Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QB07_LEIMA

TriTrypDb:

LmjF.23.1670 , LMJLV39_230024800 , LMJSD75_230025300

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QB07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB07

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.699
CLV_NRD_NRD_1	130	132	PF00675	0.474
CLV_NRD_NRD_1	141	143	PF00675	0.460
CLV_NRD_NRD_1	362	364	PF00675	0.566
CLV_NRD_NRD_1	564	566	PF00675	0.520
CLV_NRD_NRD_1	596	598	PF00675	0.456
CLV_PCSK_KEX2_1	130	132	PF00082	0.471
CLV_PCSK_KEX2_1	362	364	PF00082	0.566
CLV_PCSK_KEX2_1	564	566	PF00082	0.520
CLV_PCSK_KEX2_1	596	598	PF00082	0.455
CLV_PCSK_SKI1_1	106	110	PF00082	0.388
CLV_PCSK_SKI1_1	433	437	PF00082	0.346
CLV_PCSK_SKI1_1	600	604	PF00082	0.465
DEG_APCC_DBOX_1	608	616	PF00400	0.761
DEG_SPOP_SBC_1	288	292	PF00917	0.798
DEG_SPOP_SBC_1	304	308	PF00917	0.811
DEG_SPOP_SBC_1	318	322	PF00917	0.618
DEG_SPOP_SBC_1	329	333	PF00917	0.711
DOC_ANK_TNKS_1	578	585	PF00023	0.763
DOC_CKS1_1	1	6	PF01111	0.699
DOC_MAPK_gen_1	130	136	PF00069	0.709
DOC_MAPK_gen_1	596	605	PF00069	0.637
DOC_MAPK_MEF2A_6	26	33	PF00069	0.512
DOC_MAPK_MEF2A_6	372	381	PF00069	0.712
DOC_PP1_RVXF_1	104	110	PF00149	0.659
DOC_PP1_RVXF_1	133	139	PF00149	0.705
DOC_PP2B_LxvP_1	194	197	PF13499	0.632
DOC_PP2B_LxvP_1	553	556	PF13499	0.596
DOC_PP2B_LxvP_1	616	619	PF13499	0.692
DOC_PP4_FxxP_1	109	112	PF00568	0.620
DOC_PP4_FxxP_1	207	210	PF00568	0.767
DOC_PP4_FxxP_1	605	608	PF00568	0.655
DOC_USP7_MATH_1	197	201	PF00917	0.762
DOC_USP7_MATH_1	213	217	PF00917	0.712
DOC_USP7_MATH_1	236	240	PF00917	0.811
DOC_USP7_MATH_1	262	266	PF00917	0.642
DOC_USP7_MATH_1	318	322	PF00917	0.796
DOC_USP7_MATH_1	323	327	PF00917	0.709
DOC_USP7_MATH_1	329	333	PF00917	0.741
DOC_USP7_MATH_1	344	348	PF00917	0.737
DOC_USP7_MATH_1	385	389	PF00917	0.634
DOC_USP7_MATH_1	400	404	PF00917	0.546
DOC_USP7_MATH_1	447	451	PF00917	0.450
DOC_USP7_MATH_1	621	625	PF00917	0.786
DOC_USP7_MATH_2	63	69	PF00917	0.503
DOC_WW_Pin1_4	120	125	PF00397	0.709
DOC_WW_Pin1_4	182	187	PF00397	0.711
DOC_WW_Pin1_4	200	205	PF00397	0.689
DOC_WW_Pin1_4	222	227	PF00397	0.820
DOC_WW_Pin1_4	228	233	PF00397	0.762
DOC_WW_Pin1_4	242	247	PF00397	0.621
DOC_WW_Pin1_4	291	296	PF00397	0.824
DOC_WW_Pin1_4	325	330	PF00397	0.828
DOC_WW_Pin1_4	356	361	PF00397	0.661
LIG_14-3-3_CanoR_1	106	112	PF00244	0.585
LIG_14-3-3_CanoR_1	11	16	PF00244	0.724
LIG_14-3-3_CanoR_1	497	503	PF00244	0.546
LIG_14-3-3_CanoR_1	565	574	PF00244	0.740
LIG_14-3-3_CanoR_1	74	78	PF00244	0.457
