Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAY9_LEIMA

TriTrypDb:

LmjF.23.1490 , LMJLV39_230026600 , LMJSD75_230027200

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

Q4QAY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.397
CLV_NRD_NRD_1	145	147	PF00675	0.466
CLV_NRD_NRD_1	230	232	PF00675	0.541
CLV_NRD_NRD_1	244	246	PF00675	0.303
CLV_NRD_NRD_1	281	283	PF00675	0.599
CLV_PCSK_FUR_1	143	147	PF00082	0.532
CLV_PCSK_KEX2_1	145	147	PF00082	0.482
CLV_PCSK_KEX2_1	230	232	PF00082	0.541
CLV_PCSK_KEX2_1	244	246	PF00082	0.303
CLV_PCSK_SKI1_1	102	106	PF00082	0.427
CLV_PCSK_SKI1_1	200	204	PF00082	0.533
CLV_PCSK_SKI1_1	34	38	PF00082	0.504
CLV_PCSK_SKI1_1	43	47	PF00082	0.476
CLV_Separin_Metazoa	241	245	PF03568	0.634
DEG_APCC_DBOX_1	116	124	PF00400	0.544
DOC_CDC14_PxL_1	130	138	PF14671	0.456
DOC_CYCLIN_RxL_1	194	205	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.536
DOC_MAPK_gen_1	34	44	PF00069	0.382
DOC_MAPK_MEF2A_6	153	162	PF00069	0.546
DOC_PP2B_LxvP_1	156	159	PF13499	0.522
DOC_PP4_MxPP_1	132	135	PF00568	0.574
DOC_USP7_MATH_1	119	123	PF00917	0.479
DOC_USP7_MATH_1	168	172	PF00917	0.499
DOC_USP7_MATH_1	84	88	PF00917	0.614
DOC_USP7_UBL2_3	34	38	PF12436	0.560
DOC_USP7_UBL2_3	93	97	PF12436	0.609
LIG_14-3-3_CanoR_1	102	107	PF00244	0.513
LIG_14-3-3_CanoR_1	146	156	PF00244	0.501
LIG_14-3-3_CanoR_1	181	186	PF00244	0.494
LIG_14-3-3_CanoR_1	230	235	PF00244	0.550
LIG_14-3-3_CanoR_1	244	251	PF00244	0.277
LIG_Actin_WH2_2	29	45	PF00022	0.521
LIG_BRCT_BRCA1_1	213	217	PF00533	0.556
LIG_Clathr_ClatBox_1	69	73	PF01394	0.491
LIG_CtBP_PxDLS_1	159	163	PF00389	0.598
LIG_FHA_1	103	109	PF00498	0.565
LIG_FHA_1	113	119	PF00498	0.584
LIG_FHA_1	14	20	PF00498	0.506
LIG_FHA_1	153	159	PF00498	0.524
LIG_FHA_1	182	188	PF00498	0.533
LIG_FHA_1	21	27	PF00498	0.550
LIG_FHA_1	210	216	PF00498	0.491
LIG_FHA_1	31	37	PF00498	0.470
LIG_FHA_2	152	158	PF00498	0.511
LIG_FHA_2	3	9	PF00498	0.657
LIG_IRF3_LxIS_1	119	126	PF10401	0.519
LIG_LIR_Gen_1	28	36	PF02991	0.514
LIG_LIR_Nem_3	193	199	PF02991	0.505
LIG_LIR_Nem_3	28	32	PF02991	0.490
LIG_LIR_Nem_3	64	69	PF02991	0.422
LIG_NRBOX	198	204	PF00104	0.452
LIG_PDZ_Class_3	300	305	PF00595	0.760
LIG_SH2_NCK_1	10	14	PF00017	0.565
LIG_SH2_STAP1	10	14	PF00017	0.643
LIG_SH2_STAP1	58	62	PF00017	0.526
LIG_SH3_3	189	195	PF00018	0.557
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.511
LIG_SUMO_SIM_par_1	16	23	PF11976	0.493
LIG_SUMO_SIM_par_1	43	48	PF11976	0.516
LIG_SUMO_SIM_par_1	68	73	PF11976	0.503
LIG_TRAF2_1	219	222	PF00917	0.637
LIG_UBA3_1	18	25	PF00899	0.651
LIG_WRC_WIRS_1	182	187	PF05994	0.483
MOD_CK1_1	28	34	PF00069	0.538
MOD_CK2_1	230	236	PF00069	0.543
MOD_GlcNHglycan	125	128	PF01048	0.550
MOD_GlcNHglycan	246	249	PF01048	0.365
MOD_GlcNHglycan	39	42	PF01048	0.498
MOD_GSK3_1	102	109	PF00069	0.640
MOD_GSK3_1	119	126	PF00069	0.444
MOD_GSK3_1	13	20	PF00069	0.511
MOD_GSK3_1	147	154	PF00069	0.535
MOD_GSK3_1	271	278	PF00069	0.524
MOD_GSK3_1	61	68	PF00069	0.507
MOD_N-GLC_1	123	128	PF02516	0.455
MOD_N-GLC_1	151	156	PF02516	0.606
MOD_NEK2_1	123	128	PF00069	0.455
MOD_NEK2_1	209	214	PF00069	0.479
MOD_NEK2_1	65	70	PF00069	0.412
MOD_NEK2_1	72	77	PF00069	0.403
MOD_NEK2_1	91	96	PF00069	0.569
MOD_NMyristoyl	1	7	PF02799	0.617
MOD_PIKK_1	20	26	PF00454	0.578
MOD_PKA_1	230	236	PF00069	0.553
MOD_PKA_1	244	250	PF00069	0.282
MOD_PKA_1	37	43	PF00069	0.437
MOD_PKA_2	230	236	PF00069	0.553
MOD_PKA_2	244	250	PF00069	0.282
MOD_PKA_2	271	277	PF00069	0.472
MOD_PKB_1	100	108	PF00069	0.439
MOD_PKB_1	179	187	PF00069	0.485
MOD_Plk_1	151	157	PF00069	0.607
MOD_Plk_1	188	194	PF00069	0.559
MOD_Plk_4	181	187	PF00069	0.617
MOD_Plk_4	271	277	PF00069	0.559
MOD_Plk_4	61	67	PF00069	0.529
MOD_SUMO_rev_2	290	296	PF00179	0.645
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.467
TRG_ER_diArg_1	100	103	PF00400	0.579
TRG_ER_diArg_1	142	145	PF00400	0.486
TRG_ER_diArg_1	179	182	PF00400	0.358
TRG_ER_diArg_1	229	231	PF00400	0.538
TRG_ER_diArg_1	243	245	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL46	Leptomonas seymouri	52%	100%
A0A3Q8ICP4	Leishmania donovani	93%	100%
A0A3R7NP81	Trypanosoma rangeli	37%	100%
A4HD33	Leishmania braziliensis	77%	100%
A4I0M0	Leishmania infantum	94%	100%
E9AWI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%