-bound acid phosphatase 2
Species:
Leishmania major
UniProt:
Q4QB35_LEIMA
TriTrypDb:
LmjF.23.1170 , LMJLV39_230021600 * , LMJSD75_230022000 *
Length:
542

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 40, no: 4
NetGPI no yes: 0, no: 44
Cellular components
Term Name Level Count
GO:0016020 membrane 2 33
GO:0110165 cellular anatomical entity 1 33

Expansion

Sequence features

Q4QB35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB35

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 6
GO:0044237 cellular metabolic process 2 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0016787 hydrolase activity 2 8
GO:0016788 hydrolase activity, acting on ester bonds 3 8
GO:0016791 phosphatase activity 5 8
GO:0042578 phosphoric ester hydrolase activity 4 8
GO:0003993 acid phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 325 329 PF00656 0.367
CLV_NRD_NRD_1 200 202 PF00675 0.552
CLV_NRD_NRD_1 430 432 PF00675 0.505
CLV_NRD_NRD_1 522 524 PF00675 0.450
CLV_PCSK_KEX2_1 200 202 PF00082 0.523
CLV_PCSK_KEX2_1 432 434 PF00082 0.554
CLV_PCSK_PC1ET2_1 432 434 PF00082 0.436
CLV_PCSK_SKI1_1 121 125 PF00082 0.504
CLV_PCSK_SKI1_1 2 6 PF00082 0.645
DEG_APCC_DBOX_1 1 9 PF00400 0.567
DEG_APCC_DBOX_1 230 238 PF00400 0.310
DEG_APCC_DBOX_1 446 454 PF00400 0.209
DEG_Nend_UBRbox_1 1 4 PF02207 0.608
DOC_ANK_TNKS_1 406 413 PF00023 0.270
DOC_CDC14_PxL_1 221 229 PF14671 0.388
DOC_CYCLIN_yCln2_LP_2 15 21 PF00134 0.608
DOC_CYCLIN_yCln2_LP_2 310 313 PF00134 0.201
DOC_MAPK_MEF2A_6 2 9 PF00069 0.600
DOC_MAPK_NFAT4_5 2 10 PF00069 0.354
DOC_PP1_RVXF_1 380 387 PF00149 0.401
DOC_PP2B_LxvP_1 15 18 PF13499 0.585
DOC_PP2B_LxvP_1 310 313 PF13499 0.201
DOC_USP7_MATH_1 278 282 PF00917 0.364
DOC_USP7_MATH_1 390 394 PF00917 0.417
DOC_USP7_MATH_1 422 426 PF00917 0.306
DOC_USP7_MATH_1 43 47 PF00917 0.373
DOC_USP7_MATH_1 484 488 PF00917 0.564
DOC_WW_Pin1_4 340 345 PF00397 0.353
DOC_WW_Pin1_4 471 476 PF00397 0.538
DOC_WW_Pin1_4 479 484 PF00397 0.410
DOC_WW_Pin1_4 525 530 PF00397 0.679
DOC_WW_Pin1_4 53 58 PF00397 0.422
LIG_14-3-3_CanoR_1 105 113 PF00244 0.302
LIG_14-3-3_CanoR_1 200 208 PF00244 0.326
LIG_14-3-3_CanoR_1 297 303 PF00244 0.331
LIG_14-3-3_CanoR_1 374 378 PF00244 0.339
LIG_14-3-3_CanoR_1 447 451 PF00244 0.296
LIG_14-3-3_CanoR_1 79 87 PF00244 0.379
LIG_deltaCOP1_diTrp_1 349 356 PF00928 0.295
LIG_EH1_1 501 509 PF00400 0.370
LIG_FHA_1 105 111 PF00498 0.312
LIG_FHA_1 145 151 PF00498 0.284
LIG_FHA_1 315 321 PF00498 0.327
LIG_FHA_1 379 385 PF00498 0.333
LIG_FHA_1 492 498 PF00498 0.285
LIG_FHA_1 499 505 PF00498 0.360
LIG_FHA_1 511 517 PF00498 0.450
LIG_FHA_2 134 140 PF00498 0.328
LIG_FHA_2 205 211 PF00498 0.295
LIG_FHA_2 227 233 PF00498 0.283
LIG_FHA_2 303 309 PF00498 0.317
LIG_GBD_Chelix_1 318 326 PF00786 0.401
LIG_GSK3_LRP6_1 525 530 PF00069 0.535
LIG_LIR_Gen_1 178 186 PF02991 0.352
LIG_LIR_Gen_1 203 213 PF02991 0.278
LIG_LIR_Gen_1 379 388 PF02991 0.278
LIG_LIR_Gen_1 393 403 PF02991 0.290
LIG_LIR_Nem_3 128 134 PF02991 0.296
LIG_LIR_Nem_3 141 146 PF02991 0.303
LIG_LIR_Nem_3 173 179 PF02991 0.370
LIG_LIR_Nem_3 203 209 PF02991 0.252
LIG_LIR_Nem_3 222 227 PF02991 0.290
LIG_LIR_Nem_3 280 286 PF02991 0.267
LIG_LIR_Nem_3 379 383 PF02991 0.299
LIG_LIR_Nem_3 393 399 PF02991 0.334
LIG_LIR_Nem_3 400 406 PF02991 0.255
LIG_LIR_Nem_3 418 423 PF02991 0.318
LIG_LIR_Nem_3 62 66 PF02991 0.390
LIG_LYPXL_S_1 130 134 PF13949 0.518
LIG_LYPXL_yS_3 131 134 PF13949 0.300
LIG_LYPXL_yS_3 224 227 PF13949 0.394
LIG_NRBOX 4 10 PF00104 0.412
LIG_PCNA_yPIPBox_3 263 271 PF02747 0.280
LIG_Pex14_2 119 123 PF04695 0.370
LIG_Pex14_2 153 157 PF04695 0.320
