Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAY8_LEIMA

TriTrypDb:

LmjF.23.1500 , LMJLV39_230026700 , LMJSD75_230027300

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.415
CLV_NRD_NRD_1	222	224	PF00675	0.506
CLV_PCSK_KEX2_1	10	12	PF00082	0.455
CLV_PCSK_KEX2_1	222	224	PF00082	0.506
CLV_PCSK_SKI1_1	170	174	PF00082	0.546
CLV_PCSK_SKI1_1	307	311	PF00082	0.451
DEG_SPOP_SBC_1	333	337	PF00917	0.585
DOC_ANK_TNKS_1	18	25	PF00023	0.521
DOC_CKS1_1	71	76	PF01111	0.510
DOC_MAPK_DCC_7	404	413	PF00069	0.584
DOC_MAPK_gen_1	10	16	PF00069	0.443
DOC_MAPK_gen_1	219	228	PF00069	0.497
DOC_MAPK_MEF2A_6	219	228	PF00069	0.510
DOC_MAPK_MEF2A_6	404	413	PF00069	0.584
DOC_MAPK_NFAT4_5	223	231	PF00069	0.558
DOC_PP4_FxxP_1	213	216	PF00568	0.594
DOC_PP4_FxxP_1	71	74	PF00568	0.494
DOC_USP7_MATH_1	103	107	PF00917	0.531
DOC_USP7_MATH_1	152	156	PF00917	0.467
DOC_USP7_MATH_1	334	338	PF00917	0.619
DOC_USP7_MATH_1	36	40	PF00917	0.427
DOC_USP7_MATH_1	447	451	PF00917	0.540
DOC_USP7_MATH_1	83	87	PF00917	0.628
DOC_WW_Pin1_4	161	166	PF00397	0.597
DOC_WW_Pin1_4	70	75	PF00397	0.500
LIG_14-3-3_CanoR_1	194	202	PF00244	0.504
LIG_14-3-3_CanoR_1	260	268	PF00244	0.657
LIG_14-3-3_CanoR_1	31	35	PF00244	0.489
LIG_14-3-3_CanoR_1	51	57	PF00244	0.307
LIG_AP2alpha_2	299	301	PF02296	0.555
LIG_APCC_ABBA_1	12	17	PF00400	0.426
LIG_APCC_ABBAyCdc20_2	11	17	PF00400	0.439
LIG_BIR_II_1	1	5	PF00653	0.724
LIG_BIR_III_2	162	166	PF00653	0.457
LIG_CtBP_PxDLS_1	408	412	PF00389	0.616
LIG_FHA_1	151	157	PF00498	0.459
LIG_FHA_1	301	307	PF00498	0.509
LIG_FHA_1	322	328	PF00498	0.469
LIG_FHA_1	334	340	PF00498	0.629
LIG_FHA_1	351	357	PF00498	0.410
LIG_FHA_1	398	404	PF00498	0.483
LIG_FHA_1	57	63	PF00498	0.469
LIG_FHA_2	180	186	PF00498	0.525
LIG_FHA_2	370	376	PF00498	0.536
LIG_FHA_2	4	10	PF00498	0.508
LIG_FHA_2	64	70	PF00498	0.437
LIG_FHA_2	76	82	PF00498	0.461
LIG_LIR_Apic_2	211	216	PF02991	0.518
LIG_LIR_Apic_2	69	74	PF02991	0.486
LIG_LIR_Gen_1	175	183	PF02991	0.457
LIG_LIR_Gen_1	299	309	PF02991	0.477
LIG_LIR_Nem_3	175	179	PF02991	0.467
LIG_LIR_Nem_3	240	245	PF02991	0.512
LIG_LIR_Nem_3	299	304	PF02991	0.505
LIG_LIR_Nem_3	410	416	PF02991	0.574
LIG_LIR_Nem_3	43	49	PF02991	0.509
LIG_NRBOX	452	458	PF00104	0.537
LIG_PCNA_PIPBox_1	206	215	PF02747	0.450
LIG_Pex14_2	360	364	PF04695	0.428
LIG_Pex14_2	391	395	PF04695	0.457
LIG_Pex14_2	71	75	PF04695	0.476
LIG_REV1ctd_RIR_1	13	23	PF16727	0.456
LIG_SH2_STAP1	431	435	PF00017	0.460
LIG_SH2_STAT5	146	149	PF00017	0.453
LIG_SH2_STAT5	394	397	PF00017	0.466
LIG_SH2_STAT5	431	434	PF00017	0.487
LIG_SH2_STAT5	46	49	PF00017	0.472
LIG_SH3_2	417	422	PF14604	0.575
LIG_SH3_3	342	348	PF00018	0.584
LIG_SH3_3	411	417	PF00018	0.590
LIG_SUMO_SIM_par_1	323	332	PF11976	0.488
LIG_SUMO_SIM_par_1	39	45	PF11976	0.467
LIG_TRAF2_1	205	208	PF00917	0.421
LIG_TRAF2_1	372	375	PF00917	0.496
LIG_WRC_WIRS_1	68	73	PF05994	0.468
