Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB18_LEIMA

TriTrypDb:

LmjF.23.1340 , LMJLV39_230023500 , LMJSD75_230023900

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.430
CLV_MEL_PAP_1	478	484	PF00089	0.283
CLV_NRD_NRD_1	172	174	PF00675	0.744
CLV_NRD_NRD_1	498	500	PF00675	0.316
CLV_NRD_NRD_1	624	626	PF00675	0.466
CLV_NRD_NRD_1	645	647	PF00675	0.429
CLV_PCSK_KEX2_1	141	143	PF00082	0.630
CLV_PCSK_KEX2_1	172	174	PF00082	0.692
CLV_PCSK_KEX2_1	337	339	PF00082	0.500
CLV_PCSK_KEX2_1	498	500	PF00082	0.316
CLV_PCSK_KEX2_1	624	626	PF00082	0.481
CLV_PCSK_KEX2_1	645	647	PF00082	0.412
CLV_PCSK_KEX2_1	672	674	PF00082	0.508
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.552
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.500
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.412
CLV_PCSK_PC1ET2_1	672	674	PF00082	0.508
CLV_PCSK_PC7_1	620	626	PF00082	0.470
CLV_PCSK_SKI1_1	141	145	PF00082	0.651
CLV_PCSK_SKI1_1	308	312	PF00082	0.394
CLV_PCSK_SKI1_1	408	412	PF00082	0.449
CLV_PCSK_SKI1_1	433	437	PF00082	0.310
CLV_PCSK_SKI1_1	59	63	PF00082	0.718
CLV_PCSK_SKI1_1	612	616	PF00082	0.332
CLV_PCSK_SKI1_1	620	624	PF00082	0.368
DEG_SCF_FBW7_2	418	423	PF00400	0.417
DEG_SPOP_SBC_1	183	187	PF00917	0.511
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.422
DOC_MAPK_gen_1	191	201	PF00069	0.460
DOC_MAPK_gen_1	243	250	PF00069	0.306
DOC_MAPK_HePTP_8	435	447	PF00069	0.276
DOC_MAPK_MEF2A_6	438	447	PF00069	0.277
DOC_PP1_RVXF_1	126	133	PF00149	0.501
DOC_PP1_RVXF_1	479	485	PF00149	0.306
DOC_PP2B_LxvP_1	367	370	PF13499	0.519
DOC_PP4_FxxP_1	665	668	PF00568	0.389
DOC_USP7_MATH_1	151	155	PF00917	0.444
DOC_USP7_MATH_1	165	169	PF00917	0.596
DOC_USP7_MATH_1	182	186	PF00917	0.582
DOC_USP7_MATH_1	195	199	PF00917	0.529
DOC_USP7_MATH_1	480	484	PF00917	0.283
DOC_USP7_MATH_1	600	604	PF00917	0.379
DOC_USP7_MATH_1	9	13	PF00917	0.687
DOC_USP7_UBL2_3	641	645	PF12436	0.390
DOC_WW_Pin1_4	278	283	PF00397	0.416
DOC_WW_Pin1_4	286	291	PF00397	0.396
DOC_WW_Pin1_4	361	366	PF00397	0.461
DOC_WW_Pin1_4	416	421	PF00397	0.449
DOC_WW_Pin1_4	509	514	PF00397	0.458
DOC_WW_Pin1_4	54	59	PF00397	0.667
LIG_14-3-3_CanoR_1	110	119	PF00244	0.468
LIG_14-3-3_CanoR_1	142	150	PF00244	0.445
LIG_14-3-3_CanoR_1	24	29	PF00244	0.464
LIG_14-3-3_CanoR_1	481	485	PF00244	0.405
LIG_14-3-3_CanoR_1	624	632	PF00244	0.415
LIG_14-3-3_CanoR_1	679	683	PF00244	0.615
LIG_BRCT_BRCA1_1	11	15	PF00533	0.486
LIG_BRCT_BRCA1_1	288	292	PF00533	0.382
LIG_BRCT_BRCA1_1	504	508	PF00533	0.325
LIG_CSL_BTD_1	205	208	PF09270	0.357
LIG_CSL_BTD_1	296	299	PF09270	0.303
LIG_EH1_1	636	644	PF00400	0.509
LIG_EVH1_2	119	123	PF00568	0.361
LIG_FHA_1	119	125	PF00498	0.296
LIG_FHA_1	2	8	PF00498	0.654
LIG_FHA_1	23	29	PF00498	0.438
LIG_FHA_1	279	285	PF00498	0.450
LIG_FHA_1	362	368	PF00498	0.432
LIG_FHA_1	417	423	PF00498	0.400
LIG_FHA_1	560	566	PF00498	0.416
