Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB30_LEIMA

TriTrypDb:

LmjF.23.1240 , LMJLV39_230022100 , LMJSD75_230022500

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.768
CLV_C14_Caspase3-7	591	595	PF00656	0.572
CLV_MEL_PAP_1	193	199	PF00089	0.490
CLV_NRD_NRD_1	244	246	PF00675	0.447
CLV_NRD_NRD_1	3	5	PF00675	0.339
CLV_NRD_NRD_1	311	313	PF00675	0.554
CLV_NRD_NRD_1	316	318	PF00675	0.597
CLV_NRD_NRD_1	361	363	PF00675	0.416
CLV_NRD_NRD_1	372	374	PF00675	0.486
CLV_NRD_NRD_1	468	470	PF00675	0.509
CLV_NRD_NRD_1	478	480	PF00675	0.507
CLV_NRD_NRD_1	634	636	PF00675	0.578
CLV_NRD_NRD_1	644	646	PF00675	0.456
CLV_NRD_NRD_1	651	653	PF00675	0.404
CLV_NRD_NRD_1	666	668	PF00675	0.515
CLV_NRD_NRD_1	691	693	PF00675	0.517
CLV_NRD_NRD_1	697	699	PF00675	0.548
CLV_NRD_NRD_1	94	96	PF00675	0.554
CLV_PCSK_FUR_1	370	374	PF00082	0.581
CLV_PCSK_KEX2_1	244	246	PF00082	0.447
CLV_PCSK_KEX2_1	3	5	PF00082	0.317
CLV_PCSK_KEX2_1	316	318	PF00082	0.636
CLV_PCSK_KEX2_1	361	363	PF00082	0.416
CLV_PCSK_KEX2_1	372	374	PF00082	0.483
CLV_PCSK_KEX2_1	468	470	PF00082	0.511
CLV_PCSK_KEX2_1	478	480	PF00082	0.499
CLV_PCSK_KEX2_1	633	635	PF00082	0.592
CLV_PCSK_KEX2_1	644	646	PF00082	0.469
CLV_PCSK_KEX2_1	664	666	PF00082	0.365
CLV_PCSK_KEX2_1	690	692	PF00082	0.546
CLV_PCSK_KEX2_1	94	96	PF00082	0.554
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.573
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.561
CLV_PCSK_PC7_1	312	318	PF00082	0.621
CLV_PCSK_PC7_1	90	96	PF00082	0.608
CLV_PCSK_SKI1_1	105	109	PF00082	0.564
CLV_PCSK_SKI1_1	228	232	PF00082	0.480
CLV_PCSK_SKI1_1	239	243	PF00082	0.385
CLV_PCSK_SKI1_1	494	498	PF00082	0.606
CLV_PCSK_SKI1_1	52	56	PF00082	0.505
CLV_PCSK_SKI1_1	59	63	PF00082	0.549
CLV_PCSK_SKI1_1	613	617	PF00082	0.515
DEG_APCC_DBOX_1	195	203	PF00400	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DEG_SPOP_SBC_1	109	113	PF00917	0.748
DEG_SPOP_SBC_1	151	155	PF00917	0.715
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.547
DOC_MAPK_MEF2A_6	188	197	PF00069	0.514
DOC_MAPK_MEF2A_6	3	12	PF00069	0.378
DOC_MAPK_MEF2A_6	334	342	PF00069	0.489
DOC_PP1_SILK_1	308	313	PF00149	0.551
DOC_PP2B_LxvP_1	304	307	PF13499	0.658
DOC_PP4_FxxP_1	581	584	PF00568	0.565
DOC_USP7_MATH_1	110	114	PF00917	0.721
DOC_USP7_MATH_1	144	148	PF00917	0.787
DOC_USP7_MATH_1	151	155	PF00917	0.801
DOC_USP7_MATH_1	321	325	PF00917	0.618
DOC_USP7_MATH_1	529	533	PF00917	0.638
DOC_USP7_MATH_1	557	561	PF00917	0.748
DOC_USP7_UBL2_3	660	664	PF12436	0.530
DOC_WW_Pin1_4	131	136	PF00397	0.795
DOC_WW_Pin1_4	269	274	PF00397	0.749
DOC_WW_Pin1_4	297	302	PF00397	0.593
DOC_WW_Pin1_4	408	413	PF00397	0.629
DOC_WW_Pin1_4	494	499	PF00397	0.570
DOC_WW_Pin1_4	513	518	PF00397	0.731
LIG_14-3-3_CanoR_1	196	200	PF00244	0.577
