Glyoxalase_6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QB04_LEIMA

TriTrypDb:

LmjF.23.1700 , LMJLV39_230025100 , LMJSD75_230025700

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB04

Function

Biological processes
Term	Name	Level	Count
GO:0006140	regulation of nucleotide metabolic process	5	2
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010155	regulation of proton transport	7	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018023	peptidyl-lysine trimethylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0022898	regulation of transmembrane transporter activity	4	2
GO:0030808	regulation of nucleotide biosynthetic process	6	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0032259	methylation	2	2
GO:0032409	regulation of transporter activity	3	2
GO:0032411	positive regulation of transporter activity	4	2
GO:0032412	regulation of monoatomic ion transmembrane transporter activity	5	2
GO:0032414	positive regulation of ion transmembrane transporter activity	5	2
GO:0032879	regulation of localization	3	2
GO:0034762	regulation of transmembrane transport	4	2
GO:0034764	positive regulation of transmembrane transport	5	2
GO:0034765	regulation of monoatomic ion transmembrane transport	5	2
GO:0034767	positive regulation of monoatomic ion transmembrane transport	6	2
GO:0036211	protein modification process	4	2
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043269	regulation of monoatomic ion transport	5	2
GO:0043270	positive regulation of monoatomic ion transport	5	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044093	positive regulation of molecular function	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051049	regulation of transport	4	2
GO:0051050	positive regulation of transport	4	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051340	regulation of ligase activity	4	2
GO:0051351	positive regulation of ligase activity	5	2
GO:0062012	regulation of small molecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1900371	regulation of purine nucleotide biosynthetic process	7	2
GO:1900542	regulation of purine nucleotide metabolic process	6	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903578	regulation of ATP metabolic process	7	2
GO:1904062	regulation of monoatomic cation transmembrane transport	6	2
GO:1904064	positive regulation of cation transmembrane transport	7	2
GO:1905271	regulation of proton-transporting ATP synthase activity, rotational mechanism	5	2
GO:1905273	positive regulation of proton-transporting ATP synthase activity, rotational mechanism	6	2
GO:1905706	regulation of mitochondrial ATP synthesis coupled proton transport	9	2
GO:2001169	regulation of ATP biosynthetic process	8	2
GO:2001257	regulation of cation channel activity	6	2
GO:2001259	positive regulation of cation channel activity	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008168	methyltransferase activity	4	9
GO:0008170	N-methyltransferase activity	5	9
GO:0008276	protein methyltransferase activity	3	9
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	9
GO:0016278	lysine N-methyltransferase activity	6	9
GO:0016279	protein-lysine N-methyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.426
CLV_PCSK_SKI1_1	160	164	PF00082	0.334
DEG_APCC_DBOX_1	159	167	PF00400	0.353
DEG_APCC_DBOX_1	248	256	PF00400	0.393
DOC_CYCLIN_RxL_1	157	167	PF00134	0.264
DOC_MAPK_gen_1	277	285	PF00069	0.489
DOC_MAPK_MEF2A_6	207	215	PF00069	0.472
DOC_MAPK_MEF2A_6	279	287	PF00069	0.432
DOC_PP4_FxxP_1	226	229	PF00568	0.475
DOC_USP7_MATH_1	178	182	PF00917	0.483
DOC_USP7_MATH_1	190	194	PF00917	0.422
DOC_USP7_MATH_1	23	27	PF00917	0.431
DOC_WW_Pin1_4	149	154	PF00397	0.589
DOC_WW_Pin1_4	186	191	PF00397	0.425
DOC_WW_Pin1_4	64	69	PF00397	0.508
DOC_WW_Pin1_4	87	92	PF00397	0.475
LIG_14-3-3_CanoR_1	32	37	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_CaM_IQ_9	130	146	PF13499	0.390
LIG_Clathr_ClatBox_1	194	198	PF01394	0.381
LIG_deltaCOP1_diTrp_1	257	267	PF00928	0.455
LIG_FHA_1	197	203	PF00498	0.491
LIG_FHA_2	162	168	PF00498	0.431
LIG_FHA_2	23	29	PF00498	0.448
LIG_LIR_Apic_2	225	229	PF02991	0.479
LIG_LIR_Apic_2	264	270	PF02991	0.386
LIG_LIR_Apic_2	85	91	PF02991	0.395
LIG_NRBOX	158	164	PF00104	0.267
LIG_SH2_CRK	237	241	PF00017	0.433
LIG_SH2_CRK	33	37	PF00017	0.466
LIG_SH2_SRC	286	289	PF00017	0.472
LIG_SH2_STAT5	234	237	PF00017	0.337
LIG_SH2_STAT5	239	242	PF00017	0.369
LIG_SH2_STAT5	286	289	PF00017	0.448
LIG_SH2_STAT5	88	91	PF00017	0.440
LIG_SH3_3	107	113	PF00018	0.543
LIG_SH3_3	210	216	PF00018	0.468
LIG_SH3_3	226	232	PF00018	0.566
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.470
LIG_SUMO_SIM_par_1	192	199	PF11976	0.554
LIG_SUMO_SIM_par_1	250	257	PF11976	0.441
LIG_TRAF2_2	57	62	PF00917	0.509
LIG_TYR_ITIM	235	240	PF00017	0.437
LIG_TYR_ITIM	31	36	PF00017	0.471
MOD_CK1_1	181	187	PF00069	0.435
MOD_CK1_1	189	195	PF00069	0.570
MOD_CK1_1	196	202	PF00069	0.458
MOD_CK1_1	26	32	PF00069	0.449
MOD_CK2_1	22	28	PF00069	0.444
MOD_GlcNHglycan	180	183	PF01048	0.481
MOD_GlcNHglycan	47	50	PF01048	0.474
MOD_GlcNHglycan	7	10	PF01048	0.470
MOD_GSK3_1	186	193	PF00069	0.462
MOD_GSK3_1	196	203	PF00069	0.517
MOD_GSK3_1	22	29	PF00069	0.446
MOD_GSK3_1	70	77	PF00069	0.552
MOD_N-GLC_1	178	183	PF02516	0.445
MOD_N-GLC_1	26	31	PF02516	0.519
MOD_N-GLC_2	212	214	PF02516	0.416
MOD_NEK2_1	172	177	PF00069	0.456
MOD_PIKK_1	108	114	PF00454	0.424
MOD_PIKK_1	200	206	PF00454	0.438
MOD_PKA_2	116	122	PF00069	0.357
MOD_Plk_1	178	184	PF00069	0.463
MOD_Plk_1	26	32	PF00069	0.521
MOD_Plk_4	128	134	PF00069	0.373
MOD_Plk_4	190	196	PF00069	0.600
MOD_Plk_4	26	32	PF00069	0.504
MOD_ProDKin_1	149	155	PF00069	0.589
MOD_ProDKin_1	186	192	PF00069	0.427
MOD_ProDKin_1	64	70	PF00069	0.511
MOD_ProDKin_1	87	93	PF00069	0.474
TRG_ENDOCYTIC_2	237	240	PF00928	0.447
TRG_ENDOCYTIC_2	33	36	PF00928	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5N7	Leptomonas seymouri	50%	100%
A0A1X0NWN1	Trypanosomatidae	32%	100%
A0A3S7WXY7	Leishmania donovani	91%	100%
A4HD20	Leishmania braziliensis	74%	100%
A4I0K6	Leishmania infantum	91%	100%
C9ZVI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%