LIG_FHA_1	638	644	PF00498	0.430
LIG_FHA_1	646	652	PF00498	0.447
LIG_FHA_2	16	22	PF00498	0.638
LIG_FHA_2	345	351	PF00498	0.525
LIG_FHA_2	510	516	PF00498	0.446
LIG_FHA_2	569	575	PF00498	0.358
LIG_FHA_2	673	679	PF00498	0.541
LIG_LIR_Apic_2	253	257	PF02991	0.352
LIG_LIR_Apic_2	258	263	PF02991	0.388
LIG_LIR_Apic_2	384	388	PF02991	0.408
LIG_LIR_Apic_2	664	668	PF02991	0.388
LIG_LIR_Gen_1	121	131	PF02991	0.284
LIG_LIR_Gen_1	144	153	PF02991	0.473
LIG_LIR_Gen_1	202	212	PF02991	0.339
LIG_LIR_Gen_1	246	254	PF02991	0.321
LIG_LIR_Gen_1	32	41	PF02991	0.383
LIG_LIR_Gen_1	459	467	PF02991	0.457
LIG_LIR_LC3C_4	640	644	PF02991	0.517
LIG_LIR_Nem_3	121	126	PF02991	0.400
LIG_LIR_Nem_3	144	150	PF02991	0.476
LIG_LIR_Nem_3	202	207	PF02991	0.353
LIG_LIR_Nem_3	246	250	PF02991	0.318
LIG_LIR_Nem_3	430	435	PF02991	0.275
LIG_LIR_Nem_3	621	626	PF02991	0.375
LIG_NRBOX	15	21	PF00104	0.409
LIG_NRP_CendR_1	690	693	PF00754	0.630
LIG_PALB2_WD40_1	118	126	PF16756	0.364
LIG_PCNA_PIPBox_1	93	102	PF02747	0.418
LIG_Pex14_2	256	260	PF04695	0.468
LIG_Pex14_2	432	436	PF04695	0.294
LIG_Pex14_2	461	465	PF04695	0.359
LIG_Pex14_2	500	504	PF04695	0.338
LIG_PTB_Apo_2	564	571	PF02174	0.371
LIG_PTB_Phospho_1	564	570	PF10480	0.371
LIG_SH2_NCK_1	385	389	PF00017	0.409
LIG_SH2_PTP2	204	207	PF00017	0.456
LIG_SH2_SRC	366	369	PF00017	0.516
LIG_SH2_SRC	385	388	PF00017	0.253
LIG_SH2_SRC	47	50	PF00017	0.419
LIG_SH2_STAP1	663	667	PF00017	0.390
LIG_SH2_STAT3	374	377	PF00017	0.492
LIG_SH2_STAT3	522	525	PF00017	0.313
LIG_SH2_STAT3	570	573	PF00017	0.429
LIG_SH2_STAT5	131	134	PF00017	0.543
LIG_SH2_STAT5	204	207	PF00017	0.388
LIG_SH2_STAT5	230	233	PF00017	0.453
LIG_SH2_STAT5	247	250	PF00017	0.349
LIG_SH2_STAT5	254	257	PF00017	0.363
LIG_SH2_STAT5	366	369	PF00017	0.523
LIG_SH2_STAT5	522	525	PF00017	0.364
LIG_SH2_STAT5	570	573	PF00017	0.394
LIG_SH2_STAT5	582	585	PF00017	0.386
LIG_SH3_1	452	458	PF00018	0.347
LIG_SH3_2	83	88	PF14604	0.432
LIG_SH3_3	172	178	PF00018	0.584
LIG_SH3_3	202	208	PF00018	0.472
LIG_SH3_3	274	280	PF00018	0.488
LIG_SH3_3	287	293	PF00018	0.397
LIG_SH3_3	296	302	PF00018	0.419
LIG_SH3_3	43	49	PF00018	0.472
LIG_SH3_3	448	454	PF00018	0.322
LIG_SH3_3	479	485	PF00018	0.323
LIG_SH3_3	80	86	PF00018	0.504
LIG_SUMO_SIM_par_1	210	216	PF11976	0.442
LIG_SUMO_SIM_par_1	24	32	PF11976	0.499
LIG_TRAF2_1	158	161	PF00917	0.419
LIG_TRAF2_1	347	350	PF00917	0.554
LIG_TRAF2_1	571	574	PF00917	0.414
LIG_TRFH_1	395	399	PF08558	0.447
LIG_UBA3_1	431	438	PF00899	0.295
LIG_WRC_WIRS_1	311	316	PF05994	0.464
LIG_WW_2	179	182	PF00397	0.506
MOD_CDK_SPK_2	54	59	PF00069	0.518
MOD_CK1_1	14	20	PF00069	0.549
MOD_CK1_1	168	174	PF00069	0.566
MOD_CK1_1	187	193	PF00069	0.688
MOD_CK1_1	265	271	PF00069	0.368
MOD_CK1_1	278	284	PF00069	0.351
MOD_CK2_1	15	21	PF00069	0.468
MOD_CK2_1	344	350	PF00069	0.494
MOD_CK2_1	568	574	PF00069	0.363
MOD_GlcNHglycan	11	14	PF01048	0.566
