Putative Csl4p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome component CSL4, putative

Species:

Leishmania major

UniProt:

Q4QAZ6_LEIMA

TriTrypDb:

LmjF.23.1770 , LMJLV39_230025900 , LMJSD75_230026500

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	2
GO:0000177	cytoplasmic exosome (RNase complex)	5	2
GO:0000178	exosome (RNase complex)	4	11
GO:0005737	cytoplasm	2	10
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	10
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11

Expansion

Sequence features

Q4QAZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAZ6

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.446
CLV_PCSK_KEX2_1	264	266	PF00082	0.419
CLV_PCSK_SKI1_1	164	168	PF00082	0.702
CLV_PCSK_SKI1_1	181	185	PF00082	0.291
CLV_PCSK_SKI1_1	190	194	PF00082	0.401
DEG_SPOP_SBC_1	60	64	PF00917	0.407
DOC_CYCLIN_yCln2_LP_2	199	202	PF00134	0.540
DOC_MAPK_DCC_7	196	206	PF00069	0.419
DOC_MAPK_gen_1	264	270	PF00069	0.486
DOC_MAPK_MEF2A_6	132	141	PF00069	0.409
DOC_PP1_SILK_1	181	186	PF00149	0.365
DOC_PP2B_LxvP_1	199	202	PF13499	0.429
DOC_PP4_FxxP_1	18	21	PF00568	0.476
DOC_USP7_MATH_1	113	117	PF00917	0.640
DOC_USP7_MATH_1	61	65	PF00917	0.586
DOC_USP7_MATH_1	93	97	PF00917	0.581
DOC_USP7_MATH_1	98	102	PF00917	0.625
DOC_WW_Pin1_4	120	125	PF00397	0.665
DOC_WW_Pin1_4	17	22	PF00397	0.496
LIG_14-3-3_CanoR_1	87	92	PF00244	0.383
LIG_BRCT_BRCA1_1	176	180	PF00533	0.564
LIG_BRCT_BRCA1_1	204	208	PF00533	0.432
LIG_CtBP_PxDLS_1	203	207	PF00389	0.450
LIG_FHA_1	134	140	PF00498	0.436
LIG_FHA_1	271	277	PF00498	0.500
LIG_FHA_2	229	235	PF00498	0.364
LIG_FHA_2	242	248	PF00498	0.418
LIG_LIR_Apic_2	15	21	PF02991	0.468
LIG_LIR_Apic_2	53	58	PF02991	0.512
LIG_LIR_Nem_3	177	183	PF02991	0.434
LIG_PTAP_UEV_1	57	62	PF05743	0.508
LIG_SH2_PTP2	55	58	PF00017	0.522
LIG_SH2_STAT3	250	253	PF00017	0.559
LIG_SH2_STAT3	51	54	PF00017	0.341
LIG_SH2_STAT5	51	54	PF00017	0.541
LIG_SH2_STAT5	55	58	PF00017	0.580
LIG_SH3_1	279	285	PF00018	0.470
LIG_SH3_1	55	61	PF00018	0.498
LIG_SH3_2	191	196	PF14604	0.449
LIG_SH3_3	118	124	PF00018	0.594
LIG_SH3_3	125	131	PF00018	0.483
LIG_SH3_3	188	194	PF00018	0.409
LIG_SH3_3	279	285	PF00018	0.470
LIG_SH3_3	55	61	PF00018	0.551
LIG_SUMO_SIM_par_1	1	7	PF11976	0.487
LIG_TRAF2_1	35	38	PF00917	0.632
LIG_WRC_WIRS_1	239	244	PF05994	0.453
MOD_CDK_SPK_2	120	125	PF00069	0.586
MOD_CK1_1	116	122	PF00069	0.615
MOD_CK1_1	159	165	PF00069	0.509
MOD_CK1_1	241	247	PF00069	0.535
MOD_CK1_1	59	65	PF00069	0.611
MOD_CK2_1	228	234	PF00069	0.358
MOD_CK2_1	241	247	PF00069	0.436
MOD_CK2_1	269	275	PF00069	0.489
MOD_Cter_Amidation	262	265	PF01082	0.454
MOD_GlcNHglycan	100	103	PF01048	0.579
MOD_GlcNHglycan	117	121	PF01048	0.640
MOD_GlcNHglycan	167	170	PF01048	0.619
MOD_GlcNHglycan	176	179	PF01048	0.454
MOD_GlcNHglycan	58	61	PF01048	0.641
MOD_GlcNHglycan	63	66	PF01048	0.607
MOD_GSK3_1	116	123	PF00069	0.734
MOD_GSK3_1	238	245	PF00069	0.461
MOD_GSK3_1	56	63	PF00069	0.566
MOD_GSK3_1	70	77	PF00069	0.433
MOD_N-GLC_1	156	161	PF02516	0.398
MOD_NEK2_1	139	144	PF00069	0.382
MOD_NEK2_1	269	274	PF00069	0.523
MOD_NEK2_2	133	138	PF00069	0.488
MOD_PIKK_1	217	223	PF00454	0.374
MOD_PK_1	87	93	PF00069	0.468
MOD_PKA_2	139	145	PF00069	0.368
MOD_PKA_2	270	276	PF00069	0.488
MOD_Plk_1	156	162	PF00069	0.481
MOD_Plk_4	238	244	PF00069	0.459
MOD_Plk_4	87	93	PF00069	0.425
MOD_ProDKin_1	120	126	PF00069	0.664
MOD_ProDKin_1	17	23	PF00069	0.512
MOD_SUMO_for_1	256	259	PF00179	0.469
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.374
TRG_NES_CRM1_1	198	212	PF08389	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ0	Leptomonas seymouri	59%	97%
A0A0S4IM15	Bodo saltans	34%	98%
A0A3Q8IBW8	Leishmania donovani	94%	100%
A0A422NJG6	Trypanosoma rangeli	45%	100%
A4HD27	Leishmania braziliensis	80%	100%
A4I0L4	Leishmania infantum	94%	100%
C9ZNQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	92%
E9AWH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AR97	Trypanosoma cruzi	45%	100%