Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 12, putative

Species:

Leishmania major

UniProt:

Q4QB09_LEIMA

TriTrypDb:

LmjF.23.1420 , LMJLV39_230024600 , LMJSD75_230025100

Length:

321

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QB09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB09

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.557
CLV_NRD_NRD_1	263	265	PF00675	0.442
CLV_NRD_NRD_1	307	309	PF00675	0.360
CLV_NRD_NRD_1	47	49	PF00675	0.451
CLV_PCSK_KEX2_1	265	267	PF00082	0.371
CLV_PCSK_KEX2_1	307	309	PF00082	0.360
CLV_PCSK_KEX2_1	47	49	PF00082	0.451
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.407
CLV_PCSK_SKI1_1	131	135	PF00082	0.284
CLV_PCSK_SKI1_1	168	172	PF00082	0.259
CLV_PCSK_SKI1_1	249	253	PF00082	0.203
CLV_PCSK_SKI1_1	287	291	PF00082	0.325
DEG_Nend_UBRbox_4	1	3	PF02207	0.584
DOC_MAPK_FxFP_2	194	197	PF00069	0.274
DOC_PP4_FxxP_1	194	197	PF00568	0.274
DOC_PP4_FxxP_1	317	320	PF00568	0.592
DOC_PP4_FxxP_1	86	89	PF00568	0.573
DOC_WW_Pin1_4	316	321	PF00397	0.591
LIG_14-3-3_CanoR_1	10	17	PF00244	0.583
LIG_14-3-3_CanoR_1	106	115	PF00244	0.557
LIG_14-3-3_CanoR_1	125	130	PF00244	0.484
LIG_14-3-3_CanoR_1	242	248	PF00244	0.487
LIG_Actin_WH2_2	36	52	PF00022	0.437
LIG_BRCT_BRCA1_1	166	170	PF00533	0.474
LIG_BRCT_BRCA1_1	190	194	PF00533	0.335
LIG_BRCT_BRCA1_1	217	221	PF00533	0.314
LIG_deltaCOP1_diTrp_1	282	292	PF00928	0.517
LIG_EH1_1	64	72	PF00400	0.380
LIG_FHA_2	201	207	PF00498	0.167
LIG_GBD_Chelix_1	68	76	PF00786	0.390
LIG_IBAR_NPY_1	111	113	PF08397	0.587
LIG_LIR_Apic_2	191	197	PF02991	0.348
LIG_LIR_Apic_2	314	320	PF02991	0.585
LIG_LIR_Gen_1	110	121	PF02991	0.576
LIG_LIR_Gen_1	15	25	PF02991	0.536
LIG_LIR_Gen_1	167	178	PF02991	0.474
LIG_LIR_Gen_1	187	197	PF02991	0.122
LIG_LIR_Gen_1	218	229	PF02991	0.314
LIG_LIR_Nem_3	110	116	PF02991	0.573
LIG_LIR_Nem_3	15	20	PF02991	0.621
LIG_LIR_Nem_3	167	173	PF02991	0.505
LIG_LIR_Nem_3	187	193	PF02991	0.122
LIG_LIR_Nem_3	218	224	PF02991	0.314
LIG_LIR_Nem_3	270	276	PF02991	0.524
LIG_LIR_Nem_3	59	65	PF02991	0.255
LIG_MLH1_MIPbox_1	166	170	PF16413	0.474
LIG_PCNA_yPIPBox_3	242	251	PF02747	0.532
LIG_PDZ_Class_1	316	321	PF00595	0.718
LIG_Pex14_2	129	133	PF04695	0.474
LIG_Pex14_2	169	173	PF04695	0.397
LIG_Pex14_2	190	194	PF04695	0.359
LIG_Pex14_2	196	200	PF04695	0.270
LIG_Pex14_2	232	236	PF04695	0.290
LIG_PTB_Apo_2	54	61	PF02174	0.328
LIG_SH2_CRK	286	290	PF00017	0.503
LIG_SH2_CRK	65	69	PF00017	0.354
LIG_SH2_PTP2	176	179	PF00017	0.270
LIG_SH2_SRC	176	179	PF00017	0.326
LIG_SH2_STAP1	305	309	PF00017	0.557
LIG_SH2_STAT3	241	244	PF00017	0.518
LIG_SH2_STAT5	126	129	PF00017	0.432
LIG_SH2_STAT5	176	179	PF00017	0.290
LIG_SH2_STAT5	24	27	PF00017	0.299
LIG_SH2_STAT5	65	68	PF00017	0.310
LIG_SH3_3	288	294	PF00018	0.499
LIG_SH3_3	90	96	PF00018	0.523
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.292
