Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAZ7_LEIMA

TriTrypDb:

LmjF.23.1760 , LMJLV39_230025800 , LMJSD75_230026400

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.761
CLV_C14_Caspase3-7	197	201	PF00656	0.732
CLV_C14_Caspase3-7	353	357	PF00656	0.667
CLV_C14_Caspase3-7	360	364	PF00656	0.496
CLV_C14_Caspase3-7	837	841	PF00656	0.639
CLV_NRD_NRD_1	13	15	PF00675	0.722
CLV_NRD_NRD_1	173	175	PF00675	0.638
CLV_NRD_NRD_1	293	295	PF00675	0.626
CLV_NRD_NRD_1	449	451	PF00675	0.763
CLV_NRD_NRD_1	552	554	PF00675	0.714
CLV_NRD_NRD_1	667	669	PF00675	0.506
CLV_NRD_NRD_1	97	99	PF00675	0.579
CLV_PCSK_KEX2_1	12	14	PF00082	0.732
CLV_PCSK_KEX2_1	173	175	PF00082	0.622
CLV_PCSK_KEX2_1	293	295	PF00082	0.664
CLV_PCSK_KEX2_1	451	453	PF00082	0.788
CLV_PCSK_KEX2_1	552	554	PF00082	0.714
CLV_PCSK_KEX2_1	667	669	PF00082	0.467
CLV_PCSK_KEX2_1	97	99	PF00082	0.579
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.788
CLV_PCSK_SKI1_1	174	178	PF00082	0.574
CLV_PCSK_SKI1_1	185	189	PF00082	0.633
CLV_PCSK_SKI1_1	204	208	PF00082	0.538
CLV_PCSK_SKI1_1	345	349	PF00082	0.609
CLV_PCSK_SKI1_1	436	440	PF00082	0.710
CLV_PCSK_SKI1_1	603	607	PF00082	0.536
CLV_PCSK_SKI1_1	660	664	PF00082	0.427
CLV_PCSK_SKI1_1	701	705	PF00082	0.432
CLV_PCSK_SKI1_1	713	717	PF00082	0.447
CLV_PCSK_SKI1_1	811	815	PF00082	0.439
DEG_APCC_DBOX_1	262	270	PF00400	0.657
DEG_APCC_DBOX_1	344	352	PF00400	0.636
DEG_APCC_DBOX_1	712	720	PF00400	0.543
DEG_SCF_FBW7_2	302	309	PF00400	0.515
DEG_SPOP_SBC_1	416	420	PF00917	0.664
DOC_CYCLIN_RxL_1	198	210	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.661
DOC_MAPK_MEF2A_6	18	27	PF00069	0.742
DOC_MAPK_MEF2A_6	258	266	PF00069	0.752
DOC_MAPK_MEF2A_6	317	325	PF00069	0.532
DOC_PP2B_LxvP_1	323	326	PF13499	0.462
DOC_PP2B_LxvP_1	56	59	PF13499	0.664
DOC_PP2B_LxvP_1	83	86	PF13499	0.544
DOC_PP4_FxxP_1	215	218	PF00568	0.760
DOC_PP4_FxxP_1	793	796	PF00568	0.458
DOC_SPAK_OSR1_1	294	298	PF12202	0.561
DOC_USP7_MATH_1	160	164	PF00917	0.632
DOC_USP7_MATH_1	189	193	PF00917	0.727
DOC_USP7_MATH_1	268	272	PF00917	0.509
DOC_USP7_MATH_1	340	344	PF00917	0.476
DOC_USP7_MATH_1	41	45	PF00917	0.661
DOC_USP7_MATH_1	459	463	PF00917	0.704
DOC_USP7_MATH_1	48	52	PF00917	0.538
DOC_USP7_MATH_1	536	540	PF00917	0.771
DOC_USP7_MATH_1	57	61	PF00917	0.618
DOC_USP7_MATH_1	579	583	PF00917	0.640
DOC_USP7_MATH_1	586	590	PF00917	0.604
DOC_USP7_MATH_1	765	769	PF00917	0.515
DOC_WW_Pin1_4	214	219	PF00397	0.814
DOC_WW_Pin1_4	302	307	PF00397	0.560
DOC_WW_Pin1_4	362	367	PF00397	0.702
DOC_WW_Pin1_4	412	417	PF00397	0.715
