Putative Ran-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ran-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QB12_LEIMA

TriTrypDb:

LmjF.23.1400 , LMJLV39_230024300 , LMJSD75_230024700

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB12

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	2

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0031267	small GTPase binding	5	2
GO:0051020	GTPase binding	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.330
CLV_PCSK_KEX2_1	181	183	PF00082	0.564
CLV_PCSK_KEX2_1	53	55	PF00082	0.330
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.525
CLV_PCSK_SKI1_1	178	182	PF00082	0.553
CLV_PCSK_SKI1_1	189	193	PF00082	0.315
CLV_Separin_Metazoa	50	54	PF03568	0.530
DEG_SCF_FBW7_1	150	157	PF00400	0.534
DOC_CYCLIN_RxL_1	178	188	PF00134	0.555
DOC_MAPK_gen_1	137	145	PF00069	0.469
DOC_MAPK_MEF2A_6	139	147	PF00069	0.454
DOC_PP2B_LxvP_1	112	115	PF13499	0.446
DOC_PP2B_LxvP_1	207	210	PF13499	0.408
DOC_PP4_FxxP_1	152	155	PF00568	0.451
DOC_USP7_MATH_1	172	176	PF00917	0.394
DOC_USP7_MATH_1	196	200	PF00917	0.405
DOC_WW_Pin1_4	150	155	PF00397	0.507
LIG_14-3-3_CanoR_1	15	19	PF00244	0.480
LIG_14-3-3_CanoR_1	182	191	PF00244	0.457
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BRCT_BRCA1_1	116	120	PF00533	0.557
LIG_CaM_IQ_9	124	139	PF13499	0.506
LIG_deltaCOP1_diTrp_1	204	208	PF00928	0.389
LIG_FHA_1	122	128	PF00498	0.534
LIG_FHA_1	151	157	PF00498	0.486
LIG_FHA_1	2	8	PF00498	0.491
LIG_FHA_1	85	91	PF00498	0.511
LIG_FHA_2	183	189	PF00498	0.496
LIG_FHA_2	19	25	PF00498	0.478
LIG_FHA_2	37	43	PF00498	0.520
LIG_LIR_Gen_1	117	127	PF02991	0.492
LIG_LIR_Nem_3	117	123	PF02991	0.512
LIG_LIR_Nem_3	142	147	PF02991	0.500
LIG_LIR_Nem_3	204	208	PF02991	0.389
LIG_LIR_Nem_3	26	31	PF02991	0.465
LIG_LIR_Nem_3	93	98	PF02991	0.469
LIG_LYPXL_yS_3	95	98	PF13949	0.441
LIG_SH2_GRB2like	133	136	PF00017	0.469
LIG_SH2_NCK_1	38	42	PF00017	0.506
LIG_SH2_STAT5	133	136	PF00017	0.461
LIG_SH2_STAT5	38	41	PF00017	0.469
LIG_SH3_3	101	107	PF00018	0.520
LIG_SH3_3	161	167	PF00018	0.534
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.422
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.445
LIG_SUMO_SIM_par_1	157	165	PF11976	0.480
LIG_SUMO_SIM_par_1	188	195	PF11976	0.270
LIG_SUMO_SIM_par_1	21	27	PF11976	0.507
LIG_TRAF2_1	185	188	PF00917	0.512
LIG_TRAF2_1	210	213	PF00917	0.583
MOD_CK1_1	131	137	PF00069	0.468
MOD_CK2_1	182	188	PF00069	0.414
MOD_GlcNHglycan	100	103	PF01048	0.295
MOD_GlcNHglycan	92	95	PF01048	0.319
MOD_GSK3_1	14	21	PF00069	0.518
MOD_GSK3_1	150	157	PF00069	0.507
MOD_GSK3_1	192	199	PF00069	0.434
MOD_GSK3_1	36	43	PF00069	0.463
MOD_GSK3_1	80	87	PF00069	0.535
MOD_N-GLC_2	75	77	PF02516	0.268
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	14	19	PF00069	0.389
MOD_NEK2_1	192	197	PF00069	0.463
MOD_NEK2_1	97	102	PF00069	0.538
MOD_PIKK_1	80	86	PF00454	0.540
MOD_PKA_1	53	59	PF00069	0.530
MOD_PKA_2	128	134	PF00069	0.506
MOD_PKA_2	14	20	PF00069	0.502
MOD_PKA_2	53	59	PF00069	0.557
MOD_Plk_2-3	36	42	PF00069	0.492
MOD_Plk_4	18	24	PF00069	0.487
MOD_Plk_4	43	49	PF00069	0.506
MOD_ProDKin_1	150	156	PF00069	0.507
TRG_AP2beta_CARGO_1	142	151	PF09066	0.500
TRG_DiLeu_BaEn_1	186	191	PF01217	0.502
TRG_DiLeu_BaEn_2	203	209	PF01217	0.509
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.552
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.474
TRG_DiLeu_LyEn_5	186	191	PF01217	0.292
TRG_ENDOCYTIC_2	68	71	PF00928	0.489
TRG_ENDOCYTIC_2	95	98	PF00928	0.441
TRG_ER_diArg_1	52	54	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA3	Leptomonas seymouri	67%	100%
A0A0S4JIB8	Bodo saltans	47%	100%
A0A1X0NWS3	Trypanosomatidae	49%	96%
A0A3S7WY05	Leishmania donovani	95%	100%
A0A422NXZ5	Trypanosoma rangeli	54%	100%
A3KPP3	Danio rerio	31%	100%
A4HD13	Leishmania braziliensis	86%	100%
A4I0J9	Leishmania infantum	95%	100%
C9ZVC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AWG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P47123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	98%
Q32PE2	Bos taurus	31%	100%
Q54ML6	Dictyostelium discoideum	30%	100%
Q9HD47	Homo sapiens	33%	100%
Q9JIB0	Mus musculus	30%	100%