Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3b, putative

Species:

Leishmania major

UniProt:

Q4QB17_LEIMA

TriTrypDb:

LmjF.23.1350 , LMJLV39_230023600 , LMJSD75_230024000

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0005819	spindle	5	2
GO:0032991	protein-containing complex	1	3
GO:0033588	elongator holoenzyme complex	3	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:0016020	membrane	2	1
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

Q4QB17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB17

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	3
GO:0002098	tRNA wobble uridine modification	8	3
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006399	tRNA metabolic process	7	3
GO:0006400	tRNA modification	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008033	tRNA processing	8	3
GO:0008152	metabolic process	1	3
GO:0009451	RNA modification	5	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0034470	ncRNA processing	7	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034660	ncRNA metabolic process	6	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	1
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051276	chromosome organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051539	4 iron, 4 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0097159	organic cyclic compound binding	2	23
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	12
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.499
CLV_NRD_NRD_1	120	122	PF00675	0.432
CLV_NRD_NRD_1	161	163	PF00675	0.430
CLV_NRD_NRD_1	190	192	PF00675	0.429
CLV_NRD_NRD_1	344	346	PF00675	0.240
CLV_NRD_NRD_1	644	646	PF00675	0.279
CLV_PCSK_KEX2_1	120	122	PF00082	0.429
CLV_PCSK_KEX2_1	13	15	PF00082	0.683
CLV_PCSK_KEX2_1	344	346	PF00082	0.233
CLV_PCSK_KEX2_1	496	498	PF00082	0.228
CLV_PCSK_KEX2_1	644	646	PF00082	0.287
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.683
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.293
CLV_PCSK_SKI1_1	121	125	PF00082	0.417
CLV_PCSK_SKI1_1	625	629	PF00082	0.398
CLV_PCSK_SKI1_1	694	698	PF00082	0.617
DEG_APCC_DBOX_1	475	483	PF00400	0.428
DEG_APCC_DBOX_1	496	504	PF00400	0.428
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.449
DOC_MAPK_gen_1	191	202	PF00069	0.403
DOC_MAPK_gen_1	341	351	PF00069	0.481
DOC_MAPK_gen_1	628	637	PF00069	0.405
DOC_MAPK_HePTP_8	189	205	PF00069	0.386
DOC_PIKK_1	98	106	PF02985	0.462
DOC_PP2B_LxvP_1	25	28	PF13499	0.496
DOC_PP4_FxxP_1	206	209	PF00568	0.305
DOC_PP4_FxxP_1	21	24	PF00568	0.474
DOC_PP4_FxxP_1	212	215	PF00568	0.359
