LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAZ1_LEIMA

TriTrypDb:

LmjF.23.1470 , LMJLV39_230026400 , LMJSD75_230027000

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QAZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAZ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.437
CLV_C14_Caspase3-7	164	168	PF00656	0.745
CLV_C14_Caspase3-7	75	79	PF00656	0.356
CLV_NRD_NRD_1	110	112	PF00675	0.530
CLV_PCSK_KEX2_1	110	112	PF00082	0.530
CLV_PCSK_KEX2_1	210	212	PF00082	0.702
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.702
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DOC_ANK_TNKS_1	210	217	PF00023	0.527
DOC_CDC14_PxL_1	29	37	PF14671	0.413
DOC_CKS1_1	129	134	PF01111	0.554
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.481
DOC_MAPK_gen_1	151	160	PF00069	0.512
DOC_MAPK_gen_1	54	62	PF00069	0.368
DOC_MAPK_MEF2A_6	54	62	PF00069	0.480
DOC_PP2B_LxvP_1	96	99	PF13499	0.509
DOC_USP7_MATH_1	147	151	PF00917	0.427
DOC_USP7_MATH_1	89	93	PF00917	0.523
DOC_WW_Pin1_4	128	133	PF00397	0.562
DOC_WW_Pin1_4	37	42	PF00397	0.478
DOC_WW_Pin1_4	82	87	PF00397	0.557
LIG_14-3-3_CanoR_1	111	117	PF00244	0.459
LIG_Clathr_ClatBox_1	57	61	PF01394	0.468
LIG_CSL_BTD_1	38	41	PF09270	0.473
LIG_FHA_1	154	160	PF00498	0.609
LIG_FHA_1	203	209	PF00498	0.529
LIG_FHA_1	44	50	PF00498	0.481
LIG_FHA_2	164	170	PF00498	0.670
LIG_FHA_2	191	197	PF00498	0.740
LIG_FHA_2	210	216	PF00498	0.687
LIG_LIR_Gen_1	40	50	PF02991	0.399
LIG_LIR_Nem_3	115	119	PF02991	0.396
LIG_LIR_Nem_3	137	142	PF02991	0.388
LIG_LIR_Nem_3	37	42	PF02991	0.419
LIG_NRBOX	44	50	PF00104	0.505
LIG_NRBOX	92	98	PF00104	0.516
LIG_Pex14_2	135	139	PF04695	0.413
LIG_SH2_STAT5	42	45	PF00017	0.490
LIG_SH3_3	126	132	PF00018	0.554
LIG_SH3_3	30	36	PF00018	0.378
LIG_SH3_3	80	86	PF00018	0.420
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.453
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.373
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.407
LIG_SUMO_SIM_par_1	120	126	PF11976	0.459
LIG_SUMO_SIM_par_1	144	150	PF11976	0.406
LIG_SUMO_SIM_par_1	56	61	PF11976	0.544
LIG_SUMO_SIM_par_1	72	78	PF11976	0.369
LIG_TRAF2_1	105	108	PF00917	0.517
LIG_TRAF2_1	168	171	PF00917	0.650
LIG_TRAF2_1	176	179	PF00917	0.633
LIG_TRAF2_1	180	183	PF00917	0.630
LIG_TRAF2_1	197	200	PF00917	0.640
LIG_TRAF2_1	20	23	PF00917	0.557
LIG_UBA3_1	48	56	PF00899	0.468
LIG_UBA3_1	62	67	PF00899	0.420
MOD_CK1_1	115	121	PF00069	0.307
MOD_CK1_1	163	169	PF00069	0.621
MOD_CK1_1	189	195	PF00069	0.694
MOD_CK1_1	40	46	PF00069	0.374
MOD_CK2_1	101	107	PF00069	0.508
MOD_CK2_1	165	171	PF00069	0.628
MOD_CK2_1	172	178	PF00069	0.633
MOD_CK2_1	190	196	PF00069	0.508
MOD_CK2_1	200	206	PF00069	0.627
MOD_CK2_1	209	215	PF00069	0.533
MOD_GlcNHglycan	189	192	PF01048	0.760
MOD_GlcNHglycan	29	32	PF01048	0.481
MOD_GSK3_1	134	141	PF00069	0.491
MOD_GSK3_1	173	180	PF00069	0.683
MOD_GSK3_1	186	193	PF00069	0.728
MOD_GSK3_1	194	201	PF00069	0.735
MOD_NEK2_1	112	117	PF00069	0.455
MOD_NEK2_1	27	32	PF00069	0.510
MOD_NEK2_1	4	9	PF00069	0.404
MOD_PIKK_1	22	28	PF00454	0.583
MOD_PKA_2	194	200	PF00069	0.794
MOD_PKB_1	151	159	PF00069	0.608
MOD_Plk_1	22	28	PF00069	0.446
MOD_Plk_2-3	165	171	PF00069	0.613
MOD_Plk_2-3	173	179	PF00069	0.569
MOD_Plk_2-3	198	204	PF00069	0.713
MOD_Plk_4	134	140	PF00069	0.568
MOD_Plk_4	89	95	PF00069	0.422
MOD_ProDKin_1	128	134	PF00069	0.558
MOD_ProDKin_1	37	43	PF00069	0.482
MOD_ProDKin_1	82	88	PF00069	0.557
TRG_DiLeu_BaEn_4	107	113	PF01217	0.524
TRG_DiLeu_BaEn_4	22	28	PF01217	0.522
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.488
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.520
TRG_ENDOCYTIC_2	42	45	PF00928	0.490
TRG_ER_diArg_1	109	111	PF00400	0.535
TRG_NLS_MonoExtC_3	209	215	PF00514	0.738
TRG_NLS_MonoExtN_4	207	214	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B1	Leptomonas seymouri	72%	100%
A0A0S4JGB7	Bodo saltans	33%	91%
A0A1X0NX37	Trypanosomatidae	46%	100%
A0A3S5H7C5	Leishmania donovani	95%	100%
A0A422NJD9	Trypanosoma rangeli	52%	72%
A4HD31	Leishmania braziliensis	85%	96%
A4I0L8	Leishmania infantum	94%	100%
C9ZNR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AWH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BFS2	Trypanosoma cruzi	52%	81%