LIG_14-3-3_CanoR_1	228	234	PF00244	0.558
LIG_14-3-3_CanoR_1	332	338	PF00244	0.496
LIG_14-3-3_CanoR_1	608	612	PF00244	0.600
LIG_14-3-3_CanoR_1	703	711	PF00244	0.700
LIG_APCC_ABBA_1	74	79	PF00400	0.607
LIG_BRCT_BRCA1_1	577	581	PF00533	0.638
LIG_CtBP_PxDLS_1	78	82	PF00389	0.574
LIG_deltaCOP1_diTrp_1	26	33	PF00928	0.335
LIG_FHA_1	12	18	PF00498	0.324
LIG_FHA_1	158	164	PF00498	0.601
LIG_FHA_1	221	227	PF00498	0.498
LIG_FHA_1	269	275	PF00498	0.734
LIG_FHA_1	298	304	PF00498	0.662
LIG_FHA_1	347	353	PF00498	0.455
LIG_FHA_1	387	393	PF00498	0.467
LIG_FHA_1	413	419	PF00498	0.521
LIG_FHA_1	442	448	PF00498	0.477
LIG_FHA_2	189	195	PF00498	0.628
LIG_FHA_2	497	503	PF00498	0.623
LIG_FHA_2	556	562	PF00498	0.717
LIG_FHA_2	66	72	PF00498	0.520
LIG_LIR_Apic_2	578	584	PF02991	0.560
LIG_LIR_Gen_1	432	441	PF02991	0.456
LIG_LIR_Gen_1	46	54	PF02991	0.425
LIG_LIR_Nem_3	26	30	PF02991	0.324
LIG_LIR_Nem_3	432	437	PF02991	0.449
LIG_LIR_Nem_3	46	51	PF02991	0.438
LIG_NRBOX	692	698	PF00104	0.544
LIG_Pex14_2	367	371	PF04695	0.446
LIG_SH2_CRK	13	17	PF00017	0.332
LIG_SH2_PTP2	48	51	PF00017	0.431
LIG_SH2_STAP1	13	17	PF00017	0.335
LIG_SH2_STAP1	363	367	PF00017	0.418
LIG_SH2_STAP1	642	646	PF00017	0.563
LIG_SH2_STAT3	363	366	PF00017	0.485
LIG_SH2_STAT5	13	16	PF00017	0.335
LIG_SH2_STAT5	210	213	PF00017	0.517
LIG_SH2_STAT5	248	251	PF00017	0.440
LIG_SH2_STAT5	391	394	PF00017	0.593
LIG_SH2_STAT5	48	51	PF00017	0.431
LIG_SH2_STAT5	648	651	PF00017	0.581
LIG_SH3_2	414	419	PF14604	0.660
LIG_SH3_3	114	120	PF00018	0.672
LIG_SH3_3	411	417	PF00018	0.650
LIG_SH3_3	523	529	PF00018	0.764
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.529
LIG_SUMO_SIM_par_1	339	345	PF11976	0.581
LIG_TRAF2_1	673	676	PF00917	0.669
LIG_TYR_ITIM	11	16	PF00017	0.319
LIG_UBA3_1	340	346	PF00899	0.554
MOD_CDK_SPxxK_3	412	419	PF00069	0.530
MOD_CK1_1	118	124	PF00069	0.708
MOD_CK1_1	15	21	PF00069	0.285
MOD_CK1_1	154	160	PF00069	0.772
MOD_CK1_1	234	240	PF00069	0.499
MOD_CK1_1	266	272	PF00069	0.749
MOD_CK1_1	492	498	PF00069	0.546
MOD_CK1_1	531	537	PF00069	0.714
MOD_CK1_1	542	548	PF00069	0.780
MOD_CK1_1	656	662	PF00069	0.625
MOD_CK2_1	188	194	PF00069	0.642
MOD_CK2_1	333	339	PF00069	0.500
MOD_CK2_1	496	502	PF00069	0.644
MOD_CK2_1	542	548	PF00069	0.645
MOD_CK2_1	555	561	PF00069	0.689
MOD_CK2_1	65	71	PF00069	0.541
MOD_CK2_1	670	676	PF00069	0.669
MOD_GlcNHglycan	113	116	PF01048	0.699
MOD_GlcNHglycan	117	120	PF01048	0.724
MOD_GlcNHglycan	135	138	PF01048	0.546
MOD_GlcNHglycan	154	157	PF01048	0.760
MOD_GlcNHglycan	233	236	PF01048	0.566
MOD_GlcNHglycan	393	396	PF01048	0.609
MOD_GlcNHglycan	491	494	PF01048	0.531
MOD_GlcNHglycan	534	537	PF01048	0.722
MOD_GlcNHglycan	544	547	PF01048	0.710
MOD_GlcNHglycan	577	580	PF01048	0.638
MOD_GlcNHglycan	706	709	PF01048	0.665