LIG_BIR_III_2	352	356	PF00653	0.812
LIG_BRCT_BRCA1_1	387	391	PF00533	0.546
LIG_BRCT_BRCA1_1	449	453	PF00533	0.394
LIG_BRCT_BRCA1_1	509	513	PF00533	0.644
LIG_CSL_BTD_1	471	474	PF09270	0.346
LIG_deltaCOP1_diTrp_1	118	126	PF00928	0.672
LIG_deltaCOP1_diTrp_1	465	472	PF00928	0.346
LIG_EVH1_1	616	620	PF00568	0.643
LIG_FHA_1	1	7	PF00498	0.694
LIG_FHA_1	201	207	PF00498	0.656
LIG_FHA_1	243	249	PF00498	0.709
LIG_FHA_1	34	40	PF00498	0.512
LIG_FHA_1	56	62	PF00498	0.529
LIG_FHA_1	82	88	PF00498	0.444
LIG_FHA_2	347	353	PF00498	0.833
LIG_Integrin_RGD_1	579	581	PF01839	0.589
LIG_LIR_Gen_1	450	461	PF02991	0.501
LIG_LIR_Nem_3	14	18	PF02991	0.698
LIG_LIR_Nem_3	388	394	PF02991	0.546
LIG_LIR_Nem_3	450	456	PF02991	0.502
LIG_MYND_1	204	208	PF01753	0.659
LIG_MYND_1	356	360	PF01753	0.644
LIG_NRBOX	17	23	PF00104	0.619
LIG_PAM2_1	31	43	PF00658	0.286
LIG_Pex14_2	436	440	PF04695	0.411
LIG_Pex14_2	601	605	PF04695	0.655
LIG_PTAP_UEV_1	586	591	PF05743	0.786
LIG_REV1ctd_RIR_1	43	52	PF16727	0.424
LIG_SH2_CRK	25	29	PF00017	0.475
LIG_SH2_CRK	441	445	PF00017	0.394
LIG_SH2_CRK	613	617	PF00017	0.771
LIG_SH2_SRC	114	117	PF00017	0.597
LIG_SH2_STAT5	114	117	PF00017	0.608
LIG_SH2_STAT5	122	125	PF00017	0.703
LIG_SH2_STAT5	434	437	PF00017	0.512
LIG_SH2_STAT5	486	489	PF00017	0.450
LIG_SH2_STAT5	79	82	PF00017	0.508
LIG_SH3_2	116	121	PF14604	0.702
LIG_SH3_2	275	280	PF14604	0.647
LIG_SH3_3	113	119	PF00018	0.689
LIG_SH3_3	223	229	PF00018	0.754
LIG_SH3_3	272	278	PF00018	0.676
LIG_SH3_3	514	520	PF00018	0.702
LIG_SH3_3	522	528	PF00018	0.726
LIG_SH3_3	584	590	PF00018	0.832
LIG_SH3_3	614	620	PF00018	0.711
LIG_TRAF2_1	159	162	PF00917	0.659
LIG_TRFH_1	613	617	PF08558	0.771
LIG_TYR_ITIM	439	444	PF00017	0.394
LIG_TYR_ITIM	484	489	PF00017	0.450
LIG_TYR_ITIM	99	104	PF00017	0.336
MOD_CDC14_SPxK_1	359	362	PF00782	0.645
MOD_CDK_SPK_2	120	125	PF00069	0.725
MOD_CDK_SPxK_1	356	362	PF00069	0.645
MOD_CDK_SPxxK_3	356	363	PF00069	0.645
MOD_CK1_1	185	191	PF00069	0.674
MOD_CK1_1	200	206	PF00069	0.669
MOD_CK1_1	291	297	PF00069	0.747
MOD_CK1_1	314	320	PF00069	0.764
MOD_CK1_1	321	327	PF00069	0.799
MOD_CK1_1	332	338	PF00069	0.772
MOD_CK1_1	347	353	PF00069	0.626
MOD_CK1_1	530	536	PF00069	0.676
MOD_CK1_1	572	578	PF00069	0.800
MOD_CK1_1	588	594	PF00069	0.783
MOD_CK2_1	293	299	PF00069	0.764
MOD_CK2_1	497	503	PF00069	0.534
MOD_CK2_1	513	519	PF00069	0.670
MOD_GlcNHglycan	138	141	PF01048	0.505
MOD_GlcNHglycan	187	190	PF01048	0.547
MOD_GlcNHglycan	199	202	PF01048	0.514
MOD_GlcNHglycan	264	267	PF01048	0.519