LIG_Pex14_2 348 352 PF04695 0.416
LIG_SH2_CRK 403 407 PF00017 0.338
LIG_SH2_GRB2like 146 149 PF00017 0.370
LIG_SH2_STAP1 146 150 PF00017 0.329
LIG_SH2_STAP1 437 441 PF00017 0.447
LIG_SH2_STAP1 97 101 PF00017 0.306
LIG_SH2_STAT3 149 152 PF00017 0.366
LIG_SH2_STAT5 143 146 PF00017 0.331
LIG_SH2_STAT5 149 152 PF00017 0.303
LIG_SH2_STAT5 194 197 PF00017 0.329
LIG_SH2_STAT5 246 249 PF00017 0.319
LIG_SH2_STAT5 396 399 PF00017 0.333
LIG_SH2_STAT5 60 63 PF00017 0.296
LIG_SH3_1 523 529 PF00018 0.529
LIG_SH3_3 164 170 PF00018 0.309
LIG_SH3_3 465 471 PF00018 0.574
LIG_SH3_3 480 486 PF00018 0.558
LIG_SH3_3 523 529 PF00018 0.598
LIG_SH3_3 84 90 PF00018 0.337
LIG_SH3_5 93 97 PF00018 0.238
LIG_SH3_CIN85_PxpxPR_1 525 530 PF14604 0.535
LIG_SUMO_SIM_par_1 316 321 PF11976 0.306
LIG_UBA3_1 208 215 PF00899 0.383
LIG_WRC_WIRS_1 460 465 PF05994 0.309
LIG_WRC_WIRS_1 499 504 PF05994 0.391
MOD_CDK_SPK_2 525 530 PF00069 0.664
MOD_CDK_SPxK_1 479 485 PF00069 0.391
MOD_CK1_1 104 110 PF00069 0.327
MOD_CK1_1 115 121 PF00069 0.338
MOD_CK1_1 196 202 PF00069 0.344
MOD_CK1_1 327 333 PF00069 0.309
MOD_CK1_1 343 349 PF00069 0.402
MOD_CK1_1 487 493 PF00069 0.556
MOD_CK1_1 85 91 PF00069 0.368
MOD_CK2_1 133 139 PF00069 0.365
MOD_CK2_1 343 349 PF00069 0.416
MOD_CK2_1 530 536 PF00069 0.784
MOD_CK2_1 61 67 PF00069 0.187
MOD_GlcNHglycan 114 117 PF01048 0.497
MOD_GlcNHglycan 260 263 PF01048 0.542
MOD_GlcNHglycan 288 291 PF01048 0.519
MOD_GlcNHglycan 345 348 PF01048 0.573
MOD_GlcNHglycan 361 364 PF01048 0.457
MOD_GlcNHglycan 370 373 PF01048 0.499
MOD_GlcNHglycan 386 389 PF01048 0.530
MOD_GlcNHglycan 424 427 PF01048 0.574
MOD_GlcNHglycan 488 492 PF01048 0.717
MOD_GlcNHglycan 63 66 PF01048 0.579
MOD_GSK3_1 286 293 PF00069 0.292
MOD_GSK3_1 298 305 PF00069 0.294
MOD_GSK3_1 322 329 PF00069 0.337
MOD_GSK3_1 39 46 PF00069 0.382
MOD_GSK3_1 455 462 PF00069 0.391
MOD_GSK3_1 487 494 PF00069 0.526
MOD_GSK3_1 75 82 PF00069 0.371
MOD_N-GLC_1 125 130 PF02516 0.504
MOD_N-GLC_1 196 201 PF02516 0.560
MOD_N-GLC_1 248 253 PF02516 0.507
MOD_N-GLC_1 368 373 PF02516 0.541
MOD_N-GLC_1 47 52 PF02516 0.581
MOD_N-GLC_1 479 484 PF02516 0.827
MOD_N-GLC_2 373 375 PF02516 0.547
MOD_NEK2_1 277 282 PF00069 0.331
MOD_NEK2_1 314 319 PF00069 0.287
MOD_NEK2_1 322 327 PF00069 0.305
MOD_NEK2_1 361 366 PF00069 0.411
MOD_NEK2_1 61 66 PF00069 0.333
MOD_NEK2_1 69 74 PF00069 0.314
MOD_NEK2_1 75 80 PF00069 0.328
MOD_NEK2_2 204 209 PF00069 0.349
MOD_OFUCOSY 434 439 PF10250 0.534
MOD_OFUCOSY 452 459 PF10250 0.600
MOD_PIKK_1 232 238 PF00454 0.301
MOD_PIKK_1 47 53 PF00454 0.363
MOD_PKA_2 104 110 PF00069 0.307
MOD_PKA_2 199 205 PF00069 0.339
MOD_PKA_2 373 379 PF00069 0.365
MOD_PKA_2 446 452 PF00069 0.388
MOD_PKA_2 484 490 PF00069 0.564
MOD_PKB_1 431 439 PF00069 0.236
MOD_PKB_1 77 85 PF00069 0.390
MOD_Plk_1 125 131 PF00069 0.362
MOD_Plk_1 291 297 PF00069 0.294
MOD_Plk_1 327 333 PF00069 0.343
MOD_Plk_1 378 384 PF00069 0.326
MOD_Plk_1 47 53 PF00069 0.371
MOD_Plk_1 82 88 PF00069 0.342
MOD_Plk_4 115 121 PF00069 0.352
MOD_Plk_4 126 132 PF00069 0.314
MOD_Plk_4 314 320 PF00069 0.284
MOD_Plk_4 82 88 PF00069 0.331
MOD_ProDKin_1 340 346 PF00069 0.354
MOD_ProDKin_1 471 477 PF00069 0.541
MOD_ProDKin_1 479 485 PF00069 0.410
MOD_ProDKin_1 525 531 PF00069 0.683
MOD_ProDKin_1 53 59 PF00069 0.379
TRG_ENDOCYTIC_2 131 134 PF00928 0.318
TRG_ENDOCYTIC_2 156 159 PF00928 0.272
TRG_ENDOCYTIC_2 224 227 PF00928 0.347
TRG_ENDOCYTIC_2 396 399 PF00928 0.336
TRG_ENDOCYTIC_2 403 406 PF00928 0.331
TRG_ER_diArg_1 430 433 PF00400 0.326
TRG_ER_diArg_1 76 79 PF00400 0.343
TRG_NES_CRM1_1 308 321 PF08389 0.373
TRG_NLS_MonoExtC_3 430 435 PF00514 0.226

