S-adenosyl-methyltransferase mraW-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosyl-methyltransferase mraW-like protein

Species:

Leishmania major

UniProt:

Q4QB34_LEIMA

TriTrypDb:

LmjF.23.1200 , LMJLV39_230021700 , LMJSD75_230022100

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB34

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0001510	RNA methylation	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0070475	rRNA base methylation	6	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	2
GO:0008173	RNA methyltransferase activity	4	2
GO:0008649	rRNA methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016434	rRNA (cytosine) methyltransferase activity	6	2
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	6	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140102	catalytic activity, acting on a rRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.446
CLV_NRD_NRD_1	135	137	PF00675	0.465
CLV_NRD_NRD_1	292	294	PF00675	0.241
CLV_NRD_NRD_1	323	325	PF00675	0.250
CLV_NRD_NRD_1	473	475	PF00675	0.471
CLV_NRD_NRD_1	76	78	PF00675	0.585
CLV_NRD_NRD_1	8	10	PF00675	0.391
CLV_NRD_NRD_1	88	90	PF00675	0.635
CLV_PCSK_FUR_1	290	294	PF00082	0.264
CLV_PCSK_KEX2_1	135	137	PF00082	0.466
CLV_PCSK_KEX2_1	2	4	PF00082	0.459
CLV_PCSK_KEX2_1	292	294	PF00082	0.242
CLV_PCSK_KEX2_1	323	325	PF00082	0.250
CLV_PCSK_KEX2_1	473	475	PF00082	0.487
CLV_PCSK_KEX2_1	48	50	PF00082	0.506
CLV_PCSK_KEX2_1	8	10	PF00082	0.447
CLV_PCSK_KEX2_1	88	90	PF00082	0.722
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.466
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.459
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.560
CLV_PCSK_SKI1_1	204	208	PF00082	0.250
CLV_PCSK_SKI1_1	231	235	PF00082	0.250
CLV_PCSK_SKI1_1	24	28	PF00082	0.392
CLV_PCSK_SKI1_1	73	77	PF00082	0.636
DEG_Nend_UBRbox_1	1	4	PF02207	0.474
DEG_SCF_FBW7_1	276	282	PF00400	0.464
DOC_CKS1_1	276	281	PF01111	0.464
DOC_CYCLIN_RxL_1	18	29	PF00134	0.301
DOC_MAPK_FxFP_2	452	455	PF00069	0.477
DOC_PP1_RVXF_1	361	368	PF00149	0.450
DOC_PP2B_LxvP_1	101	104	PF13499	0.567
DOC_PP4_FxxP_1	452	455	PF00568	0.477
DOC_USP7_MATH_1	112	116	PF00917	0.631
DOC_USP7_MATH_1	121	125	PF00917	0.537
DOC_USP7_MATH_1	177	181	PF00917	0.541
DOC_USP7_MATH_1	219	223	PF00917	0.479
DOC_USP7_MATH_1	270	274	PF00917	0.488
DOC_USP7_MATH_1	279	283	PF00917	0.432
DOC_USP7_MATH_1	480	484	PF00917	0.707
DOC_USP7_MATH_1	87	91	PF00917	0.727
DOC_WW_Pin1_4	275	280	PF00397	0.464
DOC_WW_Pin1_4	475	480	PF00397	0.530
LIG_14-3-3_CanoR_1	138	143	PF00244	0.388
LIG_14-3-3_CanoR_1	198	207	PF00244	0.483
LIG_14-3-3_CanoR_1	323	329	PF00244	0.503
LIG_14-3-3_CanoR_1	8	16	PF00244	0.432
LIG_BIR_III_2	66	70	PF00653	0.477
LIG_BRCT_BRCA1_1	123	127	PF00533	0.504
LIG_BRCT_BRCA1_1	328	332	PF00533	0.450
LIG_BRCT_BRCA1_1	443	447	PF00533	0.419
LIG_BRCT_BRCA1_1	477	481	PF00533	0.551
LIG_CaM_NSCaTE_8	372	379	PF13499	0.541
LIG_DLG_GKlike_1	138	145	PF00625	0.376
LIG_FHA_1	153	159	PF00498	0.474
LIG_FHA_1	164	170	PF00498	0.412
LIG_FHA_1	248	254	PF00498	0.461
LIG_FHA_2	222	228	PF00498	0.450
LIG_Integrin_isoDGR_2	161	163	PF01839	0.297
LIG_LIR_Apic_2	451	455	PF02991	0.454
LIG_LIR_Gen_1	124	134	PF02991	0.667
LIG_LIR_Gen_1	141	149	PF02991	0.241
LIG_LIR_Gen_1	209	219	PF02991	0.463
LIG_LIR_Gen_1	273	279	PF02991	0.582
LIG_LIR_Gen_1	327	336	PF02991	0.582
LIG_LIR_LC3C_4	361	366	PF02991	0.450
LIG_LIR_Nem_3	124	130	PF02991	0.672
LIG_LIR_Nem_3	141	145	PF02991	0.278
LIG_LIR_Nem_3	191	196	PF02991	0.446
LIG_LIR_Nem_3	209	215	PF02991	0.481
LIG_LIR_Nem_3	273	277	PF02991	0.503
