Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania major

UniProt:

Q4QB15_LEIMA

TriTrypDb:

LmjF.23.1370 , LMJLV39_230023900 , LMJSD75_230024300

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	3
GO:0016020	membrane	2	13
GO:0019866	organelle inner membrane	4	3
GO:0031090	organelle membrane	3	3
GO:0031966	mitochondrial membrane	4	3
GO:0110165	cellular anatomical entity	1	13
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QB15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB15

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	3
GO:0005215	transporter activity	1	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015101	organic cation transmembrane transporter activity	5	3
GO:0022857	transmembrane transporter activity	2	3
GO:1901682	sulfur compound transmembrane transporter activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.586
CLV_NRD_NRD_1	387	389	PF00675	0.480
CLV_PCSK_KEX2_1	179	181	PF00082	0.438
CLV_PCSK_KEX2_1	387	389	PF00082	0.540
CLV_PCSK_SKI1_1	144	148	PF00082	0.256
CLV_PCSK_SKI1_1	302	306	PF00082	0.279
CLV_PCSK_SKI1_1	38	42	PF00082	0.543
CLV_PCSK_SKI1_1	382	386	PF00082	0.314
CLV_PCSK_SKI1_1	76	80	PF00082	0.239
DEG_APCC_DBOX_1	117	125	PF00400	0.281
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DEG_SPOP_SBC_1	395	399	PF00917	0.491
DOC_CYCLIN_RxL_1	73	83	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.179
DOC_MIT_MIM_1	83	92	PF04212	0.179
DOC_PP1_RVXF_1	361	367	PF00149	0.287
DOC_PP2B_LxvP_1	147	150	PF13499	0.179
DOC_PP2B_LxvP_1	202	205	PF13499	0.314
DOC_PP2B_LxvP_1	239	242	PF13499	0.372
DOC_PP2B_LxvP_1	317	320	PF13499	0.372
DOC_PP2B_LxvP_1	97	100	PF13499	0.179
DOC_USP7_MATH_1	216	220	PF00917	0.301
DOC_USP7_MATH_1	395	399	PF00917	0.606
DOC_USP7_MATH_1	65	69	PF00917	0.221
DOC_WW_Pin1_4	22	27	PF00397	0.794
DOC_WW_Pin1_4	6	11	PF00397	0.723
LIG_BIR_III_4	175	179	PF00653	0.469
LIG_BRCT_BRCA1_1	157	161	PF00533	0.248
LIG_BRCT_BRCA1_1	190	194	PF00533	0.248
LIG_BRCT_BRCA1_1	305	309	PF00533	0.310
LIG_DLG_GKlike_1	358	365	PF00625	0.179
LIG_FHA_1	316	322	PF00498	0.309
LIG_FHA_1	324	330	PF00498	0.312
LIG_FHA_1	92	98	PF00498	0.180
LIG_FHA_2	330	336	PF00498	0.339
LIG_FHA_2	337	343	PF00498	0.294
LIG_LIR_Apic_2	55	61	PF02991	0.479
LIG_LIR_Gen_1	191	202	PF02991	0.179
LIG_LIR_Gen_1	248	259	PF02991	0.340
LIG_LIR_Nem_3	191	197	PF02991	0.179
LIG_LIR_Nem_3	248	254	PF02991	0.310
LIG_LIR_Nem_3	290	296	PF02991	0.473
LIG_LIR_Nem_3	306	312	PF02991	0.257
LIG_Pex14_1	229	233	PF04695	0.243
LIG_SH2_CRK	138	142	PF00017	0.287
LIG_SH2_CRK	251	255	PF00017	0.304
LIG_SH2_GRB2like	58	61	PF00017	0.416
LIG_SH2_NCK_1	251	255	PF00017	0.279
LIG_SH2_NCK_1	58	62	PF00017	0.554
LIG_SH2_SRC	126	129	PF00017	0.277
LIG_SH2_SRC	13	16	PF00017	0.579
LIG_SH2_SRC	58	61	PF00017	0.558
LIG_SH2_STAT3	128	131	PF00017	0.363
LIG_SH2_STAT5	13	16	PF00017	0.579
LIG_SH2_STAT5	148	151	PF00017	0.341
LIG_SH2_STAT5	155	158	PF00017	0.341
LIG_SH2_STAT5	184	187	PF00017	0.381
LIG_SH2_STAT5	374	377	PF00017	0.256
LIG_TYR_ITIM	249	254	PF00017	0.269
LIG_TYR_ITIM	257	262	PF00017	0.232
LIG_UBA3_1	78	86	PF00899	0.236
MOD_CK1_1	107	113	PF00069	0.378
MOD_CK1_1	20	26	PF00069	0.783
MOD_CK1_1	291	297	PF00069	0.479
MOD_CK1_1	315	321	PF00069	0.239
MOD_CK1_1	69	75	PF00069	0.320
MOD_Cter_Amidation	177	180	PF01082	0.405