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 45% 95%
A0A0N1I756 Leptomonas seymouri 42% 100%
A0A0N1PEH4 Leptomonas seymouri 37% 100%
A0A0S4IRF5 Bodo saltans 24% 81%
A0A0S4IUV8 Bodo saltans 22% 100%
A0A0S4IV77 Bodo saltans 34% 100%
A0A0S4IXN9 Bodo saltans 23% 100%
A0A0S4JEA9 Bodo saltans 27% 100%
A0A0S4JJK3 Bodo saltans 27% 100%
A0A0S4JW09 Bodo saltans 28% 100%
A0A1X0NNY4 Trypanosomatidae 36% 98%
A0A1X0NQL4 Trypanosomatidae 28% 99%
A0A1X0NY34 Trypanosomatidae 25% 100%
A0A1X0P7V5 Trypanosomatidae 45% 100%
A0A3Q8IR23 Leishmania donovani 50% 95%
A0A3R7KSH4 Trypanosoma rangeli 24% 100%
A0A3R7MEN7 Trypanosoma rangeli 43% 100%
A0A3R7MHJ7 Trypanosoma rangeli 28% 100%
A0A3S5H827 Leishmania donovani 39% 100%
A0A3S7WXU0 Leishmania donovani 95% 100%
A0A3S7X1W4 Leishmania donovani 43% 99%
A4HCZ0 Leishmania braziliensis 87% 88%
A4HGW8 Leishmania braziliensis 42% 99%
A4HPC1 Leishmania braziliensis 39% 100%
A4HPC5 Leishmania braziliensis 50% 94%
A4HQG6 Leishmania braziliensis 34% 100%
A4HQG9 Leishmania braziliensis 34% 100%
A4I0H5 Leishmania infantum 95% 100%
A4I3Z8 Leishmania infantum 43% 99%
A4ICA5 Leishmania infantum 36% 81%
A4ICG3 Leishmania infantum 39% 100%
A4ICG5 Leishmania infantum 50% 95%
B1H1P9 Xenopus laevis 25% 100%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 95%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 99%
Q4Q0A9 Leishmania major 30% 99%
Q4Q1G2 Leishmania major 49% 100%
Q4Q1G4 Leishmania major 39% 100%
Q4Q7Z7 Leishmania major 44% 100%
V5BCI2 Trypanosoma cruzi 26% 100%
V5BK91 Trypanosoma cruzi 41% 100%
V5BL75 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS