Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC zinc finger domain-like protein

Species:

Leishmania major

UniProt:

Q4QB08_LEIMA

TriTrypDb:

LmjF.23.1430 , LMJLV39_230024700 , LMJSD75_230025200

Length:

450

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QB08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB08

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.444
CLV_C14_Caspase3-7	154	158	PF00656	0.597
CLV_C14_Caspase3-7	200	204	PF00656	0.512
CLV_NRD_NRD_1	409	411	PF00675	0.694
CLV_NRD_NRD_1	429	431	PF00675	0.545
CLV_PCSK_FUR_1	407	411	PF00082	0.554
CLV_PCSK_KEX2_1	393	395	PF00082	0.603
CLV_PCSK_KEX2_1	409	411	PF00082	0.609
CLV_PCSK_KEX2_1	429	431	PF00082	0.545
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.603
DOC_CDC14_PxL_1	83	91	PF14671	0.350
DOC_CKS1_1	6	11	PF01111	0.279
DOC_MAPK_gen_1	429	436	PF00069	0.341
DOC_MAPK_MEF2A_6	40	49	PF00069	0.303
DOC_PP1_RVXF_1	257	263	PF00149	0.295
DOC_PP1_RVXF_1	337	343	PF00149	0.475
DOC_PP2B_LxvP_1	112	115	PF13499	0.503
DOC_PP4_FxxP_1	226	229	PF00568	0.469
DOC_PP4_FxxP_1	67	70	PF00568	0.344
DOC_USP7_MATH_1	20	24	PF00917	0.388
DOC_USP7_MATH_1	85	89	PF00917	0.441
DOC_WW_Pin1_4	121	126	PF00397	0.525
DOC_WW_Pin1_4	157	162	PF00397	0.573
DOC_WW_Pin1_4	210	215	PF00397	0.513
DOC_WW_Pin1_4	218	223	PF00397	0.568
DOC_WW_Pin1_4	230	235	PF00397	0.469
DOC_WW_Pin1_4	395	400	PF00397	0.398
DOC_WW_Pin1_4	422	427	PF00397	0.437
DOC_WW_Pin1_4	5	10	PF00397	0.279
DOC_WW_Pin1_4	66	71	PF00397	0.320
LIG_14-3-3_CanoR_1	131	136	PF00244	0.519
LIG_14-3-3_CanoR_1	29	34	PF00244	0.469
LIG_14-3-3_CanoR_1	368	378	PF00244	0.308
LIG_14-3-3_CanoR_1	415	421	PF00244	0.407
LIG_AP2alpha_2	76	78	PF02296	0.384
LIG_BRCT_BRCA1_1	68	72	PF00533	0.306
LIG_eIF4E_1	360	366	PF01652	0.315
LIG_EVH1_2	222	226	PF00568	0.466
LIG_FHA_1	183	189	PF00498	0.486
LIG_FHA_1	335	341	PF00498	0.473
LIG_FHA_1	36	42	PF00498	0.558
LIG_FHA_1	6	12	PF00498	0.292
LIG_FHA_2	439	445	PF00498	0.474
LIG_IBAR_NPY_1	247	249	PF08397	0.402
LIG_LIR_Apic_2	76	81	PF02991	0.334
LIG_LIR_Gen_1	61	70	PF02991	0.373
LIG_LIR_Nem_3	37	42	PF02991	0.571
LIG_LIR_Nem_3	425	431	PF02991	0.402
LIG_LIR_Nem_3	61	66	PF02991	0.338
LIG_MYND_1	395	399	PF01753	0.389
LIG_PCNA_yPIPBox_3	368	378	PF02747	0.267
LIG_Pex14_2	99	103	PF04695	0.407
LIG_SH2_CRK	312	316	PF00017	0.352
LIG_SH2_CRK	431	435	PF00017	0.435
LIG_SH2_CRK	63	67	PF00017	0.312
LIG_SH2_CRK	84	88	PF00017	0.386
LIG_SH2_NCK_1	249	253	PF00017	0.288
LIG_SH2_NCK_1	63	67	PF00017	0.388
LIG_SH2_NCK_1	84	88	PF00017	0.337
LIG_SH2_STAP1	26	30	PF00017	0.521
LIG_SH2_STAP1	63	67	PF00017	0.388