DOC_WW_Pin1_4	467	472	PF00397	0.720
DOC_WW_Pin1_4	490	495	PF00397	0.754
DOC_WW_Pin1_4	553	558	PF00397	0.742
DOC_WW_Pin1_4	561	566	PF00397	0.663
DOC_WW_Pin1_4	679	684	PF00397	0.465
DOC_WW_Pin1_4	70	75	PF00397	0.664
DOC_WW_Pin1_4	76	81	PF00397	0.707
DOC_WW_Pin1_4	761	766	PF00397	0.450
DOC_WW_Pin1_4	840	845	PF00397	0.512
LIG_14-3-3_CanoR_1	141	150	PF00244	0.570
LIG_14-3-3_CanoR_1	173	183	PF00244	0.601
LIG_14-3-3_CanoR_1	552	557	PF00244	0.620
LIG_14-3-3_CanoR_1	772	782	PF00244	0.319
LIG_14-3-3_CanoR_1	811	816	PF00244	0.434
LIG_APCC_ABBA_1	324	329	PF00400	0.591
LIG_APCC_ABBAyCdc20_2	436	442	PF00400	0.825
LIG_APCC_ABBAyCdc20_2	745	751	PF00400	0.456
LIG_BIR_III_2	363	367	PF00653	0.564
LIG_BIR_III_4	425	429	PF00653	0.823
LIG_BIR_III_4	831	835	PF00653	0.535
LIG_BRCT_BRCA1_1	269	273	PF00533	0.468
LIG_BRCT_BRCA1_2	269	275	PF00533	0.511
LIG_CtBP_PxDLS_1	80	84	PF00389	0.617
LIG_deltaCOP1_diTrp_1	410	417	PF00928	0.697
LIG_eIF4E_1	604	610	PF01652	0.472
LIG_FHA_1	20	26	PF00498	0.739
LIG_FHA_1	387	393	PF00498	0.571
LIG_FHA_1	506	512	PF00498	0.716
LIG_FHA_1	562	568	PF00498	0.677
LIG_FHA_1	726	732	PF00498	0.443
LIG_FHA_1	76	82	PF00498	0.756
LIG_FHA_1	776	782	PF00498	0.495
LIG_FHA_1	812	818	PF00498	0.432
LIG_FHA_1	91	97	PF00498	0.483
LIG_FHA_2	14	20	PF00498	0.534
LIG_FHA_2	195	201	PF00498	0.733
LIG_FHA_2	3	9	PF00498	0.711
LIG_FHA_2	405	411	PF00498	0.756
LIG_FHA_2	418	424	PF00498	0.611
LIG_FHA_2	485	491	PF00498	0.764
LIG_FHA_2	554	560	PF00498	0.819
LIG_FHA_2	71	77	PF00498	0.556
LIG_LIR_Apic_2	212	218	PF02991	0.834
LIG_LIR_Apic_2	410	416	PF02991	0.693
LIG_LIR_Gen_1	393	404	PF02991	0.587
LIG_LIR_Gen_1	91	99	PF02991	0.436
LIG_LIR_LC3C_4	429	434	PF02991	0.713
LIG_LIR_Nem_3	393	399	PF02991	0.562
LIG_LIR_Nem_3	698	703	PF02991	0.471
LIG_LIR_Nem_3	816	822	PF02991	0.550
LIG_LIR_Nem_3	91	95	PF02991	0.443
LIG_MYND_1	565	569	PF01753	0.736
LIG_NRBOX	715	721	PF00104	0.424
LIG_PCNA_yPIPBox_3	275	288	PF02747	0.557
LIG_PDZ_Class_3	846	851	PF00595	0.605
LIG_Pex14_1	413	417	PF04695	0.641
LIG_SH2_NCK_1	521	525	PF00017	0.710
LIG_SH2_PTP2	655	658	PF00017	0.430
LIG_SH2_STAP1	521	525	PF00017	0.710
LIG_SH2_STAT3	111	114	PF00017	0.608
LIG_SH2_STAT3	289	292	PF00017	0.625
LIG_SH2_STAT5	111	114	PF00017	0.608
LIG_SH2_STAT5	604	607	PF00017	0.483
LIG_SH2_STAT5	632	635	PF00017	0.465
LIG_SH2_STAT5	646	649	PF00017	0.308
LIG_SH2_STAT5	655	658	PF00017	0.430
LIG_SH2_STAT5	819	822	PF00017	0.441
LIG_SH3_1	236	242	PF00018	0.689
LIG_SH3_3	236	242	PF00018	0.720
LIG_SH3_3	331	337	PF00018	0.488
