Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB16_LEIMA

TriTrypDb:

LmjF.23.1360 , LMJLV39_230023700 , LMJSD75_230024100

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QB16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.356
CLV_NRD_NRD_1	147	149	PF00675	0.648
CLV_NRD_NRD_1	186	188	PF00675	0.617
CLV_NRD_NRD_1	233	235	PF00675	0.384
CLV_NRD_NRD_1	3	5	PF00675	0.488
CLV_NRD_NRD_1	99	101	PF00675	0.649
CLV_PCSK_KEX2_1	3	5	PF00082	0.488
CLV_PCSK_KEX2_1	99	101	PF00082	0.672
CLV_PCSK_SKI1_1	187	191	PF00082	0.666
CLV_PCSK_SKI1_1	235	239	PF00082	0.414
CLV_PCSK_SKI1_1	288	292	PF00082	0.490
CLV_PCSK_SKI1_1	364	368	PF00082	0.536
CLV_Separin_Metazoa	134	138	PF03568	0.310
DEG_SPOP_SBC_1	10	14	PF00917	0.460
DOC_CKS1_1	274	279	PF01111	0.665
DOC_MAPK_gen_1	335	343	PF00069	0.655
DOC_MAPK_MEF2A_6	337	345	PF00069	0.718
DOC_PP1_RVXF_1	367	373	PF00149	0.728
DOC_PP4_FxxP_1	257	260	PF00568	0.640
DOC_PP4_FxxP_1	274	277	PF00568	0.632
DOC_PP4_FxxP_1	33	36	PF00568	0.535
DOC_USP7_MATH_1	10	14	PF00917	0.465
DOC_USP7_MATH_1	302	306	PF00917	0.695
DOC_USP7_MATH_1	336	340	PF00917	0.685
DOC_USP7_MATH_1	355	359	PF00917	0.562
DOC_USP7_UBL2_3	122	126	PF12436	0.398
DOC_WW_Pin1_4	102	107	PF00397	0.488
DOC_WW_Pin1_4	273	278	PF00397	0.608
LIG_14-3-3_CanoR_1	137	147	PF00244	0.400
LIG_14-3-3_CanoR_1	3	8	PF00244	0.690
LIG_14-3-3_CanoR_1	340	344	PF00244	0.756
LIG_14-3-3_CanoR_1	42	47	PF00244	0.493
LIG_14-3-3_CanoR_1	57	63	PF00244	0.520
LIG_APCC_ABBA_1	317	322	PF00400	0.666
LIG_FHA_1	12	18	PF00498	0.390
LIG_FHA_1	164	170	PF00498	0.421
LIG_FHA_1	294	300	PF00498	0.617
LIG_FHA_1	398	404	PF00498	0.707
LIG_FHA_2	139	145	PF00498	0.438
LIG_FHA_2	236	242	PF00498	0.577
LIG_FHA_2	276	282	PF00498	0.608
LIG_FHA_2	363	369	PF00498	0.717
LIG_FHA_2	47	53	PF00498	0.488
LIG_Integrin_isoDGR_2	286	288	PF01839	0.446
LIG_LIR_Apic_2	256	260	PF02991	0.697
LIG_LIR_Apic_2	271	277	PF02991	0.702
LIG_LIR_Apic_2	31	36	PF02991	0.544
LIG_LIR_Gen_1	107	115	PF02991	0.493
LIG_LIR_Gen_1	365	375	PF02991	0.653
LIG_LIR_Gen_1	83	94	PF02991	0.450
LIG_LIR_Nem_3	107	112	PF02991	0.504
LIG_LIR_Nem_3	365	370	PF02991	0.660
LIG_LIR_Nem_3	371	375	PF02991	0.598
LIG_LIR_Nem_3	83	89	PF02991	0.390
LIG_NBox_RRM_1	216	226	PF00076	0.449
LIG_Pex14_2	253	257	PF04695	0.673
LIG_SH2_GRB2like	273	276	PF00017	0.703
LIG_SH2_SRC	172	175	PF00017	0.356
LIG_SH2_STAP1	232	236	PF00017	0.646
LIG_SH2_STAP1	289	293	PF00017	0.625
LIG_SH2_STAT3	289	292	PF00017	0.714
LIG_SH2_STAT3	308	311	PF00017	0.488
LIG_SH2_STAT5	172	175	PF00017	0.356
LIG_SH2_STAT5	178	181	PF00017	0.417
LIG_SH2_STAT5	236	239	PF00017	0.623
LIG_SH2_STAT5	252	255	PF00017	0.589
LIG_SH2_STAT5	273	276	PF00017	0.645
LIG_SH2_STAT5	344	347	PF00017	0.723
LIG_SH3_3	24	30	PF00018	0.581
LIG_SH3_3	340	346	PF00018	0.730
LIG_SH3_3	4	10	PF00018	0.556
LIG_SH3_5	265	269	PF00018	0.625
LIG_TRAF2_1	157	160	PF00917	0.456
