Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QB23_LEIMA

TriTrypDb:

LmjF.23.1290 , LMJLV39_230023000 , LMJSD75_230023400

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QB23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.761
CLV_C14_Caspase3-7	296	300	PF00656	0.845
CLV_C14_Caspase3-7	552	556	PF00656	0.783
CLV_NRD_NRD_1	130	132	PF00675	0.629
CLV_NRD_NRD_1	133	135	PF00675	0.597
CLV_NRD_NRD_1	20	22	PF00675	0.610
CLV_NRD_NRD_1	31	33	PF00675	0.566
CLV_NRD_NRD_1	322	324	PF00675	0.547
CLV_NRD_NRD_1	346	348	PF00675	0.638
CLV_NRD_NRD_1	48	50	PF00675	0.478
CLV_NRD_NRD_1	600	602	PF00675	0.600
CLV_NRD_NRD_1	656	658	PF00675	0.517
CLV_PCSK_FUR_1	131	135	PF00082	0.512
CLV_PCSK_FUR_1	654	658	PF00082	0.526
CLV_PCSK_KEX2_1	132	134	PF00082	0.628
CLV_PCSK_KEX2_1	20	22	PF00082	0.610
CLV_PCSK_KEX2_1	31	33	PF00082	0.566
CLV_PCSK_KEX2_1	322	324	PF00082	0.547
CLV_PCSK_KEX2_1	346	348	PF00082	0.638
CLV_PCSK_KEX2_1	48	50	PF00082	0.478
CLV_PCSK_KEX2_1	600	602	PF00082	0.600
CLV_PCSK_KEX2_1	656	658	PF00082	0.517
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.617
CLV_PCSK_SKI1_1	341	345	PF00082	0.581
CLV_PCSK_SKI1_1	379	383	PF00082	0.463
CLV_PCSK_SKI1_1	400	404	PF00082	0.554
CLV_PCSK_SKI1_1	412	416	PF00082	0.525
CLV_PCSK_SKI1_1	438	442	PF00082	0.512
CLV_PCSK_SKI1_1	48	52	PF00082	0.645
CLV_PCSK_SKI1_1	538	542	PF00082	0.637
CLV_PCSK_SKI1_1	600	604	PF00082	0.613
DEG_APCC_DBOX_1	437	445	PF00400	0.674
DEG_COP1_1	385	394	PF00400	0.673
DEG_SCF_FBW7_2	237	243	PF00400	0.789
DEG_SPOP_SBC_1	384	388	PF00917	0.748
DEG_SPOP_SBC_1	405	409	PF00917	0.844
DOC_CKS1_1	101	106	PF01111	0.850
DOC_CKS1_1	237	242	PF01111	0.709
DOC_CKS1_1	270	275	PF01111	0.769
DOC_CKS1_1	391	396	PF01111	0.710
DOC_CKS1_1	648	653	PF01111	0.665
DOC_MAPK_gen_1	654	664	PF00069	0.703
DOC_MAPK_JIP1_4	229	235	PF00069	0.794
DOC_MAPK_MEF2A_6	656	664	PF00069	0.645
DOC_MAPK_RevD_3	120	134	PF00069	0.699
DOC_PP1_RVXF_1	344	351	PF00149	0.839
DOC_PP2B_LxvP_1	235	238	PF13499	0.677
DOC_PP2B_LxvP_1	38	41	PF13499	0.799
DOC_PP4_FxxP_1	339	342	PF00568	0.775
DOC_USP7_MATH_1	106	110	PF00917	0.780
DOC_USP7_MATH_1	166	170	PF00917	0.801
DOC_USP7_MATH_1	203	207	PF00917	0.829
DOC_USP7_MATH_1	26	30	PF00917	0.684
DOC_USP7_MATH_1	315	319	PF00917	0.794
DOC_USP7_MATH_1	327	331	PF00917	0.680
DOC_USP7_MATH_1	384	388	PF00917	0.764
DOC_USP7_MATH_1	392	396	PF00917	0.779
DOC_USP7_MATH_1	405	409	PF00917	0.735
DOC_USP7_MATH_1	440	444	PF00917	0.808
DOC_USP7_MATH_1	475	479	PF00917	0.721
DOC_USP7_MATH_1	485	489	PF00917	0.766
DOC_USP7_MATH_1	553	557	PF00917	0.841
DOC_USP7_MATH_1	63	67	PF00917	0.831
DOC_USP7_MATH_1	77	81	PF00917	0.723
DOC_USP7_UBL2_3	538	542	PF12436	0.847