LIG_SH3_3	408	414	PF00018	0.661
LIG_SH3_3	471	477	PF00018	0.604
LIG_SH3_3	511	517	PF00018	0.681
LIG_SH3_3	526	532	PF00018	0.644
LIG_SH3_3	563	569	PF00018	0.742
LIG_SH3_3	585	591	PF00018	0.553
LIG_SH3_3	736	742	PF00018	0.627
LIG_SH3_3	800	806	PF00018	0.509
LIG_SUMO_SIM_anti_2	375	383	PF11976	0.698
LIG_SUMO_SIM_anti_2	814	819	PF11976	0.440
LIG_SUMO_SIM_par_1	701	706	PF11976	0.430
LIG_SUMO_SIM_par_1	730	735	PF11976	0.465
LIG_SUMO_SIM_par_1	78	84	PF11976	0.619
LIG_TRAF2_1	218	221	PF00917	0.594
LIG_TRAF2_1	391	394	PF00917	0.587
LIG_TRAF2_1	88	91	PF00917	0.475
LIG_TRFH_1	655	659	PF08558	0.300
LIG_TYR_ITIM	817	822	PF00017	0.436
LIG_WW_3	657	661	PF00397	0.437
MOD_CDC14_SPxK_1	682	685	PF00782	0.487
MOD_CDK_SPK_2	557	562	PF00069	0.578
MOD_CDK_SPxK_1	679	685	PF00069	0.477
MOD_CDK_SPxxK_3	417	424	PF00069	0.592
MOD_CDK_SPxxK_3	490	497	PF00069	0.752
MOD_CDK_SPxxK_3	561	568	PF00069	0.628
MOD_CDK_SPxxK_3	840	847	PF00069	0.502
MOD_CK1_1	152	158	PF00069	0.636
MOD_CK1_1	196	202	PF00069	0.736
MOD_CK1_1	214	220	PF00069	0.760
MOD_CK1_1	225	231	PF00069	0.682
MOD_CK1_1	415	421	PF00069	0.718
MOD_CK1_1	462	468	PF00069	0.715
MOD_CK1_1	493	499	PF00069	0.744
MOD_CK1_1	551	557	PF00069	0.721
MOD_CK1_1	624	630	PF00069	0.578
MOD_CK1_1	70	76	PF00069	0.667
MOD_CK1_1	764	770	PF00069	0.419
MOD_CK1_1	785	791	PF00069	0.605
MOD_CK1_1	79	85	PF00069	0.732
MOD_CK2_1	13	19	PF00069	0.608
MOD_CK2_1	404	410	PF00069	0.749
MOD_CK2_1	417	423	PF00069	0.612
MOD_CK2_1	466	472	PF00069	0.761
MOD_CK2_1	70	76	PF00069	0.556
MOD_Cter_Amidation	10	13	PF01082	0.721
MOD_DYRK1A_RPxSP_1	553	557	PF00069	0.732
MOD_GlcNHglycan	143	146	PF01048	0.796
MOD_GlcNHglycan	191	194	PF01048	0.733
MOD_GlcNHglycan	224	227	PF01048	0.778
MOD_GlcNHglycan	228	231	PF01048	0.788
MOD_GlcNHglycan	270	273	PF01048	0.532
MOD_GlcNHglycan	435	439	PF01048	0.765
MOD_GlcNHglycan	454	457	PF01048	0.531
MOD_GlcNHglycan	461	464	PF01048	0.677
MOD_GlcNHglycan	581	584	PF01048	0.747
MOD_GlcNHglycan	588	591	PF01048	0.562
MOD_GlcNHglycan	59	62	PF01048	0.726
MOD_GlcNHglycan	623	626	PF01048	0.578
MOD_GlcNHglycan	775	778	PF01048	0.482
MOD_GlcNHglycan	783	787	PF01048	0.516
MOD_GlcNHglycan	86	89	PF01048	0.691
MOD_GSK3_1	149	156	PF00069	0.619
MOD_GSK3_1	189	196	PF00069	0.739
MOD_GSK3_1	19	26	PF00069	0.740
MOD_GSK3_1	207	214	PF00069	0.777
MOD_GSK3_1	222	229	PF00069	0.567
MOD_GSK3_1	352	359	PF00069	0.594
MOD_GSK3_1	412	419	PF00069	0.749
MOD_GSK3_1	458	465	PF00069	0.714
MOD_GSK3_1	478	485	PF00069	0.781
MOD_GSK3_1	48	55	PF00069	0.663
MOD_GSK3_1	501	508	PF00069	0.607