LIG_TRAF2_1	295	298	PF00917	0.665
LIG_TRAF2_1	307	310	PF00917	0.621
LIG_TRAF2_1	371	374	PF00917	0.662
LIG_TRAF2_2	355	360	PF00917	0.629
LIG_UBA3_1	55	63	PF00899	0.524
LIG_WRC_WIRS_1	254	259	PF05994	0.684
LIG_WRC_WIRS_1	86	91	PF05994	0.441
MOD_CK1_1	244	250	PF00069	0.496
MOD_CK1_1	28	34	PF00069	0.508
MOD_CK1_1	339	345	PF00069	0.756
MOD_CK1_1	358	364	PF00069	0.718
MOD_CK1_1	397	403	PF00069	0.699
MOD_CK2_1	138	144	PF00069	0.376
MOD_CK2_1	275	281	PF00069	0.667
MOD_CK2_1	292	298	PF00069	0.585
MOD_CK2_1	362	368	PF00069	0.735
MOD_CK2_1	395	401	PF00069	0.719
MOD_GlcNHglycan	303	307	PF01048	0.456
MOD_GlcNHglycan	33	36	PF01048	0.775
MOD_GlcNHglycan	411	414	PF01048	0.544
MOD_GlcNHglycan	73	76	PF01048	0.735
MOD_GSK3_1	237	244	PF00069	0.645
MOD_GSK3_1	25	32	PF00069	0.545
MOD_GSK3_1	355	362	PF00069	0.748
MOD_GSK3_1	374	381	PF00069	0.704
MOD_GSK3_1	390	397	PF00069	0.708
MOD_GSK3_1	42	49	PF00069	0.489
MOD_GSK3_1	66	73	PF00069	0.546
MOD_N-GLC_1	208	213	PF02516	0.650
MOD_NEK2_1	11	16	PF00069	0.400
MOD_NEK2_1	138	143	PF00069	0.476
MOD_NEK2_1	17	22	PF00069	0.355
MOD_NEK2_1	173	178	PF00069	0.470
MOD_NEK2_1	253	258	PF00069	0.621
MOD_NEK2_1	378	383	PF00069	0.609
MOD_NEK2_1	46	51	PF00069	0.477
MOD_NEK2_1	58	63	PF00069	0.535
MOD_PK_1	3	9	PF00069	0.604
MOD_PK_1	324	330	PF00069	0.615
MOD_PKA_1	100	106	PF00069	0.510
MOD_PKA_1	3	9	PF00069	0.737
MOD_PKA_2	136	142	PF00069	0.450
MOD_PKA_2	3	9	PF00069	0.725
MOD_PKA_2	336	342	PF00069	0.639
MOD_PKA_2	358	364	PF00069	0.782
MOD_PKA_2	390	396	PF00069	0.645
MOD_PKB_1	206	214	PF00069	0.453
MOD_PKB_1	407	415	PF00069	0.684
MOD_Plk_1	173	179	PF00069	0.391
MOD_Plk_1	208	214	PF00069	0.359
MOD_Plk_1	324	330	PF00069	0.698
MOD_Plk_1	362	368	PF00069	0.694
MOD_Plk_1	373	379	PF00069	0.553
MOD_Plk_1	51	57	PF00069	0.518
MOD_Plk_2-3	368	374	PF00069	0.703
MOD_Plk_4	173	179	PF00069	0.443
MOD_Plk_4	208	214	PF00069	0.331
MOD_Plk_4	253	259	PF00069	0.661
MOD_Plk_4	3	9	PF00069	0.747
MOD_Plk_4	339	345	PF00069	0.732
MOD_Plk_4	374	380	PF00069	0.641
MOD_Plk_4	51	57	PF00069	0.493
MOD_Plk_4	85	91	PF00069	0.442
MOD_ProDKin_1	102	108	PF00069	0.485
MOD_ProDKin_1	273	279	PF00069	0.608
MOD_SUMO_for_1	130	133	PF00179	0.460
MOD_SUMO_rev_2	114	124	PF00179	0.430
MOD_SUMO_rev_2	327	336	PF00179	0.669
TRG_DiLeu_BaEn_4	133	139	PF01217	0.458
TRG_DiLeu_BaEn_4	312	318	PF01217	0.595
TRG_ENDOCYTIC_2	186	189	PF00928	0.457
TRG_ENDOCYTIC_2	252	255	PF00928	0.589
TRG_ER_diArg_1	98	100	PF00400	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S8	Leptomonas seymouri	65%	98%
A0A0S4IRC9	Bodo saltans	35%	100%
A0A1X0NWQ4	Trypanosomatidae	45%	97%
A0A3Q8IMB7	Leishmania donovani	94%	100%
A0A422NXY7	Trypanosoma rangeli	44%	100%
A4HD09	Leishmania braziliensis	77%	100%
A4I0J5	Leishmania infantum	94%	100%
C9ZVC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AWF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BJ93	Trypanosoma cruzi	43%	99%