MOD_GSK3_1	11	18	PF00069	0.344
MOD_GSK3_1	111	118	PF00069	0.639
MOD_GSK3_1	146	153	PF00069	0.715
MOD_GSK3_1	178	185	PF00069	0.642
MOD_GSK3_1	229	236	PF00069	0.560
MOD_GSK3_1	268	275	PF00069	0.782
MOD_GSK3_1	342	349	PF00069	0.520
MOD_GSK3_1	387	394	PF00069	0.571
MOD_GSK3_1	408	415	PF00069	0.705
MOD_GSK3_1	492	499	PF00069	0.601
MOD_GSK3_1	527	534	PF00069	0.663
MOD_LATS_1	162	168	PF00433	0.574
MOD_LATS_1	344	350	PF00433	0.534
MOD_N-GLC_1	170	175	PF02516	0.692
MOD_N-GLC_1	263	268	PF02516	0.682
MOD_N-GLC_1	574	579	PF02516	0.652
MOD_NEK2_1	11	16	PF00069	0.335
MOD_NEK2_1	342	347	PF00069	0.495
MOD_NEK2_1	537	542	PF00069	0.754
MOD_NEK2_1	574	579	PF00069	0.578
MOD_NEK2_1	592	597	PF00069	0.586
MOD_NEK2_1	646	651	PF00069	0.593
MOD_PIKK_1	170	176	PF00454	0.638
MOD_PIKK_1	220	226	PF00454	0.513
MOD_PIKK_1	529	535	PF00454	0.767
MOD_PIKK_1	537	543	PF00454	0.755
MOD_PKA_2	195	201	PF00069	0.601
MOD_PKA_2	333	339	PF00069	0.505
MOD_PKA_2	427	433	PF00069	0.509
MOD_PKA_2	607	613	PF00069	0.595
MOD_Plk_1	170	176	PF00069	0.690
MOD_Plk_1	287	293	PF00069	0.600
MOD_Plk_4	12	18	PF00069	0.352
MOD_Plk_4	355	361	PF00069	0.425
MOD_Plk_4	376	382	PF00069	0.436
MOD_Plk_4	387	393	PF00069	0.456
MOD_Plk_4	44	50	PF00069	0.428
MOD_Plk_4	653	659	PF00069	0.517
MOD_ProDKin_1	131	137	PF00069	0.796
MOD_ProDKin_1	269	275	PF00069	0.750
MOD_ProDKin_1	297	303	PF00069	0.587
MOD_ProDKin_1	408	414	PF00069	0.623
MOD_ProDKin_1	494	500	PF00069	0.578
MOD_ProDKin_1	513	519	PF00069	0.733
MOD_SUMO_rev_2	465	473	PF00179	0.605
TRG_DiLeu_BaEn_1	337	342	PF01217	0.584
TRG_DiLeu_BaEn_1	7	12	PF01217	0.335
TRG_ENDOCYTIC_2	13	16	PF00928	0.319
TRG_ENDOCYTIC_2	30	33	PF00928	0.325
TRG_ENDOCYTIC_2	434	437	PF00928	0.482
TRG_ENDOCYTIC_2	48	51	PF00928	0.431
TRG_ER_diArg_1	2	4	PF00400	0.480
TRG_ER_diArg_1	332	335	PF00400	0.598
TRG_ER_diArg_1	360	362	PF00400	0.417
TRG_ER_diArg_1	371	373	PF00400	0.498
TRG_ER_diArg_1	467	469	PF00400	0.531
TRG_ER_diArg_1	477	479	PF00400	0.468
TRG_ER_diArg_1	57	60	PF00400	0.529
TRG_ER_diArg_1	633	635	PF00400	0.602
TRG_ER_diArg_1	644	646	PF00400	0.490
TRG_ER_diArg_1	665	667	PF00400	0.685
TRG_ER_diArg_1	691	693	PF00400	0.528
TRG_NES_CRM1_1	254	267	PF08389	0.568
TRG_NES_CRM1_1	64	80	PF08389	0.586
TRG_NLS_Bipartite_1	652	668	PF00514	0.690
TRG_NLS_MonoCore_2	663	668	PF00514	0.616
TRG_NLS_MonoExtN_4	688	694	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP3	Leptomonas seymouri	66%	92%
A0A1X0NWS4	Trypanosomatidae	49%	79%
A0A3S5IS90	Trypanosoma rangeli	52%	96%
A0A3S7WXT9	Leishmania donovani	96%	100%
A4HCZ5	Leishmania braziliensis	84%	100%
A4I0I0	Leishmania infantum	96%	100%
C9ZVA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	91%
E9AWE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BJA5	Trypanosoma cruzi	51%	100%