DOC_WW_Pin1_4	100	105	PF00397	0.854
DOC_WW_Pin1_4	186	191	PF00397	0.821
DOC_WW_Pin1_4	195	200	PF00397	0.770
DOC_WW_Pin1_4	233	238	PF00397	0.825
DOC_WW_Pin1_4	269	274	PF00397	0.814
DOC_WW_Pin1_4	281	286	PF00397	0.709
DOC_WW_Pin1_4	31	36	PF00397	0.848
DOC_WW_Pin1_4	390	395	PF00397	0.753
DOC_WW_Pin1_4	448	453	PF00397	0.762
DOC_WW_Pin1_4	473	478	PF00397	0.769
DOC_WW_Pin1_4	481	486	PF00397	0.731
DOC_WW_Pin1_4	50	55	PF00397	0.663
DOC_WW_Pin1_4	585	590	PF00397	0.789
DOC_WW_Pin1_4	638	643	PF00397	0.841
DOC_WW_Pin1_4	647	652	PF00397	0.728
DOC_WW_Pin1_4	8	13	PF00397	0.778
LIG_14-3-3_CanoR_1	174	178	PF00244	0.734
LIG_14-3-3_CanoR_1	20	30	PF00244	0.811
LIG_14-3-3_CanoR_1	232	236	PF00244	0.795
LIG_14-3-3_CanoR_1	31	35	PF00244	0.767
LIG_14-3-3_CanoR_1	438	446	PF00244	0.814
LIG_14-3-3_CanoR_1	448	452	PF00244	0.713
LIG_14-3-3_CanoR_1	48	54	PF00244	0.672
LIG_14-3-3_CanoR_1	491	498	PF00244	0.761
LIG_14-3-3_CanoR_1	569	573	PF00244	0.755
LIG_14-3-3_CanoR_1	600	606	PF00244	0.762
LIG_CtBP_PxDLS_1	591	595	PF00389	0.698
LIG_deltaCOP1_diTrp_1	568	573	PF00928	0.788
LIG_eIF4E_1	605	611	PF01652	0.738
LIG_FHA_1	187	193	PF00498	0.818
LIG_FHA_1	199	205	PF00498	0.730
LIG_FHA_1	237	243	PF00498	0.682
LIG_FHA_1	307	313	PF00498	0.828
LIG_FHA_1	365	371	PF00498	0.825
LIG_FHA_1	384	390	PF00498	0.662
LIG_FHA_1	449	455	PF00498	0.674
LIG_FHA_1	59	65	PF00498	0.783
LIG_FHA_1	593	599	PF00498	0.802
LIG_FHA_1	601	607	PF00498	0.744
LIG_FHA_1	96	102	PF00498	0.800
LIG_FHA_2	218	224	PF00498	0.761
LIG_FHA_2	391	397	PF00498	0.766
LIG_LIR_Apic_2	337	342	PF02991	0.774
LIG_LIR_Nem_3	142	148	PF02991	0.821
LIG_LIR_Nem_3	599	605	PF02991	0.680
LIG_LIR_Nem_3	80	85	PF02991	0.793
LIG_PCNA_PIPBox_1	674	683	PF02747	0.413
LIG_PTAP_UEV_1	641	646	PF05743	0.710
LIG_SH2_NCK_1	83	87	PF00017	0.685
LIG_SH2_SRC	530	533	PF00017	0.855
LIG_SH2_STAP1	83	87	PF00017	0.685
LIG_SH2_STAT5	605	608	PF00017	0.707
LIG_SH3_2	40	45	PF14604	0.838
LIG_SH3_3	117	123	PF00018	0.776
LIG_SH3_3	174	180	PF00018	0.832
LIG_SH3_3	234	240	PF00018	0.707
LIG_SH3_3	261	267	PF00018	0.819
LIG_SH3_3	309	315	PF00018	0.823
LIG_SH3_3	37	43	PF00018	0.848
LIG_SH3_3	388	394	PF00018	0.745
LIG_SH3_3	529	535	PF00018	0.853
LIG_SH3_3	639	645	PF00018	0.758
LIG_SH3_4	538	545	PF00018	0.846
LIG_SUMO_SIM_par_1	188	194	PF11976	0.813
LIG_SUMO_SIM_par_1	200	206	PF11976	0.738
LIG_SUMO_SIM_par_1	3	11	PF11976	0.756
LIG_SUMO_SIM_par_1	308	314	PF11976	0.778
LIG_SUMO_SIM_par_1	590	596	PF11976	0.667
LIG_TRAF2_1	620	623	PF00917	0.763
LIG_UBA3_1	660	668	PF00899	0.580
MOD_CDK_SPxxK_3	100	107	PF00069	0.851
MOD_CDK_SPxxK_3	647	654	PF00069	0.665
MOD_CK1_1	14	20	PF00069	0.758
MOD_CK1_1	141	147	PF00069	0.793
