RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QB00_LEIMA

TriTrypDb:

LmjF.23.1730 , LMJLV39_230025500 , LMJSD75_230026100

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QB00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB00

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004842	ubiquitin-protein transferase activity	4	8
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	8
GO:0019787	ubiquitin-like protein transferase activity	3	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	8
GO:0061659	ubiquitin-like protein ligase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.751
CLV_C14_Caspase3-7	316	320	PF00656	0.640
CLV_NRD_NRD_1	73	75	PF00675	0.606
CLV_PCSK_KEX2_1	3	5	PF00082	0.648
CLV_PCSK_KEX2_1	73	75	PF00082	0.606
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.648
CLV_PCSK_SKI1_1	247	251	PF00082	0.627
CLV_PCSK_SKI1_1	66	70	PF00082	0.561
CLV_PCSK_SKI1_1	74	78	PF00082	0.548
DEG_APCC_DBOX_1	73	81	PF00400	0.620
DEG_SPOP_SBC_1	398	402	PF00917	0.713
DOC_CYCLIN_yClb5_NLxxxL_5	255	264	PF00134	0.601
DOC_PP4_FxxP_1	371	374	PF00568	0.518
DOC_USP7_MATH_1	185	189	PF00917	0.677
DOC_USP7_MATH_1	312	316	PF00917	0.533
DOC_USP7_MATH_1	397	401	PF00917	0.704
DOC_USP7_UBL2_3	359	363	PF12436	0.580
DOC_WW_Pin1_4	201	206	PF00397	0.769
DOC_WW_Pin1_4	223	228	PF00397	0.718
DOC_WW_Pin1_4	25	30	PF00397	0.667
DOC_WW_Pin1_4	350	355	PF00397	0.609
DOC_WW_Pin1_4	66	71	PF00397	0.519
LIG_14-3-3_CanoR_1	6	14	PF00244	0.688
LIG_Clathr_ClatBox_1	287	291	PF01394	0.472
LIG_FHA_1	29	35	PF00498	0.637
LIG_FHA_1	320	326	PF00498	0.383
LIG_FHA_1	383	389	PF00498	0.523
LIG_FHA_2	130	136	PF00498	0.713
LIG_FHA_2	211	217	PF00498	0.730
LIG_FHA_2	246	252	PF00498	0.744
LIG_FHA_2	281	287	PF00498	0.625
LIG_FHA_2	314	320	PF00498	0.502
LIG_FHA_2	70	76	PF00498	0.494
LIG_FHA_2	85	91	PF00498	0.663
LIG_LIR_Gen_1	135	144	PF02991	0.756
LIG_LIR_Gen_1	17	26	PF02991	0.602
LIG_LIR_Gen_1	281	290	PF02991	0.532
LIG_LIR_Nem_3	17	23	PF02991	0.604
LIG_LIR_Nem_3	281	287	PF02991	0.535
LIG_SH2_STAP1	137	141	PF00017	0.690
LIG_SH2_STAP1	284	288	PF00017	0.478
LIG_SH3_3	171	177	PF00018	0.700
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.666
LIG_SUMO_SIM_par_1	285	292	PF11976	0.478
LIG_SUMO_SIM_par_1	31	38	PF11976	0.700
LIG_TRAF2_1	161	164	PF00917	0.826
LIG_TRAF2_1	249	252	PF00917	0.669
LIG_TRAF2_1	283	286	PF00917	0.479
LIG_TRAF2_1	35	38	PF00917	0.618
LIG_WRC_WIRS_1	108	113	PF05994	0.786
MOD_CDK_SPxxK_3	223	230	PF00069	0.728
MOD_CDK_SPxxK_3	66	73	PF00069	0.514
MOD_CK1_1	188	194	PF00069	0.559
MOD_CK1_1	28	34	PF00069	0.691
MOD_CK1_1	349	355	PF00069	0.437
MOD_CK1_1	400	406	PF00069	0.636
MOD_CK2_1	245	251	PF00069	0.705
MOD_CK2_1	280	286	PF00069	0.483
MOD_CK2_1	32	38	PF00069	0.623
MOD_CK2_1	84	90	PF00069	0.615
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.561
MOD_GlcNHglycan	103	106	PF01048	0.622
MOD_GlcNHglycan	243	246	PF01048	0.681
MOD_GlcNHglycan	316	319	PF01048	0.624
MOD_GlcNHglycan	333	336	PF01048	0.251
MOD_GlcNHglycan	354	357	PF01048	0.289
MOD_GlcNHglycan	402	405	PF01048	0.640
MOD_GSK3_1	125	132	PF00069	0.700
MOD_GSK3_1	185	192	PF00069	0.741
MOD_GSK3_1	21	28	PF00069	0.577
MOD_GSK3_1	241	248	PF00069	0.723
MOD_GSK3_1	331	338	PF00069	0.526
MOD_GSK3_1	342	349	PF00069	0.556
MOD_GSK3_1	350	357	PF00069	0.491
MOD_GSK3_1	378	385	PF00069	0.564
MOD_GSK3_1	399	406	PF00069	0.624
MOD_GSK3_1	6	13	PF00069	0.750
MOD_N-GLC_1	295	300	PF02516	0.574
MOD_N-GLC_1	382	387	PF02516	0.309
MOD_N-GLC_1	7	12	PF02516	0.649
MOD_NEK2_1	125	130	PF00069	0.636
MOD_NEK2_1	269	274	PF00069	0.458
MOD_NEK2_1	305	310	PF00069	0.554
MOD_NEK2_1	313	318	PF00069	0.509
MOD_NEK2_1	39	44	PF00069	0.705
MOD_NEK2_1	61	66	PF00069	0.486
MOD_PIKK_1	125	131	PF00454	0.689
MOD_PIKK_1	28	34	PF00454	0.727
MOD_PIKK_1	378	384	PF00454	0.555
MOD_PIKK_1	39	45	PF00454	0.555
MOD_PKA_2	241	247	PF00069	0.710
MOD_PKA_2	313	319	PF00069	0.606
MOD_PKA_2	61	67	PF00069	0.547
MOD_PKB_1	4	12	PF00069	0.680
MOD_Plk_1	10	16	PF00069	0.724
MOD_Plk_1	280	286	PF00069	0.483
MOD_Plk_2-3	280	286	PF00069	0.483
MOD_Plk_4	210	216	PF00069	0.685
MOD_ProDKin_1	201	207	PF00069	0.767
MOD_ProDKin_1	223	229	PF00069	0.722
MOD_ProDKin_1	25	31	PF00069	0.665
MOD_ProDKin_1	350	356	PF00069	0.609
MOD_ProDKin_1	66	72	PF00069	0.517
TRG_DiLeu_BaEn_2	174	180	PF01217	0.725
TRG_DiLeu_BaEn_4	148	154	PF01217	0.692
TRG_DiLeu_BaEn_4	285	291	PF01217	0.473
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.667
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.576
TRG_ENDOCYTIC_2	137	140	PF00928	0.757
TRG_ENDOCYTIC_2	284	287	PF00928	0.479
TRG_NES_CRM1_1	88	101	PF08389	0.600
TRG_NLS_MonoExtN_4	2	7	PF00514	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS7	Leptomonas seymouri	44%	100%
A0A3Q8IBP7	Leishmania donovani	92%	100%
A4HD23	Leishmania braziliensis	78%	100%
A4I0L0	Leishmania infantum	93%	100%
C9ZVI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AWH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%