Putative DNA polymerase theta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase theta (helicase domain only), putative

Species:

Leishmania major

UniProt:

Q4QB14_LEIMA

TriTrypDb:

LmjF.23.1380 , LMJLV39_230024100 , LMJSD75_230024500

Length:

1881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	4
GO:0004386	helicase activity	2	4
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1145	1149	PF00656	0.417
CLV_C14_Caspase3-7	1588	1592	PF00656	0.405
CLV_C14_Caspase3-7	766	770	PF00656	0.492
CLV_MEL_PAP_1	519	525	PF00089	0.454
CLV_NRD_NRD_1	1022	1024	PF00675	0.316
CLV_NRD_NRD_1	125	127	PF00675	0.529
CLV_NRD_NRD_1	1277	1279	PF00675	0.342
CLV_NRD_NRD_1	1299	1301	PF00675	0.342
CLV_NRD_NRD_1	1701	1703	PF00675	0.444
CLV_NRD_NRD_1	1707	1709	PF00675	0.347

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXX8	Leishmania donovani	88%	100%
A4HD11	Leishmania braziliensis	67%	84%
A4I0J7	Leishmania infantum	88%	84%
E9AWF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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