MOD_GSK3_1	542	549	PF00069	0.806
MOD_GSK3_1	551	558	PF00069	0.668
MOD_GSK3_1	620	627	PF00069	0.574
MOD_GSK3_1	72	79	PF00069	0.692
MOD_GSK3_1	761	768	PF00069	0.465
MOD_N-GLC_1	546	551	PF02516	0.813
MOD_N-GLC_1	586	591	PF02516	0.479
MOD_NEK2_1	105	110	PF00069	0.589
MOD_NEK2_1	23	28	PF00069	0.739
MOD_NEK2_1	253	258	PF00069	0.720
MOD_NEK2_1	267	272	PF00069	0.583
MOD_NEK2_1	484	489	PF00069	0.749
MOD_NEK2_1	52	57	PF00069	0.564
MOD_NEK2_1	548	553	PF00069	0.746
MOD_NEK2_1	596	601	PF00069	0.454
MOD_OFUCOSY	747	753	PF10250	0.539
MOD_PIKK_1	174	180	PF00454	0.594
MOD_PIKK_1	207	213	PF00454	0.637
MOD_PIKK_1	426	432	PF00454	0.815
MOD_PIKK_1	530	536	PF00454	0.667
MOD_PIKK_1	542	548	PF00454	0.650
MOD_PIKK_1	662	668	PF00454	0.446
MOD_PIKK_1	722	728	PF00454	0.451
MOD_PIKK_1	90	96	PF00454	0.676
MOD_PKA_1	13	19	PF00069	0.521
MOD_PKA_1	552	558	PF00069	0.583
MOD_PKA_2	114	120	PF00069	0.675
MOD_PKA_2	13	19	PF00069	0.608
MOD_PKA_2	443	449	PF00069	0.765
MOD_PKA_2	498	504	PF00069	0.713
MOD_PKA_2	551	557	PF00069	0.737
MOD_PKB_1	450	458	PF00069	0.720
MOD_Plk_1	434	440	PF00069	0.824
MOD_Plk_1	546	552	PF00069	0.615
MOD_Plk_1	782	788	PF00069	0.445
MOD_Plk_1	90	96	PF00069	0.443
MOD_Plk_4	114	120	PF00069	0.675
MOD_Plk_4	19	25	PF00069	0.744
MOD_Plk_4	501	507	PF00069	0.678
MOD_ProDKin_1	214	220	PF00069	0.815
MOD_ProDKin_1	302	308	PF00069	0.554
MOD_ProDKin_1	362	368	PF00069	0.701
MOD_ProDKin_1	412	418	PF00069	0.715
MOD_ProDKin_1	467	473	PF00069	0.720
MOD_ProDKin_1	490	496	PF00069	0.754
MOD_ProDKin_1	553	559	PF00069	0.744
MOD_ProDKin_1	561	567	PF00069	0.665
MOD_ProDKin_1	679	685	PF00069	0.473
MOD_ProDKin_1	70	76	PF00069	0.665
MOD_ProDKin_1	761	767	PF00069	0.445
MOD_ProDKin_1	81	87	PF00069	0.608
MOD_ProDKin_1	840	846	PF00069	0.504
TRG_DiLeu_BaEn_1	376	381	PF01217	0.702
TRG_DiLeu_BaEn_1	91	96	PF01217	0.436
TRG_DiLeu_BaEn_4	167	173	PF01217	0.606
TRG_ENDOCYTIC_2	632	635	PF00928	0.541
TRG_ENDOCYTIC_2	819	822	PF00928	0.441
TRG_ER_diArg_1	12	14	PF00400	0.732
TRG_ER_diArg_1	172	174	PF00400	0.633
TRG_ER_diArg_1	262	265	PF00400	0.744
TRG_ER_diArg_1	293	295	PF00400	0.664
TRG_ER_diArg_1	497	500	PF00400	0.708
TRG_ER_diArg_1	96	98	PF00400	0.579
TRG_NES_CRM1_1	100	116	PF08389	0.583
TRG_NLS_MonoExtC_3	449	454	PF00514	0.668
TRG_NLS_MonoExtN_4	448	455	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P625	Leptomonas seymouri	45%	99%
A0A3S7WXX2	Leishmania donovani	92%	100%
A4HD26	Leishmania braziliensis	71%	100%
A4I0L3	Leishmania infantum	92%	100%
E9AWH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%