MOD_GlcNHglycan	272	275	PF01048	0.590
MOD_GlcNHglycan	284	287	PF01048	0.515
MOD_GlcNHglycan	295	298	PF01048	0.412
MOD_GlcNHglycan	316	319	PF01048	0.603
MOD_GlcNHglycan	321	324	PF01048	0.579
MOD_GlcNHglycan	325	328	PF01048	0.555
MOD_GlcNHglycan	33	36	PF01048	0.411
MOD_GlcNHglycan	576	579	PF01048	0.571
MOD_GlcNHglycan	587	590	PF01048	0.539
MOD_GSK3_1	185	192	PF00069	0.792
MOD_GSK3_1	211	218	PF00069	0.704
MOD_GSK3_1	236	243	PF00069	0.763
MOD_GSK3_1	284	291	PF00069	0.712
MOD_GSK3_1	293	300	PF00069	0.653
MOD_GSK3_1	303	310	PF00069	0.733
MOD_GSK3_1	314	321	PF00069	0.724
MOD_GSK3_1	325	332	PF00069	0.685
MOD_GSK3_1	503	510	PF00069	0.659
MOD_GSK3_1	569	576	PF00069	0.804
MOD_GSK3_1	73	80	PF00069	0.488
MOD_LATS_1	361	367	PF00433	0.768
MOD_N-GLC_2	424	426	PF02516	0.338
MOD_NEK2_1	100	105	PF00069	0.466
MOD_NEK2_1	134	139	PF00069	0.749
MOD_NEK2_1	33	38	PF00069	0.286
MOD_NEK2_1	440	445	PF00069	0.377
MOD_NEK2_1	452	457	PF00069	0.411
MOD_NEK2_1	513	518	PF00069	0.671
MOD_NEK2_1	566	571	PF00069	0.736
MOD_NEK2_1	573	578	PF00069	0.781
MOD_NEK2_1	77	82	PF00069	0.458
MOD_NEK2_2	385	390	PF00069	0.626
MOD_PIKK_1	520	526	PF00454	0.727
MOD_PIKK_1	622	628	PF00454	0.682
MOD_PKA_2	335	341	PF00069	0.799
MOD_PKA_2	503	509	PF00069	0.574
MOD_PKA_2	73	79	PF00069	0.452
MOD_Plk_1	250	256	PF00069	0.789
MOD_Plk_4	215	221	PF00069	0.838
MOD_Plk_4	447	453	PF00069	0.501
MOD_Plk_4	457	463	PF00069	0.308
MOD_Plk_4	569	575	PF00069	0.672
MOD_Plk_4	65	71	PF00069	0.466
MOD_ProDKin_1	120	126	PF00069	0.707
MOD_ProDKin_1	182	188	PF00069	0.712
MOD_ProDKin_1	200	206	PF00069	0.692
MOD_ProDKin_1	222	228	PF00069	0.819
MOD_ProDKin_1	242	248	PF00069	0.677
MOD_ProDKin_1	291	297	PF00069	0.824
MOD_ProDKin_1	325	331	PF00069	0.830
MOD_ProDKin_1	356	362	PF00069	0.662
TRG_DiLeu_BaEn_1	65	70	PF01217	0.466
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.512
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.253
TRG_ENDOCYTIC_2	101	104	PF00928	0.561
TRG_ENDOCYTIC_2	42	45	PF00928	0.378
TRG_ENDOCYTIC_2	432	435	PF00928	0.546
TRG_ENDOCYTIC_2	441	444	PF00928	0.411
TRG_ENDOCYTIC_2	486	489	PF00928	0.450
TRG_ENDOCYTIC_2	613	616	PF00928	0.765
TRG_ER_diArg_1	10	13	PF00400	0.669
TRG_ER_diArg_1	362	364	PF00400	0.766
TRG_ER_diArg_1	564	566	PF00400	0.791

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P628	Leptomonas seymouri	36%	98%
A0A3S7WXW1	Leishmania donovani	90%	100%
A4HD17	Leishmania braziliensis	60%	100%
A4I0K3	Leishmania infantum	91%	100%
E9AWG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%