LIG_SUMO_SIM_par_1	212	218	PF11976	0.264
LIG_SUMO_SIM_par_1	81	87	PF11976	0.459
LIG_TYR_ITIM	174	179	PF00017	0.296
LIG_WRC_WIRS_1	126	131	PF05994	0.474
MOD_CK1_1	188	194	PF00069	0.285
MOD_GlcNHglycan	14	17	PF01048	0.353
MOD_GlcNHglycan	311	314	PF01048	0.357
MOD_GSK3_1	184	191	PF00069	0.311
MOD_GSK3_1	215	222	PF00069	0.318
MOD_N-GLC_1	56	61	PF02516	0.488
MOD_N-GLC_2	159	161	PF02516	0.243
MOD_NEK2_1	199	204	PF00069	0.273
MOD_NEK2_1	234	239	PF00069	0.419
MOD_NEK2_1	250	255	PF00069	0.567
MOD_PKB_1	10	18	PF00069	0.513
MOD_PKB_1	123	131	PF00069	0.438
MOD_Plk_1	200	206	PF00069	0.234
MOD_Plk_1	56	62	PF00069	0.313
MOD_Plk_4	185	191	PF00069	0.358
MOD_Plk_4	209	215	PF00069	0.295
MOD_Plk_4	220	226	PF00069	0.342
MOD_Plk_4	56	62	PF00069	0.291
TRG_ENDOCYTIC_2	113	116	PF00928	0.561
TRG_ENDOCYTIC_2	126	129	PF00928	0.518
TRG_ENDOCYTIC_2	176	179	PF00928	0.310
TRG_ENDOCYTIC_2	286	289	PF00928	0.540
TRG_ENDOCYTIC_2	64	67	PF00928	0.299
TRG_ENDOCYTIC_2	78	81	PF00928	0.357
TRG_ER_diArg_1	123	126	PF00400	0.529
TRG_ER_diArg_1	307	309	PF00400	0.560
TRG_ER_diArg_1	46	48	PF00400	0.252
TRG_ER_diArg_1	9	12	PF00400	0.627
TRG_NLS_Bipartite_1	254	268	PF00514	0.570
TRG_NLS_MonoExtC_3	263	269	PF00514	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I542	Leptomonas seymouri	24%	100%
A0A0N1PEH3	Leptomonas seymouri	75%	100%
A0A0S4IYT3	Bodo saltans	30%	100%
A0A0S4J1K8	Bodo saltans	30%	70%
A0A0S4JCH4	Bodo saltans	25%	87%
A0A0S4KLP7	Bodo saltans	29%	79%
A0A1X0NUX2	Trypanosomatidae	25%	87%
A0A1X0NVK1	Trypanosomatidae	23%	100%
A0A1X0NY23	Trypanosomatidae	46%	100%
A0A3Q8ICT4	Leishmania donovani	94%	100%
A0A3R7MRW9	Trypanosoma rangeli	32%	100%
A0A422NXW5	Trypanosoma rangeli	47%	100%
A2VDT6	Bos taurus	26%	100%
A4H7G8	Leishmania braziliensis	23%	100%
A4HD15	Leishmania braziliensis	78%	100%
A4I0K1	Leishmania infantum	94%	100%
B1H1H3	Danio rerio	27%	100%
C9ZVD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	81%
E9AWG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
O60069	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	90%
P59267	Mus musculus	31%	88%
Q2TGK3	Rattus norvegicus	26%	100%
Q4R7E2	Macaca fascicularis	24%	85%
Q4WC37	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	75%
Q555N7	Dictyostelium discoideum	25%	90%
Q58CU4	Bos taurus	23%	85%
Q5M757	Arabidopsis thaliana	27%	100%
Q5PNZ1	Arabidopsis thaliana	23%	78%
Q5REH2	Pongo abelii	27%	78%
Q8R173	Mus musculus	27%	100%
Q8VYP5	Arabidopsis thaliana	23%	100%
Q94C49	Arabidopsis thaliana	26%	100%
Q969W1	Homo sapiens	24%	85%
Q9D270	Mus musculus	27%	100%
Q9ESG8	Mus musculus	26%	89%
Q9H6R6	Homo sapiens	27%	78%
Q9JKR5	Rattus norvegicus	28%	88%
Q9NYG2	Homo sapiens	27%	100%
Q9UIJ5	Homo sapiens	31%	87%
V5B7I7	Trypanosoma cruzi	27%	100%
V5BJ88	Trypanosoma cruzi	44%	100%
V5DFI9	Trypanosoma cruzi	30%	100%