MOD_GlcNHglycan	135	138	PF01048	0.452
MOD_GlcNHglycan	167	170	PF01048	0.691
MOD_GlcNHglycan	186	189	PF01048	0.652
MOD_GlcNHglycan	447	450	PF01048	0.344
MOD_GlcNHglycan	602	605	PF01048	0.336
MOD_GlcNHglycan	74	77	PF01048	0.665
MOD_GSK3_1	11	18	PF00069	0.577
MOD_GSK3_1	183	190	PF00069	0.729
MOD_GSK3_1	224	231	PF00069	0.347
MOD_GSK3_1	24	31	PF00069	0.524
MOD_GSK3_1	261	268	PF00069	0.380
MOD_GSK3_1	441	448	PF00069	0.434
MOD_GSK3_1	503	510	PF00069	0.366
MOD_GSK3_1	668	675	PF00069	0.488
MOD_LATS_1	406	412	PF00433	0.455
MOD_N-GLC_2	489	491	PF02516	0.342
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	15	20	PF00069	0.447
MOD_NEK2_1	250	255	PF00069	0.375
MOD_NEK2_1	28	33	PF00069	0.565
MOD_NEK2_1	402	407	PF00069	0.358
MOD_NEK2_2	516	521	PF00069	0.426
MOD_PIKK_1	265	271	PF00454	0.442
MOD_PIKK_1	345	351	PF00454	0.577
MOD_PIKK_1	465	471	PF00454	0.387
MOD_PKA_1	141	147	PF00069	0.496
MOD_PKA_1	645	651	PF00069	0.383
MOD_PKA_1	672	678	PF00069	0.537
MOD_PKA_2	141	147	PF00069	0.466
MOD_PKA_2	480	486	PF00069	0.395
MOD_PKA_2	645	651	PF00069	0.383
MOD_PKA_2	672	678	PF00069	0.537
MOD_Plk_1	195	201	PF00069	0.510
MOD_Plk_2-3	678	684	PF00069	0.485
MOD_Plk_4	11	17	PF00069	0.481
MOD_Plk_4	118	124	PF00069	0.417
MOD_Plk_4	427	433	PF00069	0.319
MOD_Plk_4	516	522	PF00069	0.417
MOD_ProDKin_1	278	284	PF00069	0.407
MOD_ProDKin_1	286	292	PF00069	0.392
MOD_ProDKin_1	361	367	PF00069	0.469
MOD_ProDKin_1	416	422	PF00069	0.440
MOD_ProDKin_1	509	515	PF00069	0.453
MOD_ProDKin_1	54	60	PF00069	0.675
MOD_SUMO_rev_2	444	454	PF00179	0.324
MOD_SUMO_rev_2	70	76	PF00179	0.698
TRG_DiLeu_BaEn_2	458	464	PF01217	0.382
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.444
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.370
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.410
TRG_DiLeu_BaLyEn_6	687	692	PF01217	0.590
TRG_ENDOCYTIC_2	204	207	PF00928	0.382
TRG_ENDOCYTIC_2	247	250	PF00928	0.327
TRG_ENDOCYTIC_2	333	336	PF00928	0.510
TRG_ENDOCYTIC_2	35	38	PF00928	0.359
TRG_ENDOCYTIC_2	521	524	PF00928	0.477
TRG_ER_diArg_1	498	500	PF00400	0.319
TRG_ER_diArg_1	539	542	PF00400	0.365
TRG_ER_diArg_1	623	625	PF00400	0.477
TRG_NES_CRM1_1	442	457	PF08389	0.335
TRG_NLS_MonoExtC_3	644	649	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN6	Leptomonas seymouri	76%	99%
A0A0S4ISW7	Bodo saltans	49%	93%
A0A1X0NY35	Trypanosomatidae	59%	99%
A0A3Q8IBV8	Leishmania donovani	96%	82%
A0A3Q8IE69	Leishmania donovani	27%	100%
A0A3R7MZ34	Trypanosoma rangeli	60%	100%
A4HAI4	Leishmania braziliensis	26%	100%
A4HD07	Leishmania braziliensis	90%	89%
A4I0J3	Leishmania infantum	96%	82%
C9ZN08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AHS5	Leishmania infantum	27%	100%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B4P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q3D1	Leishmania major	27%	100%
V5BEM5	Trypanosoma cruzi	54%	100%