Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB26_LEIMA

TriTrypDb:

LmjF.23.1267 , LMJLV39_230022600 , LMJSD75_230023000

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QB26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.668
CLV_C14_Caspase3-7	312	316	PF00656	0.709
CLV_NRD_NRD_1	16	18	PF00675	0.504
CLV_NRD_NRD_1	224	226	PF00675	0.624
CLV_NRD_NRD_1	228	230	PF00675	0.571
CLV_PCSK_KEX2_1	16	18	PF00082	0.504
CLV_PCSK_KEX2_1	224	226	PF00082	0.578
CLV_PCSK_KEX2_1	228	230	PF00082	0.540
CLV_PCSK_PC7_1	224	230	PF00082	0.520
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DEG_SCF_FBW7_1	213	218	PF00400	0.736
DEG_SCF_FBW7_1	289	296	PF00400	0.716
DEG_SPOP_SBC_1	268	272	PF00917	0.731
DEG_SPOP_SBC_1	348	352	PF00917	0.655
DEG_SPOP_SBC_1	362	366	PF00917	0.647
DOC_CKS1_1	290	295	PF01111	0.710
DOC_MAPK_gen_1	16	23	PF00069	0.580
DOC_MAPK_MEF2A_6	353	362	PF00069	0.699
DOC_PP2B_LxvP_1	339	342	PF13499	0.708
DOC_PP2B_PxIxI_1	357	363	PF00149	0.721
DOC_USP7_MATH_1	106	110	PF00917	0.636
DOC_USP7_MATH_1	117	121	PF00917	0.691
DOC_USP7_MATH_1	133	137	PF00917	0.827
DOC_USP7_MATH_1	156	160	PF00917	0.795
DOC_USP7_MATH_1	166	170	PF00917	0.768
DOC_USP7_MATH_1	182	186	PF00917	0.614
DOC_USP7_MATH_1	201	205	PF00917	0.669
DOC_USP7_MATH_1	215	219	PF00917	0.733
DOC_USP7_MATH_1	227	231	PF00917	0.690
DOC_USP7_MATH_1	268	272	PF00917	0.712
DOC_USP7_MATH_1	293	297	PF00917	0.734
DOC_WW_Pin1_4	135	140	PF00397	0.746
DOC_WW_Pin1_4	211	216	PF00397	0.780
DOC_WW_Pin1_4	289	294	PF00397	0.725
DOC_WW_Pin1_4	298	303	PF00397	0.686
DOC_WW_Pin1_4	315	320	PF00397	0.683
DOC_WW_Pin1_4	337	342	PF00397	0.749
DOC_WW_Pin1_4	354	359	PF00397	0.719
DOC_WW_Pin1_4	370	375	PF00397	0.724
LIG_14-3-3_CanoR_1	208	214	PF00244	0.703
LIG_14-3-3_CanoR_1	228	234	PF00244	0.671
LIG_14-3-3_CanoR_1	311	320	PF00244	0.754
LIG_14-3-3_CanoR_1	353	358	PF00244	0.696
LIG_BRCT_BRCA1_1	185	189	PF00533	0.733
LIG_CSL_BTD_1	303	306	PF09270	0.726
LIG_FHA_1	27	33	PF00498	0.386
LIG_FHA_1	284	290	PF00498	0.701
LIG_FHA_2	245	251	PF00498	0.722
LIG_FHA_2	310	316	PF00498	0.710
LIG_FHA_2	341	347	PF00498	0.714
LIG_GBD_Chelix_1	53	61	PF00786	0.260
LIG_LIR_Gen_1	186	196	PF02991	0.763
LIG_LIR_Gen_1	232	242	PF02991	0.707
LIG_LIR_Gen_1	244	250	PF02991	0.645
LIG_LIR_Gen_1	332	341	PF02991	0.649
LIG_LIR_Nem_3	186	192	PF02991	0.726
LIG_LIR_Nem_3	244	248	PF02991	0.679
LIG_PCNA_yPIPBox_3	85	95	PF02747	0.681
LIG_Pex14_1	55	59	PF04695	0.405
LIG_SH2_CRK	8	12	PF00017	0.561
LIG_SH2_SRC	344	347	PF00017	0.723
LIG_SH2_STAP1	344	348	PF00017	0.723
LIG_SH2_STAT5	98	101	PF00017	0.748
LIG_SH3_3	284	290	PF00018	0.717
LIG_SH3_3	296	302	PF00018	0.707
LIG_SH3_3	31	37	PF00018	0.405
LIG_SH3_3	91	97	PF00018	0.730
LIG_SUMO_SIM_par_1	318	324	PF11976	0.699
LIG_SUMO_SIM_par_1	38	45	PF11976	0.486
LIG_TRAF2_1	197	200	PF00917	0.751
LIG_TRAF2_1	343	346	PF00917	0.719
