Lathosterol oxidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lathosterol oxidase-like protein

Species:

Leishmania major

UniProt:

Q4QB22_LEIMA

TriTrypDb:

LmjF.23.1300 , LMJLV39_230023100 , LMJSD75_230023500

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QB22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB22

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006694	steroid biosynthetic process	5	2
GO:0008152	metabolic process	1	11
GO:0008202	steroid metabolic process	4	2
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0016125	sterol metabolic process	4	2
GO:0016126	sterol biosynthetic process	5	2
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000248	C-5 sterol desaturase activity	5	2
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	4
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	4
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0070704	sterol desaturase activity	4	4
GO:0050046	delta7-sterol 5(6)-desaturase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	295	297	PF00675	0.627
CLV_NRD_NRD_1	50	52	PF00675	0.379
CLV_PCSK_KEX2_1	295	297	PF00082	0.663
CLV_PCSK_KEX2_1	54	56	PF00082	0.380
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.348
CLV_PCSK_SKI1_1	281	285	PF00082	0.684
CLV_PCSK_SKI1_1	51	55	PF00082	0.350
CLV_PCSK_SKI1_1	6	10	PF00082	0.462
DEG_Nend_UBRbox_2	1	3	PF02207	0.284
DOC_CKS1_1	158	163	PF01111	0.428
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.386
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.509
DOC_MAPK_gen_1	16	25	PF00069	0.271
DOC_MAPK_MEF2A_6	75	82	PF00069	0.509
DOC_PP2B_LxvP_1	91	94	PF13499	0.307
DOC_USP7_MATH_1	161	165	PF00917	0.415
DOC_USP7_MATH_1	294	298	PF00917	0.381
DOC_USP7_MATH_1	81	85	PF00917	0.269
DOC_USP7_UBL2_3	147	151	PF12436	0.509
DOC_WW_Pin1_4	118	123	PF00397	0.383
DOC_WW_Pin1_4	157	162	PF00397	0.415
LIG_14-3-3_CanoR_1	6	12	PF00244	0.335
LIG_BRCT_BRCA1_1	163	167	PF00533	0.445
LIG_BRCT_BRCA1_1	83	87	PF00533	0.269
LIG_deltaCOP1_diTrp_1	112	118	PF00928	0.249
LIG_eIF4E_1	180	186	PF01652	0.282
LIG_FHA_1	202	208	PF00498	0.251
LIG_FHA_1	253	259	PF00498	0.303
LIG_FHA_1	7	13	PF00498	0.315
LIG_FHA_2	238	244	PF00498	0.215
LIG_LIR_Apic_2	155	161	PF02991	0.415
LIG_LIR_Apic_2	266	272	PF02991	0.389
LIG_LIR_Gen_1	112	123	PF02991	0.304
LIG_LIR_Gen_1	239	249	PF02991	0.217
LIG_LIR_Gen_1	36	46	PF02991	0.328
LIG_LIR_Gen_1	77	87	PF02991	0.257
LIG_LIR_Nem_3	104	110	PF02991	0.246
LIG_LIR_Nem_3	112	118	PF02991	0.215
LIG_LIR_Nem_3	129	134	PF02991	0.251
LIG_LIR_Nem_3	164	170	PF02991	0.482
LIG_LIR_Nem_3	2	8	PF02991	0.286
LIG_LIR_Nem_3	234	238	PF02991	0.220
LIG_LIR_Nem_3	239	245	PF02991	0.213
LIG_LIR_Nem_3	271	277	PF02991	0.381
LIG_LIR_Nem_3	36	41	PF02991	0.303
LIG_LIR_Nem_3	43	49	PF02991	0.272
LIG_LIR_Nem_3	77	82	PF02991	0.257
LIG_LIR_Nem_3	84	90	PF02991	0.243
LIG_NRBOX	257	263	PF00104	0.393
LIG_PDZ_Class_2	297	302	PF00595	0.410
LIG_Pex14_2	182	186	PF04695	0.251
LIG_Pex14_2	193	197	PF04695	0.251
LIG_Pex14_2	213	217	PF04695	0.241
LIG_PTB_Apo_2	187	194	PF02174	0.306
LIG_PTB_Apo_2	229	236	PF02174	0.271
LIG_PTB_Phospho_1	229	235	PF10480	0.271
LIG_SH2_CRK	103	107	PF00017	0.276
LIG_SH2_CRK	158	162	PF00017	0.467
LIG_SH2_GRB2like	107	110	PF00017	0.246
LIG_SH2_NCK_1	158	162	PF00017	0.446
LIG_SH2_PTP2	180	183	PF00017	0.315
LIG_SH2_PTP2	269	272	PF00017	0.363
LIG_SH2_SRC	269	272	PF00017	0.363
LIG_SH2_STAP1	103	107	PF00017	0.245