DOC_USP7_MATH_1	136	140	PF00917	0.515
DOC_USP7_MATH_1	161	165	PF00917	0.407
DOC_USP7_MATH_1	308	312	PF00917	0.442
DOC_USP7_MATH_1	401	405	PF00917	0.441
DOC_USP7_MATH_1	685	689	PF00917	0.621
DOC_WW_Pin1_4	20	25	PF00397	0.533
LIG_14-3-3_CanoR_1	162	170	PF00244	0.430
LIG_14-3-3_CanoR_1	307	313	PF00244	0.453
LIG_14-3-3_CanoR_1	344	350	PF00244	0.453
LIG_14-3-3_CanoR_1	541	549	PF00244	0.263
LIG_AP2alpha_1	536	540	PF02296	0.290
LIG_BIR_II_1	1	5	PF00653	0.774
LIG_EH1_1	460	468	PF00400	0.493
LIG_eIF4E_1	461	467	PF01652	0.461
LIG_EVH1_1	25	29	PF00568	0.495
LIG_FHA_1	431	437	PF00498	0.428
LIG_FHA_1	486	492	PF00498	0.439
LIG_FHA_1	608	614	PF00498	0.344
LIG_FHA_1	655	661	PF00498	0.335
LIG_FHA_2	297	303	PF00498	0.433
LIG_FHA_2	315	321	PF00498	0.423
LIG_FHA_2	331	337	PF00498	0.432
LIG_FHA_2	604	610	PF00498	0.313
LIG_LIR_Apic_2	18	24	PF02991	0.473
LIG_LIR_Apic_2	204	209	PF02991	0.283
LIG_LIR_Apic_2	211	215	PF02991	0.378
LIG_LIR_Apic_2	93	97	PF02991	0.484
LIG_LIR_Gen_1	111	119	PF02991	0.537
LIG_LIR_Gen_1	410	418	PF02991	0.310
LIG_LIR_Gen_1	435	446	PF02991	0.428
LIG_LIR_Gen_1	546	556	PF02991	0.295
LIG_LIR_Gen_1	629	639	PF02991	0.311
LIG_LIR_Gen_1	684	693	PF02991	0.454
LIG_LIR_Gen_1	86	94	PF02991	0.494
LIG_LIR_LC3C_4	198	203	PF02991	0.384
LIG_LIR_Nem_3	111	116	PF02991	0.470
LIG_LIR_Nem_3	167	173	PF02991	0.392
LIG_LIR_Nem_3	277	281	PF02991	0.430
LIG_LIR_Nem_3	410	415	PF02991	0.316
LIG_LIR_Nem_3	426	431	PF02991	0.441
LIG_LIR_Nem_3	435	441	PF02991	0.428
LIG_LIR_Nem_3	546	552	PF02991	0.279
LIG_LIR_Nem_3	558	564	PF02991	0.261
LIG_LIR_Nem_3	594	598	PF02991	0.329
LIG_LIR_Nem_3	684	689	PF02991	0.639
LIG_LIR_Nem_3	695	699	PF02991	0.650
LIG_LIR_Nem_3	86	90	PF02991	0.479
LIG_PCNA_yPIPBox_3	175	189	PF02747	0.431
LIG_Pex14_2	242	246	PF04695	0.522
LIG_Pex14_2	412	416	PF04695	0.335
LIG_Pex14_2	536	540	PF04695	0.274
LIG_PTB_Apo_2	455	462	PF02174	0.545
LIG_PTB_Phospho_1	455	461	PF10480	0.545
LIG_SH2_CRK	170	174	PF00017	0.388
LIG_SH2_CRK	595	599	PF00017	0.290
LIG_SH2_CRK	647	651	PF00017	0.299
LIG_SH2_NCK_1	253	257	PF00017	0.439
LIG_SH2_NCK_1	301	305	PF00017	0.441
LIG_SH2_NCK_1	94	98	PF00017	0.440
LIG_SH2_STAP1	285	289	PF00017	0.453
LIG_SH2_STAP1	686	690	PF00017	0.457
LIG_SH2_STAT5	220	223	PF00017	0.428
LIG_SH2_STAT5	231	234	PF00017	0.428
LIG_SH2_STAT5	337	340	PF00017	0.439
LIG_SH2_STAT5	468	471	PF00017	0.432
LIG_SH2_STAT5	490	493	PF00017	0.432
LIG_SH2_STAT5	549	552	PF00017	0.268
LIG_SH3_2	305	310	PF14604	0.493
LIG_SH3_3	219	225	PF00018	0.428
LIG_SH3_3	23	29	PF00018	0.515
LIG_SH3_3	30	36	PF00018	0.491
LIG_SH3_3	302	308	PF00018	0.452
LIG_SH3_3	395	401	PF00018	0.428