LIG_SH2_STAT3	264	267	PF00017	0.278
LIG_SH2_STAT5	225	228	PF00017	0.523
LIG_SH2_STAT5	249	252	PF00017	0.369
LIG_SH2_STAT5	264	267	PF00017	0.200
LIG_SH2_STAT5	6	9	PF00017	0.279
LIG_SH3_3	144	150	PF00018	0.568
LIG_SH3_3	340	346	PF00018	0.267
LIG_SH3_3	71	77	PF00018	0.356
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.430
LIG_SUMO_SIM_par_1	55	61	PF11976	0.325
LIG_TYR_ITIM	310	315	PF00017	0.352
LIG_WW_1	222	225	PF00397	0.464
LIG_WW_1	81	84	PF00397	0.337
MOD_CDC14_SPxK_1	213	216	PF00782	0.478
MOD_CDK_SPxK_1	210	216	PF00069	0.483
MOD_CDK_SPxxK_3	395	402	PF00069	0.409
MOD_CDK_SPxxK_3	422	429	PF00069	0.385
MOD_CK1_1	124	130	PF00069	0.535
MOD_CK2_1	172	178	PF00069	0.481
MOD_CK2_1	369	375	PF00069	0.381
MOD_GlcNHglycan	174	177	PF01048	0.740
MOD_GlcNHglycan	255	259	PF01048	0.547
MOD_GlcNHglycan	385	388	PF01048	0.697
MOD_GSK3_1	153	160	PF00069	0.488
MOD_GSK3_1	168	175	PF00069	0.543
MOD_GSK3_1	182	189	PF00069	0.542
MOD_GSK3_1	20	27	PF00069	0.340
MOD_GSK3_1	250	257	PF00069	0.368
MOD_GSK3_1	311	318	PF00069	0.314
MOD_GSK3_1	369	376	PF00069	0.293
MOD_GSK3_1	438	445	PF00069	0.474
MOD_N-GLC_2	295	297	PF02516	0.501
MOD_NEK2_1	101	106	PF00069	0.419
MOD_NEK2_1	254	259	PF00069	0.334
MOD_NEK2_1	311	316	PF00069	0.354
MOD_NEK2_1	324	329	PF00069	0.359
MOD_NEK2_1	48	53	PF00069	0.328
MOD_PIKK_1	358	364	PF00454	0.340
MOD_PKA_2	130	136	PF00069	0.506
MOD_Plk_1	442	448	PF00069	0.444
MOD_Plk_4	143	149	PF00069	0.457
MOD_Plk_4	168	174	PF00069	0.443
MOD_Plk_4	324	330	PF00069	0.428
MOD_Plk_4	373	379	PF00069	0.295
MOD_Plk_4	49	55	PF00069	0.369
MOD_ProDKin_1	121	127	PF00069	0.524
MOD_ProDKin_1	157	163	PF00069	0.573
MOD_ProDKin_1	210	216	PF00069	0.513
MOD_ProDKin_1	218	224	PF00069	0.566
MOD_ProDKin_1	230	236	PF00069	0.469
MOD_ProDKin_1	395	401	PF00069	0.398
MOD_ProDKin_1	422	428	PF00069	0.437
MOD_ProDKin_1	5	11	PF00069	0.279
MOD_ProDKin_1	66	72	PF00069	0.322
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.505
TRG_ENDOCYTIC_2	303	306	PF00928	0.340
TRG_ENDOCYTIC_2	312	315	PF00928	0.301
TRG_ENDOCYTIC_2	431	434	PF00928	0.429
TRG_ENDOCYTIC_2	62	65	PF00928	0.346
TRG_ER_diArg_1	259	262	PF00400	0.295
TRG_ER_diArg_1	394	397	PF00400	0.402
TRG_ER_diArg_1	407	410	PF00400	0.358
TRG_ER_diArg_1	428	430	PF00400	0.367
TRG_NES_CRM1_1	334	349	PF08389	0.421
TRG_NLS_MonoCore_2	392	397	PF00514	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G9	Leptomonas seymouri	43%	90%
A0A3Q8ICN3	Leishmania donovani	82%	100%
A4HD16	Leishmania braziliensis	52%	100%
A4I0K2	Leishmania infantum	82%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%