Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meckel syndrome type 1 protein, putative

Species:

Leishmania major

UniProt:

Q4QB03_LEIMA

TriTrypDb:

LmjF.23.1710 , LMJLV39_230025200 , LMJSD75_230025800

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0032991	protein-containing complex	1	2
GO:0036038	MKS complex	2	2
GO:0110165	cellular anatomical entity	1	8
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QB03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB03

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	8
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	8
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.723
CLV_NRD_NRD_1	175	177	PF00675	0.587
CLV_NRD_NRD_1	374	376	PF00675	0.555
CLV_NRD_NRD_1	415	417	PF00675	0.688
CLV_NRD_NRD_1	70	72	PF00675	0.679
CLV_PCSK_FUR_1	413	417	PF00082	0.688
CLV_PCSK_KEX2_1	175	177	PF00082	0.624
CLV_PCSK_KEX2_1	374	376	PF00082	0.555
CLV_PCSK_KEX2_1	413	415	PF00082	0.689
CLV_PCSK_KEX2_1	466	468	PF00082	0.740
CLV_PCSK_KEX2_1	70	72	PF00082	0.679
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.740
CLV_PCSK_SKI1_1	182	186	PF00082	0.572
CLV_PCSK_SKI1_1	19	23	PF00082	0.565
CLV_PCSK_SKI1_1	374	378	PF00082	0.562
CLV_PCSK_SKI1_1	456	460	PF00082	0.707
CLV_PCSK_SKI1_1	63	67	PF00082	0.547
DEG_APCC_DBOX_1	14	22	PF00400	0.461
DEG_APCC_DBOX_1	373	381	PF00400	0.609
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DEG_SPOP_SBC_1	405	409	PF00917	0.760
DEG_SPOP_SBC_1	517	521	PF00917	0.589
DOC_CDC14_PxL_1	115	123	PF14671	0.683
DOC_CYCLIN_RxL_1	13	24	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	587	593	PF00134	0.589
DOC_MAPK_gen_1	11	18	PF00069	0.530
DOC_PP1_RVXF_1	17	24	PF00149	0.441
DOC_PP2B_LxvP_1	165	168	PF13499	0.679
DOC_PP2B_LxvP_1	587	590	PF13499	0.574
DOC_PP4_FxxP_1	139	142	PF00568	0.418
DOC_PP4_FxxP_1	240	243	PF00568	0.562
DOC_PP4_FxxP_1	553	556	PF00568	0.495
DOC_PP4_FxxP_1	561	564	PF00568	0.495
DOC_USP7_MATH_1	161	165	PF00917	0.738
DOC_USP7_MATH_1	226	230	PF00917	0.793
DOC_USP7_MATH_1	252	256	PF00917	0.515
DOC_USP7_MATH_1	284	288	PF00917	0.484
DOC_USP7_MATH_1	401	405	PF00917	0.711
DOC_USP7_MATH_1	423	427	PF00917	0.587
DOC_USP7_MATH_1	473	477	PF00917	0.626
DOC_USP7_MATH_1	517	521	PF00917	0.562
DOC_USP7_MATH_1	529	533	PF00917	0.535
DOC_USP7_MATH_1	535	539	PF00917	0.495
DOC_USP7_MATH_1	565	569	PF00917	0.589
DOC_USP7_MATH_1	594	598	PF00917	0.589
DOC_USP7_MATH_2	55	61	PF00917	0.571
DOC_WW_Pin1_4	157	162	PF00397	0.673
DOC_WW_Pin1_4	201	206	PF00397	0.754
DOC_WW_Pin1_4	458	463	PF00397	0.666
DOC_WW_Pin1_4	506	511	PF00397	0.549
DOC_WW_Pin1_4	51	56	PF00397	0.428
DOC_WW_Pin1_4	566	571	PF00397	0.553
DOC_WW_Pin1_4	599	604	PF00397	0.540
DOC_WW_Pin1_4	99	104	PF00397	0.673
LIG_14-3-3_CanoR_1	133	139	PF00244	0.455
LIG_14-3-3_CanoR_1	19	24	PF00244	0.538
LIG_14-3-3_CanoR_1	196	201	PF00244	0.611