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.355
LIG_SUMO_SIM_anti_2	267	273	PF11976	0.428
LIG_SUMO_SIM_par_1	198	204	PF11976	0.355
LIG_SUMO_SIM_par_1	597	602	PF11976	0.274
LIG_TRAF2_1	573	576	PF00917	0.361
LIG_WRC_WIRS_1	686	691	PF05994	0.597
LIG_WRC_WIRS_1	693	698	PF05994	0.549
LIG_WRPW_2	450	453	PF00400	0.274
MOD_CK1_1	127	133	PF00069	0.483
MOD_CK1_1	164	170	PF00069	0.406
MOD_CK1_1	543	549	PF00069	0.297
MOD_CK1_1	64	70	PF00069	0.719
MOD_CK1_1	668	674	PF00069	0.549
MOD_CK1_1	684	690	PF00069	0.345
MOD_CK1_1	86	92	PF00069	0.493
MOD_CK2_1	136	142	PF00069	0.564
MOD_CK2_1	254	260	PF00069	0.307
MOD_CK2_1	308	314	PF00069	0.263
MOD_CK2_1	336	342	PF00069	0.327
MOD_CK2_1	400	406	PF00069	0.304
MOD_CK2_1	570	576	PF00069	0.335
MOD_CK2_1	603	609	PF00069	0.298
MOD_CK2_1	69	75	PF00069	0.543
MOD_GlcNHglycan	139	142	PF01048	0.556
MOD_GlcNHglycan	197	200	PF01048	0.396
MOD_GlcNHglycan	256	259	PF01048	0.290
MOD_GlcNHglycan	302	305	PF01048	0.316
MOD_GlcNHglycan	338	341	PF01048	0.267
MOD_GlcNHglycan	416	419	PF01048	0.508
MOD_GlcNHglycan	44	47	PF01048	0.543
MOD_GlcNHglycan	55	58	PF01048	0.749
MOD_GlcNHglycan	667	670	PF01048	0.541
MOD_GlcNHglycan	682	686	PF01048	0.496
MOD_GlcNHglycan	71	74	PF01048	0.455
MOD_GSK3_1	157	164	PF00069	0.452
MOD_GSK3_1	296	303	PF00069	0.279
MOD_GSK3_1	345	352	PF00069	0.301
MOD_GSK3_1	432	439	PF00069	0.279
MOD_GSK3_1	530	537	PF00069	0.227
MOD_GSK3_1	570	577	PF00069	0.368
MOD_GSK3_1	599	606	PF00069	0.275
MOD_GSK3_1	61	68	PF00069	0.653
MOD_GSK3_1	681	688	PF00069	0.544
MOD_N-GLC_1	419	424	PF02516	0.436
MOD_NEK2_1	124	129	PF00069	0.430
MOD_NEK2_1	157	162	PF00069	0.502
MOD_NEK2_1	201	206	PF00069	0.325
MOD_NEK2_1	274	279	PF00069	0.279
MOD_NEK2_1	290	295	PF00069	0.292
MOD_NEK2_1	349	354	PF00069	0.282
MOD_NEK2_1	411	416	PF00069	0.463
MOD_NEK2_1	53	58	PF00069	0.724
MOD_NEK2_1	654	659	PF00069	0.348
MOD_NEK2_1	689	694	PF00069	0.585
MOD_NEK2_1	69	74	PF00069	0.474
MOD_NEK2_2	276	281	PF00069	0.274
MOD_PIKK_1	247	253	PF00454	0.290
MOD_PIKK_1	555	561	PF00454	0.406
MOD_PIKK_1	599	605	PF00454	0.390
MOD_PIKK_1	607	613	PF00454	0.239
MOD_PIKK_1	614	620	PF00454	0.193
MOD_PK_1	61	67	PF00069	0.549
MOD_PKA_2	161	167	PF00069	0.431
MOD_PKA_2	254	260	PF00069	0.290
MOD_PKA_2	540	546	PF00069	0.271
MOD_PKA_2	607	613	PF00069	0.451
MOD_Plk_1	314	320	PF00069	0.277
MOD_Plk_1	419	425	PF00069	0.432
MOD_Plk_1	555	561	PF00069	0.338
MOD_Plk_1	61	67	PF00069	0.479
MOD_Plk_1	654	660	PF00069	0.356
MOD_Plk_1	681	687	PF00069	0.646
MOD_Plk_2-3	314	320	PF00069	0.309
MOD_Plk_4	201	207	PF00069	0.344
MOD_Plk_4	290	296	PF00069	0.265
