Adenylate kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QB05_LEIMA

TriTrypDb:

LmjF.23.1690 , LMJLV39_230025000 , LMJSD75_230025600

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.707
CLV_PCSK_KEX2_1	236	238	PF00082	0.709
CLV_PCSK_SKI1_1	108	112	PF00082	0.556
CLV_PCSK_SKI1_1	133	137	PF00082	0.636
CLV_PCSK_SKI1_1	276	280	PF00082	0.611
CLV_PCSK_SKI1_1	42	46	PF00082	0.734
DEG_APCC_DBOX_1	275	283	PF00400	0.613
DEG_APCC_DBOX_1	37	45	PF00400	0.729
DEG_ODPH_VHL_1	65	77	PF01847	0.559
DOC_CKS1_1	183	188	PF01111	0.561
DOC_CKS1_1	69	74	PF01111	0.610
DOC_MAPK_gen_1	8	16	PF00069	0.599
DOC_MAPK_RevD_3	222	237	PF00069	0.630
DOC_USP7_MATH_1	102	106	PF00917	0.591
DOC_USP7_MATH_1	147	151	PF00917	0.625
DOC_WW_Pin1_4	182	187	PF00397	0.585
DOC_WW_Pin1_4	236	241	PF00397	0.669
DOC_WW_Pin1_4	36	41	PF00397	0.721
DOC_WW_Pin1_4	68	73	PF00397	0.483
LIG_14-3-3_CanoR_1	141	145	PF00244	0.575
LIG_14-3-3_CanoR_1	190	196	PF00244	0.548
LIG_14-3-3_CanoR_1	245	250	PF00244	0.578
LIG_Actin_WH2_2	117	135	PF00022	0.418
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BIR_III_3	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	192	196	PF00533	0.645
LIG_CtBP_PxDLS_1	157	161	PF00389	0.603
LIG_FHA_1	183	189	PF00498	0.574
LIG_FHA_1	190	196	PF00498	0.475
LIG_FHA_1	273	279	PF00498	0.586
LIG_FHA_1	69	75	PF00498	0.563
LIG_FHA_2	203	209	PF00498	0.439
LIG_FHA_2	214	220	PF00498	0.411
LIG_LIR_Nem_3	193	199	PF02991	0.440
LIG_LIR_Nem_3	251	255	PF02991	0.585
LIG_LYPXL_SIV_4	254	262	PF13949	0.528
LIG_PCNA_yPIPBox_3	18	29	PF02747	0.576
LIG_Pex14_2	252	256	PF04695	0.582
LIG_SH2_STAT3	7	10	PF00017	0.668
LIG_SH2_STAT5	123	126	PF00017	0.637
LIG_SH3_1	237	243	PF00018	0.672
LIG_SH3_2	240	245	PF14604	0.579
LIG_SH3_2	37	42	PF14604	0.726
LIG_SH3_3	119	125	PF00018	0.669
LIG_SH3_3	180	186	PF00018	0.662
LIG_SH3_3	237	243	PF00018	0.672
LIG_SH3_3	34	40	PF00018	0.707
LIG_SUMO_SIM_par_1	73	78	PF11976	0.501
LIG_TRAF2_1	216	219	PF00917	0.629
LIG_TRAF2_1	281	284	PF00917	0.456
LIG_WRC_WIRS_1	249	254	PF05994	0.530
MOD_CDC14_SPxK_1	39	42	PF00782	0.732
MOD_CDK_SPK_2	68	73	PF00069	0.554
MOD_CDK_SPxK_1	36	42	PF00069	0.724
MOD_CK1_1	151	157	PF00069	0.545
MOD_CK1_1	248	254	PF00069	0.532
MOD_CK2_1	181	187	PF00069	0.593
MOD_CK2_1	202	208	PF00069	0.437
MOD_CK2_1	213	219	PF00069	0.414
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.717
MOD_GlcNHglycan	111	114	PF01048	0.420
MOD_GlcNHglycan	2	5	PF01048	0.667
MOD_GlcNHglycan	256	259	PF01048	0.606
MOD_GlcNHglycan	57	60	PF01048	0.699
MOD_GSK3_1	147	154	PF00069	0.509
MOD_GSK3_1	218	225	PF00069	0.521
MOD_GSK3_1	32	39	PF00069	0.508
MOD_GSK3_1	83	90	PF00069	0.453
MOD_NEK2_1	152	157	PF00069	0.424
MOD_NEK2_2	191	196	PF00069	0.638
MOD_PKA_2	140	146	PF00069	0.576
MOD_PKA_2	189	195	PF00069	0.489
MOD_Plk_1	218	224	PF00069	0.589
MOD_Plk_4	102	108	PF00069	0.600
MOD_Plk_4	148	154	PF00069	0.573
MOD_Plk_4	191	197	PF00069	0.564
MOD_ProDKin_1	182	188	PF00069	0.587
MOD_ProDKin_1	236	242	PF00069	0.667
MOD_ProDKin_1	36	42	PF00069	0.724
MOD_ProDKin_1	68	74	PF00069	0.475
MOD_SUMO_for_1	17	20	PF00179	0.591
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.481
TRG_ER_diArg_1	236	238	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICN4	Leishmania donovani	94%	100%
A4HD19	Leishmania braziliensis	75%	100%
A4I0K5	Leishmania infantum	94%	100%
E9AWG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%