LIG_14-3-3_CanoR_1	268	274	PF00244	0.484
LIG_14-3-3_CanoR_1	305	309	PF00244	0.489
LIG_14-3-3_CanoR_1	451	456	PF00244	0.756
LIG_14-3-3_CanoR_1	467	472	PF00244	0.471
LIG_14-3-3_CanoR_1	624	628	PF00244	0.591
LIG_14-3-3_CanoR_1	87	94	PF00244	0.713
LIG_Actin_WH2_2	363	380	PF00022	0.664
LIG_APCC_ABBA_1	59	64	PF00400	0.529
LIG_APCC_ABBAyCdc20_2	653	659	PF00400	0.553
LIG_Clathr_ClatBox_1	546	550	PF01394	0.569
LIG_deltaCOP1_diTrp_1	493	497	PF00928	0.589
LIG_DLG_GKlike_1	451	459	PF00625	0.753
LIG_FHA_1	20	26	PF00498	0.466
LIG_FHA_1	233	239	PF00498	0.565
LIG_FHA_1	291	297	PF00498	0.454
LIG_FHA_1	301	307	PF00498	0.397
LIG_FHA_1	493	499	PF00498	0.530
LIG_FHA_1	529	535	PF00498	0.504
LIG_FHA_1	56	62	PF00498	0.574
LIG_FHA_1	661	667	PF00498	0.550
LIG_FHA_2	537	543	PF00498	0.537
LIG_FHA_2	616	622	PF00498	0.495
LIG_LIR_Apic_2	137	142	PF02991	0.372
LIG_LIR_Apic_2	550	556	PF02991	0.499
LIG_LIR_Apic_2	558	564	PF02991	0.488
LIG_LIR_Gen_1	360	370	PF02991	0.687
LIG_LIR_Gen_1	476	485	PF02991	0.481
LIG_LIR_Gen_1	492	502	PF02991	0.403
LIG_LIR_Nem_3	360	365	PF02991	0.693
LIG_LIR_Nem_3	476	482	PF02991	0.481
LIG_LIR_Nem_3	492	497	PF02991	0.403
LIG_LIR_Nem_3	511	516	PF02991	0.364
LIG_LIR_Nem_3	60	65	PF02991	0.533
LIG_NBox_RRM_1	23	33	PF00076	0.544
LIG_PCNA_TLS_4	141	148	PF02747	0.586
LIG_Pex14_2	553	557	PF04695	0.495
LIG_PTB_Apo_2	551	558	PF02174	0.538
LIG_REV1ctd_RIR_1	136	141	PF16727	0.423
LIG_REV1ctd_RIR_1	279	285	PF16727	0.562
LIG_SH2_CRK	28	32	PF00017	0.510
LIG_SH2_CRK	513	517	PF00017	0.504
LIG_SH2_CRK	593	597	PF00017	0.519
LIG_SH2_NCK_1	593	597	PF00017	0.528
LIG_SH2_SRC	657	660	PF00017	0.546
LIG_SH2_STAP1	302	306	PF00017	0.387
LIG_SH2_STAP1	657	661	PF00017	0.553
LIG_SH2_STAT5	280	283	PF00017	0.508
LIG_SH2_STAT5	300	303	PF00017	0.207
LIG_SH3_2	567	572	PF14604	0.553
LIG_SH3_3	110	116	PF00018	0.606
LIG_SH3_3	153	159	PF00018	0.645
LIG_SH3_3	49	55	PF00018	0.477
LIG_SH3_3	561	567	PF00018	0.527
LIG_SH3_3	593	599	PF00018	0.553
LIG_SH3_3	605	611	PF00018	0.553
LIG_SH3_3	97	103	PF00018	0.605
LIG_SUMO_SIM_par_1	544	550	PF11976	0.531
LIG_TYR_ITIM	591	596	PF00017	0.519
LIG_WRC_WIRS_1	301	306	PF05994	0.389
MOD_CDC14_SPxK_1	569	572	PF00782	0.553
MOD_CDK_SPxK_1	566	572	PF00069	0.553
MOD_CK1_1	137	143	PF00069	0.405
MOD_CK1_1	404	410	PF00069	0.759
MOD_CK1_1	446	452	PF00069	0.759
MOD_CK1_1	492	498	PF00069	0.598
MOD_CK1_1	519	525	PF00069	0.531
MOD_CK1_1	660	666	PF00069	0.544
MOD_CK1_1	80	86	PF00069	0.765
MOD_CK2_1	261	267	PF00069	0.538
MOD_CK2_1	354	360	PF00069	0.650
MOD_CK2_1	404	410	PF00069	0.720
MOD_CK2_1	51	57	PF00069	0.429
MOD_CK2_1	536	542	PF00069	0.537
MOD_CK2_1	615	621	PF00069	0.495
MOD_CK2_1	66	72	PF00069	0.517
MOD_GlcNHglycan	218	221	PF01048	0.699
MOD_GlcNHglycan	243	246	PF01048	0.715
MOD_GlcNHglycan	263	266	PF01048	0.275
MOD_GlcNHglycan	427	430	PF01048	0.722
MOD_GlcNHglycan	467	470	PF01048	0.687