MOD_GlcNHglycan	190	193	PF01048	0.315
MOD_GlcNHglycan	198	201	PF01048	0.317
MOD_GlcNHglycan	214	217	PF01048	0.260
MOD_GlcNHglycan	218	221	PF01048	0.331
MOD_GlcNHglycan	285	288	PF01048	0.636
MOD_GlcNHglycan	305	308	PF01048	0.286
MOD_GlcNHglycan	309	312	PF01048	0.288
MOD_GSK3_1	106	113	PF00069	0.426
MOD_GSK3_1	151	158	PF00069	0.312
MOD_GSK3_1	16	23	PF00069	0.595
MOD_GSK3_1	2	9	PF00069	0.588
MOD_GSK3_1	212	219	PF00069	0.391
MOD_GSK3_1	283	290	PF00069	0.532
MOD_GSK3_1	303	310	PF00069	0.271
MOD_GSK3_1	61	68	PF00069	0.411
MOD_GSK3_1	70	77	PF00069	0.244
MOD_N-GLC_1	389	394	PF02516	0.509
MOD_NEK2_1	116	121	PF00069	0.381
MOD_NEK2_1	2	7	PF00069	0.550
MOD_NEK2_1	282	287	PF00069	0.626
MOD_NEK2_1	300	305	PF00069	0.245
MOD_NEK2_1	312	317	PF00069	0.287
MOD_NEK2_1	365	370	PF00069	0.307
MOD_NEK2_1	66	71	PF00069	0.276
MOD_NEK2_2	205	210	PF00069	0.279
MOD_NEK2_2	218	223	PF00069	0.279
MOD_NEK2_2	81	86	PF00069	0.306
MOD_OFUCOSY	102	108	PF10250	0.230
MOD_PIKK_1	263	269	PF00454	0.473
MOD_PKA_2	178	184	PF00069	0.568
MOD_Plk_1	61	67	PF00069	0.516
MOD_Plk_4	151	157	PF00069	0.281
MOD_Plk_4	241	247	PF00069	0.259
MOD_Plk_4	249	255	PF00069	0.301
MOD_Plk_4	288	294	PF00069	0.573
MOD_Plk_4	312	318	PF00069	0.358
MOD_Plk_4	74	80	PF00069	0.305
MOD_ProDKin_1	22	28	PF00069	0.795
MOD_ProDKin_1	6	12	PF00069	0.725
TRG_ENDOCYTIC_2	138	141	PF00928	0.287
TRG_ENDOCYTIC_2	251	254	PF00928	0.284
TRG_ENDOCYTIC_2	259	262	PF00928	0.291
TRG_ENDOCYTIC_2	374	377	PF00928	0.280
TRG_ER_diArg_1	117	120	PF00400	0.281
TRG_ER_diArg_1	324	327	PF00400	0.278
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX21	Leptomonas seymouri	57%	100%
A0A0N1I0W9	Leptomonas seymouri	24%	100%
A0A0N1I6I9	Leptomonas seymouri	24%	100%
A0A0S4KJX8	Bodo saltans	26%	100%
A0A1X0NWP7	Trypanosomatidae	44%	79%
A0A1X0P952	Trypanosomatidae	22%	100%
A0A3Q8IFM5	Leishmania donovani	25%	100%
A0A3R7M746	Trypanosoma rangeli	46%	100%
A0A3S7WXX9	Leishmania donovani	92%	100%
A4HD10	Leishmania braziliensis	72%	100%
A4HJZ1	Leishmania braziliensis	24%	100%
A4I0J6	Leishmania infantum	92%	100%
A4I7H4	Leishmania infantum	25%	100%
A4RF23	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
A6QR09	Bos taurus	23%	100%
A6ZV78	Saccharomyces cerevisiae (strain YJM789)	24%	100%
C9ZKK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AEE0	Leishmania major	22%	100%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
E9AWF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B2D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F4HT41	Arabidopsis thaliana	22%	100%
P0CAT2	Danio rerio	25%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53257	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q08CI8	Danio rerio	26%	100%
Q09461	Caenorhabditis elegans	21%	100%
Q4Q5S5	Leishmania major	26%	89%
Q54S10	Dictyostelium discoideum	21%	100%
Q641C8	Xenopus laevis	24%	100%
Q66H23	Rattus norvegicus	23%	100%
Q6GLA2	Xenopus tropicalis	24%	100%
Q70HW3	Homo sapiens	22%	100%
Q86AV5	Dictyostelium discoideum	23%	100%
Q920G8	Mus musculus	23%	100%
Q94AG6	Arabidopsis thaliana	23%	100%
Q9BZJ4	Homo sapiens	22%	100%
Q9H1K4	Homo sapiens	24%	100%
Q9NYZ2	Homo sapiens	23%	100%
Q9VBN7	Drosophila melanogaster	24%	100%
Q9VM51	Drosophila melanogaster	24%	100%
V5DFJ2	Trypanosoma cruzi	47%	100%