LIG_WW_1	341	344	PF00397	0.704
MOD_CDK_SPK_2	354	359	PF00069	0.713
MOD_CK1_1	118	124	PF00069	0.754
MOD_CK1_1	159	165	PF00069	0.790
MOD_CK1_1	169	175	PF00069	0.685
MOD_CK1_1	203	209	PF00069	0.750
MOD_CK1_1	271	277	PF00069	0.723
MOD_CK1_1	321	327	PF00069	0.789
MOD_CK1_1	340	346	PF00069	0.758
MOD_CK1_1	351	357	PF00069	0.652
MOD_CK2_1	117	123	PF00069	0.707
MOD_CK2_1	178	184	PF00069	0.695
MOD_CK2_1	194	200	PF00069	0.659
MOD_CK2_1	244	250	PF00069	0.720
MOD_CK2_1	340	346	PF00069	0.731
MOD_Cter_Amidation	222	225	PF01082	0.565
MOD_DYRK1A_RPxSP_1	137	141	PF00069	0.750
MOD_GlcNHglycan	158	161	PF01048	0.629
MOD_GlcNHglycan	162	165	PF01048	0.599
MOD_GlcNHglycan	168	171	PF01048	0.507
MOD_GlcNHglycan	178	181	PF01048	0.391
MOD_GlcNHglycan	184	188	PF01048	0.461
MOD_GlcNHglycan	215	218	PF01048	0.571
MOD_GlcNHglycan	219	222	PF01048	0.569
MOD_GlcNHglycan	263	266	PF01048	0.538
MOD_GlcNHglycan	295	298	PF01048	0.533
MOD_GSK3_1	115	122	PF00069	0.760
MOD_GSK3_1	133	140	PF00069	0.797
MOD_GSK3_1	152	159	PF00069	0.668
MOD_GSK3_1	166	173	PF00069	0.719
MOD_GSK3_1	178	185	PF00069	0.672
MOD_GSK3_1	190	197	PF00069	0.727
MOD_GSK3_1	199	206	PF00069	0.752
MOD_GSK3_1	209	216	PF00069	0.667
MOD_GSK3_1	246	253	PF00069	0.730
MOD_GSK3_1	266	273	PF00069	0.633
MOD_GSK3_1	285	292	PF00069	0.652
MOD_GSK3_1	309	316	PF00069	0.756
MOD_GSK3_1	331	338	PF00069	0.714
MOD_GSK3_1	347	354	PF00069	0.745
MOD_GSK3_1	362	369	PF00069	0.722
MOD_N-GLC_1	156	161	PF02516	0.598
MOD_NEK2_1	176	181	PF00069	0.809
MOD_NEK2_1	183	188	PF00069	0.714
MOD_NEK2_1	190	195	PF00069	0.660
MOD_NEK2_1	243	248	PF00069	0.670
MOD_NEK2_1	309	314	PF00069	0.736
MOD_NEK2_1	349	354	PF00069	0.655
MOD_NEK2_1	363	368	PF00069	0.704
MOD_PIKK_1	321	327	PF00454	0.742
MOD_PIKK_1	331	337	PF00454	0.700
MOD_PIKK_1	366	372	PF00454	0.699
MOD_PKA_2	227	233	PF00069	0.720
MOD_PKA_2	352	358	PF00069	0.696
MOD_Plk_1	243	249	PF00069	0.691
MOD_Plk_2-3	244	250	PF00069	0.720
MOD_Plk_2-3	254	260	PF00069	0.710
MOD_Plk_4	26	32	PF00069	0.330
MOD_Plk_4	48	54	PF00069	0.426
MOD_ProDKin_1	135	141	PF00069	0.746
MOD_ProDKin_1	211	217	PF00069	0.781
MOD_ProDKin_1	289	295	PF00069	0.726
MOD_ProDKin_1	298	304	PF00069	0.687
MOD_ProDKin_1	315	321	PF00069	0.684
MOD_ProDKin_1	337	343	PF00069	0.750
MOD_ProDKin_1	354	360	PF00069	0.720
MOD_ProDKin_1	370	376	PF00069	0.726
MOD_SUMO_rev_2	314	319	PF00179	0.691
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.405
TRG_ENDOCYTIC_2	333	336	PF00928	0.656
TRG_ENDOCYTIC_2	8	11	PF00928	0.564
TRG_ER_diArg_1	15	17	PF00400	0.706
TRG_ER_diArg_1	227	229	PF00400	0.715
TRG_ER_diArg_1	86	89	PF00400	0.706
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXU4	Leishmania donovani	86%	100%
A4HCZ9	Leishmania braziliensis	64%	100%
A4I0I4	Leishmania infantum	86%	100%
E9AWE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%