LIG_LIR_Nem_3	468	472	PF02991	0.475
LIG_MYND_1	19	23	PF01753	0.452
LIG_Pex14_2	149	153	PF04695	0.541
LIG_SH2_CRK	165	169	PF00017	0.450
LIG_SH2_CRK	196	200	PF00017	0.535
LIG_SH2_GRB2like	258	261	PF00017	0.465
LIG_SH2_STAP1	165	169	PF00017	0.450
LIG_SH2_STAP1	391	395	PF00017	0.464
LIG_SH2_STAT5	165	168	PF00017	0.450
LIG_SH2_STAT5	258	261	PF00017	0.465
LIG_SH2_STAT5	422	425	PF00017	0.487
LIG_SH3_3	13	19	PF00018	0.434
LIG_Sin3_3	127	134	PF02671	0.429
LIG_SUMO_SIM_par_1	354	361	PF11976	0.447
LIG_TRAF2_1	304	307	PF00917	0.547
LIG_TRAF2_1	371	374	PF00917	0.465
LIG_TRAF2_1	434	437	PF00917	0.547
LIG_TRAF2_1	50	53	PF00917	0.455
LIG_TYR_ITIM	140	145	PF00017	0.318
MOD_CK1_1	406	412	PF00069	0.516
MOD_CK2_1	177	183	PF00069	0.490
MOD_CK2_1	221	227	PF00069	0.450
MOD_CK2_1	38	44	PF00069	0.465
MOD_CK2_1	387	393	PF00069	0.466
MOD_GlcNHglycan	10	13	PF01048	0.450
MOD_GlcNHglycan	109	112	PF01048	0.715
MOD_GlcNHglycan	115	118	PF01048	0.705
MOD_GlcNHglycan	124	127	PF01048	0.407
MOD_GlcNHglycan	150	153	PF01048	0.291
MOD_GlcNHglycan	179	182	PF01048	0.352
MOD_GlcNHglycan	267	270	PF01048	0.267
MOD_GlcNHglycan	443	446	PF01048	0.390
MOD_GlcNHglycan	89	92	PF01048	0.741
MOD_GSK3_1	103	110	PF00069	0.651
MOD_GSK3_1	148	155	PF00069	0.497
MOD_GSK3_1	275	282	PF00069	0.471
MOD_GSK3_1	319	326	PF00069	0.485
MOD_GSK3_1	375	382	PF00069	0.515
MOD_GSK3_1	414	421	PF00069	0.373
MOD_GSK3_1	424	431	PF00069	0.390
MOD_N-GLC_1	122	127	PF02516	0.533
MOD_N-GLC_1	457	462	PF02516	0.412
MOD_NEK2_1	113	118	PF00069	0.593
MOD_NEK2_1	122	127	PF00069	0.501
MOD_NEK2_1	145	150	PF00069	0.465
MOD_NEK2_1	26	31	PF00069	0.277
MOD_NEK2_1	332	337	PF00069	0.439
MOD_NEK2_1	376	381	PF00069	0.490
MOD_NEK2_1	424	429	PF00069	0.423
MOD_NEK2_1	76	81	PF00069	0.532
MOD_NEK2_2	279	284	PF00069	0.464
MOD_PIKK_1	221	227	PF00454	0.439
MOD_PIKK_1	316	322	PF00454	0.464
MOD_PIKK_1	379	385	PF00454	0.497
MOD_PIKK_1	414	420	PF00454	0.420
MOD_PIKK_1	424	430	PF00454	0.411
MOD_PKA_1	323	329	PF00069	0.543
MOD_PKA_1	8	14	PF00069	0.483
MOD_PKA_2	104	110	PF00069	0.614
MOD_PKA_2	323	329	PF00069	0.497
MOD_PKA_2	406	412	PF00069	0.408
MOD_PKA_2	76	82	PF00069	0.657
MOD_PKA_2	8	14	PF00069	0.458
MOD_PKA_2	87	93	PF00069	0.701
MOD_PKB_1	136	144	PF00069	0.375
MOD_Plk_1	122	128	PF00069	0.534
MOD_Plk_1	145	151	PF00069	0.439
MOD_Plk_1	175	181	PF00069	0.461
MOD_Plk_1	208	214	PF00069	0.464
MOD_Plk_1	436	442	PF00069	0.438
MOD_Plk_1	457	463	PF00069	0.414
MOD_Plk_2-3	38	44	PF00069	0.411
MOD_Plk_4	418	424	PF00069	0.469
MOD_ProDKin_1	275	281	PF00069	0.464
MOD_ProDKin_1	475	481	PF00069	0.537
MOD_SUMO_rev_2	201	206	PF00179	0.464
MOD_SUMO_rev_2	368	377	PF00179	0.535
TRG_DiLeu_BaEn_1	230	235	PF01217	0.450
TRG_ENDOCYTIC_2	142	145	PF00928	0.305
TRG_ENDOCYTIC_2	165	168	PF00928	0.450
TRG_ENDOCYTIC_2	274	277	PF00928	0.448
TRG_ER_diArg_1	136	139	PF00400	0.435
TRG_ER_diArg_1	289	292	PF00400	0.452
TRG_ER_diArg_1	472	474	PF00400	0.507
TRG_ER_diArg_1	7	9	PF00400	0.394
TRG_NES_CRM1_1	346	361	PF08389	0.449
TRG_NLS_Bipartite_1	59	81	PF00514	0.610
TRG_NLS_MonoCore_2	134	139	PF00514	0.449
TRG_NLS_MonoExtN_4	132	139	PF00514	0.462
TRG_NLS_MonoExtN_4	74	81	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB41	Leptomonas seymouri	72%	98%
A0A0S4J2S9	Bodo saltans	42%	100%
A0A1X0NY59	Trypanosomatidae	58%	100%
A0A3Q8IM97	Leishmania donovani	95%	100%
A0A3R7KU88	Trypanosoma rangeli	60%	100%
A4HCZ1	Leishmania braziliensis	86%	100%
A4I0H6	Leishmania infantum	96%	100%
C9ZVA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AWD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BEN6	Trypanosoma cruzi	62%	100%