MOD_Plk_4	375	381	PF00069	0.344
MOD_Plk_4	411	417	PF00069	0.448
MOD_Plk_4	486	492	PF00069	0.274
MOD_Plk_4	654	660	PF00069	0.341
MOD_Plk_4	685	691	PF00069	0.574
MOD_Plk_4	692	698	PF00069	0.540
MOD_Plk_4	86	92	PF00069	0.523
MOD_ProDKin_1	20	26	PF00069	0.531
MOD_SUMO_rev_2	93	103	PF00179	0.499
TRG_DiLeu_BaEn_4	575	581	PF01217	0.262
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.518
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.261
TRG_ENDOCYTIC_2	170	173	PF00928	0.376
TRG_ENDOCYTIC_2	453	456	PF00928	0.377
TRG_ENDOCYTIC_2	549	552	PF00928	0.253
TRG_ENDOCYTIC_2	561	564	PF00928	0.241
TRG_ENDOCYTIC_2	595	598	PF00928	0.274
TRG_ENDOCYTIC_2	632	635	PF00928	0.315
TRG_ENDOCYTIC_2	647	650	PF00928	0.228
TRG_ENDOCYTIC_2	686	689	PF00928	0.638
TRG_ER_diArg_1	12	15	PF00400	0.689
TRG_ER_diArg_1	323	326	PF00400	0.274
TRG_ER_diArg_1	343	345	PF00400	0.290
TRG_ER_diArg_1	475	478	PF00400	0.239
TRG_ER_diArg_1	508	511	PF00400	0.428
TRG_ER_diArg_1	564	567	PF00400	0.274
TRG_ER_diArg_1	643	645	PF00400	0.259
TRG_ER_FFAT_2	332	342	PF00635	0.262
TRG_NES_CRM1_1	342	355	PF08389	0.299
TRG_NLS_MonoExtC_3	11	16	PF00514	0.516
TRG_NLS_MonoExtC_3	190	195	PF00514	0.430
TRG_NLS_MonoExtN_4	12	17	PF00514	0.510
TRG_NLS_MonoExtN_4	191	196	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	87%	100%
A0A0N1PFU7	Leptomonas seymouri	45%	94%
A0A0S4IQT9	Bodo saltans	69%	100%
A0A0S4KPU1	Bodo saltans	45%	100%
A0A1X0NG94	Trypanosomatidae	41%	96%
A0A1X0NX69	Trypanosomatidae	75%	100%
A0A3Q8ICG0	Leishmania donovani	46%	93%
A0A3R7KUY9	Trypanosoma rangeli	74%	100%
A0A3S7WXV4	Leishmania donovani	96%	99%
A0A422NDG5	Trypanosoma rangeli	41%	94%
A4H8F0	Leishmania braziliensis	44%	93%
A4HD08	Leishmania braziliensis	94%	100%
A4HWS3	Leishmania infantum	46%	93%
A4I0J4	Leishmania infantum	96%	99%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	36%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q02908	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q1ZXC6	Dictyostelium discoideum	34%	100%
Q23651	Caenorhabditis elegans	34%	100%
Q2KJ61	Bos taurus	34%	100%
Q4QEZ6	Leishmania major	45%	92%
Q58536	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
Q5HZM6	Xenopus laevis	33%	100%
Q5RIC0	Danio rerio	33%	100%
Q5ZHS1	Gallus gallus	33%	100%
Q60LW7	Caenorhabditis briggsae	34%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q7X7L3	Oryza sativa subsp. japonica	35%	100%
Q93ZR1	Arabidopsis thaliana	34%	100%
Q9CZX0	Mus musculus	32%	100%
Q9H9T3	Homo sapiens	32%	100%
Q9VQZ6	Drosophila melanogaster	33%	100%
V5B5L2	Trypanosoma cruzi	42%	100%
V5BNQ5	Trypanosoma cruzi	76%	100%