MOD_GlcNHglycan	524	527	PF01048	0.304
MOD_GlcNHglycan	81	85	PF01048	0.779
MOD_GlcNHglycan	89	92	PF01048	0.527
MOD_GSK3_1	157	164	PF00069	0.751
MOD_GSK3_1	228	235	PF00069	0.744
MOD_GSK3_1	280	287	PF00069	0.433
MOD_GSK3_1	300	307	PF00069	0.202
MOD_GSK3_1	401	408	PF00069	0.675
MOD_GSK3_1	439	446	PF00069	0.773
MOD_GSK3_1	51	58	PF00069	0.557
MOD_GSK3_1	515	522	PF00069	0.506
MOD_GSK3_1	660	667	PF00069	0.544
MOD_GSK3_1	73	80	PF00069	0.726
MOD_N-GLC_2	181	183	PF02516	0.612
MOD_NEK2_1	21	26	PF00069	0.321
MOD_NEK2_1	304	309	PF00069	0.416
MOD_NEK2_1	354	359	PF00069	0.595
MOD_NEK2_1	425	430	PF00069	0.621
MOD_NEK2_1	443	448	PF00069	0.657
MOD_NEK2_1	557	562	PF00069	0.530
MOD_NEK2_1	573	578	PF00069	0.443
MOD_NEK2_1	6	11	PF00069	0.498
MOD_NEK2_1	622	627	PF00069	0.535
MOD_NEK2_1	664	669	PF00069	0.533
MOD_NEK2_2	300	305	PF00069	0.497
MOD_PIKK_1	446	452	PF00454	0.759
MOD_PIKK_1	529	535	PF00454	0.495
MOD_PIKK_1	6	12	PF00454	0.509
MOD_PKA_2	129	135	PF00069	0.545
MOD_PKA_2	140	146	PF00069	0.447
MOD_PKA_2	304	310	PF00069	0.541
MOD_PKA_2	473	479	PF00069	0.556
MOD_PKA_2	623	629	PF00069	0.560
MOD_Plk_1	252	258	PF00069	0.648
MOD_Plk_1	259	265	PF00069	0.597
MOD_Plk_1	42	48	PF00069	0.518
MOD_Plk_1	492	498	PF00069	0.530
MOD_Plk_1	557	563	PF00069	0.504
MOD_Plk_1	63	69	PF00069	0.558
MOD_Plk_4	161	167	PF00069	0.683
MOD_Plk_4	290	296	PF00069	0.476
MOD_Plk_4	467	473	PF00069	0.528
MOD_Plk_4	508	514	PF00069	0.553
MOD_Plk_4	536	542	PF00069	0.537
MOD_Plk_4	557	563	PF00069	0.482
MOD_Plk_4	57	63	PF00069	0.574
MOD_Plk_4	623	629	PF00069	0.535
MOD_ProDKin_1	157	163	PF00069	0.674
MOD_ProDKin_1	201	207	PF00069	0.757
MOD_ProDKin_1	458	464	PF00069	0.663
MOD_ProDKin_1	506	512	PF00069	0.549
MOD_ProDKin_1	51	57	PF00069	0.429
MOD_ProDKin_1	566	572	PF00069	0.553
MOD_ProDKin_1	599	605	PF00069	0.540
MOD_ProDKin_1	99	105	PF00069	0.675
MOD_SUMO_rev_2	34	38	PF00179	0.517
MOD_SUMO_rev_2	43	53	PF00179	0.388
TRG_DiLeu_BaEn_1	542	547	PF01217	0.589
TRG_DiLeu_BaEn_2	492	498	PF01217	0.519
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.601
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.545
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.553
TRG_ENDOCYTIC_2	28	31	PF00928	0.502
TRG_ENDOCYTIC_2	362	365	PF00928	0.696
TRG_ENDOCYTIC_2	479	482	PF00928	0.530
TRG_ENDOCYTIC_2	513	516	PF00928	0.514
TRG_ENDOCYTIC_2	593	596	PF00928	0.495
TRG_ENDOCYTIC_2	62	65	PF00928	0.533
TRG_ER_diArg_1	12	15	PF00400	0.535
TRG_ER_diArg_1	195	198	PF00400	0.646
TRG_ER_diArg_1	374	376	PF00400	0.591
TRG_ER_diArg_1	413	416	PF00400	0.655
TRG_NES_CRM1_1	544	558	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B5	Leptomonas seymouri	55%	100%
A0A0S4IRB4	Bodo saltans	27%	84%
A0A1X0NWQ0	Trypanosomatidae	26%	100%
A0A3Q8IB52	Leishmania donovani	90%	100%
A4I0K7	Leishmania infantum	90%	100%
E9AWG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%