MOD_CK1_1	175	181	PF00069	0.853
MOD_CK1_1	198	204	PF00069	0.764
MOD_CK1_1	217	223	PF00069	0.620
MOD_CK1_1	248	254	PF00069	0.796
MOD_CK1_1	256	262	PF00069	0.764
MOD_CK1_1	293	299	PF00069	0.791
MOD_CK1_1	300	306	PF00069	0.705
MOD_CK1_1	308	314	PF00069	0.657
MOD_CK1_1	318	324	PF00069	0.635
MOD_CK1_1	326	332	PF00069	0.666
MOD_CK1_1	385	391	PF00069	0.795
MOD_CK1_1	404	410	PF00069	0.631
MOD_CK1_1	413	419	PF00069	0.742
MOD_CK1_1	442	448	PF00069	0.770
MOD_CK1_1	460	466	PF00069	0.649
MOD_CK1_1	484	490	PF00069	0.857
MOD_CK1_1	502	508	PF00069	0.619
MOD_CK1_1	516	522	PF00069	0.703
MOD_CK1_1	53	59	PF00069	0.799
MOD_CK1_1	545	551	PF00069	0.840
MOD_CK1_1	593	599	PF00069	0.797
MOD_CK1_1	647	653	PF00069	0.835
MOD_CK1_1	7	13	PF00069	0.830
MOD_CK2_1	7	13	PF00069	0.752
MOD_CMANNOS	570	573	PF00535	0.643
MOD_Cter_Amidation	654	657	PF01082	0.532
MOD_DYRK1A_RPxSP_1	448	452	PF00069	0.762
MOD_GlcNHglycan	16	19	PF01048	0.637
MOD_GlcNHglycan	164	167	PF01048	0.617
MOD_GlcNHglycan	177	180	PF01048	0.512
MOD_GlcNHglycan	205	208	PF01048	0.623
MOD_GlcNHglycan	217	220	PF01048	0.504
MOD_GlcNHglycan	247	250	PF01048	0.603
MOD_GlcNHglycan	304	307	PF01048	0.487
MOD_GlcNHglycan	325	328	PF01048	0.619
MOD_GlcNHglycan	336	339	PF01048	0.493
MOD_GlcNHglycan	403	406	PF01048	0.622
MOD_GlcNHglycan	415	418	PF01048	0.531
MOD_GlcNHglycan	455	458	PF01048	0.601
MOD_GlcNHglycan	487	490	PF01048	0.590
MOD_GlcNHglycan	501	504	PF01048	0.539
MOD_GlcNHglycan	509	512	PF01048	0.516
MOD_GlcNHglycan	521	524	PF01048	0.420
MOD_GlcNHglycan	551	554	PF01048	0.585
MOD_GlcNHglycan	585	588	PF01048	0.485
MOD_GlcNHglycan	622	627	PF01048	0.637
MOD_GSK3_1	108	115	PF00069	0.725
MOD_GSK3_1	162	169	PF00069	0.781
MOD_GSK3_1	182	189	PF00069	0.838
MOD_GSK3_1	194	201	PF00069	0.718
MOD_GSK3_1	214	221	PF00069	0.653
MOD_GSK3_1	22	29	PF00069	0.635
MOD_GSK3_1	253	260	PF00069	0.782
MOD_GSK3_1	286	293	PF00069	0.740
MOD_GSK3_1	302	309	PF00069	0.672
MOD_GSK3_1	318	325	PF00069	0.643
MOD_GSK3_1	327	334	PF00069	0.724
MOD_GSK3_1	366	373	PF00069	0.815
MOD_GSK3_1	4	11	PF00069	0.831
MOD_GSK3_1	401	408	PF00069	0.780
MOD_GSK3_1	442	449	PF00069	0.768
MOD_GSK3_1	453	460	PF00069	0.715
MOD_GSK3_1	481	488	PF00069	0.848
MOD_GSK3_1	49	56	PF00069	0.858
MOD_GSK3_1	505	512	PF00069	0.818
MOD_GSK3_1	513	520	PF00069	0.748
MOD_GSK3_1	545	552	PF00069	0.818
MOD_GSK3_1	553	560	PF00069	0.770
MOD_GSK3_1	564	571	PF00069	0.640
MOD_GSK3_1	581	588	PF00069	0.738
MOD_GSK3_1	640	647	PF00069	0.826
MOD_GSK3_1	77	84	PF00069	0.700
MOD_GSK3_1	96	103	PF00069	0.803
MOD_N-GLC_1	186	191	PF02516	0.548
MOD_N-GLC_1	214	219	PF02516	0.597
MOD_N-GLC_1	405	410	PF02516	0.643
MOD_N-GLC_1	446	451	PF02516	0.480