LIG_SH2_STAP1	238	242	PF00017	0.309
LIG_SH2_STAT5	117	120	PF00017	0.246
LIG_SH2_STAT5	134	137	PF00017	0.275
LIG_SH2_STAT5	158	161	PF00017	0.446
LIG_SH2_STAT5	180	183	PF00017	0.296
LIG_SH2_STAT5	184	187	PF00017	0.305
LIG_SH2_STAT5	238	241	PF00017	0.223
LIG_SH2_STAT5	269	272	PF00017	0.363
LIG_SH2_STAT5	38	41	PF00017	0.286
LIG_SH2_STAT5	46	49	PF00017	0.304
LIG_SUMO_SIM_par_1	203	209	PF11976	0.251
LIG_TYR_ITIM	144	149	PF00017	0.491
MOD_CK1_1	45	51	PF00069	0.255
MOD_CK2_1	273	279	PF00069	0.319
MOD_GlcNHglycan	31	34	PF01048	0.350
MOD_GSK3_1	152	159	PF00069	0.415
MOD_GSK3_1	218	225	PF00069	0.215
MOD_GSK3_1	252	259	PF00069	0.323
MOD_GSK3_1	29	36	PF00069	0.407
MOD_N-GLC_1	108	113	PF02516	0.520
MOD_N-GLC_1	218	223	PF02516	0.415
MOD_NEK2_1	152	157	PF00069	0.441
MOD_NEK2_1	217	222	PF00069	0.228
MOD_NEK2_1	245	250	PF00069	0.378
MOD_NEK2_1	28	33	PF00069	0.254
MOD_NEK2_1	40	45	PF00069	0.288
MOD_NEK2_1	7	12	PF00069	0.375
MOD_NEK2_2	203	208	PF00069	0.289
MOD_NEK2_2	222	227	PF00069	0.124
MOD_NEK2_2	33	38	PF00069	0.407
MOD_PKA_2	294	300	PF00069	0.396
MOD_Plk_4	237	243	PF00069	0.284
MOD_Plk_4	257	263	PF00069	0.357
MOD_Plk_4	33	39	PF00069	0.251
MOD_Plk_4	7	13	PF00069	0.361
MOD_ProDKin_1	118	124	PF00069	0.383
MOD_ProDKin_1	157	163	PF00069	0.415
MOD_SUMO_for_1	288	291	PF00179	0.444
MOD_SUMO_rev_2	260	270	PF00179	0.336
MOD_SUMO_rev_2	275	283	PF00179	0.424
TRG_DiLeu_BaEn_2	278	284	PF01217	0.397
TRG_ENDOCYTIC_2	103	106	PF00928	0.276
TRG_ENDOCYTIC_2	107	110	PF00928	0.285
TRG_ENDOCYTIC_2	117	120	PF00928	0.313
TRG_ENDOCYTIC_2	146	149	PF00928	0.445
TRG_ENDOCYTIC_2	179	182	PF00928	0.415
TRG_ENDOCYTIC_2	238	241	PF00928	0.215
TRG_ENDOCYTIC_2	38	41	PF00928	0.302
TRG_ER_diLys_1	298	302	PF00400	0.480
TRG_NLS_MonoExtC_3	50	55	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SNE8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	93%
A0A0N1HQY0	Leptomonas seymouri	83%	100%
A0A0S4IWX4	Bodo saltans	53%	100%
A0A1X0NWS0	Trypanosomatidae	63%	100%
A0A3R7MRY7	Trypanosoma rangeli	64%	100%
A0A3S7WXZ2	Leishmania donovani	97%	100%
A4HD03	Leishmania braziliensis	88%	100%
A4I0I8	Leishmania infantum	97%	100%
C9ZVB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AWF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
I1RFM2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	87%
O13666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	92%
O35532	Rattus norvegicus	26%	100%
O75845	Homo sapiens	38%	100%
O88822	Mus musculus	38%	100%
O93875	Candida albicans	36%	78%
O94457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P32353	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	83%
P50860	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	40%	83%
Q39208	Arabidopsis thaliana	27%	100%
Q4WB51	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	94%
Q4WDL3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	86%
Q4WIX5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	90%
Q55D52	Dictyostelium discoideum	25%	100%
Q59VG6	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	78%
Q754B9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	86%
Q7SBB6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	88%
Q8J207	Leptosphaeria maculans	44%	85%
Q8NJ57	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	40%	78%
Q9EQS5	Rattus norvegicus	42%	100%
Q9M883	Arabidopsis thaliana	29%	100%
Q9ZT29	Nicotiana tabacum	31%	100%