MOD_CDK_SPxxK_3	161	168	PF00069	0.464
MOD_CK1_1	145	151	PF00069	0.555
MOD_CK1_1	2	8	PF00069	0.562
MOD_CK1_1	332	338	PF00069	0.702
MOD_CK1_1	343	349	PF00069	0.622
MOD_CK1_1	52	58	PF00069	0.531
MOD_CK1_1	70	76	PF00069	0.448
MOD_CK2_1	145	151	PF00069	0.494
MOD_CK2_1	179	185	PF00069	0.576
MOD_CK2_1	288	294	PF00069	0.662
MOD_CK2_1	369	375	PF00069	0.514
MOD_CK2_1	63	69	PF00069	0.428
MOD_GlcNHglycan	1	4	PF01048	0.627
MOD_GlcNHglycan	156	159	PF01048	0.541
MOD_GlcNHglycan	197	200	PF01048	0.582
MOD_GlcNHglycan	262	265	PF01048	0.600
MOD_GlcNHglycan	330	334	PF01048	0.578
MOD_GlcNHglycan	342	345	PF01048	0.608
MOD_GlcNHglycan	458	461	PF01048	0.670
MOD_GlcNHglycan	51	54	PF01048	0.546
MOD_GlcNHglycan	56	59	PF01048	0.421
MOD_GlcNHglycan	85	88	PF01048	0.614
MOD_GlcNHglycan	92	95	PF01048	0.531
MOD_GSK3_1	1	8	PF00069	0.570
MOD_GSK3_1	141	148	PF00069	0.401
MOD_GSK3_1	150	157	PF00069	0.440
MOD_GSK3_1	251	258	PF00069	0.665
MOD_GSK3_1	328	335	PF00069	0.550
MOD_GSK3_1	339	346	PF00069	0.500
MOD_GSK3_1	36	43	PF00069	0.433
MOD_GSK3_1	369	376	PF00069	0.613
MOD_GSK3_1	52	59	PF00069	0.489
MOD_GSK3_1	63	70	PF00069	0.447
MOD_LATS_1	65	71	PF00433	0.430
MOD_N-GLC_2	108	110	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.649
MOD_NEK2_1	130	135	PF00069	0.511
MOD_NEK2_1	141	146	PF00069	0.492
MOD_NEK2_1	277	282	PF00069	0.675
MOD_NEK2_1	30	35	PF00069	0.482
MOD_NEK2_1	321	326	PF00069	0.510
MOD_NEK2_1	329	334	PF00069	0.461
MOD_NEK2_1	339	344	PF00069	0.442
MOD_NEK2_1	42	47	PF00069	0.452
MOD_NEK2_1	456	461	PF00069	0.631
MOD_NEK2_1	56	61	PF00069	0.441
MOD_NEK2_1	75	80	PF00069	0.591
MOD_NEK2_2	300	305	PF00069	0.486
MOD_NEK2_2	397	402	PF00069	0.531
MOD_PIKK_1	130	136	PF00454	0.642
MOD_PIKK_1	150	156	PF00454	0.272
MOD_PIKK_1	36	42	PF00454	0.455
MOD_PK_1	118	124	PF00069	0.507
MOD_PKA_2	193	199	PF00069	0.435
MOD_PKA_2	218	224	PF00069	0.629
MOD_PKA_2	248	254	PF00069	0.696
MOD_PKA_2	259	265	PF00069	0.565
MOD_PKA_2	30	36	PF00069	0.559
MOD_Plk_1	103	109	PF00069	0.578
MOD_Plk_1	315	321	PF00069	0.590
MOD_Plk_1	397	403	PF00069	0.493
MOD_Plk_4	118	124	PF00069	0.507
MOD_Plk_4	142	148	PF00069	0.440
MOD_Plk_4	208	214	PF00069	0.496
MOD_Plk_4	251	257	PF00069	0.730
MOD_Plk_4	288	294	PF00069	0.721
MOD_Plk_4	30	36	PF00069	0.462
MOD_Plk_4	315	321	PF00069	0.536
MOD_Plk_4	42	48	PF00069	0.451
MOD_ProDKin_1	161	167	PF00069	0.585
MOD_ProDKin_1	70	76	PF00069	0.507
MOD_SUMO_rev_2	423	430	PF00179	0.629
TRG_ENDOCYTIC_2	242	245	PF00928	0.705
TRG_ENDOCYTIC_2	27	30	PF00928	0.488
TRG_ER_diArg_1	10	12	PF00400	0.415
TRG_ER_diArg_1	222	224	PF00400	0.508
TRG_ER_diArg_1	401	404	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G3	Leptomonas seymouri	38%	100%
A0A3Q8ICP2	Leishmania donovani	93%	100%
A4HD34	Leishmania braziliensis	74%	100%
A4I0M1	Leishmania infantum	93%	100%
E9AWI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5ARA2	Trypanosoma cruzi	23%	100%