MOD_NEK2_1	112	117	PF00069	0.675
MOD_NEK2_1	366	371	PF00069	0.764
MOD_NEK2_1	446	451	PF00069	0.763
MOD_NEK2_1	453	458	PF00069	0.699
MOD_NEK2_1	592	597	PF00069	0.664
MOD_NEK2_1	96	101	PF00069	0.869
MOD_NEK2_2	26	31	PF00069	0.682
MOD_NEK2_2	4	9	PF00069	0.785
MOD_NEK2_2	457	462	PF00069	0.713
MOD_PIKK_1	112	118	PF00454	0.810
MOD_PIKK_1	87	93	PF00454	0.774
MOD_PKA_1	322	328	PF00069	0.746
MOD_PKA_1	48	54	PF00069	0.826
MOD_PKA_1	600	606	PF00069	0.684
MOD_PKA_2	106	112	PF00069	0.860
MOD_PKA_2	126	132	PF00069	0.647
MOD_PKA_2	173	179	PF00069	0.732
MOD_PKA_2	231	237	PF00069	0.792
MOD_PKA_2	291	297	PF00069	0.742
MOD_PKA_2	30	36	PF00069	0.857
MOD_PKA_2	322	328	PF00069	0.790
MOD_PKA_2	370	376	PF00069	0.821
MOD_PKA_2	447	453	PF00069	0.687
MOD_PKA_2	48	54	PF00069	0.669
MOD_PKA_2	490	496	PF00069	0.791
MOD_PKA_2	517	523	PF00069	0.718
MOD_PKA_2	545	551	PF00069	0.773
MOD_PKA_2	568	574	PF00069	0.730
MOD_PKA_2	600	606	PF00069	0.687
MOD_PKB_1	295	303	PF00069	0.763
MOD_Plk_1	107	113	PF00069	0.867
MOD_Plk_1	141	147	PF00069	0.766
MOD_Plk_1	172	178	PF00069	0.734
MOD_Plk_1	26	32	PF00069	0.796
MOD_Plk_2-3	108	114	PF00069	0.867
MOD_Plk_4	11	17	PF00069	0.775
MOD_Plk_4	260	266	PF00069	0.777
MOD_Plk_4	410	416	PF00069	0.671
MOD_Plk_4	457	463	PF00069	0.778
MOD_Plk_4	593	599	PF00069	0.739
MOD_Plk_4	601	607	PF00069	0.675
MOD_Plk_4	78	84	PF00069	0.687
MOD_ProDKin_1	100	106	PF00069	0.851
MOD_ProDKin_1	186	192	PF00069	0.820
MOD_ProDKin_1	195	201	PF00069	0.770
MOD_ProDKin_1	233	239	PF00069	0.826
MOD_ProDKin_1	269	275	PF00069	0.815
MOD_ProDKin_1	281	287	PF00069	0.711
MOD_ProDKin_1	31	37	PF00069	0.847
MOD_ProDKin_1	390	396	PF00069	0.756
MOD_ProDKin_1	448	454	PF00069	0.760
MOD_ProDKin_1	473	479	PF00069	0.772
MOD_ProDKin_1	481	487	PF00069	0.732
MOD_ProDKin_1	50	56	PF00069	0.662
MOD_ProDKin_1	585	591	PF00069	0.790
MOD_ProDKin_1	638	644	PF00069	0.841
MOD_ProDKin_1	647	653	PF00069	0.723
MOD_ProDKin_1	8	14	PF00069	0.778
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.773
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.658
TRG_ER_diArg_1	130	133	PF00400	0.824
TRG_ER_diArg_1	20	22	PF00400	0.784
TRG_ER_diArg_1	30	32	PF00400	0.717
TRG_ER_diArg_1	346	348	PF00400	0.838
TRG_ER_diArg_1	47	49	PF00400	0.665
TRG_ER_diArg_1	600	602	PF00400	0.760
TRG_ER_diArg_1	615	618	PF00400	0.642
TRG_ER_diArg_1	654	657	PF00400	0.732
TRG_NLS_MonoCore_2	130	135	PF00514	0.703
TRG_NLS_MonoExtN_4	131	136	PF00514	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFX5	Leishmania donovani	86%	100%
A4HD02	Leishmania braziliensis	52%	100%
A4I0I7	Leishmania infantum	86%	100%
E9AWE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%