LeishMANIAdb
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Putative Qb-SNARE protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative Qb-SNARE protein
Gene product:
Qb-SNARE protein, putative
Species:
Leishmania major
UniProt:
Q4QAZ9_LEIMA
TriTrypDb:
LmjF.23.1740 , LMJLV39_230025600 * , LMJSD75_230026200
Length:
250

Annotations

LeishMANIAdb annotations

Similar to other Eukaryotic vesicle-associated V-SNARE proteins, especially VTI1.. Localization: Vesicular (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 19
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 16
GO:0005789 endoplasmic reticulum membrane 4 3
GO:0005794 Golgi apparatus 5 6
GO:0010008 endosome membrane 5 3
GO:0012506 vesicle membrane 4 3
GO:0012507 ER to Golgi transport vesicle membrane 6 3
GO:0016020 membrane 2 21
GO:0030658 transport vesicle membrane 5 3
GO:0030659 cytoplasmic vesicle membrane 5 3
GO:0030662 coated vesicle membrane 5 3
GO:0031090 organelle membrane 3 3
GO:0031201 SNARE complex 3 3
GO:0031902 late endosome membrane 6 3
GO:0032991 protein-containing complex 1 3
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0098588 bounding membrane of organelle 4 3
GO:0098796 membrane protein complex 2 3
GO:0110165 cellular anatomical entity 1 21

Expansion

Sequence features

Q4QAZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAZ9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 20
GO:0006886 intracellular protein transport 4 15
GO:0006906 vesicle fusion 6 3
GO:0006996 organelle organization 4 3
GO:0008104 protein localization 4 20
GO:0009987 cellular process 1 20
GO:0015031 protein transport 4 20
GO:0016043 cellular component organization 3 3
GO:0016050 vesicle organization 5 3
GO:0033036 macromolecule localization 2 20
GO:0045184 establishment of protein localization 3 20
GO:0046907 intracellular transport 3 15
GO:0048284 organelle fusion 5 3
GO:0051179 localization 1 20
GO:0051234 establishment of localization 2 20
GO:0051641 cellular localization 2 20
GO:0051649 establishment of localization in cell 3 15
GO:0061024 membrane organization 4 3
GO:0061025 membrane fusion 5 3
GO:0070727 cellular macromolecule localization 3 20
GO:0071702 organic substance transport 4 20
GO:0071705 nitrogen compound transport 4 20
GO:0071840 cellular component organization or biogenesis 2 3
GO:0090174 organelle membrane fusion 6 3
GO:0016192 vesicle-mediated transport 4 11
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 6 2
GO:0048193 Golgi vesicle transport 5 2
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 3
GO:0005484 SNAP receptor activity 3 8
GO:0005488 binding 1 3
GO:0005515 protein binding 2 3
GO:0030674 protein-macromolecule adaptor activity 2 8
GO:0060090 molecular adaptor activity 1 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 169 171 PF00675 0.479
CLV_NRD_NRD_1 98 100 PF00675 0.235
CLV_PCSK_SKI1_1 70 74 PF00082 0.239
DEG_APCC_DBOX_1 183 191 PF00400 0.677
DOC_CYCLIN_RxL_1 149 160 PF00134 0.695
DOC_MAPK_gen_1 227 235 PF00069 0.420
DOC_MAPK_MEF2A_6 229 237 PF00069 0.272
DOC_PP4_FxxP_1 127 130 PF00568 0.521
LIG_14-3-3_CanoR_1 191 200 PF00244 0.624
LIG_Actin_WH2_2 98 115 PF00022 0.418
LIG_BIR_II_1 1 5 PF00653 0.548
LIG_BRCT_BRCA1_1 1 5 PF00533 0.537
LIG_Clathr_ClatBox_1 153 157 PF01394 0.523
LIG_FHA_1 120 126 PF00498 0.638
LIG_FHA_1 157 163 PF00498 0.568
LIG_FHA_1 164 170 PF00498 0.578
LIG_FHA_1 177 183 PF00498 0.583
LIG_FHA_1 192 198 PF00498 0.562
LIG_FHA_1 202 208 PF00498 0.649
LIG_FHA_1 48 54 PF00498 0.520
LIG_FHA_2 190 196 PF00498 0.613
LIG_FHA_2 201 207 PF00498 0.599
LIG_LIR_Apic_2 41 47 PF02991 0.662
LIG_LIR_Nem_3 2 8 PF02991 0.553
LIG_LIR_Nem_3 96 101 PF02991 0.376
LIG_SH2_CRK 44 48 PF00017 0.618
LIG_SH2_STAP1 8 12 PF00017 0.540
LIG_SH2_STAT3 175 178 PF00017 0.587
LIG_SH2_STAT5 175 178 PF00017 0.675
LIG_SUMO_SIM_par_1 152 160 PF11976 0.708
LIG_TRAF2_1 7 10 PF00917 0.564
LIG_UBA3_1 153 161 PF00899 0.694
MOD_CK1_1 186 192 PF00069 0.658
MOD_CK2_1 189 195 PF00069 0.599
MOD_CK2_1 31 37 PF00069 0.613
MOD_CK2_1 4 10 PF00069 0.528
MOD_GlcNHglycan 1 4 PF01048 0.382
MOD_GlcNHglycan 33 36 PF01048 0.396
MOD_GSK3_1 47 54 PF00069 0.459
MOD_LATS_1 36 42 PF00433 0.584
MOD_N-GLC_1 12 17 PF02516 0.339
MOD_NEK2_1 112 117 PF00069 0.604
MOD_NEK2_1 12 17 PF00069 0.532
MOD_NEK2_1 176 181 PF00069 0.683
MOD_NEK2_1 221 226 PF00069 0.572
MOD_NEK2_1 72 77 PF00069 0.455
MOD_NEK2_2 165 170 PF00069 0.653
MOD_PIKK_1 145 151 PF00454 0.671
MOD_PIKK_1 189 195 PF00454 0.591
MOD_PKA_2 112 118 PF00069 0.622
MOD_PKA_2 183 189 PF00069 0.721
MOD_Plk_1 12 18 PF00069 0.559
MOD_Plk_4 72 78 PF00069 0.486
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.697
TRG_ER_diArg_1 213 216 PF00400 0.618
TRG_Pf-PMV_PEXEL_1 152 157 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G6 Leptomonas seymouri 35% 92%
A0A0N1HXG1 Leptomonas seymouri 69% 99%
A0A0S4IRD2 Bodo saltans 29% 86%
A0A1X0NWY4 Trypanosomatidae 35% 81%
A0A1X0NY79 Trypanosomatidae 37% 86%
A0A3Q8IEP1 Leishmania donovani 96% 100%
A0A3S5IRB0 Trypanosoma rangeli 42% 90%
A0A3S7WY13 Leishmania donovani 39% 72%
A0A422NJV1 Trypanosoma rangeli 40% 100%
A4HD24 Leishmania braziliensis 84% 100%
A4HD25 Leishmania braziliensis 38% 88%
A4I0L1 Leishmania infantum 96% 100%
A4I0L2 Leishmania infantum 39% 89%
C9ZVI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AWH2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AWH3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 89%
O89116 Mus musculus 23% 100%
Q4QAZ8 Leishmania major 36% 100%
Q96AJ9 Homo sapiens 23% 100%
Q9JI51 Rattus norvegicus 22% 100%
V5ARB2 Trypanosoma cruzi 38% 90%
V5BFR7 Trypanosoma cruzi 40% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS